TransplantTransplantsDonorsUmbilicalAplasticCord bloodHSCTMultiple myelomaMobilized peripheral bloodKidney transplantationAllogeneic hemaGraft-versus-HematologicHigh-doseBlood and marrowAcute myeloidHarvestDonor's bone marrowTherapyNormal bone marrow2000Progenitor cellLeukemiaRemissionLymphomaAutologous boneMorbidity and mortaSolid tumorsEndothelial progenitorASCTHematopoietic progenitor cellsDonor stem cellsImmature stem cellsAllogenicPBSCTMobilization of hematopoieticFluorescence in situ hybriOrgans and livingEngraftmentMesenchymal stemPatient's own cellsDiseasesDonationGranulocyte
Transplant37
- The first therapy using stem cells was a bone marrow transplant performed by French oncologist Georges Mathé in 1958 on five workers at the Vinča Nuclear Institute in Yugoslavia who had been affected by a criticality accident. (wikipedia.org)
- GVHD is a common problem after a transplant using donor cells. (bmtinfonet.org)
- Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)
- Transplant Cell Ther. (stembook.org)
- Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant. (stembook.org)
- Biol Blood Marrow Transplant. (stembook.org)
- What is bone marrow transplant (BMT)? (medtravelhelp.com)
- A bone marrow transplant is a process of transferring healthy bone marrow cells from a donor to a patient who has unhealthy bone marrow. (medtravelhelp.com)
- Bone marrow transplant is a recommended therapy for patients with certain types of cancers or diseases. (medtravelhelp.com)
- The Apollo Cancer Centre at Teynampet, Chennai is India's first standalone cancer treatment facility with bone marrow transplant (BMT) expertise that has been serving patients since 1993. (medtravelhelp.com)
- The bone marrow cells that make other blood cells are called stem cells which are needed in a bone marrow transplant. (medtravelhelp.com)
- Who may benefit from bone marrow transplant? (medtravelhelp.com)
- Bone marrow or peripheral blood stem cell transplantation includes mobilization, harvesting and transplant of bone marrow or peripheral blood stem cells, and the administration of high dose chemotherapy or radiotherapy before the actual transplant. (hinshawlaw.com)
- A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
- A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)
- What is Stem Cell Transplant? (differencebetween.net)
- This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
- Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
- Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
- A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
- A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
- A bone marrow transplant is when stem cells are harvested directly from the bone marrow. (differencebetween.net)
- In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
- The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
- Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
- The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
- It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
- Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. (biologynews.net)
- Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
- Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. (qxmd.com)
- People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
- Autologous bone marrow transplant is when people donate their own bone marrow. (medlineplus.gov)
- Allogenic bone marrow transplant is when another person donates bone marrow. (medlineplus.gov)
- But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
- Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
- Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Transplants9
- The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
- Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
- bone marrow or stem cell transplants. (hinshawlaw.com)
- Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
- Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
- Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
- In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
- Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
- Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
Donors11
- In cases where such donors are not available, the process can extend to non-related donors or even a patient's own cells, demonstrating the flexibility and innovation inherent in this field. (medistateinternational.com)
- Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
- Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
- Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
- Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
- Neither vitiligo nor evidences of autoimmune diseases were found in their stem cell donors. (koreamed.org)
- These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
- Protecting the Selfless: Toward More Comprehensive Care for Pediatric Related Stem Cell Donors. (childrensmercy.org)
- Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
- The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
- Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
Umbilical5
- She underwent hematopoietic stem cell transplantation which uses stem cells derived from bone marrow, peripheral blood, or umbilical cord blood. (turnto23.com)
- Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood. (biologynews.net)
- Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
- The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
- peripheral blood, or placental/umbilical cord blood). (cdc.gov)
Aplastic4
- Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia. (stembook.org)
- The first patient was received an allogeneic bone marrow transplantation and subsequent allogeneic peripheral blood stem cell transplantation for severe aplastic anemia from his sister. (koreamed.org)
- Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
- A Japanese man who had been diagnosed with aplastic anemia underwent allogenic bone marrow transplantation from an unrelated donor at 51 years of age. (biomedcentral.com)
Cord blood16
- An overview of bone marrow, peripheral blood stem cell and cord blood transplantation. (bmtinfonet.org)
- 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
- On occasions when the patient does not have a good matched relative / unrelated donor, a partially matched, unrelated cord blood with adequate cell dose would be an option. (medtravelhelp.com)
- Cord blood is rich in peripheral stem cells and can be used instead of bone marrow for transplantation. (medtravelhelp.com)
- The patient's own, or the donated bone marrow or peripheral stem cells or cord blood will then be given through the central line into a vein. (medtravelhelp.com)
- In addition to bone marrow, alternative sources of haemopoietic progenitor cells such as mobilized peripheral blood donations or cord blood are being used increasingly. (rlbuht.nhs.uk)
- Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
- Previous efforts to expand cord blood have resulted in ineffective NK cells. (biologynews.net)
- However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells. (biologynews.net)
- Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
- However, in 1988, researchers found cord blood to be another source for stem cell transplantation. (biologynews.net)
- Zweidler-McKay's study involves selecting out NK cells from cord blood. (biologynews.net)
- As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion. (biologynews.net)
- These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias. (biologynews.net)
- Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
- One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
HSCT8
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
- This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
- The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
- The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
- Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Multiple myeloma6
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- Reduction in late mortality among patients with Multiple Myeloma treated with Autologous Peripheral Blood Stem Cell Transplantation - a BMTSS Report. (stembook.org)
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- ABSTRACT Multiple myeloma (MM) is a systemic malignancy of pathologic plasma cells that is treat able with chemotherapeutic agents and irradiation, but rarely curable. (who.int)
- Multiple myeloma (MM) is a cancer of the The largest series, 23 patients with lepto- plasma cells. (who.int)
Mobilized peripheral blood1
- We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
Kidney transplantation2
- For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
- The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
Allogeneic hema1
- Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
Graft-versus-2
- Purpose: Diarrhea associated with acute gastrointestinal (GI) graft- versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) can result in severe morbidity and mortality. (elsevierpure.com)
- After transplantation, he suffered acute graft-versus-host disease with a systemic rash and severe diarrhea. (biomedcentral.com)
Hematologic4
- From various cancer types like leukemia to congenital or acquired hematologic conditions leading to bone marrow insufficiency and immune system deficiencies, this method addresses diverse health concerns. (medistateinternational.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
- We assessed late mortality in 854 individuals who had survived 2 or more years after autologous hematopoietic cell transplantation (HCT) for hematologic malignancies. (qxmd.com)
High-dose8
- Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
- The Peripheral stem cells can even be frozen until the patient has had the high-dose treatment. (medtravelhelp.com)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
Blood and marrow4
- Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic cell transplantation program (Part I): Minimum requirements and beyond. (stembook.org)
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
- Blood and Marrow Transplantation is where we replace parts of the body called stem cells as a way to cure difficult diseases and cancer. (rlbuht.nhs.uk)
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)
Acute myeloid1
- Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
Harvest10
- 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
- OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
- If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)
- Peripheral stem cell harvest is done usually on the 4th / 5th / 6th day. (medtravelhelp.com)
- About a week or two before the bone marrow harvest is done, the patient (or the donor, for an Allogeneic transplantation) may have 1 to 2 units of blood taken. (medtravelhelp.com)
- This will be given back during the bone marrow harvest. (medtravelhelp.com)
- In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
- Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
- Bone marrow harvest. (medlineplus.gov)
- After a bone marrow harvest, the donor stays in the hospital until they're fully awake and can eat and drink. (medlineplus.gov)
Donor's bone marrow1
- Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
Therapy10
- The decision to proceed with transplantation hinges on a thorough assessment of patients' chances for successful results, along with a comprehensive understanding of therapy-related risks. (medistateinternational.com)
- As of 2016[update], the only established medical therapy using stem cells is hematopoietic stem cell transplantation, first performed in 1958 by French oncologist Georges Mathé. (wikipedia.org)
- Somatic cell nuclear transfer is a cloning method that can be used to create a cloned embryo for the use of its embryonic stem cells in stem cell therapy. (wikipedia.org)
- Patients undergoing fludarabine therapy (purine analog) , bone marrow transplantation or peripheral blood stem cell transplantation. (utmb.edu)
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- My condition improved a lot after stem cell therapy and ozone bath. (placidway.com)
- Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
- Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
- At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Normal bone marrow1
- Characterize the time to recovery of normal bone marrow function after transplantation in these patients. (knowcancer.com)
20003
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
- Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
- Malignant plasma cells in meningeal MM out of 2000 patients with bone marrow produce an immunoglobulin, MM, was reported was by Schluterman et al. (who.int)
Progenitor cell3
- Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
- The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
- The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
Leukemia6
- While stem cell transplantation often finds its place in addressing leukemia and cancer cases, its scope extends far beyond these realms, particularly in childhood ailments. (medistateinternational.com)
- [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
- Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
- The second patient underwent allogeneic bone marrow transplantation for acute myelogeneous leukemia from his sister. (koreamed.org)
- When given to mice with aggressive human leukemias, these NK cells reduced the circulating human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells by 60 to 85 percent. (biologynews.net)
- These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. (biologynews.net)
Remission3
- LOS ANGELES (AP) - Selma Blair says she's in remission from multiple sclerosis as a result of undergoing stem cell transplantation. (turnto23.com)
- These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)
- Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
Lymphoma11
- I. Determine the response rate (complete and partial) in patients with relapsed or refractory Burkitt's, mantle cell or diffuse large cell non-Hodgkin's lymphoma treated with FR901228 (depsipeptide). (knowcancer.com)
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
- These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
- Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
- Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
- Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
- Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
- it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Autologous bone2
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
- MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
Morbidity and morta1
- 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
Solid tumors1
- Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Endothelial progenitor3
- Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of these diseases. (hindawi.com)
- The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)
- Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. (southernbiotech.com)
ASCT1
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Hematopoietic progenitor cells3
- Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
- In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Donor stem cells2
- Donor stem cells can be collected in two ways. (medlineplus.gov)
- Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
Immature stem cells1
- These immature stem cells were easier to match to patients, especially those from non-Caucasian ethnicities, and could be stored for use as needed. (biologynews.net)
Allogenic4
- with genotype T18 in an immunodeficient patient in Japan after allogenic bone marrow transplantation, along with the morphological characteristics and genetic analysis. (biomedcentral.com)
- A 52-year old man, who had undergone allogenic bone marrow transplantation, suffered from rapid-growing brain masses in addition to pneumonia and died within 1 month from the onset of the symptoms including fever, headache and disorientation. (biomedcentral.com)
- Allogenic hematopoietic stem cell transplantation recipients often develop several opportunistic infections associated with fatal outcomes. (biomedcentral.com)
- with genotype T18 after allogenic bone marrow transplantation with review of the literature. (biomedcentral.com)
PBSCT1
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
Mobilization of hematopoietic1
- Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population. (cdc.gov)
Fluorescence in situ hybri2
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
- In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
Organs and living1
- Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
Engraftment1
- Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
Mesenchymal stem1
- Poly(ADP-ribose): a signalling molecule in mesenchymal stem cells? (remedicon.hu)
Patient's own cells1
- Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Diseases5
- Furthermore, stem cell transplantation proves invaluable in addressing various familial diseases, each marked by distinct trajectories that primarily manifest during childhood. (medistateinternational.com)
- Hereditary diseases encompass a vast spectrum, with differing suitability for stem cell transplantation. (medistateinternational.com)
- However, for certain hereditary diseases characterized by severe, life-threatening, or progressive courses, stem cell transplantation may present a lifeline. (medistateinternational.com)
- These diseases can variably impact different bodily systems, from skeletal (bone, cartilage, joint) disorders to progressive neurological symptoms. (medistateinternational.com)
- In this study, in attempt to provide fresh information about the impact of CS on proliferation of EPCs to elucidate the pathophysiological mechanisms of the diseases related to CS in cellular level, we assessed the proliferation of EPCs after interfering the cells with a series of concentrations of CSE for various times of exposure in vitro . (hindawi.com)
Donation3
- Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results. (childrensmercy.org)
- Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. (childrensmercy.org)
- Then, a counselor meets with the donor to discuss the bone marrow donation process. (medlineplus.gov)
Granulocyte2
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)