Peripheral blood stem cells malignancies bone marrow transplantation. Medical search. Frequent questions

19. A phase I dose escalation study of high-dose thiotepa, melphalan and carboplatin (TMCb) followed by autologous peripheral blood stem cell transplantation (PBSCT) in patients with solid tumors and hematologic malignancies. (nih.gov)
However, the most commonly reported infection is bacteremia in the setting of chemotherapy for hematologic malignancies ( 1 , 2 ). (cdc.gov)
All 3 patients had grades 1-2 mucositis, which in the presence of neutropenia, is a known risk factor for anaerobic bacteremia in patients undergoing chemotherapy for hematologic malignancies ( 3 , 7 , 8 ). (cdc.gov)
In our study, 97 adults with advanced hematologic malignancies who received allogeneic PBSC transplants were compared with 97 adults who received allogeneic BMTs using identical preparative regimens and support parameters. (umn.edu)
In today's era, bone marrow transplantation has become standard care for hematologic malignancies and congenital or acquired disorders of the hematopoietic system. (zenonco.io)
Induction and salvage chemotherapies This is to treat newly diagnosed, relapsed and refractory hematologic malignancies. (ucsd.edu)
Abatacept for graft versus host disease prophylaxis in patients 60 years and older receiving mismatched unrelated donor transplantation for hematologic malignancies. (amedeo.com)
Abatacept for the prevention of graft versus host disease in pediatric patients receiving 7/8 HLA-mismatched unrelated transplant for hematologic malignancies: a real-world analysis. (amedeo.com)
The FDA granted ECT-001 Orphan Drug Designation for the prevention of graft-versus-host disease in 2018 and Regenerative Medicine Advanced Therapy Designation in the treatment of hematologic malignancies in 2019. (excellthera.com)
ExCellThera is an advanced clinical stage biotechnology company delivering molecules and bioengineering solutions to expand stem and immune cells for use in novel one-time curative therapies for patients with hematologic malignancies, autoimmune and other diseases. (excellthera.com)
Another trial is looking at how to give unapproved cord blood to patients with hematologic malignancies. (ucsf.edu)
A third trial is testing a drug called tagraxofusp in children with relapsed or resistant hematologic malignancies. (ucsf.edu)
This trial will study how well this treatment works in patients with hematologic malignancies. (ucsf.edu)
This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. (ucsf.edu)
3 The product is intended for use in adult and pediatric patients 12 years and older with hematologic malignancies who are undergoing umbilical cord blood transplantation following myeloablative conditioning. (cryo-cell.com)
Hematologic Malignancies: 3. (libreriastudium.it)
In our quest to discover other actionable prognostic factors in the AHSCT group, we turned to the evaluation of nutritional factors in light of the recent discovery of X-linked immunodeficiency with magnesium defect, Epstein-Barr virus, and neoplasia (XMEN) disease which suggests a role of magnesium in the development of hematologic malignancies and lymphocyte function 15 . (nature.com)
Although complications from the underlying hemoglobinopathies did not occur during the period of mixed chimerism, these results suggest that stable (full or partial) donor engraftment after nonmyeloablative HCT is more difficult to achieve among immunocompetent pediatric patients with hemoglobinopathies than among adults with hematologic malignancies, perhaps in part because recipients may have been sensitized to minor histocompatibility antigens of their donor by preceding blood transfusions. (johnshopkins.edu)
Hematopoietic stem cell transplantation (HSCT) with high-dose chemo-radiotherapy is frequently used in the treatment of patients with hematologic malignancies. (bmrat.org)
Herein, we conducted a non-randomized peripheral blood stem cell (PBSC) mobilization study aimed to compare the potential differences in the expressions of several CAMs and chemokines on CD34+ cells obtained from bone marrow aspirate before and after HPC mobilization from patients with hematologic malignancies and healthy donors. (koreamed.org)

Approximately 10%-20% of children suffering hematological malignancies or refractory solid tumors need hematopoietic stem cell transplantation (HSCT), which includes both bone marrow transplantation (BMT) and peripheral blood stem cell transplantation. (medscape.com)
Natural killer (NK) cells play a significant role in reducing relapse in patients with hematological malignancies after allogeneic stem cell transplantation, but NK cell number and naturally occurring inhibitory signals limit their capability. (bioinst.com)
Allogeneic stem cell transplantation has continued to evolve as a common procedure for the treatment of hematological malignancies and bone marrow failure. (bioinst.com)
Biokine Therapeutics Ltd. announced today that it has received Orphan Drug designation from the US Food and Drug Administration (FDA) for the mobilization of hematopoietic stem cells from bone marrow into peripheral blood for collection and subsequent transplantation in patients with hematological cancers. (news-medical.net)
Dr. Laurence Shaw, the Chairman of Biokine's board of directors , said today that 'BKT140 is uniquely positioned to enter the fast evolving market for stem cell mobilization for hematological malignancies. (news-medical.net)
a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Autologous peripheral blood stem cells transplantation (APBSCT) is a therapeutic option which can be used in various hematological, neoplastic disorders including lymphoproliferative disease (LPD). (omjournal.org)
L ymphoproliferative diseases (LPDs) such as multiple myeloma (MM) and lymphoma are a group of hematological malignancies, which are growing in number and a challenge to treat. (omjournal.org)
Autologous peripheral blood stem cell transplantation (APBSCT) has dramatically increased worldwide involving peripheral blood stem cells as a source of hematopoietic stem cells 1 for the treatment of hematological neoplasms particularly in patients with LPD. (omjournal.org)
To date, there is no available local data/study to see the successful engraftment in patients with hematological malignancies patients treated with APBSCT. (omjournal.org)
In this prospective cohort study, 18 patients with hematological malignancies were divided into three groups: dose 1 group (0.1 mg/kg, n = 5), dose 2 group (0.5 mg/kg, n = 8), and dose 3 group (1 mg/kg, n = 5), and followed up for six months. (ac.ir)
Adequate mobilization of hematopoietic stem cells (HSC), especially CD34+ cells, is necessary for stem cell transplantation in patients with hematological malignancies. (gpcr.co.kr)
GPCR Therapeutics is developing multiple programs with the aim of advancing therapies for hematological malignancies as well as solid tumors. (gpcr.co.kr)

Is bone marrow or peripheral blood better for unrelated donor HSCT? (nih.gov)
Advances in clinical NK cell studies:Donor selection, manufacturing andquality control. (bioinst.com)
He did not go into complete remission, but had an excellent response," said Dr. Vusirikala, Director of UT Southwestern's National Marrow Donor Program, part of the stem cell transplant program. (utsouthwestern.edu)
Additionally, minorities are under-represented in the registry, with about 70 percent of donors in the National Marrow Donor Registry being Caucasian. (utsouthwestern.edu)
Immune cells (T cells) from the relative (donor) are separated from the rest of the stem cells and genetically engineered in the Bellicum laboratory, and then given to the patient along with the stem cell transplant. (utsouthwestern.edu)
In addition, the immune cells from the donor are implanted into the recipient s body and help to fight off infection and kill remaining cancerous cells. (nih.gov)
It is categorized into two significant subtypes: autologous, where a patient donates the marrow stem cells to themselves, and allogeneic, which is a complex process of bone marrow transplantation where a patient receives the stem cell graft from a healthy donor. (zenonco.io)
This medical treatment involves preparing and caring for a healthy donor volunteer who must undergo a medical procedure for stem cell collection. (zenonco.io)
It entirely depends upon the effect of the graft and donor immunity against malignant cells in recipients. (zenonco.io)
2012). The allogenic bone marrow transplantation involves the process of stem cell transplantation where a stem cell donor is matched with their related siblings or any other family member who is closely related (haploidentical). (zenonco.io)
This procedure is called hematopoietic stem cell harvest apheresis and is much gentler on the donor. (ucsd.edu)
Allogeneic transplant This approach uses stem cells from a related donor, unrelated matched donor or half-matched related (haploidentical) donor. (ucsd.edu)
Donor lymphocyte infusions (DLI) These harness the patient's immune system to fight cancer that recurs after transplantation. (ucsd.edu)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
Each of the abstracts selected for this year's session addresses an emergent topic in transfusion medicine, such as patient outcomes based on blood donor sex and platelet bacterial detection. (aabb.org)
The stem cells in autologous transplants come from the same person who will get the transplant, so the patient is their own donor. (cancer.org)
The stem cells in allogeneic transplants are from a person other than the patient, either a matched related or unrelated donor. (cancer.org)
New chapters discuss global trends in stem cell transplantation, cellular therapies including donor lymphocytes, and pediatric neurologic and metabolic disorders. (libreriastudium.it)
In an allogeneic stem cell transplant , the patient gets blood-forming stem cells from another person - the donor. (thenewsmakers.info)
The best treatment results occur when the donor's cells are closely matched to the patient's cell type and the donor is closely related to the patient, such as a brother or sister. (thenewsmakers.info)
We describe previously transfused patients with sickle cell disease (n = 6) and thalassemia (n = 1) who received nonmyeloablative hematopoietic stem cell transplantation (HCT) to induce stable (full or partial) donor engraftment. (johnshopkins.edu)
Risk factors for de novo hepatitis B infection in pediatric living donor liver transplantation. (notifylibrary.org)
The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006. (notifylibrary.org)
Transmission of donor illness by stem cell transplantation: should screening be different in older donors? (notifylibrary.org)
De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of anti-HBc positivity in the donor population. (notifylibrary.org)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Additionally, all patients without a sibling donor in complete remission after the first consolidation course were randomized to either autologous peripheral blood stem cell transplantation or a second consolidation course consisting of high-dose cytarabine. (haematologica.org)
Conclusions Patients with a donor and candidates for allogeneic stem cell transplantation in first complete remission may have a better disease-free survival than those without a donor in case of myelodysplastic syndromes with intermediate/high-risk cytogenetics. (haematologica.org)
6 - 8 However, the outcome of autologous peripheral blood SCT for patients lacking a suitable donor, appeared, in some studies, comparable to that of allogeneic SCT. (haematologica.org)
From 2 wk to 6 mo after injection, the peripheral blood demonstrated increasing ESC-derived mononuclear cells that included donor-derived T and B lymphocytes, monocytes, and granulocytes without clinical or histologic evidence of graft-versus-host disease (GVHD). (rupress.org)
Mixed lymphocyte culture assays demonstrated T cell tolerance to both recipient and donor but intact third party proliferative responses and interferon γ production. (rupress.org)
ESCs might be used as a renewable alternate marrow donor source that reconstitutes hematopoiesis with intact immune responsiveness without GVHD despite crossing MHC barriers. (rupress.org)
Studies on GVHD pathophysiology have primarily focused on the induction phase of GVHD, particularly the mechanisms of donor T-cell activation by professional and non-professional antigen-presenting cells. (apbmt.org)
These observations include the reduced risk of relapse after BMT in patients who develop graft-versus-host disease and the increased risk of relapse in patients who receive AZD0156 T cell-depleted donor marrow (3, 4). (niepokorny.org)
The demonstration that adoptive immunotherapy with donor T cells can provide long-lasting remissions provides compelling evidence that these cells play an important role in mediating a graft-versus-leukemia (GVL) response after allogeneic BMT (8, 9). (niepokorny.org)
Appreciation of the importance of GVL has led to the development of less intensive nonmyeloablative approaches for transplantation of allogeneic hematopoietic stem cells with subsequent infusion of donor AZD0156 T cells to enhance antitumor immunity (10C12). (niepokorny.org)
Although reconstitution with allogeneic stem cells can provide effective antitumor immunity, the mechanisms whereby donor T cells exert this activity are unknown and the target antigens of this response have not been well defined. (niepokorny.org)
To better characterize the antitumor effect LeptinR antibody of DLI we previously examined the reconstitution of T AZD0156 and B cell immunity in patients with chronic myelocytic leukemia (CML) who received infusions of CD4+ donor lymphocytes for treatment of relapse after allogeneic BMT (14). (niepokorny.org)
Peripheral blood stem cell (PBSC) transplant uses stem cells from the patient or a donor and may be able to replace immune cells that were destroyed by chemotherapy. (mycancergenome.org)
Bone marrow transplant known as a nonmyeloablative transplant uses stem cells from a haploidentical family donor. (mycancergenome.org)

Although allogeneic stem cell transplantation is not a standard therapy for multiple myeloma, some patients can benefit from this intense therapy. (haematologica.org)
There are few reports on outcomes after umbilical cord blood transplantation in multiple myeloma, and investigation of this procedure is warranted. (haematologica.org)
We retrospectively analyzed 95 patients, 85 with multiple myeloma and 10 with plasma cell leukemia, receiving single or double umbilical cord blood transplantation from 2001 to 2013. (haematologica.org)
In conclusion, umbilical cord blood transplantation is feasible for multiple myeloma patients. (haematologica.org)
The current standard of care for patients with multiple myeloma (MM) is the use of drugs such as bortezomib, thalidomide and lenalidomide followed by autologous stem cell transplantation (ASCT). (haematologica.org)
Earlier in 2012, Biokine received FDA approval to conduct a Phase 2 clinical study for stem cell mobilization in Multiple Myeloma and Non-Hodgkin's lymphoma patients utilizing BKT140. (news-medical.net)
4. Angelopoulou MK, Tsirkinidis P, Boutsikas G, Vassilakopoulos TP, Tsirigotis P. New insights in the mobilization of hematopoietic stem cells in lymphoma and multiple myeloma patients. (koreamed.org)

1. [High-dose chemotherapy with stem cell support for solid tumors in adults]. (nih.gov)
3. [High-dose chemotherapy and autologous bone marrow transplantation in solid tumors. (nih.gov)
12. High-dose chemotherapy with stem cell reinfusion and growth factor support for solid tumors. (nih.gov)
16. High-dose chemotherapy with bone marrow support for solid tumors. (nih.gov)
Some involve leukaemias, bone marrow failures, hemoglobinopathies (thalassemia, sickle cell disease), immunodeficiencies, and other HSC transplant-based treatments for solid tumors and other genetic disorders such as lysosomal storage disease along with autoimmunity. (zenonco.io)
Initial reports using these approaches are encouraging and provide evidence that the therapeutic effects of DLI can be extended to provide effective immunity against solid tumors as well as hematopoietic malignancies (13). (niepokorny.org)
given as a tandemly administered pair of doses to subjects with one or more solid tumor(s) in the bone or metastatic solid tumors to the bone that are visible on bone scan. (rwjbh.org)
2. To assess the clinical response of solid tumors to the bone or metastatic to the bone to therapy with infusional CylcoSam? (rwjbh.org)

Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
The purpose of this controlled trial was to assess the effect of an approximately 3-wk intrahospital exercise intervention performed during inpatient hospitalization for pediatric allogeneic hematopoietic stem cell transplant (HSCT) on (i) immune cell recovery and (ii) body composition. (medscape.com)
Immune (i.e., blood counts of leukocytes, monocytes, lymphocytes, and lymphocyte subpopulations) and anthropometric variables (i.e., body mass, body mass index, and estimated fat-free mass) were measured before and after (+15 and 30 d) HSCT. (medscape.com)
The rest of the immune cell parameters measured showed a similar response from pre-HSCT to post-HSCT in both groups. (medscape.com)
[ 19 ] Graft-versus-host disease (GVHD), infections, and delay in immune cell recovery are the major sources of HSCT comorbidities as well as major limiting factors to consolidate transplant success. (medscape.com)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
It is also known as hematopoietic stem cell transplantation (HSCT) in the medical domain. (zenonco.io)
Hematopoietic stem cell transplantation (HSCT) involves the regeneration of haematopoiesis, and the recipient's immune system is found within the bone marrow. (zenonco.io)
The process, known as a hematopoietic stem cell transplantation or HSCT, has remained mostly the same since then, but with some very important technological and clinical improvements. (thenewsmakers.info)
It is aptly called as a pediatric emergency as it invariably leads to fatality in infancy without early aggressive therapy and Hematopoietic stem cell transplantation (HSCT) or other specific therapy [ 5 ]. (omicsonline.org)
One cause of tumor relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the alteration of the graft-versus-tumor effect of early reconstituting natural killer (NK) cells due to overexpression of the NKG2A inhibitory receptor. (ac.ir)
This study aims to determine the effect of Monalizumab, an anti- NKG2A receptor, on the effector functions of reconstituting NK cells after allo-HSCT. (ac.ir)
We suggest that using Monalizumab improves the phenotype and cytotoxicity of reconstituting NK cells after allo-HSCT. (ac.ir)
Oral mucositis (OM) is one of the most common side effects after hematopoietic stem cell transplantation (HSCT) and palifermin is used for prophylactic use to prevent OM. (bmrat.org)
We conducted a meta-analysis study that evaluates the efficacy of palifermin on OM after HSCT in hematologic malignancy patients. (bmrat.org)
Effective control of the graft-versus-host disease (GVHD) and immune reconstitution are crucial in improving the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) as well as the quality of life of the transplant survivors. (apbmt.org)
Graft-versus-host disease (GVHD) is a major devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT). (apbmt.org)
Acute GVHD develops early after HSCT, typically within 100 d post-transplantation. (apbmt.org)
In particular, T-cell recapitulation takes a long time after HSCT. (apbmt.org)

2. [High-dose therapy and hematopoietic cell autotransplantation in the treatment of adult gynecologic tumors]. (nih.gov)
18. [Is still there an indication for high-dose chemotherapy with hematopoietic stem-cell support in the treatment of germ-cell tumors? (nih.gov)
Another explanation of this observation is provided by a study that shows the ability of CXCL12 (and CCL2) producing tumors to entrain neutrophils that inhibit seeding of tumor cells in the lung. (wikipedia.org)
NK cells provide a line of defense against tumors and virus-infected cells that have lost the expression of one or more MHC class I isoforms. (bioinst.com)

Our findings suggest routine use of 16S rRNA gene sequencing and increased numbers of bone marrow transplants as the major reasons. (cdc.gov)
We have seen an increase in the number of bone marrow transplants performed, but there has been no major change in myeloablative regimens. (cdc.gov)
Peripheral blood hematopoietic stem cell (PBSC) transplants have been shown to result in more rapid engraftment than standard bone marrow transplants (BMTs). (umn.edu)
Little comparative data exist regarding complications in patients receiving transplants using these stem cell sources. (umn.edu)
With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
Allogenic transplants are cells collected from relatives of the patient. (nih.gov)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
UC San Diego Health has performed more than 3,500 stem cell transplants since 1989, more than any health system in the region. (ucsd.edu)
Cord blood transplants are also a type of allogeneic transplant. (ucsd.edu)
Stem cell transplants are used to put blood stem cells back into the body after the bone marrow has been destroyed by disease, chemotherapy (chemo), or radiation. (cancer.org)
All of these can also be called hematopoietic stem cell transplants . (cancer.org)
In addition, ECT-001 has shown potential to overcome the disadvantages of unexpanded cord blood transplants while maintaining their benefits of low risk of chronic GVHD and relapse. (excellthera.com)
These results indicate that ECT-001 transplants combine the advantages of conventional grafts using bone marrow (low treatment-related mortality), peripheral blood (fast engraftment) and cord blood (greater accessibility, low relapse and chronic GvHD) in a single, low cost, easy to produce 7-day culture product, which could lead to a paradigm shift in bone marrow transplantation. (excellthera.com)
A Phase 3 clinical trial showed faster neutrophil engraftment and reduced bacterial and fungal infections as compared to standard cord blood transplants. (cryo-cell.com)
Omisirge may increase access to stem cell transplants, including among patients from diverse backgrounds. (cryo-cell.com)
Historically, usage of cord blood for transplants have been limited by the comparatively lower number of cells as compared to other sources (e.g. bone marrow, peripheral blood apheresis). (cryo-cell.com)
Results from a phase I-II trial using UM171-expanded CB transplants showed prompt neutrophil engraftment at 18 days, low incidence of infectious complications, rapid resolution of febrile neutropenia, and shorter hospitalization after transplantation when compared to conventional cord blood transplants. (cryo-cell.com)
For this reason, they are now called stem cell transplants. (thenewsmakers.info)
Balassa K, Danby R, Rocha V. Haematopoietic stem cell transplants: principles and indications. (ac.ir)

Patients with LPD who presented at an early stage and with no history of radiotherapy had faster neutrophil engraftment after APBSCT, while a younger age at transplantation with a higher dose of CD34+ cells may predict faster platelet engraftment. (omjournal.org)
The clinical trial findings indicate that ECT-001 cell therapy is feasible, safe (as suggested by the low transplant-related mortality, low incidence of severe acute graft-vs-host disease (GVHD), and absence of moderate to severe chronic GVHD) and allows for the use of small cords without compromising engraftment. (excellthera.com)
11 While it took one hour to maximally mobilise HSCs/HPCs to the blood of mice, it took six to nine hours to maximally mobilise human CD34+ cells (which contain HSCs/HPCs, but are not a pure population of these cells), HPC and CD34+ human cells with functional HSC capacity as assessed by their engraftment of mice with a non-obese diabetic (NOD)/severe combined immunodeficiency (SCID) genotype. (touchoncology.com)

In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
CD16+ CD56- NK cells in the peripheralblood of cord blood transplant recipients:a unique subset of NK cells possiblyassociated with graft-versus-leukemiaeffect. (bioinst.com)
8 Conversely, allogeneic stem cell transplantation (alloSCT) is a potentially curative alternative, offering a tumor-free graft along with the benefit of a graft- versus -MM (GvM) effect. (haematologica.org)
Similarly, the editors have completely reviewed material on stem cell transplantation in regards to both benign and malignant disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors. (etextpdf.com)
Nestin+ Mesenchymal Stromal Cells Fibrotic Transition Mediated by CD169+ Macrophages in Bone Marrow Chronic Graft-versus-Host Disease. (amedeo.com)
When you get your own stem cells back, you don't have to worry about them (called the engrafted cells or the "graft") being rejected by your body. (cancer.org)
The patient was treated with corticosteroids for acute graft versus host disease following bone marrow transplantation for chronic myeloid leukemia. (medscape.com)
p = 0.01], but there were no significant differences in acute graft versus host disease (aGVHD) grades, infection and blood stream infection between two groups. (bmrat.org)
Autologous stem cell transplantation uses the patient's stem cells and does not cause graft versus host disease (GVHD) and has a very low risk of death, while minimizing the number of cancer cells. (mycancergenome.org)

Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients - the randomized phase III PRIMA-CNS trial. (amedeo.com)

14. Immune reconstitution after autologous hematopoietic stem cell transplantation in relation to underlying disease, type of high-dose therapy and infectious complications. (nih.gov)
Umbilical cord blood transplantation: basic biologyand clinical challenges to immune reconstitution. (bioinst.com)
Natural killer (NK) cells are part of the innate immune system and are an alluring option for immunotherapy due to their ability to kill infected cells or cancer cells without prior sensitization. (bioinst.com)
Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of cell‐to‐cell cytolysis executed by immune cells expressing FcRIIIA (CD16A). (bioinst.com)
I have my son Jon's DNA in my blood stream, bone marrow, and immune system. (utsouthwestern.edu)
Myelodysplastic syndrome (MDS) is comprised of a group of myeloid malignancies that arise from a combination of factors-notably, stem cell function that is distorted, inflammatory and innate immune deregulation, and genomic events. (medpagetoday.com)
It helps increase the bone marrow function that depends upon the treatment of the disease in eliminating the tumor cells with malignancy or generating the functional cells that replace the dysfunctional cells in certain disorders such as immune deficiency syndromes, hemoglobinopathies, and other diseases. (zenonco.io)
Engineered hematopoietic and immune cells derived from human pluripotent stem cells. (amedeo.com)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
MONTRÉAL, November 5, 2019 - ExCellThera Inc., an advanced biotechnology company delivering molecules and bioengineering solutions to expand stem and immune cells for therapeutic use, announced today the publication of full data from the first clinical trial using ECT-001 (single UM171-expanded cord blood) in patients with haematological malignancies. (excellthera.com)
The precise mechanism remains unclear, but in the majority of acquired cases, the mechanism involves an immune attack on the hematopoietic stem cell. (msdmanuals.com)

Promising results of umbilical cord blood transplantation (UCBT) from unrelated donors have been reported in patients with hematologic disorders. (bioinst.com)
Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Cord blood transplant This uses stem cells from the umbilical cord blood or placenta of healthy newborns. (ucsd.edu)
Gamida Cell investigators showed the expansion of the umbilical cord blood (UCB) stem cells and inhibition of differentiation of the stem cells using nicotinamide in cell culture.2 Median CD34+ cell expansion was 130-fold. (cryo-cell.com)
Omidubicel vs standard myeloablative umbilical cord blood transplantation: Results of a phase 3 randomized study. (cryo-cell.com)
HSCs/HPCs are also found in high numbers in umbilical cord blood (CB) at birth, and circulate in the peripheral blood of adults - although in very low numbers. (touchoncology.com)

Within these units, there is a heavy emphasis on the morphological exam of the peripheral blood smear, lymph nodes, bone marrow, and other tissues. (etextpdf.com)
Hematologic malignancy is a type of cancer that affects the blood, bone marrow, and lymph nodes. (ucsf.edu)

high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (ucsf.edu)
Fig. 3 The mean expression of CD106, CD-44, and CD49d on the CD34+ cells assessed in BMA before mobilization and its association with the yield of CD34+ cells collected via LVL in both donors and patients. (koreamed.org)

We're pleased that these important results from the first clinical trial using ECT-001 in haematological malignancies are now fully available to the broader bone marrow transplant community," said Dr. Guy Sauvageau, CEO and founder of ExCellThera, and co-senior author of the paper. (excellthera.com)
According to WHO classification (2008), pediatric MDS accounts for less than 5% of all haematological malignancies in childhood. (sagepub.com)

In conclusion, although PBSC transplant recipients engraft more quickly than BMT recipients and have somewhat better 2-year survival rates, they develop more frequent late-onset chronic GVHD and may have more late fungal and cytomegalovirus infections than marrow recipients. (umn.edu)
Once again, Mr. Dandridge volunteered for a cutting-edge clinical trial, known as BP-001, which processed the stem cells used in the transplant to reduce the risk of rejection and engineered blood cells that can be targeted if GvHD develops after the transplant. (utsouthwestern.edu)
Acute GVHD is an alloreactive T cell-mediated systemic inflammatory disorder, typically involving the skin, gut, and liver 2 . (apbmt.org)
However, several recent studies on the mechanisms of target tissue injury have revealed tissue stem cells as targets of GVHD, leading to impaired tissue homeostasis and regeneration. (apbmt.org)
Emerging data indicate that intestinal stem cells (ISCs) and their niche Paneth cells are targeted in acute GVHD, leading to the dysregulation of intestinal homeostasis and microbiota 5 - 7 . (apbmt.org)

Natural cytotoxicity, mediated by natural killer (NK) cells plays an important role in the inhibition and elimination of malignant tumor cells. (bioinst.com)
Because normal HSCs/HPCs can be used in a transplant setting to cure non-malignant and malignant blood-cell - as well as other non-blood-cell - disorders, knowledge of how HSC/HPC movement is regulated has clinical impact. (touchoncology.com)
The clinical manifestations of Waldenström macroglobulinemia result from the presence of the IgM paraprotein and malignant lymphoplasmacytic cell infiltration of the bone marrow and other tissue sites. (medscape.com)
Malignant Epithelioma A malignant tumor arising from epithelial cells. (nih.gov)
Neoplastic Growth A benign or malignant tissue growth resulting from uncontrolled cell proliferation. (nih.gov)
Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. (nih.gov)
Carcinoma of the Adrenal Cortex A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. (nih.gov)
C138190 CTS-API Disease Main Type Terminology C3088 Angiosarcoma A malignant tumor arising from the endothelial cells of the blood vessels. (nih.gov)
Core Clinical Centers and Consortia are expected to support and conduct multi-site trials to compare novel treatment approaches and management strategies for children and adults undergoing hematopoietic stem cell transplantation (HCT) for non-malignant and malignant blood diseases, either alone or in combination with novel adoptive cell-based therapies. (nih.gov)

A marked increase in CD16+ CD56- NK cells in the peripheral blood (PB) was observed in a cord blood transplant (CBT) recipient with refractory acute myeloid leukaemia (AML) in association with attaining molecular remission. (bioinst.com)
Efficacy and safety of venetoclax combined with hypomethylating agents for relapse of acute myeloid leukemia and myelodysplastic syndrome post allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis. (amedeo.com)
Clonal hematopoiesis is frequently present, and there is a risk of progression to a myeloid malignancy. (msdmanuals.com)
Peripheral smear of a patient with agnogenic myeloid metaplasia (myelofibrosis) shows leukoerythroblastosis. (medscape.com)
Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. (haematologica.org)
Plank, L 2016-08-01 00:00:00 Myelodysplastic syndrome (MDS) represent very heterogenous group of clonal stem cell bone marrow disorders with ineffective haematopoesis leading to cytopenias in peripheral blood and increased risk of blastic transformation and evolution of acute myeloid leukemia. (sagepub.com)
Key words: Myelodysplastic syndrome, types of myelodysplastic syndrome, risk stratification, adults, children INTRODUCTION Myelodysplastic syndromes (MDS) represent group of clonal stem cell bone marrow (BM) disorders with ineffective haematopoesis leading to cytopenias in peripheral blood (PB) and increased risk of blastic transformation and evolution of acute myeloid leukemia (AML) (1,2). (sagepub.com)
They are very heterogenous myeloid malignancies, mainly of older age, with slightly predominant incidence in men (excluding type with isolated deletion of 5q) (3). (sagepub.com)
Hematopoeitic - Acute Myleogenous Leukemia (AML) A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. (nih.gov)

Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Precursor Lymphoblastic Leukemia Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. (nih.gov)
De D. Acute nursing care and management of patients with sickle cell. (medscape.com)
Bone and mineral abnormalities in childhood acute lymphoblastic leukemia: affect of disease, medication and nutrition. (gov.ph)
Determination of selenium in blood serum of youngsters with acute leukemia and results of chemotherapy on serum selenium level. (gov.ph)

Reduced post-transplant cyclophosphamide dose with antithymocyte globulin in peripheral blood stem cell haploidentical transplantation. (amedeo.com)
Treatment usually involves immunosuppression with equine antithymocyte globulin and cyclosporine, or bone marrow transplantation. (msdmanuals.com)

Peripheral blood stem cell mobilization is very important in hematopoietic stem cell transplantation (as a recent alternative to transplantation of surgically harvested bone marrow) and is currently performed using drugs such as G-CSF. (wikipedia.org)
It is a very efficient inducer of hematopoietic stem cell mobilization in animal and human studies. (wikipedia.org)
In a small human clinical trial to evaluate the safety and efficacy of fucoidan ingestion (brown seaweed extract), 3g daily of 75% w/w oral fucoidan for 12 days increased the proportion of CD34+CXCR4+ from 45 to 90% and the serum SDF-1 levels, which could be useful in CD34+ cells homing/mobilization via SDF-1/CXCR4 axis. (wikipedia.org)
The stem cell mobilization result was poor. (cdc.gov)
Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
Cell adhesion molecules (CAMs) expressed on hematopoietic progenitor cells (HPCs), endothelial cells, and stromal cells play a pivotal role in the mobilization of CD34+ cells. (koreamed.org)
Three-color cytofluorometric analysis was used to compare the expressions of CAMs and chemokines in the bone marrow before and after mobilization. (koreamed.org)
We attempted to identify particular aspects of CAMs involved in CD34+ cell mobilization, which is a highly complex mechanism that involves adhesion molecules and matrix metalloproteases. (koreamed.org)
The mechanism by which CD34+ cell mobilization is activated through proteolytic enzymes is not fully understood. (koreamed.org)
We believe that CXCR4, VLA-4, CD44, and VCAM-1 are the most important molecules implicated in HPC mobilization, particularly because they show a correlation with the yield of CD34+ cells collected via large volume leukapheresis. (koreamed.org)
Fig. 1 Representative flow cytometric scattergrams from bone marrow aspirate specimens after HPC mobilization showing a 3-color cytofluorometric analysis of the expression of adhesion molecule antigens on CD34+ cells population. (koreamed.org)
Fig. 4 Distribution of CD106, CD135, CD11a, CD44, CD49d, and CD184 assessed in mononuclear cells of the BMA, before and after mobilization according to the yield of CD34+ cells obtained via LGV. (koreamed.org)
1. Arslan O, Moog R. Mobilization of peripheral blood stem cells. (koreamed.org)
PK profile and marked increase of peripheral CD34+ cells after GPC-100 administration support further clinical development of GPC-100 for mobilization of hematopoietic stem/progenitor cells. (gpcr.co.kr)
9. A stem cell product collected either by peripheral stem cell mobilization or bone marrow harvest prior to the infusion of CycloSam® must be available, prior to trial entry. (rwjbh.org)

The survival rate at 2 years was 38% in PBSC transplant recipients and 28% in marrow recipients (P = .08). (umn.edu)
C) Low grade follicular or small lymphocytic lymphoma (1) high risk patients who have relapsed following conventional chemotherapy, (2) relapsed following autologous marrow or PBSC transplant, or (3) chemo resistant disease. (nih.gov)

This basic knowledge will be applied clinically to enhance our ability to achieve successful hematopoietic stem cell therapy to cure both genetic and acquired diseases and to perform successful gene therapy using the hematopoietic stem cell as the target for gene transfection and for life-long expression of normal genes. (nih.gov)
The are a variety of cancerous diseases of the blood and bone marrow that can be potentially cured by bone marrow transplantation (BMT). (nih.gov)
The expansion in the integration of bone marrow transplantation for different diseases across the globe while evolving modern techniques. (zenonco.io)
The article by Dr. Burt provides an excellent summary of the rationale for using high-dose therapy with autologous or allogeneic bone marrow transplantation (BMT) in patients with severe autoimmune diseases (SADS). (cancernetwork.com)
Since it remains unclear whether allogeneic transplantation will berequired for reversal of human autoimmune diseases, it seems prudent tofirst test its efficacy using the least toxic procedure. (cancernetwork.com)
For patients who have certain malignancies of the blood and bone marrow such as leukemias and lymphomas, or autoimmune diseases such as systemic lupus and erythematosus, or other blood-related disorders including aplastic anemia and thalassemia major, bone marrow transplant has been part of the standard treatment regimen, backed by large and long-term studies on efficacy. (thenewsmakers.info)
Although the buzz term of "stem cells" has only recently come to the limelight, the science and technology behind its utility to treat certain diseases has been present in some form or another since the late 1930s. (thenewsmakers.info)
Certain cancers and other diseases keep hematopoietic stem cells from developing normally. (thenewsmakers.info)
At The Medical City IPMM, each patient's treatment can be personalized and tailored uniquely, ensuring safety and efficacy because of the presence of cutting-edge technology coupled with the expertise of internationally-trained specialists in the fields of Hematology and Oncology, Transplantation, and Infectious Diseases," says Dr. Alma R. Calavera, hematologist and transplant specialist. (thenewsmakers.info)
The CCCs will collaborate with the DCC, the NHLBI, the NCI, and other stakeholders to facilitate trials for HCT and cell therapies for blood diseases. (nih.gov)

There were no complications attributable to sickle cell disease during the interval of transient mixed chimerism. (johnshopkins.edu)
Which medications in the drug class Nonsteroidal Analgesics are used in the treatment of Sickle Cell Disease (SCD)? (medscape.com)
Pecker LH, Lanzkron S. Sickle Cell Disease. (medscape.com)
Shatat IF, Jakson SM, Blue AE, Johnson MA, Orak JK, Kalpatthi R. Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. (medscape.com)
Olujohungbe A, Howard J. The clinical care of adult patients with sickle cell disease. (medscape.com)
Johnson L, Carmona-Bayonas A, Tick L. Management of pain due to sickle cell disease. (medscape.com)
Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. (medscape.com)
B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. (medscape.com)
How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life. (medscape.com)

APBSCT has become the standard of care for patients newly diagnosed with MM, which has prolonged the median survival rate to five to six years 3 and in patients with relapsed high-risk diffuse large B-cell lymphoma. (omjournal.org)
Few studies have reported whether a serum magnesium level below the reference range (RR) is associated with prognosis in patients with diffuse large B cell lymphoma (DLBCL). (nature.com)
Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) 1 . (nature.com)

B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)

Aetna considers allogeneic hematopoietic cell transplantation medically necessary for the treatment of persons with relapsed NHL (including persons who have relapsed after autologous hematopoietic cell transplantation) or primary refractory (see "Note" below) NHL (low-grade, intermediate-grade, and high-grade) if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)
Aetna considers non-myeloablative allogeneic hematopoietic cell transplantation medically necessary ("mini-transplant", reduced intensity conditioning transplant) for the treatment of persons with relapsed NHL (including persons who have relapsed after ABMT) or primary refractory (see note below) NHL (low-grade, intermediate-grade, and high-grade) when they are eligible for conventional allografting or a reduced intensity regimen is preferred by the transplant center. (aetna.com)

Moreover, we noticed that CD56dim NK cells of dose 2- and dose 3-related patients produced significant levels of perforin, interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α) in response to K562 stimulation post-Monalizumab treatment compared with controls and dose 1-treated patients. (ac.ir)
Total RNA was prepared from AZD0156 cultured tumor cell lines, patient CML cells, and normal human PBMC by using RNAzole (Tel-Test, Friendswood, TX). (niepokorny.org)
Chinese hamster ovarian cells transfected with the murine interleukin-6 gene trigger hypercalcemia in addition to cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. (gov.ph)
153Sm-DOTMP) to Treat Solid Tumor(s) in the Bone or Metastatic to the Bone (Metastatic Prostate, Breast, and Lung, Osteosarcoma, Ewings Sarcoma, and other solid tumor(s) to the bone all eligible). (rwjbh.org)
2. Subjects must have a histologically confirmed diagnosis of a solid tumor metastatic to bone, or a histologically confirmed diagnosis of a solid tumor to the bone or metastatic to the bone. (rwjbh.org)

High-dose thiotepa and autologous bone marrow transplantation may represent an alternative therapeutic modality for patients with advanced cancer. (nih.gov)
Phosphoryl guanidine oligo-2′-O-methylribonucleotides in neutral therapeutic oligonucleotides enable enhanced cell penetration! (biosyn.com)
1 Efforts to expand the number of therapeutic cells in cord blood has been researched for decades and now those efforts are set to bear fruit. (cryo-cell.com)
Cord blood expansion can greatly impact the therapeutic availability and usage of cord blood and may help the many patients in need of a stem cell transplant. (cryo-cell.com)
Complement Factor D Is a Novel Biomarker and Putative Therapeutic Target in Cutaneous Squamous Cell Carcinoma. (helsinki.fi)
The therapeutic benefits of allogeneic bone marrow transplantation (BMT) derive in part from the antitumor effect of high-dose chemotherapy and radiation (1, 2). (niepokorny.org)

The stem cells help to build new functioning bone marrow, red cells, white cells, and platelets. (nih.gov)
Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (msdmanuals.com)
White blood cells and platelets are not affected. (msdmanuals.com)
Симптоми та ознаки Platelets are circulating cell fragments that function in the clotting system. (msdmanuals.com)
Thrombopoietin helps control the number of circulating platelets by stimulating the bone marrow to produce megakaryocytes. (msdmanuals.com)
The peripheral smear below shows leukoerythroblastosis and giant platelets in a patient with myelofibrosis. (medscape.com)

Bone marrow transplantation is employed for novel indications in treating autoimmune and inherited metabolic disorders (Daikeler et al. (zenonco.io)
Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders. (amedeo.com)
ECT-001 is currently being used for the treatment of blood disorders in other ongoing and approved clinical trials in the United States and Canada. (excellthera.com)
The Institute of Personalized Molecular Medicine (IPMM) of premier health institution The Medical City (TMC) offers bone marrow and stem cell transplantation which have evolved into the standard of care for many people with hematologic cancers and other blood disorders. (thenewsmakers.info)
Bone marrow histology shows hypercellularity in most of these disorders. (medscape.com)

1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
Haematopoietic stem cells (HSCs) are adult stem cells that represent almost 0.05 to 0.5% of the cellular density of the normal bone marrow. (zenonco.io)

Background Allogeneic stem cell transplantation is usually considered the only curative treatment option for patients with advanced or transformed myelodysplastic syndromes in complete remission, but post-remission chemotherapy and autologous stem cell transplantation are potential alternatives, especially in patients over 45 years old. (haematologica.org)

An advantage of an autologous stem cell transplant is that you're getting your own cells back. (cancer.org)
For an autologous stem cell transplant, the patient's own stem cells are removed from his or her bone marrow or peripheral blood before the transplant. (thenewsmakers.info)
Using a retrospective approach in DLBCL patients undergoing autologous stem cell transplant (AHSCT), we evaluated the association of hypomagnesemia with survival. (nature.com)

The study is evaluating patients with blood cell cancers who have a peripheral blood stem cell transplant from a partially matched relative. (utsouthwestern.edu)
In order to reduce the complications of BMT, and make it a safer available option for patients with cancers of the blood and bone marrow, researchers have developed a new approach to the BMT. (nih.gov)
This approval provides a much-needed new treatment option for patients with blood cancers and could potentially improve their outcomes. (cryo-cell.com)
Such data are consistent with the observation that early disseminated cancer cells (DCCs) often lack critical genetic and genomic alterations, which they need to acquire at the distant site in breast and other cancers. (nature.com)

Genetically re-engineered K562 cells significantly expand and functionallyactivate cord blood natural killer cells:Potential for adoptive cellular immunotherapy. (bioinst.com)
In the last decade, the number of transplantations of HPCs derived from cord blood has increased, particularly for children. (nationalacademies.org)
Since then cord blood banking programs throughout the world have expanded rapidly (Broxmeyer, 1998), with the estimated number of units stored to date exceeding 155,000 (BMDW, 2004). (nationalacademies.org)
Gamida Cell received FDA approval for its allogeneic cell therapy, Omisirge: a new expanded cord blood cell source for stem cell transplantation. (cryo-cell.com)
3 Incidence of moderate to serious bacterial or fungal infections through 100 days following transplantation occurred in 39% of patients in the Omisirge arm versus 60% of patients in the standard cord blood arm. (cryo-cell.com)
This is a significant milestone for Gamida Cell and for the field of cord blood cell therapy. (cryo-cell.com)
In other exciting cord blood expansion news, ExCellthera has recently published results of its Phase I/II study investigating its UM-171 product. (cryo-cell.com)
4 Moreover, they achieved this expansion using lower cell dose cord blood units than previous studies. (cryo-cell.com)
2. E. Shpall, K. Rezvani, Cord blood expansion has arrived, Comments on on Horwitz et al, page 1429: Results of a phase 3 randomized study. (cryo-cell.com)

We used a standardized data collection form to abstract clinical data from the comprehensive electronic medical records of patients with blood culture results positive for VGS. (cdc.gov)

Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
Human natural killer (NK) cells comprise ≈15% of all circulating lymphocytes. (bioinst.com)
If the triggering environmental stimulus persists and there is an inherentpropensity of the stem cells to produce autoreactive lymphocytes due tothis antigen, there is little chance that a more aggressive form of immunosuppressioncould completely eradicate the disease. (cancernetwork.com)
3] Sinceapproaches to remove lymphocytes that have little impact on treatment-relatedtoxicity are available,[4] the theoretical benefit from these purging proceduresseems to be warranted if autologous transplantation is used. (cancernetwork.com)
Labeled probe was combined with sheared human DNA and hybridized to metaphase chromosomes derived from phytohemagglutinin-stimulated peripheral blood lymphocytes in a solution containing 50% formamide, 10% dextran sulfate, and 2 SSC. (niepokorny.org)

There have also been improvements in the therapy of those patients who relapse after AHSCT with the recent approval of CAR-T cell therapy 14 . (nature.com)

Receive standard-of-care therapies, as well as the most promising investigational chemotherapy agents, immunotherapies, and novel stem cell transplant methods. (ucsd.edu)
Educational experiences combining clinical CTL staff, medical director, and quality and regulatory team perspectives can provide a well-rounded approach for potential future medical directors of clinical CTLs or TM services handling existing and developing cell therapies in the clinical realm. (aabb.org)
The success and trajectory of established and novel cell therapies and nature of CP and BB/TM training to prepare medical directors underscores the importance of including formal and dedicated educational CTL experiences in CP and BB/TM training programs. (aabb.org)
Anemia caused by occult bleeding, hemolysis, marrow replacement, or a nutritional deficiency is unlikely to respond to epoetin treatment but may be corrected using other therapies. (webharvest.gov)
6. Have secondary malignancy, except MDS, treated basal cell carcinoma or localised squamous skin carcinomas, localised prostate cancer, or other malignancies for which patients are not on active anti-cancer therapies and have had no evidence of active malignancy for at least 1 year. (who.int)
and ultimately improve the life and quality of life for patients who receive HCT or adoptive cell therapies. (nih.gov)

If you can target that mutation and stop the abnormal protein from being produced, then cells start behaving normally," said Dr. Madhuri Vusirikala , Professor of Internal Medicine and the primary investigator of many UT Southwestern clinical trials related to bone marrow transplantation. (utsouthwestern.edu)
Our joint BMT program was one of the charter members of the prestigious Blood and Marrow Transplant Clinical Trials Network, the premier BMT clinical trials group in the world. (ucsd.edu)
This Notice of Funding Opportunity (NOFO) issued by the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI) invites applications to participate as Core Clinical Centers and Consortia (CCCs) in the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). (nih.gov)

Our study investigated the incidence of secondary nonhematologic malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT) and explored its risk compared to the general population. (nih.gov)
CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension. (medscape.com)

6 , 9 , 10 Moreover, a retrospective study comparing intensive chemotherapy alone against chemotherapy followed by transplantation did not show a clear benefit for chemotherapy followed by SCT. (haematologica.org)

Anatomy31

Organisms9

Diseases57

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology2

Phenomena and Processes34

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Information Science5

Named Groups4

Health Care18

Hematologic malignancies20

Hematological15

Donor43

Multiple myeloma7

Solid tumors8

HSCT21

Tumors4

Transplants20

Engraftment3

Graft9

Followed by autologous stem cell trans1

Immune11

Umbilical-cord6

Lymph nodes2

Donors6

Haematological malignancies2

GVHD5

Malignant9

Myeloid9

Acute5

Antithymocyte globulin2

Mobilization15

PBSC2

Diseases10

Sickle cell di9

Diffuse large B-3

Hematopoietic progenitor cells1

Allogeneic hematopoietic cell transplantation2

Tumor5

Therapeutic6

Platelets6

Disorders5

Haematopoietic stem cells2

Myelodysplastic1

Autologous stem cell trans3

Cancers4

Cord9

Abstract1

Lymphocytes5

Relapse1

Therapies6

Clinical trials3

Secondary2

Chemotherapy followed1