• When patients need a stem cell transplant, it means that their bone marrow (stem cell factory) has failed due to an illness. (blood.ca)
  • Stem cells, specifically blood stem cells, are immature cells that can develop into any cell present in the bloodstream. (blood.ca)
  • Learn about Canadian Blood Services Stem Cell Registry, donor eligibility, important registration information, how stem cell donation works and more. (blood.ca)
  • After stem cells saved her life, her story is helping to save others Mackenzie Curran's support of Canadian Blood Services Stem Cell Registry directly helped a patient in need. (blood.ca)
  • What is Canadian Blood Services Stem Cell Registry? (blood.ca)
  • Canadian Blood Services Stem Cell Registry-formerly known as the OneMatch Stem Cell and Marrow Network-is dedicated to recruiting and finding healthy, committed volunteer donors for patients in need of blood stem cell transplants. (blood.ca)
  • Canadian Blood Services Stem Cell Registry operates according to international standards established by the World Marrow Donor Association (WMDA), the international organization that promotes the ethical, technical, medical and financial aspects of stem cell transplantation. (blood.ca)
  • When you register to join Canadian Blood Services Stem Cell Registry, a sample of your DNA is obtained to identify your HLA which is entered into our database. (blood.ca)
  • They come from bone marrow, circulating (peripheral) blood or umbilical cord blood . (blood.ca)
  • Umbilical cord blood - rich lifesaving stem cells - are collected from the umbilical cord and placenta after the safe delivery of a baby. (blood.ca)
  • Bone marrow deficiency diseases such as thalassemia or sickle cell disease. (blood.ca)
  • Bone marrow stem cells are collected from the back of the hip bones which is a surgical procedure performed under general anesthetic. (blood.ca)
  • Bone marrow is the soft tissue inside our bones that acts as a factory, producing blood-forming stem cells. (blood.ca)
  • When diseases affect the bone marrow, and they cannot produce healthy stem cells, a stem cell transplant may be a patient's best treatment option. (blood.ca)
  • Patients who undergo chemotherapy or radiation treatment may also need a transplant of healthy stem cells to help heal and re-boost their immune system. (blood.ca)
  • Learn about Canadian Blood Services' Cord Blood Bank, donor eligibility, important registration information, how cord blood donation works and more. (blood.ca)
  • You could be a hero to a patient in need by joining Canada's national stem cell registry or, if you're an expectant mother, consenting to donate cord blood. (blood.ca)
  • Also, once you've joined the stem cell registry, it's very important that you let us know when your contact information changes. (blood.ca)
  • Without stem cells, the body cannot make the blood cells needed for the immune system to function. (blood.ca)
  • Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19), with macrophages as one of the main cell types involved. (nature.com)
  • The progression from mild to severe disease or death is principally attributed to dysfunctional immune responses 2 , 3 coupled with viral damage of target cells. (nature.com)
  • In addition to local damage, the pro-inflammatory macrophages release cytokines/chemoattractants and prime adaptive immune cell responses In some cases, this lead to cytokine release syndromes including macrophage activation syndrome (MAS) 7 , followed by respiratory and even multi-organ failure 5 . (nature.com)
  • These antigens are found on the surface of white blood cells and are inherited from our parents. (blood.ca)
  • Whether you're a donor or a patient, understanding the stem cell donation and transplant process is an important part of your journey. (blood.ca)
  • Stem cell matches are determined according to DNA markers called Human Leukocyte Antigens (HLA) which are known to be important when matching a patient to a donor. (blood.ca)
  • It is urgent to understand the interactions among permissive cells, macrophages, and the SARS-CoV-2 virus, thereby offering important insights into effective therapeutic strategies. (nature.com)
  • Despite the approval of some vaccines for disease prevention and emergency use, a deeper understanding of the interactions among targeted cells and SARS-CoV-2 is critically important for studying viral pathobiology and offering better ideas to help combat this deadly contagious disease. (nature.com)
  • We coordinate searches in Canada and with other international registries to work towards a single goal: helping patients get the stem cells they need. (blood.ca)
  • Recent studies 5 , 6 on the immunity of COVID-19 patients indicated that the cells damaged by SARS-CoV-2 infection triggered innate inflammation in the lungs, which is largely mediated by pro-inflammatory macrophages and granulocytes. (nature.com)
  • In general, M1φ cells destroy pathogens by producing a large amount of pro-inflammatory cytokines. (nature.com)
  • The type of stem cell donation is determined by the transplant physician and transplant team based on the needs of the patient. (blood.ca)
  • Several factors are taken into consideration by the transplant team to best determine the type of stem cell donation for the patient. (blood.ca)
  • This database allows us to search for potential donors who match a patient requiring a stem cell transplant. (blood.ca)