• Experimental Approach: Inhibition of oxaliplatin-induced mechanical hypersensitivity was measured following intraperitoneal administration of MG. Both male and female C57BL/6J mice were used to characterize potential sex-differences in MG's therapeutic efficacy. (authorea.com)
  • Mechanistically, activity at µ-opioid, α1- and α2-adrenergic receptors, but not β-adrenergic receptors contributed to the effects of MG against oxaliplatin-induced mechanical hypersensitivity. (authorea.com)
  • Conclusions and Implications: Repeated MG exposure significantly attenuated oxaliplatin-induced mechanical hypersensitivity with greater potency and efficacy in males, which has crucial implications in the context of individualized pain management. (authorea.com)
  • BACKGROUND: Oxaliplatin-induced peripheral neuropathy (OIPN) is a common and dose-limiting toxicity that markedly limits the use of oxaliplatin and affects quality of life. (bvsalud.org)
  • 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). (wikipedia.org)
  • These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)
  • This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment. (kanker-actueel.nl)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • Paclitaxel triggers anti-mitotic actions by impeding the cell cycle in the late Everolimus mTOR inhibitor stages of mitosis, backing microtubule formation, and eventually inducing apoptosis. (gp120-inhibitors.com)
  • It has been reported to reduce growth of these cancer cells mainly by reducing inhibitory phosphorylation of PDH, thereby promoting mitochondrial oxidative phosphorylation and inducing apoptosis through mitochondrial, NFAT-Kv 1.5, and p53 upregulated modulator of apoptosis (PUMA)-mediated pathways. (dcaguide.org)
  • Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • We demonstrate how the Common demo, that in contrast immunotherapy vs . chemotherapy throughout non-small-cell lung cancer, could have been re-designed to become better quality to the existence of the delayed effect while using modestly-weighted log-rank examination inside a group-sequential environment. (acyltransferase-receptor.com)
  • Conventional medical treatment could include surgery, radiotherapy, immunotherapy and chemotherapy. (asjo.in)
  • Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. (bmj.com)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent side effect of paclitaxel and oxaliplatin treatment of cancer (70-90% of patients receiving these drugs). (painchannels.com)
  • iii) To design and pharmacologically validate lead compounds that attenuate paclitaxel and oxaliplatin CIPN sensory symptoms. (painchannels.com)
  • Chemotherapy induced peripheral neuropathy (CIPN) is a frequent, disabling side effect of anticancer drugs. (painchannels.com)
  • INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting side effects of chemotherapeutic drugs. (bvsalud.org)
  • BACKGROUND: Cancer treatment frequently results in chemotherapy-induced peripheral neuropathy (CIPN), which is a side effect that is now neither properly preventable nor treatable. (bvsalud.org)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (wikipedia.org)
  • Pyruvate dehydrogenase kinase inhibition attenuates glycolysis and facilitates mitochondrial oxidative phosphorylation, leading to reduced growth of colorectal cancer cells but not of non-cancerous cells. (dcaguide.org)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (wikipedia.org)
  • Over 15 randomized clinical studies have shown that intravenous administration of 300-600 mg of lipoic acid a day greatly improves nerve function and relieves pain symptoms in diabetic neuropathy patients. (lifeextension.com)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • Intensification of intra-arterial chemotherapy with high-dose cisplatin and concomitant reduction of toxicity under the conditions of the head and neck was aimed at by combination of antineoplastic activity and embolizing effect in the same pharmacon. (omicsdi.org)
  • 2 Chemotherapy is associated with several adverse effects and signs of immediate and delayed toxicity. (asjo.in)
  • Paclitaxel evoked neuropathy is described as discomfort in the distal extremities, forming a glove and stocking pattern. (gp120-inhibitors.com)
  • In this study, the antinociceptive activity of (-)-linalool was examined in two different pain models in mice: the acetic acid-induced writhing response, a model of inflammatory pain, and the hot plate test, a model of supraspinal analgesia. (researchgate.net)
  • CNS and behavioral activity of rutin were on hole board, thiopental-induced sleeping time and locomotor activity tests in mice. (fuqna.com)
  • CONCLUSIONS: The efficacy of statins to attenuate OIPN during adjuvant CAPOX therapy was not apparent in the current study. (bvsalud.org)
  • PURPOSE: This study set out to thoroughly review randomised controlled trials (RCTs) examining the efficacy of physical therapy for patients with chemotherapy-induced peripheral neuropathy. (bvsalud.org)
  • If positive, our findings will establish the pilot efficacy of HIIT on chemotherapy-induced cognitive function in patients with breast cancer, providing the foundation for future larger phase-II and phase-III trials to confirm the findings and potentially establish HIIT as a standard of care for women undergoing chemotherapy for breast cancer. (researchprotocols.org)
  • This 2-arm, single-center, pilot randomized controlled trial will randomize 50 patients with breast cancer undergoing chemotherapy to HIIT or attention control. (researchprotocols.org)
  • Preloading magnesium attenuates cisplatin-associated nephrotoxicity: pilot randomized controlled trial (PRAGMATIC study). (omicsdi.org)
  • Live-attenuated vaccines should be avoided for at least 3mo after cessation of immunosuppressive therapy. (medscape.com)
  • Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model. (omicsdi.org)
  • Rutin caused attenuation of streptozotocin-induced inflammation by decreasing the activity of the glial fibrillary acidic protein, interleukin-8, cyclooxygenase-2, inducible nitric oxide synthase and nuclear factor-kB and thereby prevented gross anatomical changes in rat hippocampus. (fuqna.com)
  • In a study, in haloperidol-induced orofacial dyskinesia, rutin treatment reversed behavioral changes such as orofacial dyskinetic movements, stereotypic rearing, locomotor activity, and percent retention along with restoration of biochemical and neurochemical parameters. (fuqna.com)
  • Significant research into lipoic acid has centered on its benefits in diabetic neuropathy . (lifeextension.com)
  • Despite years of research, a cure for diabetic neuropathy remains elusive. (lifeextension.com)
  • Lipoic acid's benefits in diabetic neuropathy-and in diabetes as a whole-arise from its striking ability to dramatically improve glucose control and restore insulin sensitivity. (lifeextension.com)
  • The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (wikipedia.org)
  • 55-59 : 17-18 Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. (wikipedia.org)
  • 55-59 Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • GM-CSF is also involved in bone cancer pain development by regulating tumor-nerve interactions, remodeling of peripheral nerves and sensitization of damage-sensing (nociceptive) nerves. (iasp-pain.org)
  • In contrast, optogenetic manipulations of VTA DA neurons revealed their roles in sustaining recurrent scratching episodes through signaling scratching-induced reward. (iasp-pain.org)
  • Patients with CHS frequently exhibit hypopigmentation, enhanced susceptibility to bruising, recurrent infections, and peripheral neuropathy. (biomedcentral.com)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • The chemotherapeutic agent used, dosing schedule, type of cancer, and presence of additional medical complications make a difference to the occurrence and severity of chemotherapy-induced neuropathy. (gp120-inhibitors.com)
  • Peripheral neuropathy may reduce length and dosing of chemotherapeutic Eumycetoma treatment. (gp120-inhibitors.com)
  • More than 75% of patients with breast cancer treated with chemotherapy experience cognitive impairments (eg, memory and attention problems), commonly known as chemo-brain . (researchprotocols.org)
  • However, clinical trials testing the impact of exercise interventions on chemotherapy-induced cognitive decline in patients with cancer are lacking, and the mechanisms through which exercise could improve cognitive function are unclear. (researchprotocols.org)
  • The objective of the Improving Cognitive Function Through High-Intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy trial is to examine the effects of HIIT on cognitive function in patients with breast cancer undergoing chemotherapy. (researchprotocols.org)
  • 2016), nocifensive behaviors induced by chemical irritants (Peana et al. (researchgate.net)
  • Attended video-PSG excluded RBD showing REM sleep with atonia and without increased phasic EMG activity, and diagnosed with severe obstructive sleep apnea (OSA) with an apnea-hypopnea index of 30.1 demonstrating that the reported abnormal sleep behaviors occurred only during respiratory event-induced arousals. (go.jp)
  • Key Results: Oxaliplatin produced significant mechanical allodynia of equal magnitude in both male and females, which was dose-dependently attenuated by repeated MG exposure. (authorea.com)
  • Direct activation of PVA neurons using optogenetics and pharmacological approaches were sufficient to induce persistent mechanical hyperalgesia in naive animals. (iasp-pain.org)
  • As a result, activation of right central nucleus of amygdala with blue light was enough to induce persistent mechanical hyperalgesia. (iasp-pain.org)
  • This study established an in vivo PINK1 / Parkin -induced photoreceptor neuron degeneration model in Drosophila with the aim of dissecting the PINK1/Parkin pathway in detail. (sdbonline.org)
  • Affecting up to around two out of every three people with diabetes, neuropathy is nervous system damage that can produce unbearable pain in the legs and feet. (lifeextension.com)
  • Changes in the peripheral nervous system also cause reduced energy metabolism, which hampers the response of muscles to stimuli, possibly even limiting endurance. (medscape.com)
  • Performance status is often used as a measure to determine whether a person can receive chemotherapy, or whether dose reduction is required. (worldsbest.rehab)
  • The results show that this compound induced a significant reduction of the acid-induced writhing at doses ranging from 25 to 75 mg/kg. (researchgate.net)
  • In cats undergoing ovariohysterectomy, electroacupuncture at ST-36 along with GB-34 has been reported to induce greater reduction in the required isoflurane concentration and better stabilization of cardiorespiratory parameters relative to morphine [22]. (biomedgrid.com)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • 11 However, doctors in Germany have used lipoic acid for more than a decade to reduce pain and inflammation in those suffering from diabetic peripheral neuropathy. (lifeextension.com)
  • Cannabinoids curb neuropathic pain induced by traumatic nerve damage, harmful insults and metabolic changes. (gp120-inhibitors.com)
  • Lipoic acid displays striking benefits in components of metabolic syndrome, including inducing weight loss, improving insulin resistance, and lowering blood pressure. (lifeextension.com)
  • The ceramide-induced down-regulation of PKC results in abnormal cellular phenotypes, suggesting these metabolic cascades are responsible for the beige phenotype [ 13 ]. (biomedcentral.com)
  • As the underlying cellular mechanisms remain incompletely understood pharmacotherapies for chemotherapy-induced neuropathy are limited. (gp120-inhibitors.com)
  • This nutrient protects vital cellular energy and shields against diabetes, obesity, cardiovascular disease, and neurodegeneration. (lifeextension.com)
  • Tocopherols are lipophilic in nature and are found in association with lipoproteins, fat deposits and cellular membranes and protect the polyunsaturated fatty acids from peroxidation reactions. (biomedcentral.com)
  • Acute lung damage (non-cardiogenic В¦ It has been proposed that delayed peripheral neuropathy pulmonary oedema) is a common manifestation of attributable to organophosphates is because of phosphorylation extreme poisoning. (ehd.org)
  • Phosphorylation of PINK1 is not only required for the PINK1-mediated mitochondrial recruitment of Parkin but also induces its kinase activity toward Parkin. (sdbonline.org)
  • 55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
  • Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments. (oaepublish.com)
  • Linalool induced a dose dependent increase of motility effects, thus ruling out the confounding influence of a possible sedative effect. (researchgate.net)
  • However, trypanosomatids have an important and unique mechanism for the trypanothione-dependent detoxification of peroxides that differs from the mechanism found in vertebrates and, as such, is indicated as a rational target for chemotherapy [ 9 ]. (biomedcentral.com)
  • The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
  • It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
  • The Effects of Melatonin on the Descending Pain Inhibitory System and Neural Plasticity Markers in Breast Cancer Patients Receiving Chemotherapy: Randomized, Double-Blinded, Placebo-Controlled Trial is het volledige studierapport vrij in te zien. (kanker-actueel.nl)
  • However soon after the drug's release in Europe reports linked thalidomide to causing peripheral neuropathy in adult patients (which prevented its licensing and general release in the USA) as well as being behind the occurrence of a high and sudden increase of rare birth defects [ 3 , 5 - 8 ]. (hindawi.com)
  • Dr. Kelsey was concerned about the peripheral neuropathy side effect that had been experienced and reported in some patients in Europe following thalidomide exposure [ 3 , 5 , 25 , 26 ]. (hindawi.com)
  • Obtaining vitamin B6 through diet may help to reduce the risk of certain cancers, but using B6 supplements does not prevent cancer or reduce chemotherapy side effects. (mskcc.org)
  • Getting B6 through diet along with other nutrients is associated with cancer-preventive effects, but it cannot reduce side effects from chemotherapy. (mskcc.org)
  • Furthermore, medical mushrooms and other substances were used to improve the immune system and to reduce chemotherapy side effects. (asjo.in)
  • 55-59 Combination chemotherapy involves treating a person with a number of different drugs simultaneously. (wikipedia.org)
  • L-dopa is now rarely used by itself, but rather in combination with carbidopa (Sinemet) or benserazide (Madopar) that protects it from breaking down before it reaches the brain tissue. (digitalnaturopath.com)
  • A vaccine in which a live virus is weakened (attenuated) through chemical or physical processes in order to produce an immune response without the severe effects of the disease. (cdc.gov)
  • Thalidomide remains one of the world's most notorious drugs due to the severe birth defects it induced in children between 1957 and 1962. (hindawi.com)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Surface staining of thioglycolate-induced peritoneal exudate cells (PECs) with Anti-Mouse CD115 (c-fms) PE. (thermofisher.com)
  • The largest apoptotic effect was evident in metastatic LoVo cells, in which DCA induced up to a ten-fold increase in apoptotic cell counts after 48 h. (dcaguide.org)
  • Dichloroacetate reduced lactate levels in growth media and induced dephosphorylation of E1 α subunit of pyruvate dehydrogenase complex in all cell lines, but the intrinsic mitochondrial membrane potential was reduced in only cancer cells ( P =0.04). (dcaguide.org)
  • Enhanced ceramide production induces calpain-mediated proteolysis of PKC. (biomedcentral.com)
  • Lipoic acid increases the abundance of other protective antioxidants while improving mitochondrial function and preventing glycation-induced damage in the kidney and blood vessels of those with diabetes-thus defending against diabetic kidney disease, vision loss, and vascular dysfunction. (lifeextension.com)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • A medical condition where the immune system cannot function properly and protect the body from disease. (cdc.gov)
  • Antibodies protect the body from disease by binding to invading organisms and destroying them. (cdc.gov)
  • A small number of individuals have the attenuated form of the disease and do not benefit from transplant. (biomedcentral.com)
  • Many of these are driven by the same immunologic mechanisms responsible for the drugs' therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. (bmj.com)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • However, none of the drugs has been shown to totally attenuate neuropathic pain. (gp120-inhibitors.com)
  • Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF induced pain. (iasp-pain.org)
  • Combined laser stimulation of ST-36 and LI-4 has also induced significant analgesia based on tooth pulp generated somatosensory evoked potential in rabbit [20]. (biomedgrid.com)
  • It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including chemotherapy. (worldsbest.rehab)
  • In addition, to assess fatigue, the diagnostic process consists of documenting the start, type, and duration of the fatigue, as well as the presence of attenuating factors and interference with activities of daily living and leisure activities. (medscape.com)
  • Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (oaepublish.com)
  • TRPM8-deficiency increased the amplitude of Tc oscillations and, under dim constant light, induced a greater phase delay and instability of Tc rhythmicity. (painchannels.com)
  • Detecting these signals is obviously useful and can protect our body from harm. (painchannels.com)
  • The absence of approved medicines designed for preventing or managing this debilitating neuropathy makes the identification of alternative effective analgesics an essential medical need. (gp120-inhibitors.com)
  • Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. (wikipedia.org)
  • Annas' take on the decision is that it is rather remarkable insofar as it upholds a law which criminalizes physician behavior (performing a specific medical procedure) which at times is necessary to protect the health of a patient ( this is per the ACOG ) and offers no protection to physicians even if they perform the procedure to protect a patient's health. (pallimed.org)
  • Finally, the activation of opioidergic and cholinergic systems appears to play a crucial role in (-)-linalool-induced antinociception. (researchgate.net)