Peripheral membrane proteins. Medical search. Frequent questions

It also may involve the formation or dissociation of protein quaternary structures or oligomeric complexes, and specific binding of ions, ligands, or regulatory lipids. (wikipedia.org)
These include the enzymatic processing of lipids and other hydrophobic substances, membrane anchoring, and the binding and transfer of small nonpolar compounds between different cellular membranes. (wikipedia.org)
These proteins may be anchored to the bilayer as a result of hydrophobic interactions between the bilayer and exposed nonpolar residues at the surface of a protein, by specific non-covalent binding interactions with regulatory lipids , or through their attachment to covalently bound lipid anchors. (wikipedia.org)
With its PDZ domain interacting with membrane proteins and its BAR domain binding to lipids, the unique structure of PICK1 enables it to couple membrane proteins to protein-trafficking machinery. (karger.com)
Work encompasses the design of peptides that have the potential to form stable pores in lipid membranes, the characterisation of peptide interactions with membrane lipids and the physical organic chemistry of peptide reactions in membranes. (dur.ac.uk)
Recent work has begun to establish the factors that control the innate reactivity of peptides towards acyl transfer from membrane lipids (intrinsic lipidation). (dur.ac.uk)
To obtain information about BIN1's interaction with themembrane in near native environments, we used artificial lipid systems suchas liposomes and lipids nanotubes.First, we have shown that electrostatic interactions are more important forBIN1 when binding to membranes with low curvature. (kth.se)
The formation ofinvaginations (or tubules) is regulated by the composition of negativecharged lipids in membrane bilayer or electrostatic residues on the BARdomain. (kth.se)
We emphasize that the SANS signal coming from the deuterated isotropic bicelles can be contrast-matched in 100% D 2 O-based buffer, allowing us to separately and specifically focus on the signal coming from the protein in interaction with membrane lipids. (cea.fr)
We applied this method to the DYS-R11-15 protein, a fragment of the central domain of human dystrophin known to interact with lipids, and we were able to recover the signal from the protein alone. (cea.fr)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. (thermofisher.com)
Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. (antibodies-online.com)

This facilitates the assembly of multi-protein complexes by increasing the probability of any appropriate protein-protein interactions. (wikipedia.org)
This membrane anchor is attached to the protein surface by hydrophobic interactions with the protein core. (uni-goettingen.de)
The research for my thesis focused on studying the interactions between nanoparticles and cellular membranes in an attempt to understand potentially toxic effects of nanoparticles. (columbiabasin.edu)
Current work is directed towards the study of protein-membrane interactions over all timescales and the preparation of asymmetric lipid membranes for biophysical studies of membrane activity (funded by an EPSRC programme grant). (dur.ac.uk)
In particular, the SANS-based approach is a unique technique to obtain low-resolution structures of proteins in interactions with partners by contrast-matching the signal coming from the latter. (cea.fr)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
2017) The human antimicrobial peptides dermcidin and LL-37 show novel distinct pathways in membrane interactions. (birmingham.ac.uk)

The phospholipid bilayer that forms the cell surface membrane consists of a hydrophobic inner core region sandwiched between two regions of hydrophilicity, one at the inner surface and one at the outer surface of the cell membrane (see lipid bilayer article for a more detailed structural description of the cell membrane). (wikipedia.org)
The hydrophobic inner core region of typical biological membranes may have a thickness of around 27 to 32 Å, as estimated by Small angle X-ray scattering (SAXS). (wikipedia.org)
막 지질(membrane lipid)처럼 대부분의 막 단백질은 친수성(hydrophilic) 영역과 소수성(hydrophobic) 영역을 지니고 있습니다. (jove.com)
Similar to the stabilization at the protein the membrane anchor is also bound to the membrane by hydrophobic contacts. (uni-goettingen.de)
We develop web tools such as WEBnma , for ENM-NMA, and PePrMInt , our new resource for the exploration of peripheral membrane proteins surfaces, and of their hydrophobic protrusions. (uib.no)

These proteins attach to integral membrane proteins, or penetrate the peripheral regions of the lipid bilayer. (wikipedia.org)
Peripheral membrane proteins may interact with other proteins or directly with the lipid bilayer. (wikipedia.org)
Some proteins, such as G-proteins and certain protein kinases, interact with transmembrane proteins and the lipid bilayer simultaneously. (wikipedia.org)
The association of a protein with a lipid bilayer may involve significant changes within tertiary structure of a protein. (wikipedia.org)
Typical amphitropic proteins must interact strongly with the lipid bilayer in order to perform their biological functions. (wikipedia.org)
Association of EcPOX to the lipid bilayer is conferred by the last 23 amino acids of the C-terminal part which form an amphipathic helix in the presence of membranes. (uni-goettingen.de)
Bilayer association of the enzyme is thereby promoted by the formation of an amphipathic helix from the membrane anchor. (uni-goettingen.de)
In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)

Current work is examining the chemistry exhibited by drug molecules after their adsorbtion to lipid membranes. (dur.ac.uk)
This approach gives rise to new perspectives to determine the solution structure of peripheral membrane proteins interacting with lipid membranes and might be extended to integral membrane proteins. (cea.fr)

In addition to phragmoplastin, PHIP1 interacts with two Arabidopsis small GTP-binding proteins, Rop1 and Ran2. (nih.gov)
The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. (antibodies-online.com)
Interacts with the snare proteins SNAP-23 and VAMP. (lu.se)

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)

The long-term research goal of the lab is to apply computer modeling to gain insight into cellular signal transduction pathways, specifically to provide deeper insight into both the normal and aberrant subcellular targeting of domains contained in proteins which are part of macromolecular complexes and function in various biological processes. (cuny.edu)
Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. (elifesciences.org)
Protein function is critically determined by subcellular localization, as organelles offer different chemical environments and interaction partners. (elifesciences.org)
In order to regulate protein activity, many biological processes involve changes in protein subcellular localization. (elifesciences.org)

The reversible attachment of proteins to biological membranes has shown to regulate cell signaling and many other important cellular events, through a variety of mechanisms. (wikipedia.org)
Some polypeptide hormones, antimicrobial peptides, and neurotoxins accumulate at the membrane surface prior to locating and interacting with their cell surface receptor targets, which may themselves be peripheral membrane proteins. (wikipedia.org)
세포막(cell membrane) 또는 원형질막(plasma membrane)은 끊임없이 변화하는 풍경과 같습니다. (jove.com)
A. thaliana PHIP1 and its homologs represent a novel class of plant-specific RNA-binding proteins that may play a unique role in the polarized mRNA transport to the vicinity of the cell plate. (nih.gov)
PHIP1 is a peripheral membrane protein and is localized at the cell plate during cytokinesis in plants. (nih.gov)
Non-transfected (-) and transfected (+) HeLa whole cell extracts (50 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with FAK (phospho Tyr576) antibody (GTX132140) diluted at 1:500. (genetex.com)
FAK (phospho Tyr576) antibody detects FAK (phospho Tyr576) protein at cell membrane by immunohistochemical analysis. (genetex.com)
Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with FAK (phospho Tyr576) antibody (GTX132140) diluted at 1:1000. (genetex.com)
Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
Disrupting any component in this pathway led to disrupted SD on the cell surface and intracellular accumulation of mislocalized SD proteins. (sdbonline.org)
Cell membranes need to change their shapes during many cellular processeslike protein trafficking, cytokinesis and membrane homeostasis. (kth.se)
This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. (thermofisher.com)
Red blood cells are a special case of cells filled quasi exclusively (95% of the dry weight of the cell) with an almost spherical protein: hemoglobin. (cea.fr)
Combining spatial and abundance information yielded an unprecedented quantitative view of HeLa cell anatomy and organellar composition, at the protein level. (elifesciences.org)
Dynamic Organellar Maps enable the proteome-wide analysis of physiological protein movements, without requiring any reagents specific to the investigated process, and will thus be widely applicable in cell biology. (elifesciences.org)
Proteins are the tools and machines of the cell, and each organelle has its own set of proteins that it requires to work correctly. (elifesciences.org)
Each cell contains ten or more organelles, and several thousand different types of proteins. (elifesciences.org)
The location of many proteins in a cell is unclear or simply not known. (elifesciences.org)
set out to develop a method that reveals the locations of all the proteins in a cell at any given time. (elifesciences.org)
The resulting technique maps the location of most of the proteins in a human cancer cell line and, in addition, determines how many copies of each protein there are. (elifesciences.org)
Hereditary pyropoikilocytosis (HPP) is an autosomal recessive disorder of the red blood cell (RBC) membrane that is clinically related to, and is considered a subtype of, hereditary elliptocytosis (HE). (medscape.com)
HPP involves a functional defect in spectrin, which is the major cytoskeletal protein of the RBC cell membrane. (medscape.com)
Hereditary pyropoikilocytosis (HPP) is a disease emanating from a defect in spectrin, which is the major peripheral protein of the red blood cell (RBC) membrane. (medscape.com)
Hereditary pyropoikilocytosis (HPP) is subtype of hereditary elliptocytosis (HE) , a red blood cell (RBC) membrane disorder that results from mutations in the genes encoding α-spectrin ( SPTA1 ), β-spectrin ( SPTB ), or protein 4.1R ( EPB41 ). (medscape.com)
page 765 ) find that a previously uncharacterized protein, Inp1p, tethers a fraction of the peroxisomes to the cortex of the mother cell during bud formation in S. cerevisiae . (rupress.org)
Through the judicial selection of lipophilic iron chelators with high affinity for Fe(III) as the ionophores, we have demonstrated that certain octahedral Fe(III) complexes with D3 symmetry have the remarkable ability to transport iron across the cell membrane to trigger intracellular Fenton reaction, which affords potent broad-spectrum in vitro anticancer activity against a plethora of cancer cell lines including the Pt-resistant ovarian cancer cell line. (kent.edu)
We applied time-independent component analysis (tICA) and protein connectivity network model, on all-atom molecular dynamics trajectories, to identify key non-RBD residues, playing crucial role in the conformational transition facilitating spike-receptor binding and infection of human cell. (biorxiv.org)
In the last years, Enea extended her expertise to the crystallization of peripheral and integral membrane proteins while working with proteins involved in the biosynthesis of the cell envelope of Mycobacterium tuberculosis , endolysins and glycosyltransferases. (birmingham.ac.uk)
These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)
The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)
Our research projects will contribute to new insights into the mechanism behind cell dysfunction and demise as well as the mechanism behind the development of insulin resistance in peripheral insulin-targeted tissues. (lu.se)
This protein has been mistargeted to the cell membrane, causing ATP loss that results in cell dysfunctionality. (lu.se)
Notable laboratory findings included a peripheral white blood cell (WBC) count of 11,000/uL (normal: 4000-10,000/uL), cerebrospinal fluid (CSF) protein of 67 mg/dL (normal: less than 45 mg/dL), and CSF WBC count of 17/uL (normal: less than 5/uL). (cdc.gov)
The common denominator in the disease, a biochemical defect, appears to be a genetic mutation leading to the inability to synthesize the glycosyl-phosphatidylinositol (GPI) anchor that binds these proteins to cell membranes. (medscape.com)
Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)

Dr John M Sanderson has research interests in Biophysical Chemistry, with a particular emphasis on biological membranes. (dur.ac.uk)
Here, we employed transmission electronmicroscopy and other biophysical methods to elucidate how BAR domainproteins steer processes at the membrane.In this work we studied the BAR protein bridging integrator 1 (BIN1), whichhas an established role in cancer, Alzheimer's disease and skeletalmyopathies. (kth.se)
She is also interested in the study of the structure-function relationships in proteins through crystallographic, biochemical and biophysical approaches. (birmingham.ac.uk)
After graduating, she moved to the antimicrobial resistance field studying the mechanism of membrane insertion of the well-known LL-37 antimicrobial peptide through crystallographic, biochemical and biophysical techniques. (birmingham.ac.uk)

It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters. (researchgate.net)

All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)
Nested PCRs selective for outer membrane protein A ( omp A) and citrate synthase ( glt A) genes were concurrently performed to detect SFG rickettsial DNA ( Technical Appendix Table 1). (cdc.gov)
Phylogenetic analyses based on nucleotide sequences of the outer member protein A (307-bp) (A) and citrate synthase (1,150-bp) (B) genes of Rickettsia . (cdc.gov)

This has led to the structure determination for RSV M protein (in collaboration with Dr V. Money), 3 and studies of membrane bindign using tensiometry, electron microscopy, circular dichroism and Brewster angle microscopy. (dur.ac.uk)

HPP is characterized by an abnormality in both horizontal (spectrin self association defect) and vertical (spectrin deficiency) RBC membrane protein interaction. (medscape.com)

Gilkerson, R. W., Selker, J. M. L. & Capaldi, R. A. The cristal membrane of mitochondria is the principal site of oxidative phosphorylation. (nature.com)
The membrane anchor of SQR in mammalian mitochondria and proteobacteria, such as Escherichia coli , consists of two polypeptides (SdhC and SdhD) and contains one heme group. (lu.se)

New technologies for purifying membrane-bound protein complexes in combination with cryo-electron microscopy (EM) have recently allowed the exploration of such complexes under near-native conditions. (researchgate.net)
[ 9 ] All of these proteins interact with complement proteins, particularly C3b and C4b, dissociate the convertase complexes of the classic and alternative pathways, and halt the amplification of the activation process. (medscape.com)

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. (genetex.com)
G (His81Gln) mutation in the MPZ gene, which encodes the major integral membrane protein of the peripheral nerve system. (nih.gov)
This gene encodes a protein belonging to the syntrophin family. (antibodies-online.com)

The aim of this chapter is to describe the different possibilities for the functional characterization of peripheral or intrinsic membrane proteins expressed in Lactococcus lactis . (springer.com)

It also helps form red blood cells and maintain the central and peripheral nervous systems . (medlineplus.gov)

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

A total of 46 persons (four personal contacts and 42 health-care workers) received postexposure prophylaxis (PEP) because of possible percutaneous or mucous membrane exposure to the patient's saliva or CSF. (cdc.gov)

The hallmark of eukaryotic cells is their compartmentalization into distinct membrane-bound organelles. (elifesciences.org)

Snare that acts to regulate protein transport between late endosomes and the trans-golgi network. (lu.se)

We identified a subset of lipotoxic monounsaturated fatty acids associated with decreased membrane fluidity. (bvsalud.org)

Peripheral membrane proteins, or extrinsic membrane proteins, are membrane proteins that adhere only temporarily to the biological membrane with which they are associated. (wikipedia.org)
For example, the close association between many enzymes and biological membranes may bring them into close proximity with their lipid substrate(s). (wikipedia.org)
Membrane binding may also promote rearrangement, dissociation, or conformational changes within many protein structural domains, resulting in an activation of their biological activity. (wikipedia.org)
The inner and outer surfaces, or interfacial regions, of model phospholipid bilayers have been shown to have a thickness of around 8 to 10 Å, although this may be wider in biological membranes that include large amounts of gangliosides or lipopolysaccharides. (wikipedia.org)
Research expertise in the group includes amino acid and peptide synthesis, liposome technology and techniques for studying biological membranes, including surface tensiometry, calorimetry, x-ray scattering, optical microscopy and mass spectrometry. (dur.ac.uk)
Post-translational modifications to aquaporin-0 are being examined by mass spectrometry and reveal a diverse lipidation profile at each of the two lipidation sites of the protein (with Prof. R. A. Quinlan, Biological Sciences, Durham University). (dur.ac.uk)
The membrane-binding properties of proteins from enveloped viruses are being characterised by a combination of microscopy, chemical biology and structral biology approaches (with Dr R. P. Yeo, Biological Sciences, Durham University). (dur.ac.uk)
Overall, his work contributed significantly to understanding the organisation of biological membranes and the role of mobility and hydration of enzymes in their function. (cas.cz)

Combined with protein bioinformatics to, for example, evaluate how general our findings are, we look at the structure-dynamics-function relationships, its conservation in families and its importance for membrane peripheral binding and enzyme activity, which is the main focus of our lab at the moment. (uib.no)
NDH-2, also known as type II dehydrogenase, is a peripheral membrane protein functioning as an enzyme (EC: 1.6.99.3) to catalyze the electron transfer in respiratory chain of certain pathogenic organisms e.g. (kent.edu)
1 , 2 Largely expressed on the surface of SARS-CoV-2, the spike (S) protein plays a crucial role in binding to the host angiotensin-converting enzyme 2 (ACE2) through the receptor-binding domain (RBD) and facilitating viral entry, 3 , 4 which is therefore considered as one of the most preferred targets against SARS-CoV-2. (biorxiv.org)

Thus, the flavin acts as redox switch and a signal transfer cascade starting from the reduced flavin leads to exposure of the hitherto protein-bound membrane anchor. (uni-goettingen.de)
Upon activation these contacts are disturbed by conformational changes of the protein and the lipid binding domain to ensure membrane anchor exposure. (uni-goettingen.de)
Concomitant to release of the membrane anchor also an autoinhibitory helix is removed from the protein which leads to a great enhancement of the catalytic activity of EcPOX. (uni-goettingen.de)
Finally, the membrane anchor undergoes a last conformational transition in the presence of membranes. (uni-goettingen.de)
SQR consists of a membrane-peripheral heterodimer domain (often called succinate dehydrogenase) which is tightly bound to a membrane-spanning anchor, which is a cytochrome with one or two heme groups depending on the organism. (lu.se)
The flavin together with the iron-sulfur clusters function to mediate electron transfer from the dicarboxylate binding site on the Fp subunit to the membrane-anchor domain where quinone is reduced to quinol. (lu.se)
With the full complement of prosthetic groups they are then bound to the heme-containing membrane-anchor to form the active SQR. (lu.se)
If the membrane-anchor is missing or defective, Fp and Ip subunits accumulate as soluble proteins in the cytoplasm. (lu.se)
Flavinylation of Fp in B. subtilis does not require the Ip subunit or the membrane anchor but depends on folding of the Fp polypeptide into a state that can bind FAD and subsequent mediate covalent binding of the FAD [3, 4]. (lu.se)

We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global mapping of protein translocation events. (elifesciences.org)
1. Zeth K, Sancho-Vaello E, Okuda M. (2019) Metal positions and translocation pathways of the dodecameric ferritin-like protein Dps. (birmingham.ac.uk)
Studying the mechanisms underlying increased VDAC1 expression and membrane translocation in pancreatic beta cells, vascular endothelial cells, adipocytes, and macrophages in pathological conditions such as long-lasting hyperglycemia or low-grade inflammation. (lu.se)

The regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral membrane proteins. (wikipedia.org)
Infection of human cells by the novel coronavirus (SARS-Cov-2) involves the attachment of the receptor binding domain (RBD) of the spike protein to the peripheral membrane ACE2 receptors. (biorxiv.org)

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. (nature.com)

In: Mus-Veteau I (ed) Membrane proteins production for structural analysis. (springer.com)
Obtaining structural information on integral or peripheral membrane proteins is currently arduous due to the difficulty of their solubilization, purification, and crystallization (for X-ray crystallography (XRC) application). (cea.fr)
For proteins not compatible with these high-resolution methods, small-angle X-ray and neutron scattering (SAXS and SANS, respectively) are powerful alternatives to obtain structural information directly in solution. (cea.fr)
In the present study, isotropic bicelles are used as a membrane mimic model for SANS-based structural studies of bound peripheral membrane proteins. (cea.fr)
2017) Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. (birmingham.ac.uk)

Conversely, broad spectrum therapeutics like drugs and monoclonal antibodies can be generated targeting these key distant regions of the spike protein. (biorxiv.org)
Large scale screening of therapeutic molecules and antibodies are underway aiming to target the spike protein and consequently prevent infection. (biorxiv.org)

The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. (genetex.com)

The PDZ domain of PICK1 binds to a large number of membrane proteins, especially proteins with C-terminal type II PDZ-binding motifs. (karger.com)
After saturating the haptoglobin, free forms of hemoglobin circulates and binds irreversibly with nitric oxide (NO) and depletes NO levels in peripheral blood. (medscape.com)

The thiamine- and flavin-dependent peripheral membrane protein pyruvate oxidase from E. coli (EcPOX) catalyzes the oxidative decarboxylation of the central metabolite pyruvate to CO2 and acetate with a concomitant electron transfer step to ubiquinone 8 (Q8), a membrane-bound mobile carrier of the respiratory chain. (uni-goettingen.de)
It was shown that amino acids within the active site mediate pyruvate-induced reduction of the protein-bound flavin cofactor. (uni-goettingen.de)
Seventy percent of plasma magnesium is ionized or complexed to filterable ions (eg, oxalate, phosphate, citrate) and is available for glomerular filtration, while 20% is protein-bound. (medscape.com)
Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
SQR in E. coli and B. subtilis can be assembled in the membrane without covalently bound FAD but are enzymatically inactive [3, 4, 6]. (lu.se)
It is unexpected that B. subtilis SQR without covalently bound FAD is not assembled in the E. coli membrane provided that all other aspects of assembly, including iron-sulfur cluster biogenesis, are functional in the heterologous system. (lu.se)
Notably, certain B. subtilis mutants with mutated Fp lack covalently bound flavin and do not assemble the SQR polypeptides in the membrane [3]. (lu.se)

The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. (researchgate.net)

Some water-soluble proteins associate with lipid bilayers irreversibly and can form transmembrane alpha-helical or beta-barrel channels. (wikipedia.org)
대부분의 내재단백질(integral protein)은 막관통단백질(transmembrane protein)로, 막 전체에 걸쳐 두 인지질층을 가로지릅니다. (jove.com)
These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)

Thisimplies that BIN1 rather bundles actin than decorates single filaments.Third, we explored a strategy to purify an aggregation prone BAR protein.Aggregation is a property common in Peripheral Membrane Proteins. (kth.se)
Platelets were analyzed by flow cytometry for relative size, shape, aggregation, fibrinogen binding, P-selectin, and lysosomal-associated membrane protein-1 (LAMP-1) expression. (cdc.gov)

The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)
PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)
In the Fp subunit of SQR, and the closely related membrane-associated fumarate reductase of anaerobic organisms, FAD is covalently attached via an 8α-N(3)-histidyl linkage to a histidine (His) in a conserved sequence in the N-terminal part of the polypeptide. (lu.se)

This results in severe hemolytic anemia as the RBC's lipid membrane destabilizes and loses its abilty to withstand intravascular shear stress. (medscape.com)

The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)

In this thesis the activation and membrane binding mechanism of EcPOX was investigated. (uni-goettingen.de)
Initial results suggest that Q8 leaves the membrane and penetrates the active site of EcPOX according to an out-of-the membrane mechanism. (uni-goettingen.de)
Molecular modeling and computational analyses suggests that the Sinorhizobium meliloti periplasmic regulator protein ExoR adopts a superhelical fold and is controlled by a unique mechanism of proteolysis. (cuny.edu)

We initially used maps statically to generate a database with localization and absolute copy number information for over 8700 proteins from HeLa cells, approaching comprehensive coverage. (elifesciences.org)

PICK1 is a peripheral membrane protein conserved from Caenorhabditis elegans to the human. (karger.com)
Carrier-protein conjugated synthetic peptide surrounding phospho Tyr576 of human FAK. (genetex.com)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Finally, using a simple model and the concentration dependence of the diffusion of the protein reported here, we show that hemoglobin concentration observed in human red blood cells (≃≃330 g . (cea.fr)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

The patients' spermatozoa displayed multiple midpiece defects, including absent MS and central pair, scattered or forked axoneme and incomplete plasma membrane. (nih.gov)
This study provides the first in vivo evidence of trapped SD proteins in clathrin-coated pits at the plasma membrane when this pathway is disrupted. (sdbonline.org)
Interestingly, aux depletion causes a dramatic increase in EGFR signaling, with a strong accumulation of EGFR at the plasma membrane and an increased expression of EGFR ligands in response to tissue stress. (sdbonline.org)
As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. (thermofisher.com)

Magnesium is involved in nearly every aspect of biochemical metabolism (eg, DNA and protein synthesis, glycolysis, oxidative phosphorylation). (medscape.com)
Biotin is essential for the metabolism of proteins and carbohydrates, and in the production of hormones and cholesterol. (medlineplus.gov)

Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous peripheral neuropathy. (nih.gov)

Here, using atomistic molecular dynamics simulation, we study the correlations between the RBD dynamics with physically distant residues in the spike protein, and provide a deeper understanding of their role in the infection, including the prediction of important mutations and of distant allosteric binding sites for therapeutics. (biorxiv.org)
Our model, based on time-independent component analysis (tICA) and protein graph connectivity network, was able to identify multiple residues, exhibiting long-distance coupling with the RBD opening dynamics. (biorxiv.org)

The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)

In particular, polymer-encapsulated nanodiscs enable the study of membrane proteins at high resolution while retaining protein-protein and protein-lip. (researchgate.net)
Due to their unique properties, expression and study of membrane proteins in heterologous systems remains difficult. (springer.com)
The current study confirmed Inp1p's location and defined it as a peripheral peroxisomal membrane protein. (rupress.org)
5 , 7 - 9 More specifically, a study analyzing 10,022 SARS-CoV-2 genomes from 68 countries revealed 2969 different missense variants, with 427 variants in the S protein. (biorxiv.org)

Anatomy50

Organisms13

Diseases5

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes56

Disciplines and Occupations2

Technology, Industry, Agriculture7

Information Science3

Health Care1

Lipids11

Cytoplasmic peripheral2

Interactions7

Hydrophobic5

Bilayer8

Lipid Membranes2

Interacts3

Interfaces1

Subcellular4

Cell35

Biophysical4

Synaptic vesicles1

Genes4

Studies of membrane1

Interaction1

Mitochondria2

Complexes2

Encodes3

Intrinsic1

Central and peripheral1

Intracellular1

Mucous1

Compartmentalization1

Regulate1

Fluidity1

Biological8

Enzyme3

Anchor9

Translocation3

Receptors2

Mitochondrial uncoupl1

Structural5

Antibodies2

Similarity1

Binds2

Bound7

SNARE1

Transmembrane3

Aggregation2

Sequence3

Hemolytic1

Fibrinogen1

Mechanism3

Localization1

Human5

Plasma4

Metabolism2

Clinically1

Residues2

Proteomics1

Study4