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  • PBSC
  • Evaluate the effectiveness of TXA127 in accelerating the time to initial platelet recovery following PBSC transplant with a limited number of CD34+ cells, defined as CD34+ cell concentrations ≥1.5 x 106 and ≤5.0 x 106 CD34+ cells/kg. (clinicaltrials.gov)
  • rescue
  • Consolidation therapy followed by stem cell rescue repeats every 28 days for 3 courses (C) and 3D-CRT to the brain (and the spine if needed) 5 days a week for 5-6 weeks (R), the order of which depends on patient age, in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
  • Transplants
  • To make sure that all of the tumor cells are destroyed, patients in this study will undergo two separate transplants using two different preparative regimens. (knowcancer.com)
  • Researchers are also evaluating how well the blood stem cells grow in the patient's body, and whether CliniMACS T-cell depleted transplants can prevent GvHD. (mskcc.org)
  • patients
  • These patients, who frequently have amyloid deposits in bone marrow blood vessels and interstitium and impaired function of kidneys, liver, spleen, and heart, represent an unusual population for stem cell transplantation, with unique problems. (nih.gov)
  • Patients who benefit most from this treatment are those whose marrow is infiltrated with tumor cells or who have hypoplastic marrows due to extensive prior chemo- and/or radiotherapy [8-and those who might not tolerate marrow harvests under general anesthesia [6, (springer.com)
  • Lasky L, Bostrom B, Smith J, Moss T, Ramsay N (1989) Clinical collection and use of peripheral blood stem cells in pediatric patients. (springer.com)
  • Beginning 28-120 days later, patients eligible for in vivo selection after detection of gene-marked cells receive O6-benzylguanine IV over 1 hour and carmustine IV over 3 hours on days 14, 28, and then monthly until completion of therapy. (clinicaltrials.gov)
  • Consolidation therapy: On day 77, stem cells are collected from patients if the marrow is clear of disease. (clinicaltrials.gov)
  • Prior to study treatment, patients undergo a biopsy of the gut to confirm diagnosis and a blood sample is taken. (clinicaltrials.gov)
  • clinical
  • Although stem cell-based treatments for stroke and other neurodegenerative diseases have advanced rapidly, there are still few clinical treatments available. (jneurosci.org)
  • Therefore, the use of autologous stem cells without in vitro expansion may be an appropriate strategy for clinical applications. (jneurosci.org)
  • mobilize
  • 4-7 Cytokines mobilize long-term culture-initiating cells (LTC-IC) and young colony-forming unit-spleen (CFU-S) with high proliferative potential into circulation. (bloodjournal.org)
  • vivo
  • 500 cells/uL receive up to 2 courses of structured treatment interruption without undergoing in vivo selection. (clinicaltrials.gov)