AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationHepatic Veno-Occlusive DiseaseTransplantation, HomologousGraft vs Host DiseaseWhole-Body IrradiationAnemia, AplasticLeukemiaTransplantation ConditioningHematopoietic Stem Cell TransplantationBone MarrowBone Marrow CellsTransplantation, AutologousT-LymphocytesMice, Inbred C57BLHematopoietic Stem CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBone and BonesTransplantation ChimeraLiver TransplantationGraft SurvivalTissue DonorsBusulfanBone Marrow PurgingHistocompatibility TestingHistocompatibilityCyclophosphamideImmunosuppressionTime FactorsTransplantation, IsogeneicHematopoiesisBone Marrow DiseasesKidney TransplantationRecurrenceCombined Modality TherapyRadiation ChimeraLeukemia, Myeloid, AcuteHematologic NeoplasmsTreatment OutcomeBone Marrow ExaminationImmunosuppressive AgentsRemission InductionRetrospective StudiesGraft RejectionPrecursor Cell Lymphoblastic Leukemia-LymphomaLymphocyte DepletionTransplantation ImmunologyBone RemodelingLeukemia, MyeloidGraft vs Host ReactionBone Marrow NeoplasmsStem Cell TransplantationLymphoma, Non-HodgkinAcute DiseaseSevere Combined ImmunodeficiencyLeukocyte TransfusionColony-Forming Units AssayFlow CytometryLeukocytes, MononuclearHeart TransplantationChimeraLeukocyte CountCells, CulturedHLA AntigensSurvival AnalysisMyelodysplastic SyndromesCell DifferentiationLymphocyte TransfusionPostoperative ComplicationsGranulocyte Colony-Stimulating FactorLymphocytesPeripheral Blood Stem Cell TransplantationHematologic DiseasesCyclosporineLung TransplantationBlood CellsAntineoplastic Combined Chemotherapy ProtocolsSpleenAntigens, CD34Actuarial AnalysisBone DensityImmunophenotypingCarmustineFollow-Up StudiesNuclear FamilyCytomegalovirus InfectionsPancytopeniaMice, Inbred BALB COrgan TransplantationGraft vs Leukemia EffectGraft vs Tumor EffectCytarabineSurvival RateMelphalanLymphocyte ActivationCell SeparationAntigens, CDMultiple MyelomaLymphomaAntibodies, MonoclonalThymus Gland
HSCTEngraftmentAllogeneic hematopoietic cell transplantationStem cellsUnmatched bone marrow donorPost-transplantation2000MyeloablativeDonorsAutologous marrowPatient'sUmbilicalSolid tumorsHematopoietic reconstitutionMonths after transplantationAplastic anemiaDays after transplantationProgenitor cellDifferentiationTumorsClinicalComplicationsChemotherapyLymphocyteCells1993PatientsTissueSCIDCellBloodstreamInfectionGene therapyHematologicCurativeHaploidenticalHSCsImmune system
HSCT12
Engraftment5
  • Patients who undergo allogeneic bone marrow transplantation (BMT) are clinically immunodeficient for a prolonged period after engraftment. (ashpublications.org)
  • We conclude that despite the recovery of normal numbers of T lymphocytes early after engraftment of CD6-depleted marrow, these T cells exhibit several physiologic and functional abnormalities that persist for varying intervals post-BMT. (ashpublications.org)
  • Interest of study of lymphocyte phosphoglucomutase (PGM) and adenylatokinase (AK) in the early demonstration of Bone Marrow Engraftment. (cellsilab.com)
  • Heredity explicit chimerism studies are regularly acquired at a few time guides after nonmyeloablative hematopoietic cell transplantation toward evaluate the rhythm and level of engraftment, and to screen join dismissal. (scitechnol.com)
  • Fragmented contributor engraftment was available just in the fringe blood T cells in a little level of patients. (scitechnol.com)
Allogeneic hematopoietic cell transplantation3
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
  • The ideal routine power before allogeneic Hematopoietic Cell Transplantation (HCT) is obscure. (scitechnol.com)
Stem cells23
  • Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). (bvsalud.org)
  • Physicians have also had some success with in utero transplants done before the child is born and also by using cord blood which is rich in stem cells. (wikipedia.org)
  • Since the anti-CD34 monoclonal antibody 12-8 reacts with a similar marrow population in baboons, it was possible to test whether this antigen is expressed by stem cells responsible for hematopoietic reconstitution in vivo. (nih.gov)
  • The data suggest that stem cells responsible for hematopoietic reconstitution are CD34+. (nih.gov)
  • We have tested the feasibility of using the granulocyte colony-stimulating factor (G-CSF), which is known to mobilize hematopoietic stem cells (HSCs) from the bone marrow into the peripheral blood, as a therapeutic agent for AD. (silverchair.com)
  • We evaluated hematopoietic stem cells according to CD34 expression and aldehyde dehydrogenase (ALDH) activity in peripheral blood and apheresis product samples from patients after mobilization with granulocyte-colony-stimulating factor (G-CSF) alone or G-CSF after high-dose cyclophosphamide (4 g/m(2) once daily, intravenously on day 1). (ogu.edu.tr)
  • Blood cells are produced within bone marrow by specialized stem cells and progenitor cells. (elifesciences.org)
  • Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
  • Hematopoietic stem cells (HSC) generate all of the blood cells throughout their life-span. (haematologica.org)
  • First, the use of autologous hematopoietic stem cells for gene therapy obviates the need for a matched bone marrow donor since each individual would serve as his or her own bone marrow stem cell donor. (nih.gov)
  • Third, use of autologous hematopoietic stem cells would be expected to enhance immune reconstitution after transplant. (nih.gov)
  • FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
  • 1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
  • In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
  • 1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
  • 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
  • 1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
  • Hematopoietic stem cells (HSCs) are very rare cells, representing approximately one in 100,000 bone marrow (BM) cells in the adult. (longdom.org)
  • Since there is a delay in the appearance of the T cells that come from stem cells to get out of the bone marrow and into the blood, we will give patients both gene-modified T cells for a first wave of antitumor activity and gene-modified stem cells which will provide a bridge until the stem cells have produced more T cells. (ca.gov)
  • The patient's own white blood cells and stem cells from their blood are modified in the laboratory using genetic techniques to express a specific receptor against cancer cells. (ca.gov)
  • We have demonstrated that when mouse stem cells are gene-modified with this lentiviral vector, the stem cells take up residence in the bone marrow and produce appropriate blood cells. (ca.gov)
  • There is no detrimental effect on the blood cells that are derived from the stem cells. (ca.gov)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Unmatched bone marrow donor1
  • David Vetter, the original "bubble boy", had one of the first transplantations also, but eventually died because of an unscreened virus, Epstein-Barr (tests were not available at the time), in his newly transplanted bone marrow from his sister, an unmatched bone marrow donor. (wikipedia.org)
Post-transplantation3
  • By 6 months post-transplantation, the reconstituted mice had developed a clonal myeloproliferative/myelodysplastic disorder originating from the cells with aberrantly reduced Mybl2 expression. (elifesciences.org)
  • In both pets equivalently low gene marking between GFP and clear vectors was noticed six months post-transplantation despite having effective transduction of Compact disc34+ cells assays exposed TAS-102 strong mobile and humoral immune system reactions to GFP proteins in both RIC-transplanted pets but this is not seen in controls. (ecologicalsgardens.com)
  • If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)
20002
  • Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
  • These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
Myeloablative2
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Long haul resistant recuperation in more seasoned patients given hematopoietic cell transplantation after non-myeloablative molding remains ineffectively comprehended. (scitechnol.com)
Donors7
  • The screening of peripheral blood using HLA-peptide tetramer staining might be beneficial to select donors. (ox.ac.uk)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • Dr. George Mathé explored the transplantation of bone marrow cells from healthy donors to treat patients accidentally irradiated at high dose, expanding the possibilities of this life-saving technique (Mathé et al. (revistadehematologia.org.mx)
  • Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
  • If the geno-identical transplantation is impossible, we will direct ourselves towards the national and international register donors of bone marrow. (longdom.org)
Autologous marrow1
  • After lethal irradiation, the five animals were given 15-27 X 10(6) autologous marrow cells (3.2-4.4 X 10(6) cells/kg) containing 65-91% CD34+ cells. (nih.gov)
Patient's2
  • Autologous transplantation is feasible when the patient's bone marrow is normal and there are no relevant genetic conditions. (medscape.com)
  • Second, the use of the patient's own bone marrow cells for gene replacement does not result in graft-versus-host disease (GVHD), a major complication of current allogeneic transplant. (nih.gov)
Umbilical2
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Solid tumors2
  • Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
  • a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
Hematopoietic reconstitution2
  • We collected large numbers of peripheral blood (PB) progenitors after CSF administration using either G- CSF or GM-CSF and tested their ability to affect hematopoietic reconstitution and resource utilization in patients undergoing high-dose chemotherapy and autologous BM support. (johnshopkins.edu)
  • Hematopoietic reconstitution, as well as resource utilization, was monitored in these patients. (johnshopkins.edu)
Months after transplantation3
  • Interestingly both animals displayed very high %GFP in both granulocytes (97-99%) and monocytes (81-84%) starting at 1-2 months after transplantation (Figure 3a) which later declined to undetectable levels by 3-4 months after transplantation. (ecologicalsgardens.com)
  • Equivalent VCN between GFP and empty vectors was observed in both granulocytes and lymphocytes for 6-8 months after transplantation (Figure 4). (ecologicalsgardens.com)
  • Contrasted with HLA indistinguishable matched kin giver and matched irrelevant benefactor grown up hematopoietic cell transplantation beneficiaries, quantitative lymphoid recuperation in UCB transplantation beneficiaries is more slow in the initial 3 months, however these distinctions vanished by months after transplantation. (scitechnol.com)
Aplastic anemia1
  • Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
Days after transplantation2
  • After transplantation with 4 Gy TBI gentle bone tissue marrow suppression accompanied by fairly sluggish reconstitution of peripheral bloodstream cells was seen in the two pets TAS-102 (DCFC and … At 14 days after transplantation in both pets we noticed low %GFP (1.6-2.1%) in RBCs and %GFP was undetectable in granulocytes lymphocytes monocytes and platelets (Shape 3a). (ecologicalsgardens.com)
  • In this review, a review examination was performed to survey the transfer result of grown up patients with ALL who had chimerism investigations of unfractionated BM cells or fringe blood subsets performed roughly 80 days after transplantation. (scitechnol.com)
Progenitor cell1
  • No obvious correlations between clinical parameters, including age, karyotype, existence of paroxysmal nocturnal hemoglobinuria clones, pretreatment blood counts, progenitor cell counts, and the response to immunosuppressive therapy (IST), were found. (springermedizin.at)
Differentiation4
  • 1 , 2 During aging, the function of HSC declines, featured as compromised reconstitution capacity and differentiation skewing towards myeloid line-age. (haematologica.org)
  • B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
  • These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
  • In clinical practice, these involve the life-long immunosuppression of the organ transplantation patients, the creation of the supporting environment for engineered tissues in the mended organ, the unsolved issues of cell survival and differentiation of the cell-based therapy, and the selection and development of vectors for gene therapy. (biomedcentral.com)
Tumors1
  • Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
Clinical3
  • These babies, if untreated, usually die within one year due to severe, recurrent infections unless they have undergone successful hematopoietic stem cell transplantation or gene therapy in clinical trials. (wikipedia.org)
  • Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
  • Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
Complications3
  • Despite their use, a prolonged period of absolute leukopenia persists during which infections and other complications of transplantation occur. (johnshopkins.edu)
  • Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
  • Are other atypical white blood cells an asset to address complications? (cryostem.org)
Chemotherapy2
  • Two hematopoietic colony-stimulating factors, granulocyte colony- stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF), have been shown to accelerate leukocyte and neutrophil recovery after high-dose chemotherapy and autologous bone marrow (BM) support. (johnshopkins.edu)
  • We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
Lymphocyte3
  • A full blood lymphocyte count is often considered a reliable manner of diagnosing SCID, but higher lymphocyte counts in childhood may influence results. (wikipedia.org)
  • Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
  • This provoked us to examine long haul lymphocyte reconstitution and thymic work in 80 patients given allogeneic fringe blood foundational microorganisms after nonmyeloablative molding. (scitechnol.com)
Cells30
  • We show that SRCAP mutations confer a selective advantage in human cells and in mice upon treatment with the anthracycline-class chemotherapeutic doxorubicin and bone marrow transplantation. (bvsalud.org)
  • In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. (ashpublications.org)
  • In contrast, the ability of unstimulated peripheral blood mononuclear cells (PBMC) to respond to recombinant interleukin-2 (rIL-2) is relatively intact, most likely reflecting early functional reconstitution of the NK cell population. (ashpublications.org)
  • Bone marrow transplantation from a pediatric donor with a high frequency of cytomegalovirus-specific T-cells. (ox.ac.uk)
  • A recent study reported that quantitation of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in the graft and monitoring of these T cells might identify hematopoietic stem cell transplantation-recipients at the risk for progressive CMV infection. (ox.ac.uk)
  • A 6-year-old girl underwent bone marrow transplantation from an HLA-identical sibling with a very high frequency of CMV specific tetramer-positive CD8+ T-cells. (ox.ac.uk)
  • Tetramer assay showed that the frequency of CMV-specific CD8+ T cells of the donor in the peripheral blood was 5.3%, higher than average amongst young children. (ox.ac.uk)
  • Before transplantation, the frequency of CMV specific CD8+ T cells of the recipient was 0.1% in the peripheral blood. (ox.ac.uk)
  • Surprisingly, the frequency of CMV specific CD8+ T cells increased up to 30% of CD8+ T-cells at day 27 after transplantation. (ox.ac.uk)
  • Although the phenotypic pattern of the CMV-specific T cells of the recipient was different from those of the donor before transplantation, the phenotype of the donor-derived cells retained their original phenotype in the recipient after transplantation. (ox.ac.uk)
  • Haploidentical bone marrow transplants require the donor marrow to be depleted of all mature T cells to avoid the occurrence of graft-versus-host disease (GVHD). (wikipedia.org)
  • Researchers collected samples of DeSilva's blood, isolated some of her white blood cells, and used a retrovirus to insert a healthy adenosine deaminase (ADA) gene into them. (wikipedia.org)
  • The CD34 antigen is present on 1-4% of human marrow cells including virtually all hematopoietic progenitors detected by in vitro assays. (nih.gov)
  • CD34+ cells were enriched from marrows of five baboons using avidin-biotin immunoadsorption. (nih.gov)
  • Two additional animals received 184 and 285 X 10(6) marrow cells/kg depleted of CD34+ cells. (nih.gov)
  • eg, red blood cells [RBCs], platelets, plasma based on specific gravity) to use for transfusion in different patients. (msdmanuals.com)
  • Numbers of SSClo CD45(dim) CD34(hi) cells and SSClo ALDH(br) cells were highly correlated in both peripheral blood and apheresis products (P (ogu.edu.tr)
  • In a murine competitive reconstitution model, Mybl2 knockdown by RNAi to 20-30% of normal levels in multipotent hematopoietic progenitors resulted in clonal dominance of these 'sub-haploinsufficient' cells, which was reflected in all blood cell lineages. (elifesciences.org)
  • Abnormalities in this process lead to a group of diseases known as myeloid malignancies, which include acute myeloid leukaemia-in which the bone marrow produces abnormal white blood cells-and myelodysplastic syndromes, which are caused by too few mature blood cells being produced. (elifesciences.org)
  • before transplantation.1-6 One trial showed relatively high marking amounts transduction effectiveness was evaluated TAS-102 from little aliquots of rhesus CD34+ cells before transplantation. (ecologicalsgardens.com)
  • One of the main limitations of both of these models was the lack of stable reconstitution of human immune cells in the periphery to make them a more physiologically relevant model to study HIV disease. (ca.gov)
  • or BM with G-CSF or GM-CSF and G-CSF or GM-CSF primed peripheral blood progenitor cells (PBPC). (johnshopkins.edu)
  • The use of CSF-primed PBPC led to a highly significant reduction in the duration of leukopenia with a white blood cell (WBC) count under 100 and 200 cells/mL, and neutrophil count under 100 and 200 cells/mL with both GM- and G-CSF primed PB progenitor cells, compared with the use of the CSF with BM or with historical controls using BM alone. (johnshopkins.edu)
  • provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature cellular responses in the periphery and their ultimate demise, with emphasis on mouse NK cells and viral infections. (scielo.br)
  • We have used this model to test retroviral and foamy viral gene transfer into the bone marrow cells of dogs. (nih.gov)
  • Smith and Broxmeyer, 1986), thereby making it a potential source of cells for transplantation (Bodger, 1987). (nationalacademies.org)
  • Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
  • Automatic classification of abnormal peripheral blood cells. (cellsilab.com)
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
19933
Patients9
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Thirty patients (20 males and 10 females), who were candidates for autologous peripheral blood stem cell transplantation, were included in the study. (ogu.edu.tr)
  • Patients receiving G-CSF primed PBPC also experienced a reduction in the median number of days in the hospital, red blood cell (RBC) transfusions, platelet transfusions, days on antibiotics, and discounted hospital charges. (johnshopkins.edu)
  • Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
  • Discovery and availability of biomarkers suitable for screening high risk patients using early, non-invasive, blood tests specific for GvHD-therapy resistance would significantly aid in the management of patients with this disease and would allow for rational drug development and drug approval by regulatory authorities. (cryostem.org)
  • G-CSF levels in peripheral blood are increased in patients with active Sweet syndrome, suggesting that high levels of G-CSF may one day be a useful indicator of activity level of the disease. (medscape.com)
  • Autologous bone marrow transplantation for acute leukemia: Results and prognostic factors in 90 consecutive patients. (cellsilab.com)
  • Eight patients (16 %) did not respond to treatment, and one died shortly after transplantation. (springermedizin.at)
  • Together, both IST and stem cell transplantation are reasonable treatment options for patients with AA. (springermedizin.at)
Tissue1
  • The work of Jean Dausset, whose discovery of the human leukocyte antigen (HLA) system revolutionized our understanding of tissue compatibility for transplantation (Dausset J, 1958). (revistadehematologia.org.mx)
SCID3
  • The most common treatment for SCID is bone marrow transplantation, which has been very successful using either a matched related or unrelated donor, or a half-matched donor, who would be either parent. (wikipedia.org)
  • The earlier models involved the use of C. B 17 scid/scid mice and the transplantation of human fetal thymus and fetal liver termed thy/liv (SCID-hu) (1, 2) or the adoptive transfer of human peripheral blood leukocytes (SCID-huPBL) (3). (ca.gov)
  • SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)
Cell17
Bloodstream1
  • After peripheral bloodstream reconstitution similar bloodstream counts continuing for the 1.0-1.24 months of follow-up (data not shown). (ecologicalsgardens.com)
Infection2
  • Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
  • Infection with varicella-zoster virus after marrow transplantation. (nature.com)
Gene therapy1
Hematologic1
  • To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
Curative1
  • The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)
Haploidentical2
  • The three main categories of allogeneic transplantation are HLA identical, HLA mismatched, and haploidentical. (medscape.com)
  • Consequently, a functional immune system takes longer to develop in a patient who receives a haploidentical bone marrow transplant compared to a patient receiving a matched transplant. (wikipedia.org)
HSCs1
  • HSCs are characterized by their unique ability to self-renew and give rise to the entirety of the blood and immune system throughout the lifetime of an individual. (longdom.org)
Immune system2
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • The advantage of this system is the full reconstitution of the human immune system in the periphery. (ca.gov)