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  • study
  • We launched a multi-center clinical study to examine the safety and feasibility of co-transplantation of MSCs (from third party donors) and haploidentical HSCs into 35 children with severe aplastic anemia (SAA). (confex.com)
  • 2001
  • Historically, they have been most commonly divided by the stage of maturation at which the clonal (neoplastic) lymphoid population stopped maturing: Acute lymphoblastic leukemia Chronic lymphocytic leukemia However, the influential WHO Classification (published in 2001) emphasized a greater emphasis on cell lineage. (wikipedia.org)
  • acute
  • 1988) Early lympho-hemopoietic recovery after autografting using peripheral blood stem cells in acute non-lymphoblastic leukemia. (springer.com)
  • Liver transplantation nowadays is a well accepted treatment option for end-stage liver disease and acute liver failure. (wikipedia.org)
  • Other types include (with ICD-O code): 9826/3 - Acute lymphoblastic leukemia, mature B-cell type 9833/3 - B-cell prolymphocytic leukemia 9940/3 - Hairy cell leukemia T-cell leukemia describes several different types of lymphoid leukemias which affect T cells. (wikipedia.org)
  • Indications for microtransplantation are as follows: Hematologic Malignancies Tumors Acute myeloid leukemia (AML) chronic-phase chronic myeloid leukemia (CP-CML) Myelodysplastic syndromes (MDS) Intermediate- or high-risk Non-Hodgkin lymphoma High-risk Hodgkin lymphoma Multiplemyeloma (MM) Severe aplastic anemia (SAA) The cells employed are allogeneic peripheral blood stem cells. (wikipedia.org)
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • pediatric
  • Lasky L, Bostrom B, Smith J, Moss T, Ramsay N (1989) Clinical collection and use of peripheral blood stem cells in pediatric patients. (springer.com)
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
  • Lymphoid
  • Bell A, Figes A, Oscier D, Hamblin T (1987) Peripheral blood stem cell autografts in the treatment of lymphoid malignancies: initial experience in three patients. (springer.com)
  • Lymphoid leukemias - also called lymphocytic, lymphogenous, or lymphoblastic leukemias - are a group of leukemias affecting circulating lymphocytes, a type of white blood cells. (wikipedia.org)
  • Most lymphoid leukemias involve a particular subtype of lymphocytes, the B cells. (wikipedia.org)
  • To this end, lymphoid leukemias can also be divided by the type of cells affected: B-cell leukemia T-cell leukemia NK-cell leukemia The most common type of lymphoid leukemia is B-cell chronic lymphocytic leukemia. (wikipedia.org)
  • B-cell leukemia describes several different types of lymphoid leukemia which affect B cells. (wikipedia.org)
  • Aggressive NK-cell leukemia (ANKL) is a lymphoid leukemia that is a deficiency NK cells. (wikipedia.org)
  • Natural killer (NK) cell therapy is used in pediatrics for children with relapsed lymphoid leukemia. (wikipedia.org)
  • One problem when using NK cells in order to fight off lymphoid leukemia is the fact that it is hard to amount enough of them to be effective. (wikipedia.org)
  • Oligopotent stem cells can differentiate into only a few cell types, such as lymphoid or myeloid stem cells. (wikipedia.org)
  • therapy
  • Korbling M, Dorkin B, Ho A, Pezzutto A, Hunstein W, Fliedner T (1986) Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkitt's lymphoma. (springer.com)
  • The institute's initial approach focused on gene therapy and stem cells and ALS TDI was the first to publish on the safety of the use of stem cells in ALS patients. (wikipedia.org)
  • In some cases, NK cell therapy is a choice. (wikipedia.org)
  • NK cell therapy is a possible treatment for many different cancers such as Malignant glioma. (wikipedia.org)
  • Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
  • this is the only form of stem-cell therapy that is widely practiced. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • lymphoma
  • Aggressive mantle cell lymphoma in first complete remission. (knowcancer.com)
  • PCL is histologically characterized by a mostly diffuse large B-cell lymphoma. (springer.com)
  • Primary cardiac diffuse large B-cell lymphoma: diagnosis by transesophageal echocardiography-guided transvenous biopsy. (springer.com)
  • The lymphocytic leukemias are closely related to lymphomas of the lymphocytes, to the point that some of them are unitary disease entities that can be called by either name (for example, adult T-cell leukemia/lymphoma). (wikipedia.org)
  • Other types include: Large granular lymphocytic leukemia Adult T-cell leukemia/lymphoma T-cell prolymphocytic leukemia In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together. (wikipedia.org)
  • Waldenström's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of cancer affecting two types of B cells, lymphoplasmacytoid cells and plasma cells. (wikipedia.org)
  • involves
  • The WM spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphoplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms. (wikipedia.org)
  • Of all stem cell types, autologous harvesting involves the least risk. (wikipedia.org)
  • proliferation
  • MicroRNA-155 regulates the proliferation and growth of WM cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
  • MSCs
  • Once these MSCs are ready for re-implanation, they are usually transferred with growth factors to allow for continued cell growth and engraftment to the damaged tissue. (wikipedia.org)
  • patients
  • Three patients had flares of neurologic deterioration during mobilization, 8 patients had the same manifestation during transplantation, and 2 patients had similar flares within 3 months of transplantation. (springer.com)
  • Six patients experienced continuous neurologic improvement after transplantation, 5 patients experienced neurologic progression, and 4 patients had stabilization of their disease. (springer.com)
  • Patients who benefit most from this treatment are those whose marrow is infiltrated with tumor cells or who have hypoplastic marrows due to extensive prior chemo- and/or radiotherapy [8-and those who might not tolerate marrow harvests under general anesthesia [6, (springer.com)
  • Clinically patients present with reduction in the count of all blood cells (pancytopenia), a very few blasts in the peripheral blood and no or little spleen enlargement (splenomegaly). (wikipedia.org)
  • It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
  • Heart transplantation is performed on patients with end-stage heart failure or severe coronary artery disease. (wikipedia.org)
  • Patients with RD have a genetic defect that affects the T cells and at least one other type of immune cell. (wikipedia.org)
  • Peripheral neuropathy occurs in 10% of patients. (wikipedia.org)
  • Leukemia
  • The most common T-cell leukemia is precursor T-cell lymphoblastic leukemia. (wikipedia.org)
  • Its morphology is identical to that of precursor B-cell lymphoblastic leukemia. (wikipedia.org)
  • The requirements for diagnosing ANKL are as follows: Immature-looking NK cells Certain immunophenotypes Germline configuration genes: TCR-β and IgH Restricted cytotoxicity The T-cell receptor (TCR) is an important factor when ANKL is being diagnosed along with T-cell leukemia. (wikipedia.org)
  • Led by Dr. Huisheng Ai and his medical team at MST International Clinic for Leukemia in the 307th Hospital of Chinese People's Liberation Army located in Beijing, multicenter collaborative study on Microtransplantation has started since 2013 in 9 authoritative blood institutes from China, Duke University and Keck School of Medicine-University of Southern California in United States, University of Sydney in Australia and University of Montreal in Canada. (wikipedia.org)
  • commonly
  • WM is commonly classified as a form of plasma cell dyscrasia. (wikipedia.org)
  • Similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma, WM is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance (i.e. (wikipedia.org)
  • Lymphoma
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • Adult T-cell lymphoma (ATL) was discovered in 1977 in Japan. (wikipedia.org)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • antibodies
  • This often involves the analysis of antiserum samples that contain specific antibodies against the immunizing antigen, and blood lymphocytes from lymphoid organs for examination of T cell-mediated responses. (wikipedia.org)
  • B cell immune responses are measured by analyzing antibodies produced through the humoral immune response. (wikipedia.org)
  • Serum is isolated from a clotted blood sample, and the circulating antibody that accumulates in the plasma is assayed by methods that include the following: Affinity chromatography, by which antibodies of interest are isolated from solution by the specific binding of antigens anchored to a solid matrix. (wikipedia.org)
  • It is similar to the ELISA assay in that antibodies bound to plastic wells are used to bind the cytokines secreted by T cells. (wikipedia.org)
  • NK cells are unique, however, as they have the ability to recognize stressed cells in the absence of antibodies and MHC, allowing for a much faster immune reaction. (wikipedia.org)
  • undergo
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • The medulla is specialized to allow thymocytes to undergo additional rounds of negative selection to remove auto-reactive T cells from the mature repertoire. (wikipedia.org)
  • tumors
  • A category of rare and aggressive haematologic tumors co-expressing CD4 and CD56 antigens in the absence of any specific myeloid, B-, T-lymphoid or natural killer (NK) lineage markers is classified as blastic plasmacytoid dendritic cell neoplasms (BPDCN) according to the most recent 2008 WHO classification of tumours of haematopoietic and lymphoid tissues (1). (czytelniamedyczna.pl)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • In the majority of cases the damage results from physical trauma such as car accidents, gunshots, falls, or sports injuries, but it can also result from nontraumatic causes such as infection, insufficient blood flow, and tumors. (wikipedia.org)
  • mice
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • 6,7 A recent study has demonstrated that blood flow recovery in ischemic limb and tumor angiogenesis are substantially impaired in heterozygous AM knockout mice. (ahajournals.org)
  • cells in diabetic mice, and that the anti-hyperglycemic efficacy of this combination was better than that of 1-deoxynojirimycin (DNJ) or polysachharide alone. (jove.com)
  • Strikingly, decrease of blood glucose levels was observed in all DPM treated diabetic mice, which persisted 30 days after cessation of DPM administration. (jove.com)
  • It is important to mention that Long-Term Hematopoietic Stem Cells (LT-HSCs) in mice and humans are the hematopoietic cells with the greatest self-renewal capacity. (wikipedia.org)
  • Balanced (Bala) HSCs repopulate peripheral white blood cells in the same ratio of myeloid to lymphoid cells as seen in unmanipulated mice (on average about 15% myeloid and 85% lymphoid cells, or 3 ≤ ρ ≤ 10). (wikipedia.org)
  • In contrast to NKT cells, NK cells do not express T-cell antigen receptors (TCR) or pan T marker CD3 or surface immunoglobulins (Ig) B cell receptors, but they usually express the surface markers CD16 (FcγRIII) and CD56 in humans, NK1.1 or NK1.2 in C57BL/6 mice. (wikipedia.org)
  • The NKp46 cell surface marker constitutes, at the moment, another NK cell marker of preference being expressed in both humans, several strains of mice (including BALB/c mice) and in three common monkey species. (wikipedia.org)
  • NK cell receptor types (with inhibitory, as well as some activating members) are differentiated by structure, with a few examples to follow: Ly49 (homodimers), relatively ancient, C-type lectin family receptors, are of multigenic presence in mice, while humans have only one pseudogenic Ly49, the receptor for classical (polymorphic) MHC I molecules. (wikipedia.org)
  • Severe
  • Severe cardiomyopa-thy is treated with cardiac transplantation. (phacdochuabenh.com)
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • malignant
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • vessels
  • In vivo, AM administration not only enhanced the differentiation of MNC into endothelial cells but also produced mature vessels that included smooth muscle cells. (ahajournals.org)
  • The thymus consists of two lobes, merged in the middle, surrounded by a capsule that extends with blood vessels into the interior. (wikipedia.org)
  • This network forms an adventitia to the blood vessels, which enter the cortex via septa near the junction with the medulla. (wikipedia.org)
  • Malignancy
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • epithelial cells
  • These are concentric, layered whorls of epithelial cells that increase in number throughout life. (wikipedia.org)
  • Neural retina typically refers to three layers of neural cells (photo receptor cells, bipolar cells, and ganglion cells) within the retina, while the entire retina refers to these three layers plus a layer of pigmented epithelial cells. (wikipedia.org)
  • apoptosis
  • Typically, immune cells detect major histocompatibility complex (MHC) presented on infected cell surfaces, triggering cytokine release, causing lysis or apoptosis. (wikipedia.org)
  • Natural cytotoxicity receptors directly induce apoptosis after binding to Fas ligand that directly indicate infection of a cell. (wikipedia.org)
  • The MHC-dependent receptors (described above) use an alternate pathway to induce apoptosis in infected cells. (wikipedia.org)
  • immune
  • We could predict with high accuracy (greater than or equal to 80 %) a wide range of immunological statuses such as healthy, transplantation recipient, and lymphoid cancer, suggesting as a proof of principle that diversity profiling can recover a large amount of immunodiagnostic fingerprints from immune repertoire data. (beds.ac.uk)
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)
  • Plasma cells are key effector elements of the adaptive immune system. (wikipedia.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • Patients with RD have a genetic defect that affects the T cells and at least one other type of immune cell. (wikipedia.org)
  • Patients who suffer from RD will now have more stem cells that can differentiate into immune cells. (wikipedia.org)
  • Ionizing radiation kills lymphoid cells while leaving other tissues of the body intact, and this eliminates immune function. (wikipedia.org)
  • T cells are critical to the adaptive immune system, where the body adapts specifically to foreign invaders. (wikipedia.org)
  • The role NK cells play is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response. (wikipedia.org)
  • NK cells also play a role in the adaptive immune response: numerous experiments have demonstrated their ability to readily adjust to the immediate environment and formulate antigen-specific immunological memory, fundamental for responding to secondary infections with the same antigen. (wikipedia.org)
  • Procedure
  • In addition, a safety study showed safety better than surgical alternatives for this cultured cell injection procedure at a 3-year follow-up. (wikipedia.org)
  • nerve
  • Leukodystrophies affect the growth and/or development of myelin, the fatty covering which acts as an insulator around nerve fibers throughout the central and peripheral nervous systems. (wikipedia.org)
  • The output takes the form of action potentials in retinal ganglion cells whose axons form the optic nerve. (wikipedia.org)
  • These can be simplified into 4 main processing stages: photoreception, transmission to bipolar cells, transmission to ganglion cells which also contain photoreceptors, the photosensitive ganglion cells, and transmission along the optic nerve. (wikipedia.org)
  • The optic nerve is a central tract of many axons of ganglion cells connecting primarily to the lateral geniculate body, a visual relay station in the diencephalon (the rear of the forebrain). (wikipedia.org)
  • phenotypes
  • These phenotypes were unexpectedly linked to mutations in the gene encoding a subunit of the Go-Ichi-Ni-San (GINS) complex, which is essential for DNA replication prior to cell division. (jci.org)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • fetal
  • C) Differential growth curves of SH2B3 wild-type and patient-derived SH2B3 mutant lymphoblastoid cells grown in 1% fetal bovine serum (FBS) containing media. (nih.gov)
  • gene
  • The SH2B adaptor protein 3 (SH2B3) gene encodes a negative regulator of cytokine signaling with a critical role in the homeostasis of hematopoietic stem cells and lymphoid progenitors. (nih.gov)
  • Gene expression can be stably altered through epigenetic changes which not only allow cells and organisms to quickly respond to changing environmental stimuli but also confer the ability of the cell to "memorize" these encounters once the stimulus is removed. (jove.com)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • These rearrangements result in increased expression of blood cell development genes by promoting gene transcription and through epigenetic changes. (wikipedia.org)
  • The cortex is the location of the earliest events in thymocyte development, where T-cell receptor gene rearrangement and positive selection takes place. (wikipedia.org)
  • Thymocytes that reach the medulla have already successfully undergone T-cell receptor gene rearrangement and positive selection, and have been exposed to a limited degree of negative selection. (wikipedia.org)
  • repopulation
  • This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
  • tissues
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has been embraced and researched in animal models. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • implantation
  • One cell-based replacement technique is called autologous chondrocyte implantation (ACI) or autologous chondrocyte transplantation (ACT). (wikipedia.org)
  • Research into new treatments for spinal cord injuries includes stem cell implantation, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (wikipedia.org)
  • Primary
  • The damage can also be divided into primary and secondary injury: the cell death that occurs immediately in the original injury, and biochemical cascades that are initiated by the original insult and cause further tissue damage. (wikipedia.org)
  • neoplasms
  • Artykuł zawiera opis dwóch przypadków chorych z rozpoznaniem bardzo rzadko występujących nowotworów z blastycznych plazmacytoidalnych komórek dendrytycznych ( blastic plasmacytoid dendritic cell neoplasms - BPDCN). (czytelniamedyczna.pl)
  • In this paper we report two cases of very rare blastic plasmacytoid dendritic cell neoplasms (BPDCN). (czytelniamedyczna.pl)
  • progenitors
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
  • functional
  • Stem cells can also be identified by functional assays. (wikipedia.org)
  • In addition to the knowledge that natural killer cells are effectors of innate immunity, recent research has uncovered information on both activating and inhibitory NK cell receptors which play important functional roles, including self tolerance and the sustaining of NK cell activity. (wikipedia.org)
  • precursors
  • This is in line with the recent knowledge that BPDCN are derived from the precursors of plasmacytoid dentritic cells (2-4). (czytelniamedyczna.pl)
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)