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Peripheral Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationTransplantation, AutologousTransplantation, HomologousTransplantation ConditioningHematopoietic Stem Cell MobilizationStem Cell TransplantationHematologic NeoplasmsGranulocyte Colony-Stimulating FactorGraft vs Host DiseaseAntigens, CD34Stem CellsGraft SurvivalLeukapheresisCombined Modality TherapyBone Marrow TransplantationCyclophosphamideMultiple MyelomaMelphalanHematopoietic Stem CellsTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsBlood Component RemovalBusulfanEtoposideMyeloablative AgonistsTissue DonorsCord Blood Stem Cell TransplantationTransplantation ChimeraRecurrenceRemission InductionHistocompatibilityLymphoma, Non-HodgkinHistocompatibility TestingAntineoplastic Agents, AlkylatingWhole-Body IrradiationImmunosuppressive AgentsRetrospective StudiesThiotepaPOEMS SyndromeDisease-Free SurvivalInfectionCytomegalovirus InfectionsLeukemiaVidarabineSalvage TherapyHematopoiesisTime FactorsTransplantation, IsogeneicSurvival RateAmyloidosisSurvival AnalysisGraft vs Leukemia EffectLeukemia, Myeloid, AcuteHodgkin DiseaseOpportunistic InfectionsBlood CellsIfosfamideEmbryonic Stem CellsVincristineCytarabineCarmustineAnemia, AplasticMyelodysplastic SyndromesPlatelet CountFatal OutcomeLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAdult Stem CellsMesenchymal Stem Cell TransplantationHematologic DiseasesNeoplasmsLymphomaLymphocyte DepletionFollow-Up StudiesKidney TransplantationBlood Cell CountCyclosporinePrecursor Cell Lymphoblastic Leukemia-LymphomaTransplantationHLA AntigensImmunosuppressionFeasibility StudiesCytophagocytosisLiver TransplantationProspective StudiesBlood DonorsBone MarrowImmunophenotypingCell DifferentiationPluripotent Stem CellsHistiocytosis, Non-Langerhans-CellBone Marrow PurgingLivedo ReticularisImmunocompromised HostDoxorubicinFlow CytometryRecombinant ProteinsPrognosisAntineoplastic AgentsCell Transplantation
Multiple myelomaDonorsMarrow transplantationCyclophosphamideHSCTRecipientsPatientsCord blood transplantationGraft versusHaploidenticalDonor stem cell transPatient'sUmbilicalClinicalHigh-doseComplicationsHematopoietic progenitorGranulocyte- colonAutologous peripheralCancersApheresisDonor'sOutcomesAplasticIndication for transplantationCentersAllogeneic transplantsTherapyInfectionsPatientSyngeneic transplantsSurvivalHaving a bone marrow traHematologic malignanciesOutcomeOrgans and tissuesMalignanciesKidney transplantation2021PlateletsAllogenicSignificantlyProgenitor cellMobilizationTherBone marrow stemImmuneRejectionImmature
Multiple myeloma11
Donors15
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
  • This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
  • Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
  • This site provides information, referrals, and support by trained peer volunteers who are transplant survivors, caregivers, and donors. (myeloma.org)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • To investigate cord blood as a possible solution to a critical public health need: finding appropriate hematopoietic transplants for patients who have no matched bone marrow donors. (schoolandyouth.org)
  • The hypothesis states that the 100 day mortality after this type of transplant will be significantly below the accepted standards, which is about 30% for unrelated donors. (mycancergenome.org)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Marrow transplantation21
Cyclophosphamide3
HSCT14
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • Although outcomes after HSCT have improved markedly since transplants were first utilized, infection remains an important source of morbidity. (medscape.com)
  • The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Recipients9
  • In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
  • Gassas A , Grant R , Richardson S , Dupuis LL , Doyle J , Allen U , Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. (cdc.gov)
  • Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • Prognostic value of the pre-transplant diastolic pulmonary artery pressure-to-pulmonary capillary wedge pressure gradient in cardiac transplant recipients with pulmonary hypertension. (jefferson.edu)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • With greater experience and analysis of significant numbers of cases, lung transplant recipients are living longer, and follow-up regimens are becoming streamlined. (medscape.com)
  • Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
  • Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)
Patients83
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • Cord blood and haploidentical (half-matched) transplants are used to treat an increasing number of patients. (bmtinfonet.org)
  • Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
  • Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
  • Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
  • LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
  • Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
  • After completion of study treatment, patients are followed weekly for 100 days post-transplantation and then periodically for survival. (knowcancer.com)
  • Wisplinghoff H , Reinert RR , Cornely O , Seifert H . Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients. (cdc.gov)
  • Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
  • In a study reported in The New England Journal of Medicine , R. Coleman Lindsley, MD, PhD , of Dana-Farber Cancer Institute, and colleagues found that a number of mutations present in patients with myelodysplastic syndromes (MDS) were associated with poorer clinical outcome after allogeneic hematopoietic stem cell transplantation. (ascopost.com)
  • The study involved targeted mutational analysis of samples obtained before stem cell transplant from 1,514 MDS patients enrolled at the Center for International Blood and Marrow Transplant Research Repository between 2005 and 2014. (ascopost.com)
  • Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem-cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen. (ascopost.com)
  • The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
  • The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • one of the patients reached the 30-month post-transplant mark in starkly improved health. (lww.com)
  • Those patients may be re-transplanted. (lww.com)
  • Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
  • Determining the mechanisms of viral acceleration of chronic allograft rejection from latently infected donor, which is the most common cause of HCMV-associated disease in transplant patients associated with expression during the different stages of viremia associated with CMV including. (ohsu.edu)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • This is a single arm, open-label, multi-center, Phase 1 study to determine the safety and tolerability of an experimental therapy called NKX019 (allogeneic CAR NK cells targeting CD19) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL), chronic lymphocytic. (uchicagomedicine.org)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
  • CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets. (stembook.org)
  • Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
  • BMT InfoNet provides emotional support and information about bone marrow and peripheral blood stem cell transplants to patients and their loved ones. (myeloma.org)
  • This site provides information for patients and their families ranges from data about transplant outcomes to best practices in follow-up care for patients post-transplant. (myeloma.org)
  • This site provides information about bone marrow or cord blood transplant process for patients, their families, and health care providers. (myeloma.org)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • Transplant patients, survivors and their caregivers in the U.S. (schoolandyouth.org)
  • BMT InfoNet is dedicated to providing transplant patients, survivors and their loved ones with emotional support and high quality, easy-to-understand information about bone marrow, peripheral blood stem cell and cord blood transplants. (schoolandyouth.org)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
  • Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
  • Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
  • These immature stem cells were easier to match to patients, especially those from non-Caucasian ethnicities, and could be stored for use as needed. (biologynews.net)
  • Once the process is complete, the NK cells can be transplanted to patients without prior chemotherapy. (biologynews.net)
  • Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
  • Bone marrow transplant is a recommended therapy for patients with certain types of cancers or diseases. (medtravelhelp.com)
  • The Apollo Cancer Centre at Teynampet, Chennai is India's first standalone cancer treatment facility with bone marrow transplant (BMT) expertise that has been serving patients since 1993. (medtravelhelp.com)
  • Thirty-eight patients (4.83%) had pathologic findings before transplantation. (slideshare.net)
  • 05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • After undergoing bone marrow or peripheral blood stem cell transplantation, patients experience a loss of vaccine protection. (fwf.ac.at)
  • After receiving stem cell transplants, patients lose vaccination protection. (fwf.ac.at)
  • In the first months after receiving stem cell transplantation, the patients have a considerably increased risk of all kinds of viral, bacterial or fungal infections", explains Christina Forstner from the Medical University of Vienna in the interview with scilog. (fwf.ac.at)
  • Depending on the particular vaccine, there are different recommendations when to re-immunise patients after stem cell transplantation. (fwf.ac.at)
  • The latter type presents no risk to healthy individuals but may become dangerous for immunosuppressed patients, which is why the waiting period after stem cell transplantation needs to be longer. (fwf.ac.at)
  • As a general principle, inactivated vaccines such as the TBE vaccine can be administered earlier, but: "In the first three or four months after transplantation, patients are not even capable of developing immunity", warns Forster. (fwf.ac.at)
  • Particularly in the case of TBE vaccination, there is not a single study among stem cell transplant patients anywhere in the world. (fwf.ac.at)
  • Forstner's ongoing study includes 17 patients who are given basic TBE immunisation 11 to 13 months after stem cell transplantation. (fwf.ac.at)
  • A special case is the group of patients with transplant rejection reactions, particularly the so-called "graft-versus-host-disease" (GVHD), where the new immune system attacks the body. (fwf.ac.at)
  • It was shown that more than half of the patients had a surprisingly high number of neutralising antibodies against TBE even one year after stem cell transplantation. (fwf.ac.at)
  • PURPOSE: This phase I/II trial is studying the side effects and best dose of donor natural killer cells when given after a donor stem cell transplant in treating patients with advanced cancer. (bioseek.eu)
  • To assess the safety of donor natural killer (NK) cell infusion after HLA-mismatched/haploidentical allogeneic hematopoietic stem cell transplantation from a familial donor in patients with advanced malignant disorders. (bioseek.eu)
  • To determine the maximum number of donor NK cells that can be safely given to these patients. (bioseek.eu)
  • To assess the clinical efficacy donor NK cell infusion, in terms of tumor response, response duration, and survival, in patients with progressive or recurrent malignant disorders. (bioseek.eu)
  • Phase I: Patients receive an infusion of donor natural killer (NK) cells on days 18 and 21. (bioseek.eu)
  • Phase II: Patients receive an infusion of donor NK cells on days 14 and 21. (bioseek.eu)
  • Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor. (uchicago.edu)
  • Following the that form of treatment, there is consolidation treatment that may include more high-dose chemotherapy or even a stem cell transplant for patients who have not yet reached 60 years of age. (disabilitybenefitscenter.org)
  • Transplantation is much more likely to be used on younger patients and is more likely to extend lifespan in those who are younger. (disabilitybenefitscenter.org)
  • Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
  • A paucity of platelets, red blood cells (RBCs), granulocytes, monocytes, and reticulocytes is found in patients with aplastic anemia. (medscape.com)
  • Because the extent of previous transfusion has been shown to significantly affect the outcomes of patients undergoing hematopoietic cell transplantation (HCT) for aplastic anemia, the rapidity with which these data are obtained is crucial. (medscape.com)
  • We are currently performing clinical study to characterize the phenotype and gene expression profile of peripheral blood monocytes in patients with stroke. (lu.se)
  • CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
  • In this context, patients experience the first psychological conflicts before this transplant. (bvsalud.org)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
  • The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
  • Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
Cord blood transplantation2
Graft versus2
  • Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
  • The secondary objectives are to evaluate the relapse-free and overall survival after hematopoietic stem cell transplant as well as to evaluate the incidence of acute and chronic graft-versus-host disease after this preparative regimen. (mycancergenome.org)
Haploidentical2
  • The three main categories of allogeneic transplantation are HLA identical, HLA mismatched, and haploidentical. (medscape.com)
  • 2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)
Donor stem cell trans1
  • RATIONALE: Giving an infusion of natural killer cells from a donor after a donor stem cell transplant may help kill any remaining cancer cells after the transplant. (bioseek.eu)
Patient's8
  • Autologous transplantation is feasible when the patient's bone marrow is normal and there are no relevant genetic conditions. (medscape.com)
  • They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
  • Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • The patient's own, or the donated bone marrow or peripheral stem cells or cord blood will then be given through the central line into a vein. (medtravelhelp.com)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • During transplantation, the doctors first destroy the body's own stem cells as completely as possible by radiation and chemotherapy before injecting new stem cells into the patient's bloodstream. (fwf.ac.at)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
Umbilical9
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
  • A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
  • Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
  • Cord blood stem cells can be collected from the umbilical cord and placenta after a baby is born. (schoolandyouth.org)
  • Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood. (biologynews.net)
  • This is the blood that is left behind in the placenta and the umbilical cord after the delivery of a baby. (medtravelhelp.com)
  • peripheral blood, or placental/umbilical cord blood). (cdc.gov)
Clinical8
  • CHICAGO-Noteworthy clinical gains have resulted from an allogeneic stem cell transplantation in a patient with mitochondrial neurogastrointestinal encephalomyopathy, or MNGIE, a Columbia University neurologist reported at the AAN annual meeting here in April. (lww.com)
  • Dr. Hirano's results are most encouraging, but a few more cases need to be studied with objective clinical measures pre-and post-transplant over a few years before we can conclude this treatment is definitely the right thing to do. (lww.com)
  • Established to conduct large multi-institutional clinical trials in hematopoietic stem cell transplantation. (myeloma.org)
  • This site provides information about stem cell transplants provided by the American Society of Clinical Oncology (ASCO). (myeloma.org)
  • To advance the clinical application of newborn stem cells by partnering with leading research institutions to establish FDA-regulated clinical trials, exclusive to CBR families, for conditions that have no cure today. (schoolandyouth.org)
  • Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
  • The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)
  • By linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson's disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms. (lu.se)
High-dose6
Complications2
  • CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
Hematopoietic progenitor2
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • By demonstrating compliance with the FACT-JACIE International Standards for Cellular Therapy Product Collection, Processing and Administration , the joint program of Fox Chase Cancer Center and Temple has earned FACT reaccreditation for adult allogeneic and autologous hematopoietic progenitor cell transplantation, peripheral blood cellular therapy product collection, and cellular therapy product processing with minimal manipulation. (foxchase.org)
Granulocyte- colon5
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
  • Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
Autologous peripheral1
Cancers2
Apheresis6
  • Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
  • The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
  • The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
  • Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
  • A key requisite for ASCT is mobilization of hematopoietic stem cells into peripheral blood, where they are collected by apheresis and stored for later transplantation. (bvsalud.org)
Donor's6
Outcomes1
Aplastic2
  • Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
  • Aplastic anemia is diagnosed with blood and bone marrow studies. (medscape.com)
Indication for transplantation1
Centers1
  • Since 2007, FACT accreditation has been used in determining the U.S. News & World report rankings of transplant centers for the "America's Best Hospitals" and "America's Best Children's Hospitals" list. (foxchase.org)
Allogeneic transplants4
Therapy17
  • As of 2016[update], the only established medical therapy using stem cells is hematopoietic stem cell transplantation, first performed in 1958 by French oncologist Georges Mathé. (wikipedia.org)
  • Somatic cell nuclear transfer is a cloning method that can be used to create a cloned embryo for the use of its embryonic stem cells in stem cell therapy. (wikipedia.org)
  • The first therapy using stem cells was a bone marrow transplant performed by French oncologist Georges Mathé in 1958 on five workers at the Vinča Nuclear Institute in Yugoslavia who had been affected by a criticality accident. (wikipedia.org)
  • Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
  • My condition improved a lot after stem cell therapy and ozone bath. (placidway.com)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Radiation therapy: It utilizes high-energy rays to destroy cancer cells. (ndtv.com)
  • Targeted therapy: This therapy uses drugs that target only cancer cells without harming normal cells and is most commonly used to treat leukaemia. (ndtv.com)
  • However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells. (biologynews.net)
  • At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
  • In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
  • PHILADELPHIA (February 8, 2017) - The Fox Chase-Temple University Hospital Bone Marrow Transplant Program has received internationally-recognized reaccreditation by the Foundation for the Accreditation of Cellular Therapy (FACT) at the University of Nebraska Medical Center. (foxchase.org)
  • FACT is an internationally-recognized accrediting body for hospitals and medical institutions offering stem cell transplant, and indicates the accredited institution has met the most rigorous standards in every aspect of stem cell therapy. (foxchase.org)
  • FACT-JACIE Standards are defined by leading experts based on the latest knowledge of the field of cellular therapy transplantation. (foxchase.org)
  • Transplantation and Cellular Therapy, Jul. (kyoto-u.ac.jp)
  • Transplantation and Cellular Therapy, Jun. (kyoto-u.ac.jp)
  • Manufacturing results of tisagenlecleucel for acute lymphoblastic leukemia: a survey by the CAR-T cell therapy taskforce of the Japan Society of Transfusion Medicine and Cell Therapy]. (kyoto-u.ac.jp)
Infections6
  • However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
  • During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)
  • Chronic granulomatous disease (CGD) is a type of primary immunodeficiency (PI) in which one group of the body's white blood cells, called neutrophils, fail to make the hydrogen peroxide, bleach, and other chemicals needed to fight bacterial and fungal infections. (primaryimmune.org)
  • External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
  • Leukaemia on the other hand is a type of cancer that affects all white blood cells and prevents them from carrying out their main function-fighting off infections. (ndtv.com)
  • Myeloma is a type of cancer affecting the plasma, which is also a type of white blood cells that produce antibodies to ward off infections. (ndtv.com)
Patient14
  • Dr. Hirano said he hopes the case will alert neurologists to be more vigilant in considering the possibility of MNGIE when faced with a patient with the syndrome of ophthalmoplegia, severe GI dysmotility, extreme cachexia, peripheral neuropathy, and leukoencephalopathy. (lww.com)
  • The other patient who had the transplant, however, died three months after the procedure, his condition having already reached a more severe stage before the transplant. (lww.com)
  • In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
  • These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)
  • These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. (biologynews.net)
  • A bone marrow transplant is a process of transferring healthy bone marrow cells from a donor to a patient who has unhealthy bone marrow. (medtravelhelp.com)
  • About a week or two before the bone marrow harvest is done, the patient (or the donor, for an Allogeneic transplantation) may have 1 to 2 units of blood taken. (medtravelhelp.com)
  • On occasions when the patient does not have a good matched relative / unrelated donor, a partially matched, unrelated cord blood with adequate cell dose would be an option. (medtravelhelp.com)
  • These new cells will repopulate the bone marrow, thus giving the patient a completely new immune system resembling that of the donor. (fwf.ac.at)
  • For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
  • Emphysema is end stage and generalized by the time the patient needs transplantation. (medscape.com)
  • In addition, using iPS and iN cell technology patient-specific cells can be generated for transplantation, avoiding the need for immunosuppression and risk for rejection. (lu.se)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
Syngeneic transplants1
Survival3
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Having a bone marrow tra1
Hematologic malignancies1
Outcome1
Organs and tissues4
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
Malignancies2
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Autologous Stem Cell Transplant (ASCT) is increasingly used to treat hematological malignancies. (bvsalud.org)
Kidney transplantation1
20212
Platelets3
Allogenic2
Significantly2
  • Testing blood sugar level using SMBG device is considered as accurate during exercise when blood sugar level fluctuates frequently, as it's more accurate to use the fingertip than testing at alternate sites which may give significantly different results in these situations. (thebusinessresearchcompany.com)
  • Transplantation increases treatment costs significantly. (disabilitybenefitscenter.org)
Progenitor cell2
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
Mobilization3
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • The stem cell mobilization result was poor. (cdc.gov)
  • Addition of propranolol to the G-CSF and GPC-100 combination resulted in greater stem cell mobilization than the G-CSF and plerixafor combination. (bvsalud.org)
Ther2
Bone marrow stem1
Immune9
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • In an attempt to control infection, masses of neutrophils and other immune cells continue to gather at the site of infection, forming large groups of these cells called granulomas, hence the name of the disease. (primaryimmune.org)
  • Immunotherapy: In this treatment option, the immune system is activated to kill only specific cancer cells. (ndtv.com)
  • The bone marrow is home to the stem cells that produce blood cells, including the white blood cells of the immune system. (fwf.ac.at)
  • A faulty immune system can send inflammatory cells called cytokines to your brain. (globalmedicaldata.com)
  • Your immune system attacks your own skin cells with inflammation. (globalmedicaldata.com)
  • a type of immune cell that makes antibodies) that cause them to produce excessive amounts of abnormal antibody proteins called light chains. (msdmanuals.com)
  • The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)
  • The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
Rejection3
  • Determine viral and host gene expression during the development of atherosclerosis and transplant vascular sclerosis, the vascular lesion associated with chronic allograft rejection. (ohsu.edu)
  • Although aimed at protecting the host from infection, in the context of transplantation, this injury leads to allograft rejection. (medscape.com)
  • Although advances in tissue typing and cross-match testing have helped to deter severe transplant rejection, rejection may result from direct cellular attack (cellular rejection) or be mediated by antibodies (humoral rejection). (medscape.com)
Immature3