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  • differentiate
  • Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. (wikipedia.org)
  • In a developing embryo, stem cells can differentiate into all the specialized cells-ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)-but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. (wikipedia.org)
  • Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. (wikipedia.org)
  • Totipotent (a.k.a. omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types. (wikipedia.org)
  • Pluripotent stem cells are the descendants of totipotent cells and can differentiate into nearly all cells, i.e. cells derived from any of the three germ layers. (wikipedia.org)
  • Multipotent stem cells can differentiate into a number of cell types, but only those of a closely related family of cells. (wikipedia.org)
  • Oligopotent stem cells can differentiate into only a few cell types, such as lymphoid or myeloid stem cells. (wikipedia.org)
  • Properties of stem cells can be illustrated in vitro, using methods such as clonogenic assays, in which single cells are assessed for their ability to differentiate and self-renew. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • Since they are derived from the mesoderm, they have been shown to differentiate into bone, cartilage, muscle, and adipose tissue. (wikipedia.org)
  • Most of these cells are CD34+ heme progenitors (destined to differentiate into blood components), while very few are actually MSC's capable of differentiating into bone, cartilage, or muscle. (wikipedia.org)
  • Muse cells are shown to home into the damage site and spontaneously differentiate into tissue-compatible cells according to the microenvironment to contribute to tissue regeneration when infused into the blood stream. (wikipedia.org)
  • chronic
  • the occurrence of acute and chronic graft versus host disease, survival, transplantation-related mortality, and relapse rates were compared. (clinicaltrials.gov)
  • Signs and symptoms of WM include weakness, fatigue, weight loss, and chronic oozing of blood from the nose and gums. (wikipedia.org)
  • He is best known for his research on chronic GVHD, the most common late effect in cancer survivors who underwent allogeneic stem cell transplantations as a form of treatment. (wikipedia.org)
  • The United States Embassy in Zagreb, Croatia, granted Pavletic a United States Government stipend to spend six weeks at the University Hospital Centre Zagreb, Croatia, in 2013, to assist in the establishment of a multidisciplinary center for the treatment of chronic GVHD resulting from allogeneic stem cell transplantations. (wikipedia.org)
  • Chronic fatigue, shortness of breath, and recurrent colds can also be symptoms of bone marrow failure. (wikipedia.org)
  • clinical
  • In the majority of clinical trials investigating the effects of intracoronary cell transplantation, the primary end point comprises changes in LV volumes and EF in comparison with a control group over time ( 5-7 ). (onlinejacc.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 - 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health. (wikipedia.org)
  • He then completed a clinical fellowship in bone marrow transplantation in 1992 at the Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine in Seattle, Washington. (wikipedia.org)
  • Neutrophil
  • G-CSF is a growth factor for neutrophils (a common type of white blood cells), and may act by increasing the activity of neutrophil-derived proteases such as neutrophil elastase in the bone marrow leading to proteolytic degradation of SDF-1. (wikipedia.org)
  • liver
  • Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikipedia.org)
  • Liver transplantation is the replacement of a diseased liver with a healthy liver allograft. (wikipedia.org)
  • The most commonly used technique is orthotopic transplantation, in which the native liver is removed and the donor organ is placed in the same anatomic location as the original liver. (wikipedia.org)
  • Liver transplantation nowadays is a well accepted treatment option for end-stage liver disease and acute liver failure. (wikipedia.org)
  • severe
  • In 2014, the European Medicines Agency recommended approval of limbal stem cells for people with severe limbal stem cell deficiency due to burns in the eye. (wikipedia.org)
  • Stems cells are being studied in those with severe heart disease. (wikipedia.org)
  • 2005 Treatment of Jining serious radiation accidents and extremely severe bone marrow and intestinal radiation 2006 Developed an original creativity of microtransplantation for the treatment of leukemia. (wikipedia.org)
  • immune
  • In his early career Dr Moore discovered that all stem cells of the blood and lymphoid system developed in the yolk sac at an early stage of embryo development and migrated via the blood stream to colonize the bone marrow and immune system. (wikipedia.org)
  • The diagnosis is made upon blood tests to confirm not only hemolytic anemia and immune thrombocytopenic purpura, but also a positive direct antiglobulin test (DAT) and an absence of any known underlying cause. (wikipedia.org)
  • autoimmune
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. (wikipedia.org)
  • GVHD
  • Currently, he is the Head of the Graft-versus-host disease (GVHD) and Autoimmunity Unit and Senior Clinician at the Experimental Transplantation and Immunology Branch of the National Cancer Institute's (NCI) Center for Cancer Research at the U.S. National Institutes of Health (NIH). (wikipedia.org)
  • gums
  • Blood may be seen throughout the gums, nose or the skin, and tend to last longer than normal. (wikipedia.org)
  • Spinal Cord Inj
  • Research into new treatments for spinal cord injuries includes stem cell implantation, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (wikipedia.org)
  • tissues
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • For years, the concept of harvesting stem cells and re-implanting them into one's own body to regenerate organs and tissues has been embraced and researched in animal models. (wikipedia.org)
  • articular
  • Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be exposed in the joint. (wikipedia.org)
  • Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a collagen membrane. (wikipedia.org)
  • thymus
  • Histologically, each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. (wikipedia.org)
  • The thymus consists of two lobes, merged in the middle, surrounded by a capsule that extends with blood vessels into the interior. (wikipedia.org)
  • ischemia
  • Conclusions- A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. (ahajournals.org)
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • Transplantation of bone marrow-derived MNCs and infusion of AM were performed in 40 rats immediately after hindlimb ischemia was created. (ahajournals.org)
  • fetal liver
  • In mammalian embryology, the first definitive HSCs are detected in the AGM (aorta-gonad-mesonephros), and then massively expanded in the fetal liver prior to colonising the bone marrow before birth. (wikipedia.org)
  • vessels
  • Cardiovascular disease, also called heart disease, is a broad medical term used to describe a group of conditions that affect the blood vessels or the heart. (stemcelltherapy.me)
  • This network forms an adventitia to the blood vessels, which enter the cortex via septa near the junction with the medulla. (wikipedia.org)
  • therapy
  • Until now insulin replacement is still the major therapy, because islet transplantation has been limited by donor availability and by the need for long-term immunosuppression. (jove.com)
  • Disorders
  • At one end of this spectrum of hematological disorders, detection of one of these myeloma proteins in an individual's blood or urine indicates the presence of a common and clinically silent disorder termed MGUS, i.e. monoclonal gammopathy of undetermined significance. (wikipedia.org)
  • transfusion
  • Transmission of HTLV-I is believed to occur by sexual contact, from mother to child via breastfeeding, and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles. (wikipedia.org)
  • tumors
  • In the majority of cases the damage results from physical trauma such as car accidents, gunshots, falls, or sports injuries, but it can also result from nontraumatic causes such as infection, insufficient blood flow, and tumors. (wikipedia.org)
  • laboratory
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications and screen for bone marrow toxicity. (wikipedia.org)