• Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
  • The number of viable CD45+/CD34+ cells will determine the quality of the harvested specimen for transplantation. (bdbiosciences.com)
  • An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
  • Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. (wikipedia.org)
  • citation needed] The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
  • Bone Marrow Transplantation. (wikipedia.org)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
  • 1 After transplantation, donor T cells are activated by antigen-presenting cells. (oncologynurseadvisor.com)
  • Bone marrow transplantation , 45 , S21-S22. (amsterdamumc.org)
  • Currently, doctors at the Hutch use a total of three cord-blood units for the majority of patients undergoing cord-blood transplantation. (fredhutch.org)
  • The goal is to reduce early transplant-related mortality while taking advantage of cord-blood stem cells' anti-leukemia effects after transplantation, leading to improved long-term survival. (fredhutch.org)
  • However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells. (biologynews.net)
  • However, in 1988, researchers found cord blood to be another source for stem cell transplantation. (biologynews.net)
  • BLAISE, D. Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation: results of a randomized study. (bvsalud.org)
  • Purpose: Diarrhea associated with acute gastrointestinal (GI) graft- versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) can result in severe morbidity and mortality. (elsevierpure.com)
  • Allogeneic transplant- The transplantation involves infusing stem cells, extracted from a donor who is genetically matched with the patient. (stemcelline.com)
  • Total body irradiation (TBI)-based-conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is standard of care in patients with acute myeloid leukemia (AML) but can cause long-term morbidity. (biomedcentral.com)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment modality for selected patients with acute myeloid leukemia (AML). (biomedcentral.com)
  • MSCs were obtained from the bone marrow (BM) cells remaining in the bag and filter used in the transplantation of hematopoietic stem cells. (springer.com)
  • Mild Acute Graft-Versus-Host Disease Improves Outcomes After HLA-Haploidentical-Related Donor Transplantation Using Posttransplant Cyclophosphamide and Cord Blood Transplantation. (kyoto-u.ac.jp)
  • Minimal important difference of the 6-minute walk test after allogenic hematopoietic stem cell transplantation. (kyoto-u.ac.jp)
  • Both cells have common applications in various cell-based therapies such as tissue regeneration and transplantation. (differencebetween.com)
  • Bone marrow transplantation , 51 (12), 1599-1601. (johnshopkins.edu)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD). (haematologica.org)
  • Patients undergoing fludarabine therapy (purine analog) , bone marrow transplantation or peripheral blood stem cell transplantation. (utmb.edu)
  • Hepatic sinusoidal obstruction syndrome (SOS) is a severe and life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
  • In Japan, the number of HLA-haploidentical stem cell transplantation cases exceeded related HLA-matched transplants in 2020. (bvsalud.org)
  • Recent retrospective studies using Japanese registry data have reported comparable transplantation outcomes between PTCy-haplo and HLA-matched unrelated and cord blood transplantations. (bvsalud.org)
  • This re- view discusses stem cell applications in transplantation, stem cell-based carriers, induced-pluripotent stem cells, can- cer stem cells, and potential of stem cells engineering to revolutionize cancer treatment. (bmrat.org)
  • In a study reported in The New England Journal of Medicine , R. Coleman Lindsley, MD, PhD , of Dana-Farber Cancer Institute, and colleagues found that a number of mutations present in patients with myelodysplastic syndromes (MDS) were associated with poorer clinical outcome after allogeneic hematopoietic stem cell transplantation. (ascopost.com)
  • Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem-cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen. (ascopost.com)
  • The purpose of this study is to evaluate the effects that psychological and health behavior factors have on quality of life, level if sickness, and death after blood and bone marrow transplantation. (mayo.edu)
  • The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
  • Researchers sought to determine whether vitamin D deficiency before hematopoietic stem cell transplantation would impact risk of GVHD in thalassemia major. (hematologyadvisor.com)
  • Reduction in late mortality among patients with Multiple Myeloma treated with Autologous Peripheral Blood Stem Cell Transplantation - a BMTSS Report. (stembook.org)
  • Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia. (stembook.org)
  • Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes. (stembook.org)
  • Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic cell transplantation program (Part I): Minimum requirements and beyond. (stembook.org)
  • Proteome Profiling in Lung Injury Following Hematopoietic Stem Cell Transplantation. (stembook.org)
  • Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
  • Validation and refinement of the disease risk index for allogeneic stem cell transplantation: a study from the CIBMTR. (stembook.org)
  • Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
  • Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). (unisr.it)
  • This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. (unisr.it)
  • A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitory cell transplantation. (nature.com)
  • Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
  • Infection with varicella-zoster virus after marrow transplantation. (nature.com)
  • Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
  • Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
  • Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
  • The patient, who was being followed-up with the diagnosis of Pre-B ALL, had two allogeneic bone marrow transplants, developed Graft- Versus-Host disease after peripheral blood stem cell transplantation, and had a history of ruxolitinib and high-dose dexamethasone usage, was consulted with decreased visual acuity while hospitalized in hematology clinic due to necrotizing fasciitis on his foot. (retinavitreus.com)
  • The plaintiffs consisted of relatives of sick persons in need of bone marrow transplantation, a medical expert on bone marrow transplantation, and a non-profit seeking to launch a program offering paid incentives for bone marrow donors. (pulj.org)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
  • Bone marrow transplantation 2009 Sep 44 (5): 273-8. (cdc.gov)
  • Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
  • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)
  • Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
  • In 2020, there were more than 23,000 bone marrow or cord blood transplants in the United States. (healthline.com)
  • Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
  • Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
  • Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
  • With traditional bone marrow or peripheral blood stem cell transplants, the donors must be "matched" to a patient's unique genetic background to minimize the risk of graft-vs.-host-disease , or GVHD. (fredhutch.org)
  • Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
  • Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. (biologynews.net)
  • Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
  • There are two types of stem cell transplants, namely. (stemcelline.com)
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • People who register as donors agree to donate either bone marrow or PBSC, depending on the recipient's needs. (healthline.com)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • Majority of the patients have to depend on Unrelated Blood Stem Cell Donors . (datri.org)
  • Cord-blood donors are currently considered an alternative to traditional adult hematopoietic stem cell donors. (fredhutch.org)
  • According to Milano, doctors can find suitable cord-blood donors for about 95 percent of patients. (fredhutch.org)
  • 9 Blood centers are actively urging healthy donors to contribute, bearing in mind that only 3% of eligible Americans donate blood. (cap.org)
  • Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
  • An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
  • Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
  • CD20 antagonists deregulate B cells, which are believed to contribute to the pathogenesis of GVHD. (oncologynurseadvisor.com)
  • When CD20 antagonists decrease the amount of circulating B cells, the body may not produce as many cytotoxic T cells that can potentially induce GVHD. (oncologynurseadvisor.com)
  • Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy in haploidentical hematopoietic cell transplant (haplo-HCT). (biomedcentral.com)
  • In this prospective trial, results indicated that low-dose PTCy is sufficient to lower acute GVHD in mouse model, partly due to the boosting of fast regulatory T cell (Treg) reconstitution. (biomedcentral.com)
  • HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
  • This procedure not only reduces the odds of graft failure but also seems to decrease the chances of developing graft versus host disease, according to research findings. (differencebetween.net)
  • A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. (nature.com)
  • Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. (nature.com)
  • Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (nature.com)
  • Some people return to the lives they were leading before their diagnosis, while the lives of others are significantly changed by their cancer experience, the development of graft-versus-host-disease, or other issues and challenges. (massgeneral.org)
  • Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
  • Data on the impact of chronic Graft-versus-host disease (cGvHD) on cognitive function (CF) and quality of life (QoL) of long-term transplant survivors are sparse. (biomedcentral.com)
  • The influence of total body irradiation (TBI) as part of the conditioning regimen and chronic graft-versus-host disease (cGvHD) on cognitive function (CF) and quality of life (QoL) of very long-term survivors is still unclear. (biomedcentral.com)
  • Leukoreduced RBCs still contain enough leukocytes capable of producing transfusion-associated graft versus host disease (TAGVHD) in susceptible patients. (utmb.edu)
  • This is called graft-versus-host disease. (mdanderson.org)
  • Dry eye can also be a symptom of many medical conditions, including Sjogrens' syndrome, lupus, rheumatoid arthritis, scleroderma, graft vs. host disease (after receiving donated bone marrow or peripheral blood stem cells), sarcoidosis, thyroid disorders, and a vitamin A deficiency. (midwesteyeassociates.com)
  • In a little over 4,800 cases, the blood came from an unrelated donor. (healthline.com)
  • Donating bone marrow is relatively low risk for the donor. (healthline.com)
  • The National Marrow Donor Program requires you be between 18 and 40 years old to donate. (healthline.com)
  • Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a donor (PBSC collection). (wikipedia.org)
  • The apheresis procedure typically lasts for 4-6 hours, depending on the blood volume of the donor. (wikipedia.org)
  • For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. (wikipedia.org)
  • If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required for adequate collection. (wikipedia.org)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • The process is also less painful for the donor since a needle is not being placed into bone. (differencebetween.net)
  • The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
  • The procedure in which bone marrow is extracted from a donor does require the use of either a local or a general anesthetic. (differencebetween.net)
  • The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • Donor T-cells proliferate and inflammatory mediators are recruited. (oncologynurseadvisor.com)
  • You might be wondering "Why should I become a Blood Stem Cell Donor ? (datri.org)
  • Register yourself as a potential Bone Marrow (or) Peripheral Blood Stem Cell Donor . (datri.org)
  • His only hope for a cure is to find a matching blood stem cell donor which. (datri.org)
  • He is a father of two young children and is in urgent need of a matched blood stem cell donor. (datri.org)
  • The researchers now want to eliminate the need for a second cord-blood unit from a public blood bank by using the expanded, off-the-shelf cell unit to provide an initial wave of early recovery until the long-term matched donor cells engraft. (fredhutch.org)
  • This is a very important step in the clinical development of this universal donor cell therapy, which has been under clinical investigation since the first trial in 2006," Delaney said. (fredhutch.org)
  • This complication occurs when newly transplanted donor cells attack the organs and tissues of the transplant recipient, regarding them as foreign. (fredhutch.org)
  • Since the donor cells in cord blood come from a baby whose immune system is naïve, the cells can adapt and don't have to be a complete match to the patient. (fredhutch.org)
  • This is a particularly viable option for leukemia patients of mixed-race ancestry who often can't find a matched donor in the stem cell registry. (fredhutch.org)
  • Resilient blood centers implemented operational changes and intensified donor recruitment efforts to stabilize the situation. (cap.org)
  • 16 With the goal of large-scale production of enzyme-treated universal RBC, the focus was turned on treating type A blood (40% of donor population). (cap.org)
  • The article covers the following topic:- leukemia introduction, Stem cell transplant for treatment of Leukemia, benefits of transplant, types of transplant, complications, and how to be a stem cell donor. (stemcelline.com)
  • Topics:- Leukemia therapy with stem cell transplant, advantages of transplant, different types of transplant, side effects, and how to become a stem cell donor. (stemcelline.com)
  • Usually, the donor may be a sibling or any blood-related person, just in case no one is available then, the nearest genetically equivalent person can also donate to the patient. (stemcelline.com)
  • Are you interested in being a stem cell donor? (stemcelline.com)
  • Apheresis is the process of removing whole blood from a patient or donor and separating the blood into its components (plasma, white blood cells, platelets, and red blood cells). (fmcna.com)
  • Once separated, the desired component is then removed, and the rest of the whole blood is reinfused back into the patient or donor. (fmcna.com)
  • The most commonly known apheresis procedure is plasma or platelet donation, where parts of the blood are collected from a healthy donor and used for patients requiring transfusions in the hospital. (fmcna.com)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
  • Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
  • This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)
  • The primary purpose of this study is to estimate and compare overall survival between the two arms: patients who are Very Likely to find a Matched Unrelated Donor (MUD) versus those who are Very Unlikely to find a MUD. (mayo.edu)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
  • Patients with ALL can have a high, normal, or low white blood cell (WBC) count, but they usually exhibit neutropenia. (medscape.com)
  • Appropriate cultures, in particular blood cultures, should be obtained in patients with fever and in those with other signs of infection even if fever is absent. (medscape.com)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
  • MM is often discovered through routine blood screening when patients are being evaluated for unrelated problems. (medscape.com)
  • Since there is a delay in the appearance of the T cells that come from stem cells to get out of the bone marrow and into the blood, we will give patients both gene-modified T cells for a first wave of antitumor activity and gene-modified stem cells which will provide a bridge until the stem cells have produced more T cells. (ca.gov)
  • Patients with acute lymphoblastic leukemia (ALL) present with either symptoms relating to direct infiltration of the marrow or other organs by leukemic cells, or symptoms relating to the decreased production of normal marrow elements. (medscape.com)
  • Patients with ALL often have decreased neutrophil counts, regardless of whether their total white blood cell (WBC) count is low, normal, or elevated. (medscape.com)
  • Although patients may present with symptoms of leukostasis (eg, respiratory distress, altered mental status) because of the presence of large numbers of lymphoblasts in the peripheral circulation, leukostasis is much less common in people with ALL than those with acute myelogenous leukemia (AML), and it occurs only in patients with the highest WBC counts (ie, several hundred thousand per μL). (medscape.com)
  • Occasionally, patients have rashes that result from infiltration of the skin with leukemic cells. (medscape.com)
  • These immature stem cells were easier to match to patients, especially those from non-Caucasian ethnicities, and could be stored for use as needed. (biologynews.net)
  • Once the process is complete, the NK cells can be transplanted to patients without prior chemotherapy. (biologynews.net)
  • 2 Karl Landsteiner's discovery of ABO blood groups and Rh factor in the early 20th century led to the provision of matched blood products to patients to prevent hemolytic complications and enhance safety. (cap.org)
  • 3 Today, serologic and molecular techniques, along with laboratory information systems and electronic health records, contribute to precise blood product management and personalized transfusion therapies, particularly benefiting complex patients with sickle cell disease, thalassemia, and other diseases requiring chronic transfusion support. (cap.org)
  • Patients received either peripheral- blood stem cells (n = 13) or bone marrow (n = 8). (elsevierpure.com)
  • Patients completed the Functional Assessment of Cancer Therapy-Bone marrow transplant (FACT-BMT, version 4), the FACT-Cognition Function (FACT-Cog, version 3), the Patient Health Questionaire-4 (PHQ-4) and a questionnaire about sociodemographic data. (biomedcentral.com)
  • Patients who benefit most from the transfusion of RBCs include those with chronic anemia resulting from kidney failure or gastrointestinal bleeding, and those with acute blood loss resulting from surgery or trauma. (utmb.edu)
  • Patients receiving granulocyte components, components that are HLA matched, or directed donations (from blood relatives) . (utmb.edu)
  • For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
  • The study involved targeted mutational analysis of samples obtained before stem cell transplant from 1,514 MDS patients enrolled at the Center for International Blood and Marrow Transplant Research Repository between 2005 and 2014. (ascopost.com)
  • among patients without TP53 mutations, survival was similar among those with therapy-related MDS vs primary MDS (HR = 1.10, P = .37). (ascopost.com)
  • PPM1D mutation vs no mutation was not associated with poorer survival in patients with therapy-related MDS without TP53 mutations (HR = 1.26, P = .39). (ascopost.com)
  • The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
  • The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
  • Researchers sought to determine whether greater Vδ2-positive T-cell recovery would impact mortality for patients with AML who undergo haplo-HCT. (hematologyadvisor.com)
  • A retrospective analysis sought to determine safety and tolerability of posttransplantation cyclophosphamide in patients with peripheral T-cell lymphoma. (hematologyadvisor.com)
  • CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets. (stembook.org)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. (unisr.it)
  • 1972. Details of blood changes in 32 patients with pancytopenia associated with long-term exposure to benzene. (cdc.gov)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
  • All patients can evolve into trisomy 8+ MDS [12], cells, since acquiring adequate samples diagnosed with MDS have a reduced in which 8+ appears to confer a favour- for flow cytometric analysis renders the life expectancy compared with age- able prognosis [13]. (who.int)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
  • Current literature suggests when peripheral blood (PB) is consisted of 30% blasts or higher diagnosis of acute leukemia is most likely. (medscimonit.com)
  • The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)
  • [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
  • Atul Kapur a Punjabi born and brought up in Bangalore is suffering from Leukemia, a form of blood cancer. (datri.org)
  • Farshogar is bravely fighting against Acute Myeloid Leukemia, a. (datri.org)
  • The Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation has awarded a $500,000 grant to Fred Hutchinson Cancer Research Center to support a clinical trial to improve the use of umbilical cord blood as a treatment for leukemia. (fredhutch.org)
  • Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood. (biologynews.net)
  • Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
  • When given to mice with aggressive human leukemias, these NK cells reduced the circulating human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells by 60 to 85 percent. (biologynews.net)
  • These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. (biologynews.net)
  • Leukemia is a cancer of blood cells and bone marrow, which means it results in excessive growth of white blood cells. (stemcelline.com)
  • Manufacturing results of tisagenlecleucel for acute lymphoblastic leukemia: a survey by the CAR-T cell therapy taskforce of the Japan Society of Transfusion Medicine and Cell Therapy]. (kyoto-u.ac.jp)
  • Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
  • During apheresis, blood comes out of your body through a needle in one arm. (healthline.com)
  • The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
  • The stem cells are collected by passing all the blood through an apheresis machine that draws out stem cells from the blood and returns the rest of the blood. (stemcelline.com)
  • In Flynn v. Holder (2011), the U.S. Court of Appeals for the Ninth Circuit ruled that a common method of bone marrow donation - "peripheral blood stem cell apheresis" - did not fall under the ban on compensated organ donation under the National Organ Transplant Act (NOTA) of 1984. (pulj.org)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • 6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
  • 2016). Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. (springer.com)
  • About 18,000 people each year need a bone marrow or cord blood transplant to treat a life threatening illness. (healthline.com)
  • Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
  • The three sources of stem cells include bone marrow, umbilical cord blood, and peripheral blood. (oncologynurseadvisor.com)
  • Principal investigator Dr. Filippo Milano , associate director of Fred Hutch's Cord Blood Program , and program director Dr. Colleen Delaney will use the two-year grant to examine a new cord-blood transplant regimen that could not only improve treatment outcomes but lower cost. (fredhutch.org)
  • Two of these are from a public cord- blood bank and are matched to the patient. (fredhutch.org)
  • The third, an unmatched unit, is made available "off-the-shelf" after a laboratory process pioneered by Delaney that expands the limited number of cord-blood stem cells. (fredhutch.org)
  • Now let's see if the expanded unit can be used in a setting where we use only one matched cord-blood unit along with the unmatched, expanded unit. (fredhutch.org)
  • The approach also makes lifesaving use of cord blood that would otherwise be discarded as medical waste. (fredhutch.org)
  • Previous efforts to expand cord blood have resulted in ineffective NK cells. (biologynews.net)
  • Zweidler-McKay's study involves selecting out NK cells from cord blood. (biologynews.net)
  • As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion. (biologynews.net)
  • These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias. (biologynews.net)
  • Source of stem cells were peripheral blood, bone marrow or cord blood. (biomedcentral.com)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • peripheral blood, or placental/umbilical cord blood). (cdc.gov)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
  • The source of the stem cells is either from Adult body tissues or Embryo cells. (stemcelline.com)
  • Progenitor cells are an intermediary step in the development of mature cells in tissues, organs, blood, and the central nervous system. (differencebetween.com)
  • Therefore, progenitor cells are necessary for repairs and to maintain tissues after an injury. (differencebetween.com)
  • They can create new tissues and even whole organs from a few stem cells. (differencebetween.com)
  • Resident memory (T RM ) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. (frontiersin.org)
  • Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
  • whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • Organs and tissues are built up by specialized cells from the pool of stem cells that form shortly after fertilization. (bmrat.org)
  • Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)
  • Gene therapy has attracted much attention because of its unique mechanism of action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. (bvsalud.org)
  • In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
  • Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • This study was aimed to observe if thrombin could stimulate FN secretion by human bone marrow MSCs and investigate the potential underlying mechanisms. (biomedcentral.com)
  • PCR analysis showed that human bone marrow MSCs expressed two subtypes of PARs, PAR-1 and PAR-2. (biomedcentral.com)
  • Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
  • Adult stem cells exist throughout the body. (coconutresearchcenter.org)
  • Mesenchymal stem cells (MSCs) are adult multipotent cells that were initially isolated from bone marrow[ 1 ] and characterized by the fibroblast-like appearance in culture and the capacities to form bone, adipose and cartilage. (biomedcentral.com)
  • For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
  • A blastocyst contains an inner cell mass including a clump of around 150 cells that eventually will generate the entire body of the adult animal. (bmrat.org)
  • This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)
  • Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
  • Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
  • Genetic analysis included targeted sequencing of 129 genes selected for their known or suspected involvement in the pathogenesis of myeloid cancers or inherited or acquired bone marrow failure syndromes. (ascopost.com)
  • An early example of a successful peripheral stem cell transplant was carried out in the wake of the 1999 Tokaimura nuclear accident. (wikipedia.org)
  • The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
  • The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
  • The aim of this study was to isolate and characterise equine mesenchymal stromal cells from various sources and to compare their biological properties to that of dermal fibroblasts. (waikato.ac.nz)
  • Fibronectin (FN) is commonly used in the development of serum-free media for the expansion of mesenchymal stem cells (MSCs). (biomedcentral.com)
  • Bone marrow donation can take place privately, where you directly contact a care center or transplant center caring for someone you know. (healthline.com)
  • Bone marrow donation takes place in an operating room. (healthline.com)
  • The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. (wikipedia.org)
  • Stem cell donation is life-saving for many people across the world. (stemcelline.com)
  • The volunteers can approach any health center for the stem cell donation, the extraction takes place from these three sources:- 1. (stemcelline.com)
  • Infiltration of the marrow by massive numbers of leukemic cells frequently manifests as bone pain. (medscape.com)
  • Signs relating to organ infiltration with leukemic cells and, to a lesser degree, lymphadenopathy may be present. (medscape.com)
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
  • 5-year old Tanush Poddar is diagnosed with Thalassemia Major, a blood disorder that requires him to undergo blood transfusions every 15 days that often leaves him drained of energy. (datri.org)
  • 11 The promise of developing universal blood could eliminate the barrier of matching ABO antigens for blood transfusions, which is time-consuming and limits inventory. (cap.org)
  • These efforts aim to address challenges like blood shortages, alloimmunization, and improve the overall success and safety of transfusions. (cap.org)
  • The high numbers of leukocytes remaining in a unit of pRBCs during the storage process can fragment, deteriorate, and release cytokines, and they have been implicated as a cause of reactions to a current and subsequent blood transfusions in some transfusion recipients. (utmb.edu)
  • However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • This prospective observational study aimed to assess the serological response and safety after the third booster shot of SARS-CoV-2 mRNA vaccines in 292 hematopoietic cell transplant (HCT) recipients. (bvsalud.org)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • Our emerging clinical data demonstrates that these gene-modified T cells are very active in killing tumor cells initially, but they lose their ability to function within a few weeks. (ca.gov)
  • These cell types are used in cell culture studies to analyze cellular responses in different clinical and physiological settings. (differencebetween.com)
  • Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • HSCs develop into different types of blood cells in lines called myeloid and lymphoid , which are involved in dendritic cells formation. (differencebetween.com)
  • Lymphoid cells include T cells, B cells, innate lymphoid cells, and natural killer cells. (differencebetween.com)
  • These multipotent progenitor cells differentiate into either common myeloid progenitor (CMP) or common lymphoid progenitor cells (CLP). (differencebetween.com)
  • Classical definitions of memory T cells derive from the belief that T cells localize and recirculate predominantly throughout the blood and secondary lymphoid organs ( 7 , 8 ). (frontiersin.org)
  • Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
  • Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)
  • 43-year old Pratik Vakil, a Gujarati dentist, has been diagnosed with life-threatening Myelodysplastic Syndrome , a form of blood cancer. (datri.org)
  • 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
  • He showed that short-term fasting provided complete protection to mice against the side effects of high-dose chemotherapy. (coconutresearchcenter.org)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Autologous transplant - This transplant involves the extraction of stem cells from the patient's blood or bone marrow during the most stable condition of the patient. (stemcelline.com)
  • HLA-haploidentical stem cell transplantations using posttransplant cyclophosphamide (PTCy-haplo) rapidly increased worldwide. (bvsalud.org)
  • Since allogeneic PBSCT involves transformation of blood between different individuals, this naturally carries more complications than autologous PBSCT. (wikipedia.org)
  • Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
  • However, bone marrow aspiration may also be performed as a confirmatory diagnosis. (medscimonit.com)
  • Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
  • Single-cell sequencing technology transforms the landscape of pancreatic cancer diagnosis and therapy. (frontiersin.org)
  • Blood advances 2018 9 2 (17): 2254-2261. (cdc.gov)