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  • acute
  • CNS prophylaxis: Beginning at least 2 months after transplantation, patients with acute lymphocytic leukemia (ALL) and no history of CNS leukemia receive cytarabine intrathecally (IT) monthly for 6 months and patients with ALL and a history of CNS leukemia receive cytarabine IT monthly for 12 months. (clinicaltrials.gov)
  • the occurrence of acute and chronic graft versus host disease, survival, transplantation-related mortality, and relapse rates were compared. (clinicaltrials.gov)
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • Liver transplantation nowadays is a well accepted treatment option for end-stage liver disease and acute liver failure. (wikipedia.org)
  • Procedure
  • PBSCT is now a much more common procedure than its bone marrow harvest equivalent, this is in-part due to the ease and less invasive nature of the procedure. (wikipedia.org)
  • With the success of this procedure steps were taken by professor Hobbs's team to set up the world's first unrelated bone marrow donor register. (wikipedia.org)
  • graft versus
  • Currently, he is the Head of the Graft-versus-host disease (GVHD) and Autoimmunity Unit and Senior Clinician at the Experimental Transplantation and Immunology Branch of the National Cancer Institute's (NCI) Center for Cancer Research at the U.S. National Institutes of Health (NIH). (wikipedia.org)
  • Neutrophil
  • G-CSF is a growth factor for neutrophils (a common type of white blood cells), and may act by increasing the activity of neutrophil-derived proteases such as neutrophil elastase in the bone marrow leading to proteolytic degradation of SDF-1. (wikipedia.org)
  • somatic
  • Two common methods of therapeutic cloning that are being researched are somatic-cell nuclear transfer and, more recently, pluripotent stem cell induction. (wikipedia.org)
  • With the cloning of a sheep known as Dolly in 1996 by somatic cell nuclear transfer (SCNT), the idea of human cloning became a hot debate topic. (wikipedia.org)
  • Four embryonic stem cell lines from human fetal somatic cells were derived from those blastocysts. (wikipedia.org)
  • In 2018, the first successful cloning of primates using somatic cell nuclear transfer, the same method as Dolly the sheep, with the birth of two live female clones (crab-eating macaques named Zhong Zhong and Hua Hua) was reported. (wikipedia.org)
  • In somatic cell nuclear transfer ("SCNT"), the nucleus of a somatic cell is taken from a donor and transplanted into a host egg cell, which had its own genetic material removed previously, making it an enucleated egg. (wikipedia.org)
  • doses
  • MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. (wikipedia.org)
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
  • radiation
  • Radiation therapy injures or destroys cells in the area being treated (the "target tissue") by damaging their genetic material, making it impossible for these cells to continue to grow and divide. (wikipedia.org)
  • Although radiation damages both cancer cells and normal cells, most normal cells can recover from the effects of radiation and function properly. (wikipedia.org)
  • vitro
  • MicroRNA-155 regulates the proliferation and growth of WM cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
  • Most recently Dr Moore has been studying the cancer stem cell in lung cancer and ovarian cancer and has developed some novel methods for growing human cancer stem cells in vitro allowing extensive molecular analysis and identification of targets for therapy designed to eliminate this rare cell population that is responsible for aggressive tumor growth and relapse. (wikipedia.org)
  • genetic
  • Dhawan, a senior scientist at the Center for Cellular and Molecular Biology, Hyderabad, said, "Stem cells are a potential source of repair of other tissues and can be very useful in treating genetic and inherited diseases. (medindia.net)
  • Stem cells are specially useful in treating genetic disorders associated with blood like hemophilia and thalassemia. (medindia.net)
  • Patients with RD have a genetic defect that affects the T cells and at least one other type of immune cell. (wikipedia.org)
  • However Professor Hobbs had founded the COrrection of GEnetic diseases by Transplantation or COGENT movement, with a charitable trust which attracted £13 million 1971-2007. (wikipedia.org)
  • cancer
  • Hodgkin's disease rarely affects the bone marrow, so cells from the patient are usually cancer-free. (doctors-hospital.net)
  • Research is on to try and find cures for debilitating and terminal diseases like muscular dystrophy and cancer through stem cell therapy. (medindia.net)
  • Waldenström's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of cancer affecting two types of B cells, lymphoplasmacytoid cells and plasma cells. (wikipedia.org)
  • born January 18, 1944) is the Enid A. Haupt Chair of Cell Biology at the Memorial Sloan-Kettering Cancer Center. (wikipedia.org)
  • He was the first (1970) to prove the existence of cancer stem cells in a study of leukemia. (wikipedia.org)
  • Examples of surgical procedures for cancer include mastectomy for breast cancer, prostatectomy for prostate cancer, and lung cancer surgery for non-small cell lung cancer. (wikipedia.org)
  • A single cancer cell is invisible to the naked eye but can regrow into a new tumor, a process called recurrence. (wikipedia.org)
  • For this reason, the pathologist will examine the surgical specimen to determine if a margin of healthy tissue is present, thus decreasing the chance that microscopic cancer cells are left in the patient. (wikipedia.org)
  • He then completed a clinical fellowship in bone marrow transplantation in 1992 at the Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine in Seattle, Washington. (wikipedia.org)
  • He is best known for his research on chronic GVHD, the most common late effect in cancer survivors who underwent allogeneic stem cell transplantations as a form of treatment. (wikipedia.org)
  • Pavletic's research also includes pioneering work on the use of peripheral blood cells in allogeneic stem cell transplantation as a form of cancer treatment, as opposed to the use of stem cells from the bone marrow. (wikipedia.org)
  • immune
  • Unfortunately, these medications may cause severe side-effects such as hypersensitivity reactions, bone marrow suppression, auto-immune disease and sideroblastic anemia. (clinicaltrials.gov)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • In his early career Dr Moore discovered that all stem cells of the blood and lymphoid system developed in the yolk sac at an early stage of embryo development and migrated via the blood stream to colonize the bone marrow and immune system. (wikipedia.org)
  • treatment
  • Participants may be eligible if they are between the ages of 18 to 66 years and are undergoing unrelated blood stem cell transplantation for the first time for the treatment of their hematological malignancy. (knowcancer.com)
  • The United States Embassy in Zagreb, Croatia, granted Pavletic a United States Government stipend to spend six weeks at the University Hospital Centre Zagreb, Croatia, in 2013, to assist in the establishment of a multidisciplinary center for the treatment of chronic GVHD resulting from allogeneic stem cell transplantations. (wikipedia.org)