TransplantationLymphomaChemotherapyNervousUmbilicalMononuclear cellsBlood stem cellsHematopoietic progenitor cellsMesenchymalNervesTransplantsMobilized peripheral bloodAdipose-derived stem cellsDifferentiationImmature cellsMarrowPBSCTPatientsEmbryonic stemPluripotentProgenitor cellDonorPatient'sNerveMultipotent stemAdult stemLymphocytesRadiationTherapyClinicalTherapiesRegenerationLymphoidTissuesRegenerativeDonorsTreatmentsRetinal GanglNational Cancer InResearchSchwannBrain stemRenal cell c
Transplantation21
- Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. (wikipedia.org)
- citation needed] The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
- Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- Analysis of peripheral blood mononuclear cells in operational tolerance after living-donor liver transplantation (LDLT). (ox.ac.uk)
- Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
- Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
- [ 1 ] Acute GVHD describes a distinctive syndrome of dermatitis (see the image below), hepatitis, and enteritis developing within 100 days after allogeneic hematopoietic cell transplantation (HCT). (medscape.com)
- The patient had undergone autologous peripheral blood stem-cell transplantation to treat ovarian cancer. (medscape.com)
- Effectiveness of single-dose 6 mg pegfilgrastim in mobilizing peripheral blood stem cells in allogeneic hematopoietic cell transplantation donors. (bvsalud.org)
- The purpose of this study was to determine if 6 mg of pegfilgrastim was effective and safe for mobilizing CD34+ cells in donors for allogeneic hematopoietic stem cell transplantation . (bvsalud.org)
- National Institutes of Health (NIH) Frequently Asked Questions (FAQs) Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers about these Adult/NONembryonic Stem Cells Key Points Hematopoietic or blood-forming stem cells are. (physiciansforlife.org)
- We conducted a nationwide, multicenter, prospective registry study for newly diagnosed patients with peripheral T-cell lymphoma (PTCL) to better define the clinical characteristics, treatment patterns, survival outcomes, and the role of upfront autologous stem cell transplantation (ASCT) in these patients. (e-crt.org)
- Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
- after transplantation to the recipient region, single cells are vulnerable to the interference of various factors, such as ischemia and inflammation, leading to cell loss or death [ 16 ]. (biomedcentral.com)
- 2013) Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell transplantation. (ukaachen.de)
- Geriatric assessment in adults age 50 years and older undergoing autologous hematopoietic cell transplantation for lymphoma. (ucsf.edu)
- Smith and Broxmeyer, 1986), thereby making it a potential source of cells for transplantation (Bodger, 1987). (nationalacademies.org)
- Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Lymphoma5
- Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. (wikipedia.org)
- Childhood non-Hodgkin lymphoma treatment can include chemotherapy, radiation therapy, targeted therapy, and high-dose chemotherapy with stem cell transplant. (nih.gov)
- Impact of diagnosis to treatment interval in patients with newly diagnosed mantle cell lymphoma. (ucsf.edu)
- People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
- Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
Chemotherapy8
- OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
- After the patient receives high-dose chemotherapy, the collected stem cells are thawed and given back to the cancer patient through an intravenous infusion (IV) to produce blood cells and to re-establish a healthier immune system. (tgh.org)
- They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
- After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
- The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
- Chemotherapy involves the use of drugs to kill cancer cells. (epnet.com)
- Large doses of chemotherapy and/or radiation therapy are then applied to kill the cancer cells. (epnet.com)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
Nervous12
- Dorsal root ganglia (DRG) are structures containing the sensory neurons of the peripheral nervous system. (jove.com)
- Familial dysautonomia (FD) is a rare but fatal disorder primarily affecting the peripheral nervous system. (mskcc.org)
- Neuromuscular medicine has to do with disorders of the peripheral nervous system (PNS) and its connections with the central nervous system. (floridaortho.com)
- The peripheral nervous system includes the motor and sensory neurons, neuromuscular junctions, peripheral nerves, and muscles. (floridaortho.com)
- These cells contribute to formation of many structures such as the peripheral nervous system, craniofacial skeleton, and pigmentation of the skin. (caltech.edu)
- Our discovery provides important insights into the mechanisms that determine whether a cell becomes part of the central nervous system or peripheral cell lineages. (caltech.edu)
- Development and assessment of cell- and bioengineering-based intervention strategies to promote functional tissue repair in vivo models of traumatic nervous tissue injury (PNS and CNS). (ukaachen.de)
- Cells in the peripheral nervous system can regrow, but they sometimes have trouble linking up with each other, which is essential to restore feeling and function. (upmc.com)
- This coordinated activity is regulated by the central and peripheral nervous systems. (medscape.com)
- The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)
- The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
- Hearing loss can occur after ingestion of certain drugs due to their effects on the peripheral auditory system or central nervous system. (cdc.gov)
Umbilical3
- Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
- peripheral blood, or placental/umbilical cord blood). (cdc.gov)
- Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
Mononuclear cells2
- mononuclear cells (PBMCs). (cdc.gov)
- Notably, adult stem and progenitor cells including mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have progressed into clinical trials and have shown positive benefits. (nih.gov)
Blood stem cells1
- Normally, the bone marrow makes blood stem cells (immature cells) that develop into mature blood cells over time. (piedmontcancerinstitute.com)
Hematopoietic progenitor cells4
- Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
- In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
- B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Mesenchymal3
- Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
- 2010) Expansion of human bone marrow-derived mesenchymal stromal cells: serum-reduced medium is better than conventional medium. (ukaachen.de)
- These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
Nerves2
- 2012) The role of microstructured and interconnected pore channels in a collagen-based nerve guide on axonal regeneration in peripheral nerves. (ukaachen.de)
- 2010) Repairing injured peripheral nerves: bridging the gap. (ukaachen.de)
Transplants2
- blood stem cell (PBSC) transplants, Barbara L. Haller, for which DNA was extracted from Patricia M. Denn, serum specimens collected at 6 and Christopher S. Hall,* Parvoviruses in 12 months, respectively, after trans- and Julie L. Gerberding plantation. (cdc.gov)
- The myeloma program at UAMS has seen more than 11,000 patients from every state in the United States and more than 50 foreign countries and has performed more than 9,000 peripheral blood stem cell transplants. (uams.edu)
Mobilized peripheral blood1
- We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
Adipose-derived stem cells2
- When dissociated, they can be co-cultured with SC-like adipose-derived stem cells (ASC), providing a valuable model to study in vitro nerve regeneration and myelination, mimicking the in vivo environment at the injury site. (jove.com)
- More recently, stem cells collected from adipose tissue (adipose-derived stem cells or ADSCs) have gained traction due to their relative ease of collection and differentiation potential. (psu.edu)
Differentiation7
- At the Stem Cell Differentiation and Cytogenetics Group, we are interested in the effects of ionizing radiation on organs such as the brain, the heart, and the lung trying to elucidate the risks for patients treated with ionizing radiation as well as for astronauts, who are inevitably exposed to ionizing radiation on their missions into space. (gsi.de)
- Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
- This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
- Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com)
- These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
- Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
- the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)
Immature cells2
- Stem cells are immature cells that produce blood cells. (epnet.com)
- Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
Marrow22
- Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a donor (PBSC collection). (wikipedia.org)
- The administered hematopoietic stem cells then migrate to the recipient's bone marrow, through a process known as stem cell homing, where the transplanted cells override the previous bone marrow. (wikipedia.org)
- This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
- Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into white blood cells. (wikipedia.org)
- The treatment, which cost approximately $10,000, took place in January of this year and consisted of a simple procedure in which adult stem cells were extracted from the girl's own bone marrow and then readministered via a lumbar puncture in the girl's spine. (cellmedicine.com)
- As a regenerative spine & joint doctor, Dr. Stephen Roman can administer your own regenerative cells found in your blood, bone marrow and fat. (regenespine.com)
- Tampa, FL (Oct. 3, 2022) - As part of its commitment to world-class, innovative cancer care for the Tampa Bay region and beyond, Tampa General Hospital (TGH) Cancer Institute has established an adult Bone Marrow Transplant (BMT) and Cell Therapies unit that focuses on treating patients with aggressive blood cancers such as leukemias, lymphomas, multiple myeloma as well as other cancers. (tgh.org)
- Bone marrow transplant (BMT), also known as stem cell therapy (SCT), is a proven treatment for patients with cancers of the blood for which the standard treatments have not been effective or those who have a high risk of relapsing after traditional therapies. (tgh.org)
- This therapy involves taking stem cells from the bone marrow or peripheral blood from a cancer patient or from a donor. (tgh.org)
- Bone marrow transplant and now cell therapies can significantly increase the chance of recovery from blood cancers and, hopefully soon, of patients with solid malignancies," said Dr. Abraham Schwarzberg, chief of oncology and senior vice president of network development at Tampa General. (tgh.org)
- Tampa General's cancer physicians offer a highly coordinated range of multidisciplinary specialties such as hematologic malignancies, thoracic, breast, colorectal, gynecologic oncology, and now bone marrow transplant and cell therapies. (tgh.org)
- The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
- Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
- These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
- Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
- The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
- Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. (nih.gov)
- Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (piedmontcancerinstitute.com)
- Also, as the number of leukemic cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. (piedmontcancerinstitute.com)
- Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
- First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
- B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
PBSCT1
- Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield. (wikipedia.org)
Patients17
- In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
- Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
- We address recent data showing a rewiring of such interactions in cells from FPLD2 patients, and in adipose progenitor and induced pluripotent stem cell models of FPLD2. (frontiersin.org)
- In addition to providing autologous adult stem cell therapies to patients, the XCell-Center is also actively involved in pre-clinical and clinical research. (cellmedicine.com)
- Since January of 2007, more than 1,600 patients have been treated with their own adult stem cells at the XCell-Center. (cellmedicine.com)
- Finally, using primary lung stem cells or lymphocytes from different donors, we study the effects of radon on patients, who are treated in radon spas or baths to alleviate rheumatic diseases. (gsi.de)
- Offers Stem Cell and PRP Treatments for Patients Near East Windsor, Mercer County, NJ. (regenespine.com)
- Our stem cell and PRP treatments are performed with the goal of helping patients reach their full potential without surgery and without reliance on long-term medication use. (regenespine.com)
- Study co-leader Steven D. Schwartz, MD, from the Jules Stein Institute in Los Angeles, reported that both patients reported vision improvements after being injected with the cells. (personaleyes.com.au)
- Our program can also provide improved continuity of care for our TGH Cancer Institute patients. (tgh.org)
- In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
- Alzheimer's patients exhibit high degradation of the suprachiasmatic nucleus (SCN), the central endogenous circadian timekeeper, and Parkinson's patients have highly disrupted peripheral clock gene expression. (frontiersin.org)
- Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
- For a review of guidelines covering the diagnosis, treatment, and followup of patients with renal cell carcinoma, see Renal Cell Carcinoma Guidelines . (medscape.com)
- Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. (medscape.com)
- Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. (medscape.com)
- This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)
Embryonic stem4
- The strict prohibition of embryonic stem cell therapy in Germany, as in many other countries, is based not so much on ethical concerns but on concrete scientific reasons, not the least of which is the fact that embryonic stem cells are medically unsafe. (cellmedicine.com)
- In vitro toxicity data of these metabolites derived in the development of validated and accepted in vitro and in silico embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted approaches is urgently needed. (cdc.gov)
- This approach could therefore micromass test, and the embryonic stem cell test (EST) provide a means to reduce the need for animal testing in human risk assessment practices. (cdc.gov)
- physiologically based animals because a mouse embryonic stem cell line is used. (cdc.gov)
Pluripotent5
- Other iPSC-based models affecting neural crest lineages include Schwann cell and melanocyte-related disorders, including our effort to model human melanoma in pluripotent stem cells. (mskcc.org)
- True stem cells are both pluripotent-that is they can give rise to all cell types-and capable of self-renewal. (justia.com)
- Her research program includes functional studies for recent gene (ATP7A and PDK3) and SV mutation (CMTX3 and DHMN1) discoveries using induced pluripotent stem cell derived motor neurons and animal models (C. elegans). (otago.ac.nz)
- In this review, we overview the major classes of stem and progenitor cells, including pluripotent stem cells, and summarize the state of the art in applying these cell types for treating myocardial infarction and peripheral arterial disease. (nih.gov)
- ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)
Progenitor cell1
- The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
Donor5
- Since only autologous (in which the donor and recipient are the same person) adult stem cells are used, there is no risk of immune rejection. (cellmedicine.com)
- Donor stem cells can be collected in two ways. (medlineplus.gov)
- Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
- The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
- The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
Patient's2
- However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses. (wikipedia.org)
- At the XCell-Center, we only use the patient's own stem cells for therapy. (cellmedicine.com)
Nerve12
- The ability to induce age-like features in PD-iPSC-derived dopamine nerve cells has yielded late-stage disease phenotypes not commonly observed in standard PD-iPSC models. (mskcc.org)
- Peripheral nerve injury (PNI) is one of the essential causes of physical disability with a high incidence rate. (biomedcentral.com)
- The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
- Tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. (biomedcentral.com)
- Therefore, effective autologous nerve replacement is critical in the field of peripheral nerve regeneration. (biomedcentral.com)
- Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
- Purpose of the Review Peripheral nerve injuries are common, debilitating, and costly. (psu.edu)
- The purpose of this article is to review a specific cellular, regenerative engineering technique that holds promise for the treatment of peripheral nerve injuries. (psu.edu)
- Recent Findings Over the past several decades, research has focused on the utilization of stem cells for peripheral nerve repair. (psu.edu)
- To aid peripheral nerve regeneration, McGowan Institute faculty member Kacey Marra, PhD, and researchers have developed scaffolds made of FDA-approved biodegradable polymers and protein beads. (upmc.com)
- Channels in the scaffolds act as guides for axons, the long arms of nerve cells, to grow longer and in the right directions. (upmc.com)
- In early studies, a nerve guide seeded with stem cells derived from fat restored some hind leg mobility to paralyzed rats. (upmc.com)
Multipotent stem1
- The neural crest is a group of migratory, multipotent stem cells that play a crucial role in many aspects of embryonic development. (caltech.edu)
Adult stem5
- His main research areas are developmental biology, cell morphogenesis, adult stem cells and cardiac function analysis. (amrita.edu)
- Since only adult stem cells are used at the XCell-Center, not embryonic stem cells, the treatments are ethically noncontroversial and scientifically proven to be medically safe. (cellmedicine.com)
- Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
- The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)
- Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
Lymphocytes1
- In ALL, too many stem cells develop into lymphoblasts or lymphocytes. (piedmontcancerinstitute.com)
Radiation4
- Particularly, human embryonic stem cells (hES cells), which can give rise to all tissues of an organism (Figure A), are used to generate mature cells of the heart (Figure B) allowing us to study radiation/microgravity-induced cardiovascular alterations, which may occur during long-term space missions. (gsi.de)
- hES cells also serve as a basis for cerebral organoid models (Figure C) to better understand e.g. the mechanisms of cognitive impairment and radiation necrosis as severe side effects of radiation therapies. (gsi.de)
- All research areas are substantiated by analyses (Figure D) monitoring the acute radiation-induced cytogenetic damage and the long-term genetic stability of cells. (gsi.de)
- Radiation is directed at the tumor from a source outside the body to kill the cancer cells. (epnet.com)
Therapy7
- He is currently an Associate Scientist at the Vaccine and Gene Therapy Institute and Research Assistant Professor at the Department of Molecular Microbiology and Immunology. (ohsu.edu)
- Judy DiCorcia of New York has written an open letter to President Obama in which she describes the improvement of her 10-year-old autistic daughter, Lauren, after adult stem cell therapy was administered to the child at the XCell-Center in Cologne, Germany. (cellmedicine.com)
- As explicitly stated on the website of the XCell-Center, 'therapy with embryonic stem cells is strictly prohibited in Germany. (cellmedicine.com)
- Back in the U.S., Lauren's mother, Ms. DiCorcia, wishes that this type of adult stem cell therapy were available in the U.S., so that she wouldn't have to travel to Germany for her child's treatment. (cellmedicine.com)
- In January, we took Lauren to Cologne, Germany for adult stem cell therapy. (cellmedicine.com)
- Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. (nih.gov)
- Progression-free survival as a predictor of overall survival in metastatic renal cell carcinoma treated with contemporary targeted therapy. (medscape.com)
Clinical3
- The XCell-Center is a private clinical group and institute for regenerative medicine which operates two treatment centers, one in Cologne and one in Dusseldorf, Germany. (cellmedicine.com)
- In addition to causing teratomas (a specific type of tumor), embryonic stem cells are notorious for their numerous other inherent problems which disqualify them for any type of clinical therapeutic use. (cellmedicine.com)
- This funding opportunity announcement (FOA) supports investigator-initiated mechanistic and/or minimal risk clinical trials addressing the mission and research interests of the participating NIH institutes. (nih.gov)
Therapies4
- However, we are just beginning to realize the power of an emerging field known as cell therapies. (tgh.org)
- In our BMT and Cell Therapies unit, we aim to provide these therapies as well as make groundbreaking contributions to the field through innovative research. (tgh.org)
- After several months of careful planning and designing, the TGH Cancer Institute BMT and Cell Therapies Unit opened in Spring 2022. (tgh.org)
- The TGH Cancer Institute's BMT and Cell Therapies Unit reflects the Institute's philosophy of bringing together a range of multidisciplinary specialties that strongly emphasizes compassionate and personalized care focusing on the whole patient. (tgh.org)
Regeneration1
- There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)
Lymphoid3
- A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. (piedmontcancerinstitute.com)
- Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
- immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
Tissues4
- Breast cancer, a common cancer in women, is a disease in which cancer (malignant) cells are found in the tissues of the breast. (stopgettingsick.com)
- Red blood cells that carry oxygen and other materials to all tissues of the body. (piedmontcancerinstitute.com)
- All tissues originate from stem cells. (bvsalud.org)
- A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
Regenerative6
- Its headquarters are located at the Dominikus hospital in Dusseldorf, while its second branch is located at the Eduardus Hospital's Institute of Regenerative Medicine in Cologne. (cellmedicine.com)
- Stephen J. Roman, Jr., M.D. founder of The RegeneSpine Regenerative Spine and Joint Institute, has four board certifications including Regenerative Medicine, Physical Medicine & Rehabilitation (Physiatry), Pain Management, and Headache Management. (regenespine.com)
- Before founding The RegeneSpine Regenerative Spine and Joint Institute , Doctor Roman had worked with the Trenton Orthopaedic Group (TOG) and Rothman Orthopaedics . (regenespine.com)
- The RegeneSpine Regenerative Spine and Joint Institute was founded to combine the latest in minimally invasive spinal and other musculoskeletal treatments with the modern advances in regenerative medicine. (regenespine.com)
- Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
- The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
Donors2
- A single injection of 12 mg pegfilgrastim was used to mobilize peripheral blood progenitor cells (PBPCs) from healthy donors in some studies. (bvsalud.org)
- The 73.3% of donors mobilized with pegfilgrastim yielded >4 × 106 cells /kg CD34+ cells in a single apheresis procedure when compared to the 33.3% of donors mobilized with G-CSF (P (bvsalud.org)
Treatments2
- Stem cells have long courted controversy, but a study from 2012 has shown, once again, how much potential they have for medical treatments. (personaleyes.com.au)
- The study is still in its infancy, with commonplace stem cell treatments not expected for some years to come. (personaleyes.com.au)
Retinal Gangl1
- Light, as the external stimulus, activates intrinsically photosensitive retinal ganglion cells (ipRGCs), which innervate the suprachiasmatic nucleus (SCN) in mammals, entraining the mammal to the 24-h day ( Do and Yau, 2010 ). (frontiersin.org)
National Cancer In1
- Source: National Cancer Institute, U.S. National Institutes of Health. (smartdraw.com)
Research9
- Dr. Brewer is the recipient of numerous honors and awards, including a nomination for the UCSD School of Medicine Excellence in Teaching Award, a Fulbright Scholarship in Neuroscience Research at the Weizmann Institute of Science in Israel, and several NIH awards. (ucsd.edu)
- Speaking to ABC radio, Martin Pera, professor of Stem Cell Sciences at the University of Melbourne, explained that the research is still in very early days, but it does provide hope for the future. (personaleyes.com.au)
- Prof Kennerson is a Professor of Neurogenetics/Neurosciences with the ANZAC Research Institute, Sydney Local Health District (SLHD) and the School of Medical Sciences, University of Sydney, Australia. (otago.ac.nz)
- She heads the Translational Gene Discovery and Functional Genomics Inherited Peripheral Neuropathies Program at the ANZAC Research Institute. (otago.ac.nz)
- Marina is a board member of the Charcot-Marie-Tooth and Related Neuropathies Consortium (CMTR), Chair of the Asian Oceanic Inherited Neuropathy Consortium (AOINC) serves on the Scientific Advisory Board of the CMT Research Foundation, USA and is Deputy Director (Research) of the SLHD Institute of Precision Medicine and Bioinformatics. (otago.ac.nz)
- The Neuronal Cell Culture Unit develops methods for the culture of primary neuronal cells and provides Neuroscience Center groups and other research groups in the Helsinki region with cultured neurons. (helsinki.fi)
- This is an exciting, new collaboration between the Myeloma Center and Celgene, bringing together leading institutions for consummate innovation in myeloma research," said Gareth Morgan, M.D., Ph.D., director of the institute. (uams.edu)
- He came to UAMS from The Royal Marsden Institute NHS Foundation Trust and the Institute of Cancer Research in London where he was a professor of hematology and director of the Centre for Myeloma Research. (uams.edu)
- note = "Funding Information: Acknowledgements Dr. Ravnic is supported by a Penn State Department of Surgery Grant and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under BIRCWH award number K12HD055882, {\textquoteleft}{\textquoteleft}Career Development Program in Women{\textquoteright}s Health Research at Penn State. (psu.edu)
Schwann2
- Functionalization of Electrospun Poly(epsilon-Caprolactone) Fibers with the Extracellular Matrix-Derived Peptide GRGDS Improves Guidance of Schwann Cell Migration and Axonal Growth. (ukaachen.de)
- Both undifferentiated and Schwann cell-like differentiated ADSCs have been used to seed conduits with variable results. (psu.edu)
Brain stem1
- Drugs and other substances that alter hearing or equilibrium by acting primarily at the level of the brain stem or the central auditory pathways are considered to be neurotoxic and not strictly ototoxic (Hawkins 1976). (cdc.gov)
Renal cell c1
- Prospective evaluation of analgesic use and risk of renal cell cancer. (medscape.com)