Peripheral blood stem aggressive treatment bone marrow transplantation. Medical search. Frequent questions

The hematopoietic cells are able to go to the bone marrow through tracking mechanisms. (wikipedia.org)

Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Health Professional Version. (medscape.com)
Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: a report from the FAB/LMB 96 study group. (jnccn.org)
Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
Children and teens with rare childhood non-Hodgkin lymphoma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through the Childhood Lymphoma Program in our Childhood Hematologic Malignancy Center . (dana-farber.org)
If this type of lymphoma is completely removed by surgery, no additional treatment may be necessary. (dana-farber.org)
Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)
Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
Learn more about childhood non-Hodgkin lymphoma , including diagnosis and treatment . (dana-farber.org)
Mantle cell lymphoma (MCL) with a nodular and diffuse pattern associated with hyalinized blood vessels. (basicmedicalkey.com)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Venetoclax combination with standard regimens in follicular lymphoma, multiple myeloma and aggressive B cell neoplasms has shown some promise, but further studies are required to optimize dose and scheduling to mitigate increased myelosuppression and infection risk, and to find validated biomarkers of venetoclax sensitivity. (biomedcentral.com)
Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
T-cell lymphoblastic lymphoma is an extremely aggressive form of lymphoma that is closely related to, if not a different manifestation of, T-cell acute lymphoblastic leukemia and so is included by the listing ( see Figure 2 below ). (alaska-disability.com)
Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes.Methods: A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4+CD56+ hematodermic neoplasm, and blastic natural killer cell lymphoma. (elsevierpure.com)
DLBCL is an aggressive (fast-growing) lymphoma. (lymphomaindia.com)
Approximately 30-40 % of patients with FL will eventually transform to a more aggressive form of lymphoma like Diffuse Large B Cell Lymphoma and may require intensive chemotherapy followed by autologous stem cell transplantation. (lymphomaindia.com)
Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
Non-Hodgkin lymphoma is not one disease but rather a category of lymphocyte cancers with a number of subgroups largely divided into aggressive and indolent types. (msdmanuals.com)
3 - 5 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with, or at risk of, leptomeningeal and/or brain parenchyma lymphoma relapse. (haematologica.org)
Axicabtagene ciloleucel in large B cell lymphoma ineligible for autologous stem cell transplantation: the phase 2 ALYCANTE trial. (canceropole-est.org)
Tandem haematopoietic stem cell transplantation versus single cell transplant and BV maintenance in relapsed/refractory Hodgkin lymphoma: A matched cohort analysis from the LYSA. (canceropole-est.org)
Randomized Phase III Trial Evaluating Subcutaneous Rituximab for the First-Line Treatment of Low-Tumor Burden Follicular Lymphoma: Results of a LYSA Study. (canceropole-est.org)
2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)

Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes. (elsevierpure.com)
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the gastrointestinal tract. (msdmanuals.com)
[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)

Aggressive treatment with antibiotics is required and bone marrow transplant is common. (wikipedia.org)
Patients undergoing bone marrow transplant, specifically from a matched sibling, have a higher 5 year survival rate than those receiving a transplant from other donors. (wikipedia.org)
Similarly, in bone transplant, stem cells are able to find their way back through tracking mechanisms. (wikipedia.org)
The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
Very few patients in this trial were treated with bone marrow transplant which had previously been the standard of care. (childrensmercy.org)
Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
Early transplantation, careful donor selection and improving post-transplant liver events were crucial to optimise outcomes. (bvsalud.org)
Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. (uchicago.edu)
Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. (uchicago.edu)
Allogeneic stem cell transplant in renal failure: engraftment and prolonged survival, but high incidence of neurologic toxicity. (uchicago.edu)
Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)
The patient was given salvage chemotherapy in the form of FLA-Ida with the plan to reassess at count recovery aiming for stem cell transplant. (cambridgemedicine.org)

Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (merckmanuals.com)

The acute leukemias are aggressive malignancies that originate in a hematopoietic stem cell and are rapidly fatal without immediate treatment. (hematology.org)
As with acute lymphoblastic leukemia, the successful management of patients with AML requires a therapeutic strategy determined by careful assessment of individual prognosis, aggressive supportive therapy, and early recognition and treatment of complications. (hematology.org)
Describe the unique features of acute promyelocytic leukemia (AML M3), including the morphologic appearance of the promyelocyte, hemorrhagic complications, chromosomal abnormality, and treatment with induction therapy and all trans retinoic acid. (hematology.org)
In August of 2017, tisagenlecleucel (Kymriah) was approved for the treatment of children and adolescents with B-cell acute lymphoblastic leukemia (ALL) who have relapsed or not responded to chemotherapy. (childrensmercy.org)
With acute lymphocytic leukemia, the bone marrow makes too many of these lymphocytes and they do not mature correctly. (texaschildrens.org)
Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)
Any form of acute leukemia results in an automatic allowance of disability benefits for at least 24 months from the date of diagnosis or relapse or 12 months from stem cell or marrow transplantation, whichever is later. (alaska-disability.com)
The initial diagnosis of acute leukemia is based on definitive bone marrow examination. (alaska-disability.com)
If the examining pathologist and treating hematologist-oncologist interpret the bone marrow as diagnostic of acute leukemia and therapy proceeds accordingly, any question should be resolved in favor of the claimant. (alaska-disability.com)
Laboratory findings may show anemia, thrombocytopenia, and leukocytosis, and immunophenotyping of peripheral blood may demonstrate an abundance of CD34+ cells, thus mimicking acute leukemia or juvenile myelomonocytic leukemia . (hematologyadvisor.com)
The overall response rate with aggressive acute lymphoblastic leukemia-type induction regimens was as high as 90%, but the durability of response was short. (elsevierpure.com)
Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, and is a malignant clonal disease of leukemia stem cells (LSCs). (biomedcentral.com)
The demethylating agent 5-azacytidine (AZA) can achieve substantial survival benefit for patients with higher-risk MDS and patients with acute myeloid leukemia (AML) who have a bone marrow blast count of 20-30% (RAEB-T according to the FAB classification) (Fenaux et al. (biomedcentral.com)
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. (mdpi.com)
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? (biomedcentral.com)
Following diagnosis and treatment as pre-B cell acute lymphoblastic leukaemia (pre-B ALL) the patient developed an acute myeloid leukaemia (AML) which was refractory to all available curative therapies. (cambridgemedicine.org)
Left untreated the disease inexorably progresses to blastic phase (BP), defined by the presence of 30% or more blasts in the bone marrow and a clinical picture indistinguishable from acute leukemia. (rockstarsagainstliveearth.com)

Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
The patient's own white blood cells and stem cells from their blood are modified in the laboratory using genetic techniques to express a specific receptor against cancer cells. (ca.gov)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
A) Blood film of patient's bone marrow aspirate at day 29. (cambridgemedicine.org)
C) Blood film of patient's bone marrow aspirate during maintenance therapy. (cambridgemedicine.org)

If the results show patients with low levels of lymphocytes, absence of granulocytes or absence of thymus then the patient may be suspected to have RD. RD can only be treated temporarily through hematopoietic stem cell transplantation (HSCT) and cytokine therapy. (wikipedia.org)
Hematopoietic stem cell transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged bone marrow or defective immune system. (wikipedia.org)
This study aimed to assess haematopoietic stem cell transplantation (HSCT) safety and efficacy while exploring strategies for optimising outcomes in patients with hepatitis-associated aplastic anaemia (HAAA). (bvsalud.org)
We retrospectively reviewed 35 HAAA patients who underwent HSCT at a large Chinese blood disease hospital between 2008 and 2022. (bvsalud.org)
In conclusion, HSCT was a safe and effective treatment for HAAA. (bvsalud.org)
Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). (bvsalud.org)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
MIOP diagnosis must be confirmed with molecular genetic analysis, such as whole-exome sequencing, to guide treatment planning and determine appropriateness for HSCT. (hematologyadvisor.com)
1 Hematopoietic stem cell transplantation (HSCT), has become the standard of care for MIOP and represents the only curative treatment for the disease, although it is not indicated for certain genetic subgroups. (hematologyadvisor.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) after CAR T-cell therapy has emerged as a promising strategy to prolong LFS. (biomedcentral.com)
For decades, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been regarded as the only well-established curative cellular therapy for patients with B-ALL. (biomedcentral.com)
Furthermore, r/r B-ALL patients may develop severe organ damage or infection after aggressive chemotherapy and, hence, be precluded from allo-HSCT. (biomedcentral.com)
Hematopoietic stem cell transplantation (HSCT) is the only proven curative treatment for CML, but it is applicable in only a fraction of patients, Proglumide sodium salt mainly younger patients with a matched donor [7]. (rockstarsagainstliveearth.com)

Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. (uchicago.edu)
Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
The ideal routine power before allogeneic Hematopoietic Cell Transplantation (HCT) is obscure. (scitechnol.com)

Before the advent of bone marrow and stem cell transplantation and the development of tyrosine kinase inhibitors for the treatment of CML , the prognosis was grimmer and the Social Security Administration had a policy of finding listing-level equivalence for any new diagnosis of CML even though there was no blastic transformation. (alaska-disability.com)

knowcancer.com is intended to be solely for informational purposes and should not be a substitute for professional medical advice, diagnosis or treatment. (knowcancer.com)
1 , 2 , 4 - 6 Specifically, patients with lactate dehydrogenase ≥2 times the upper limit of normal (ULN) at diagnosis, R/R disease within 6 months of diagnosis, multisite relapse, and/or R/R disease with bone marrow involvement experience a significantly decreased OS ( Table 1 ). (jnccn.org)
You will be considered under a disability until at least 24 months from the date of diagnosis or relapse, or at least 12 months from the date of bone marrow or stem cell transplantation, whichever is later. (alaska-disability.com)
The standard for diagnosis of leukemia has been unchanged for many years-microscopic evaluation of bone marrow smears. (alaska-disability.com)
However, once the initial diagnosis has been established by prior bone marrow biopsy, a recurrence can also be documented by peripheral blood smear or identification of leukemic cells in cerebrospinal fluid. (alaska-disability.com)
Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Diagnosis is typically established based on unique radiographic findings including "sclerotic bones with increased bone marrow density and the absence of bone marrow cavity," which are pathognomonic for MIOP. (hematologyadvisor.com)
Data regarding diagnosis, prognosis, and treatment were analyzed. (elsevierpure.com)
The diagnosis of BPDCN is based on the characteristic cytology and immunophenotype of malignant cells coexpressing CD4, CD56, CD123, blood dendritic cell antigens 2 and 4, and CD2AP markers. (elsevierpure.com)
Data regarding diagnosis, prognosis, and treatment were analyzed.Conclusions: BPDCN is a rare aggressive disease that typically affects elderly patients. (elsevierpure.com)
Disease is likely to be disseminated at the time of presentation, and diagnosis is usually based on lymph node or bone marrow biopsy or both. (msdmanuals.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
2 Early diagnosis of central nervous system events is critical for successful treatment and improved prognosis. (haematologica.org)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
Most patients (90%) are diagnosed in chronic phase (CP), characterized by an increase in white blood cell counts with immature granulocytes in the peripheral blood, and up to 40% are asymptomatic at time of diagnosis. (rockstarsagainstliveearth.com)

Some patients also showed complete remission according to FISH on bone marrow mononuclear cells and CD34 + peripheral blood cells, as well as by follow-up of somatic mitochondrial DNA mutations. (biomedcentral.com)

1 - 3 However, those with relapsed and/or refractory (R/R) disease have had a historically dismal OS of ≤30% despite reinduction therapy and autologous hematopoietic progenitor cell transplantation (autoHCT) ( Figure 1 ). (jnccn.org)
The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)

Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Toxic shock like syndrome caused by Streptococcus agalactiae bacteremia during treatment for multiple myeloma. (u-tokyo-hemat.com)
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)

Allogeneic stem cell transplantation should be considered for refractory disease or for very early relapsing disease. (lymphomaindia.com)
Two months later the bone marrow aspirate indicated refractory disease with 30-50% blasts and a reduced number of mature myeloid cells and abnormal monocytoid cells. (cambridgemedicine.org)

National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
In regard to relapse (recurrence), bone marrow biopsy information will probably be available. (alaska-disability.com)
A bone marrow biopsy is not required to document relapse. (alaska-disability.com)
The patient who relapse or who does not respond to initial treatment, require more intensive treatment. (lymphomaindia.com)
With few exceptions, stem cell transplantation is usually reserved for patients with aggressive lymphomas after incomplete remission or relapse. (msdmanuals.com)
Influence of systemic rituximab treatment on the incidence of CNS relapse in DLBCL and risk factors for CNS disease. (haematologica.org)
Recent clinical data indicate that patients with complex karyotypes, adverse genes, and high pre-infusion minimal residual disease (MRD) by flow cytometry in the bone marrow, were at high risk of relapse after CAR T-cell therapy. (biomedcentral.com)
High pre-lymphodepletion lactate dehydrogenase, low pre-lymphodepletion platelet count, absence of fludarabine in lymphodepletion, persistent leukemic sequence by high throughput sequencing in bone marrow after CAR T-cell infusion, and early loss of CAR T cells have also been linked to relapse after CAR T-cell therapy. (biomedcentral.com)
Phenotypically and genetically heterogeneous tumors are more aggressive, have a higher relapse rate, and are more resilient to therapy. (uni-hamburg.de)

While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been shown to counter rheumatoid arthritis, autoimmune hepatitis, and systemic sclerosis [ 8 ]. (biomedcentral.com)

Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)
mTOR also reduces the cell growth factors (eg, vascular endothelial growth factor) involved in new blood vessel development. (medscape.com)
Although most clinicians would agree that hematopoietic progenitor cell transplantation after reinduction therapy is frontline therapy for these patients, there is no consensus as to what type of hematopoietic progenitor cell transplantation promises the best event-free and overall survival. (jnccn.org)
This review outlines the disparate types of stem cell therapy that have been used in this difficult-to-treat population as well as the role of maintenance and CAR T-cell therapy in conjunction with stem cell therapy. (jnccn.org)
Others can be cured with stem cell transplantation. (hematology.org)
Describe the predominant cell types seen in the peripheral blood and/or bone marrow in each of the four major categories of leukemia (AML, ALL, CML, CLL). (hematology.org)
CMH is now one of only a handful of children's hospitals treating patients on a clinical trail for newly diagnosed patients with B-cell ALL with a slower than expected response to treatment. (childrensmercy.org)
There are different types of AML, but this is usually a cancer of the blood in which too many granulocytes, a type of white blood cell, are produced in the marrow. (texaschildrens.org)
Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune system. (bvsalud.org)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)
Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience. (uchicago.edu)
Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. (uchicago.edu)
Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. (uchicago.edu)
Long haul resistant recuperation in more seasoned patients given hematopoietic cell transplantation after non-myeloablative molding remains ineffectively comprehended. (scitechnol.com)
Contrasted with HLA indistinguishable matched kin giver and matched irrelevant benefactor grown up hematopoietic cell transplantation beneficiaries, quantitative lymphoid recuperation in UCB transplantation beneficiaries is more slow in the initial 3 months, however these distinctions vanished by months after transplantation. (scitechnol.com)
Heredity explicit chimerism studies are regularly acquired at a few time guides after nonmyeloablative hematopoietic cell transplantation toward evaluate the rhythm and level of engraftment, and to screen join dismissal. (scitechnol.com)
Pancytopenia is a condition when all three types of blood cell counts are low. (symptoma.com)
Less than 5% of people will have a low white blood cell count or platelet count without anemia . (symptoma.com)
Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. (elsevierpure.com)
Allogeneic hematopoietic stem cell transplantation, particularly when performed during the first remission, may produce durable remissions in selected adults. (elsevierpure.com)
Salvage chemotherapy followed by allogeneic stem cell transplantation. (lymphomaindia.com)
A strategy in the treatment of cancer by harnessing the immune system, called adoptive cell therapy, is to use an individual's own immune cells (T cells) and genetically modify them to target them to kill the cancer. (ca.gov)
Gene modification of cells involves the transfer of foreign genetic material (DNA) into a cell, in this case the immune system cells and stem cells. (ca.gov)
The specific receptor against cancer cells that will be transferred to the immune cells and stem cells is called NY-ESO-1 T cell receptor (or TCR). (ca.gov)
In recent years, epigenetic therapy has become a treatment option for patients with higher-risk myelodysplastic syndrome (MDS) who are not considered candidates for intensive induction chemotherapy or allogeneic stem cell transplantation (SCT). (biomedcentral.com)
Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool. (u-tokyo-hemat.com)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence [2]. (jbstjournal.com)
Campanacci's staging system for giant cell tumour of the bone [5] was used for cortical breach. (jbstjournal.com)
CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. (thermofisher.com)
The only proven effective treatment for the disease is hematopoietic stem cell transplantation. (frontiersin.org)
A recent study showed that patients with CAEBV or infectious mononucleosis have a decrease in the TCR-beta repertoire and expanded T cell clones in their peripheral blood compared with healthy carriers of EBV ( 14 ). (frontiersin.org)
We explored whether stem cell therapy was effective for animal models and patients with Crohn's disease (CD). (biomedcentral.com)
In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. (biomedcentral.com)
In clinical trials, stem cell transplantation reduced the CD activity index (SMD − 2.10, P = 0.000), the CD endoscopic index of severity (SMD − 3.40, P = 0.000) and simplified endoscopy score for CD (SMD − 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. (biomedcentral.com)
Stem cell transplantation is a valuable supplementary therapy for CD. (biomedcentral.com)
In recent years, developments in stem cell (SC) biology and regenerative medicine have revealed that SCs unexpectedly can be used to treat autoimmune diseases. (biomedcentral.com)
Several studies have evaluated the safety and effectiveness of CD stem cell therapy, but the results remain controversial. (biomedcentral.com)
Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)
An Underlying Stem Cell Defect? (cambridgemedicine.org)
Possible Juvenile Myelomonocytic Leukaemia in a Child with NF1 - An Underlying Stem Cell Defect? (cambridgemedicine.org)
It is likely that her molecular defect was at a stem cell level. (cambridgemedicine.org)
A full blood count revealed red cell count 3.31 x 10 12 /L, haemoglobin 10 8 g/L, platelets 62 x 10 9 /L, MCV 99.6fL, white cell count 15.9 x 10 9 /L, lymphocytes 7 x 10 9 /L and monocytes 2.39 x 10 9 /L. The peripheral blood film was leucoerythroblastic with 30% circulating blasts. (cambridgemedicine.org)
The translocation occurs in a primitive hematopoietic stem cell and the gene encodes a fusion protein (Bcr-Abl) that has deregulated tyrosine kinase (TK) activity and activates intracellular pathways that lead to increased cellular proliferation, resistance to apoptosis and genetic instability [1,3]. (rockstarsagainstliveearth.com)

Children's Mercy Hospital was one of the first hospitals in the country to offer this treatment to patients and was an integral part of the two clinical trials that paved the way for the approval of Kymriah. (childrensmercy.org)
While the clinical presentation of MIOP is heterogeneous, patients commonly present with failure to thrive, visual impairments, hepatosplenomegaly, and skeletal changes such as macrocephaly, frontal bossing, tooth eruption defects, and bone fractures. (hematologyadvisor.com)
Treatment with interferon (IFN)-α has also been reported to trigger autoimmune phenomena in up to 3% of cases, with AIHA being the most prevalent and most significant phenomena seen in clinical practice [ 10 ]. (biomedcentral.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
Several of those are now considered applicable for patient treatments beyond the need for regulated clinical trials. (biomedcentral.com)
The present study aims to describe the radiological, clinicopathological, and immunohistochemical findings of a case of epithelioid angiosarcoma located in the posterior mediastinum of a 65-year-old male patient who underwent surgery and clinical treatment (Doxorubicin-based chemoterapy). (bvsalud.org)

For some indolent lymphomas, no treatment may be needed for some time. (epnet.com)
Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
Most non-Hodgkin lymphomas (NHL) in children are fast growing, aggressive cancers. (dana-farber.org)
Most lymphomas are nodal with variable involvement of the bone marrow and peripheral blood. (msdmanuals.com)

Compare and contrast AML and ALL in terms of age of patients, central nervous system involvement, treatment, and outcome. (hematology.org)

The overall remission rate was 81%, with 50% of patients remaining leukemia free 1 year after treatment. (childrensmercy.org)
01). Treatment-related mortality was similar for patients with primary induction failure vs those in first complete remission after myeloablative or reduced-intensity conditioning allo-HCT (Table 1). (ascopost.com)
CD patients maintained high remission rates for 3-24 months after transplantation. (biomedcentral.com)

additional treatment given after the main treatment plan to decrease the chance of recurrence. (thewomenofhope.org)
Goals of treatment are to achieve satisfactory removal of the tumor, lessen the chance of local recurrence and to preserve as much wrist function as possible. (jbstjournal.com)

AK2 protein allows hematopoietic stem cells to differentiate and proliferate. (wikipedia.org)
Hematopoietic stem cells give rise to blood cells. (wikipedia.org)
Differentiation and proliferation of hematopoietic stem cells require a lot of energy and this energy is supplied by the mitochondria. (wikipedia.org)
If there is a mutation in the protein, that means that the mitochondria metabolism most likely will be altered and will not be able to provide enough energy to the hematopoietic stem cells. (wikipedia.org)
As a result, hematopoietic stem cells will not be able to differentiate or proliferate. (wikipedia.org)
Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. (wikipedia.org)
Patients who suffer from RD will now have more stem cells that can differentiate into immune cells. (wikipedia.org)
GM-CSF stimulates production of white blood cells. (wikipedia.org)
Stem cells are taken from an affected child's blood or bone marrow. (wikipedia.org)
Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
Stem cells are immature cells that produce blood cells. (epnet.com)
These cells are then replaced after treatment. (epnet.com)
Name at least three disease features which result from replacement of marrow cells with myeloblasts or circulation of myeloblasts. (hematology.org)
Chronic granulomatous disease (CGD) is a type of primary immunodeficiency (PI) in which one group of the body's white blood cells, called neutrophils, fail to make the hydrogen peroxide, bleach, and other chemicals needed to fight bacterial and fungal infections. (primaryimmune.org)
The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in the breast or has spread to other places in the body), the type of breast cancer, certain characteristics of the cancer cells, and whether the cancer is found in the other breast. (stopgettingsick.com)
When a child has leukemia, the bone marrow, for an unknown reason, begins to make abnormal blood cells (usually white blood cells) that do not mature correctly, but continue to reproduce themselves. (texaschildrens.org)
These abnormal cells reproduce very quickly and do not function as healthy white blood cells to help fight infection. (texaschildrens.org)
When the immature white blood cells, called blasts, begin to crowd out other healthy cells in the bone marrow, the child experiences the symptoms of leukemia (such as fevers, infections, anemia, bone pain, or bleeding). (texaschildrens.org)
The lymphocytes overproduce, thus, crowding out other blood cells. (texaschildrens.org)
Immature blood cells (blasts) do not work properly to fight infection. (texaschildrens.org)
In this review, a review examination was performed to survey the transfer result of grown up patients with ALL who had chimerism investigations of unfractionated BM cells or fringe blood subsets performed roughly 80 days after transplantation. (scitechnol.com)
Fragmented contributor engraftment was available just in the fringe blood T cells in a little level of patients. (scitechnol.com)
The resulting deficiencies of platelets and red and white blood cells cause anemia, susceptibility to infections, and easy bruising and bleeding. (symptoma.com)
To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
Furthermore, due to its inhibition of cellular growth, interference with oncogene expression and augmentation of lymphocyte cytotoxicity for target cells, IFN-α may cause bone marrow suppression, including potentially severe cytopenias and, very rarely, AA [ 11 ]. (biomedcentral.com)
In this study, we hypothesize that gene-modified stem cells will allow a sustained production of active T cells with antitumor activity. (ca.gov)
Since there is a delay in the appearance of the T cells that come from stem cells to get out of the bone marrow and into the blood, we will give patients both gene-modified T cells for a first wave of antitumor activity and gene-modified stem cells which will provide a bridge until the stem cells have produced more T cells. (ca.gov)
The purpose of the current study is to give gene-modified T cells in combination with gene-modified stem cells to reprogram the immune system to recognize and kill cancer cells that have the NY-ESO-1 protein with sustained killing activity. (ca.gov)
This process will endow the recipient immune cells and descendants of the stem cells with the ability to eliminate cancer cells that express the cancer specific protein, NY-ESO-1. (ca.gov)
In this study, the gene-modified immune cells will be given in combination with the gene-modified stem cells. (ca.gov)
To date, we have manufactured a batch of the lentiviral vector necessary to transfer the NY-ESO-1 TCR into stem cells and have demonstrated that this vector can gene-modify human stem cells. (ca.gov)
We have demonstrated that when mouse stem cells are gene-modified with this lentiviral vector, the stem cells take up residence in the bone marrow and produce appropriate blood cells. (ca.gov)
There is no detrimental effect on the blood cells that are derived from the stem cells. (ca.gov)
A preclinical study is also ongoing in mice to assess the safety of combining the gene-modified T cells and stem cells in mice. (ca.gov)
In addition, a preclinical study was performed to demonstrate that the stem cells are able to be specifically eliminated using ganciclovir, which provides a safety feature in case there was a problem when translating this research to humans. (ca.gov)
Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
A culture platform to study quiescent hematopoietic stem cells following genome editing. (u-tokyo-hemat.com)
CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
Hemoglobin is a substance in the red blood cells that enables the blood to transport oxygen through the body. (thewomenofhope.org)
a protein that is present in the blood, made by cells of the immune system to fight infection. (thewomenofhope.org)
Applications Tested: This 2H7 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
EBV is present in circulating B cells, and the level of EBV DNA is elevated in the blood for the first month of the illness. (frontiersin.org)
Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
Hematopoietic stem cells (HSC) generate all of the blood cells throughout their life-span. (haematologica.org)
[2] [9] Enlargement of the spleen and low red blood cells ( anemia ) may also occur. (wikipedia.org)
[4] These cells do not function well and crowd out healthy blood cells . (wikipedia.org)
[17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
[18] Whereas, with CLL, diseased cells propagate from within the bone marrow, in SLL they propagate from within the lymphatic tissue. (wikipedia.org)
Flow cytometry of the bone marrow revealed that the blast cells expressed B lymphoid lineage associated antigens (Figure 1 ) and hence the patient was diagnosed with pre-B ALL. (cambridgemedicine.org)
Dissemination of tumour cells and metastatic spread as well as cancer resistance to standard treatment are still the common cause of treatment failure and eventually death in prostate cancer patients. (uni-hamburg.de)
Circulating tumor cells (CTCs) can be detected in the peripheral blood and peritoneal liquid in most of the ovarian cancer patients in the different stages of the disease. (uni-hamburg.de)
The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

At the end of induction the bone marrow was hypercellular with 6% myeloid blasts by flow cytometry but no excess of lymphoid blasts (Figure 2 ). (cambridgemedicine.org)

Moreover, the impact of newly developed diagnostic tools (such as multiparameter flow cytometry [FCM]) and new treatments introduced in the last decade, in particular rituximab, has still not been fully clarified. (haematologica.org)

A woman's age, weight, menopausal status (whether or not a woman is still having menstrual periods), and general health can also affect the prognosis and choice of treatment. (stopgettingsick.com)
Although DLBCL is the most common form of NHL, there are several subtypes that may affect the prognosis (how well patients will do with standard treatment) and treatment. (lymphomaindia.com)

and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)

The survival range is estimated to be 3 days to 17 weeks without treatment. (wikipedia.org)
We theorized that lower Treatment Related Mortality (TRM) with Reduced Intensity Conditioning (RIC) would bring about better Overall Survival (OS) contrasted and Myelo ablative Conditioning (MAC). (scitechnol.com)
1 In a 2015 study of 193 patients, transplantation from a matched sibling was associated with 5- and 10-year survival rates of 62% at both time points, compared to 42% and 39%, respectively, with alternative donor transplantation. (hematologyadvisor.com)
Although in the last few years new agents have been developed for AML treatment, the overall survival prospects for AML patients are still gloomy and new therapeutic options are still urgently needed. (mdpi.com)
Therefore, the recommended treatment which offers the best chance of survival to the patient is surgery, together with radiotherapy and chemotherapy 3,4,7,8 . (bvsalud.org)

[12] The medications fludarabine , cyclophosphamide , and rituximab were previously the initial treatment in those who are otherwise healthy. (wikipedia.org)

For patient education information, see Blood in the Urine . (medscape.com)
The combination of a specific environmental precipitant represented by the hepatitis C virus infection, an altered metabolic detoxification pathway due to treatment with pegylated interferon alpha 2a and a facilitating genetic background such as polymorphism in metabolic detoxification pathways and specific human leukocyte antigen genes possibly conspired synergistically in the development of aplastic anemia in this patient. (biomedcentral.com)
SCs have been found to inhibit intestinal inflammation, promote long-term intestinal mucosal healing, and significantly improve patient quality of life, making them a valuable alternative CD treatment. (biomedcentral.com)
The peripheral monocytosis leads us to believe that this patient may have transformed via a juvenile myelomonocytic leukaemia (JMML) which subsequently transformed into a refractory AML. (cambridgemedicine.org)
The patient commenced induction with regimen A of the UKALL2011 trial which includes treatment with vincristine, pegaspargase and dexamethasone. (cambridgemedicine.org)
Al- risk of transmission of diseases through though the patient received blood compo- transfusion. (who.int)
Oral support treatment also becomes essential in an attempt to eliminate all foci of oral infections, as well as minimize morbidity and improve the general condition of the patient before, during, and after oncological treatment. (bvsalud.org)

He underwent allogeneic bone marrow transplantation after completing two courses of immunosuppressive therapy with antithymocyte globulin and cyclosporin A. (biomedcentral.com)

To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)

This provoked us to examine long haul lymphocyte reconstitution and thymic work in 80 patients given allogeneic fringe blood foundational microorganisms after nonmyeloablative molding. (scitechnol.com)

The bone marrow aspirate showed hypercellularity and a prominent blast population of 80% with markedly reduced erythropoiesis, myelopoiesis and megakaryopoiesis. (cambridgemedicine.org)
A retrospective FISH of the day 29 (post-induction) bone marrow aspirate showed that 84% of blasts were positive for monosomy 7. (cambridgemedicine.org)

Dana-Farber/Boston Children's offers internationally renowned care for children with cancers of the blood and immune system. (dana-farber.org)

Treatments depend on the stage and type of cancer. (epnet.com)
and Male Breast Cancer Treatment are also available. (stopgettingsick.com)
Dana-Farber/Boston Children's also offers a wide array of support services and programs for pediatric patients and their families during and after cancer treatment. (dana-farber.org)
Leukemia is cancer of the blood and develops in the bone marrow. (texaschildrens.org)
Antibiotics may be needed along with the cancer treatment to prevent or treat infections. (thewomenofhope.org)

Aggressive "biological therapies" are immunogenic, but their effects fade over time [ 6 ]. (biomedcentral.com)

a condition that occurs when there is not enough hemoglobin in a person's blood. (thewomenofhope.org)

Treatment depends on the etiology, severity of the bleeding, and symptoms. (medscape.com)
Treatment is needed if the tumor begins to cause symptoms. (epnet.com)
Presenting symptoms usually include peripheral lymphadenopathy. (msdmanuals.com)

It results from damage to the bladder's transitional epithelium and blood vessels by toxins, pathogens, radiation, drugs, or disease. (medscape.com)
Hemorrhagic cystitis results from damage to the bladder's transitional epithelium and blood vessels by toxins, viruses, radiation, drugs (in particular, chemotherapeutic drugs), bacterial infections, or other disease processes. (medscape.com)
Treatment repeats every 28 days for at least 6 courses in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
To plan treatment, a doctor needs to know the stage of the disease. (stopgettingsick.com)
Treatment of localized and advanced disease varies considerably. (medscape.com)
Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
Recurrent disease must be documented by peripheral blood, bone marrow, or cerebrospinal fluid examination. (alaska-disability.com)
Identifying the genes responsible for the majority of cases has helped us better understand the biology of the disease and what forms may be amenable to intervention such as transplantation. (hematologyadvisor.com)
In those with a RANK ligand genotype, the cause of the disease is extrinsic to the osteoclasts, and transplantation would not be expected to provide benefit. (hematologyadvisor.com)
Conclusions: BPDCN is a rare aggressive disease that typically affects elderly patients. (elsevierpure.com)
The first line treatment can cure up to 90% of patients in early stage of disease and upto 40% of patients in advanced stages of disease. (lymphomaindia.com)
Lengthy time to response is problematic for patients with an aggressive course of disease, particularly patients with AML. (biomedcentral.com)
Osteoporosis Osteoporosis is a progressive metabolic bone disease that decreases bone mineral density (bone mass per unit volume), with deterioration of bone structure. (merckmanuals.com)
The disease is progressive with markedly elevated levels of EBV DNA in the blood and infiltration of organs by EBV-positive lymphocytes. (frontiersin.org)
Chronic active Epstein-Barr virus disease is usually defined as a chronic illness lasting at least 6 months, an increased EBV level in either the tissue or the blood, and lack of evidence of a known underlying immunodeficiency ( 15 ). (frontiersin.org)
Other authors, particularly when defining severe CAEBV disease, require both an elevated level of EBV in the blood as well as infiltration of tissues by EBV-positive lymphocytes ( 16 ). (frontiersin.org)
Early-stage CLL in asymptomatic cases responds better to careful observation, as there is no evidence that early intervention treatment can alter the course of the disease. (wikipedia.org)

Six months into maintenance a routine blood film revealed neutropenia and monocytosis with the occasional promonocyte and some platelet clumps. (cambridgemedicine.org)
Thirty months after the 1st episode, she decided to start aggressive plasma ex- again came to the hospital as her platelet change therapy immediately. (who.int)

Muscat, from a regional hospital, suffering ted diseases, with varying incidence, con- from anaemia and thrombocytopenia with tracted even after the transfusion of episodes of generalized convulsions and properly tested blood [ 2,3 ]. (who.int)

Anatomy33

Organisms11

Diseases53

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology2

Phenomena and Processes34

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups5

Health Care18

Hematopoietic cells1

Lymphoma32

Lymph nodes4

Transplant14

Autologous peripheral blood stem2

Acute18

Patient's5

HSCT16

Allogeneic hematopoietic cell transplantation4

Tyrosine kinase inh1

Diagnosis15

Mononuclear cells1

Therapy and autologous2

Multiple myeloma3

Refractory disease2

Relapse9

Mesenchymal stem3

Cell52

Clinical8

Lymphomas4

Involvement1

Remission3

Recurrence2

Cells56

Myeloid1

Flow cytometry1

Prognosis2

Umbilical1

Survival5

Rituximab1

Patient7

Underwent1

Adults1

Nonmyeloablative1

Aspirate2

Immune1

Cancer5

Therapies1

Person's1

Symptoms3

Disease17

Platelet2

Thrombocytopenia1