Peripheral blood progenitor. Medical search. Frequent questions

It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
UDENYCA is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation. (drugs.com)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Blood and Marrow Transplantation is where we replace parts of the body called stem cells as a way to cure difficult diseases and cancer. (rlbuht.nhs.uk)
Although most clinicians would agree that hematopoietic progenitor cell transplantation after reinduction therapy is frontline therapy for these patients, there is no consensus as to what type of hematopoietic progenitor cell transplantation promises the best event-free and overall survival. (jnccn.org)
1 - 3 However, those with relapsed and/or refractory (R/R) disease have had a historically dismal OS of ≤30% despite reinduction therapy and autologous hematopoietic progenitor cell transplantation (autoHCT) ( Figure 1 ). (jnccn.org)
The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
CXCL12 gene polymorphism and hematologic recovery after transplantation of peripheral blood progenitor cells. (cdc.gov)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)

CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)

Isolating and Expanding Endothelial Progenitor Cells from Peripheral Blood on Peptide‐functionalized Polystyrene Surfaces. (anaspec.com)

Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

We report our experience of the last nine years (2000 - 2009) regarding the feasibility, security and efficacy of autologous progenitor cell apheresis in small children. (sep.hr)

The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)

In one study, the expression of ZNF280D was compared between endothelial progenitor cells in cord blood and peripheral blood. (wikipedia.org)
The results show that expression was significantly higher in cord blood. (wikipedia.org)
The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
HCT/Ps such as amnion/chorion hematopoietic stem/progenitor cells from cord blood and peripheral blood, and reproductive tissues such as semen and oocytes, have the potential for harboring Zika virus. (cdc.gov)
Nevertheless, most recent information suggests that IL-7 dependence in human lymphopoiesis increases during development in cord blood and bone marrow. (biolegend.com)
In addition to bone marrow, alternative sources of haemopoietic progenitor cells such as mobilized peripheral blood donations or cord blood are being used increasingly. (rlbuht.nhs.uk)
peripheral blood, or placental/umbilical cord blood). (cdc.gov)
Interrelationships and determinants of aging biomarkers in cord blood. (who.int)

The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Recombinant rat IL-7 induces the proliferation of PHA activated human peripheral blood lymphocytes. (biolegend.com)
After this procedure, the samples were tested by the induction of proliferation of PHA activated human peripheral blood lymphocytes. (biolegend.com)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)

Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)

Circulating hematopoietic progenitor cells giving rise to colonies containing basophilic cells (basophilic cell colony-forming units in culture [CFU-c]), nasal epithelial metachromatic cells (basophils and/or mast cells) (NMC), and blood basophils were enumerated before, during, and after a ragweed-pollen season in patients with ragweed hayfever and patients with perennial allergic rhinitis who were not ragweed allergic. (mcmaster.ca)
In all 20 Patients a sufficient amount of progenitor cells could be harvested. (sep.hr)
Patients and Methods: Women with stage II breast cancer and 10 or more involved nodes or four or more involved nodes and estrogen receptor- negative tumors and women with stage III disease received three cycles of epirubicin 200 mg/m 2 and cyclophosphamide 4 g/m 2 , with progenitor cell and filgrastim support every 28 days (n = 79) or 21 days (n = 20). (tau.ac.il)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
2 Karl Landsteiner's discovery of ABO blood groups and Rh factor in the early 20th century led to the provision of matched blood products to patients to prevent hemolytic complications and enhance safety. (cap.org)
3 Today, serologic and molecular techniques, along with laboratory information systems and electronic health records, contribute to precise blood product management and personalized transfusion therapies, particularly benefiting complex patients with sickle cell disease, thalassemia, and other diseases requiring chronic transfusion support. (cap.org)
1972. Details of blood changes in 32 patients with pancytopenia associated with long-term exposure to benzene. (cdc.gov)
Objective: Circulating progenitor cells possess immune modulatory properties and might mitigate inflammation that is characteristic of patients with coronary artery disease. (bvsalud.org)
We hypothesized that patients with fewer circulating progenitor cells (CPCs) will have higher inflammatory markers and worse outcomes. (bvsalud.org)
A paucity of platelets, red blood cells (RBCs), granulocytes, monocytes, and reticulocytes is found in patients with aplastic anemia. (medscape.com)
To compare and evaluate the relationship between anemia and periodontitis by estimation of peripheral blood between healthy patients and chronic periodontitis patients. (bvsalud.org)

1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Stem cells, also known as Hematopoetic Progenitor Cells (HPCs) are immature blood cells. (upstate.edu)
You will be given medication in a shot for several days prior to collection to help your bone marrow release the stem cells into your blood so that we can collect them. (upstate.edu)
A nurse will draw a blood sample and connect you to the machine used to collect your stem cells. (upstate.edu)
Researchers are investigating several approaches, such as enzymatic treatments of RBCs, the generation of RBCs from human induced pluripotent stem cells, and the development of artificial oxygen carriers, all with the goal of advancing universal blood. (cap.org)
We therefore investigated whether Pentaisomaltose (PIM), a low-molecular-weight carbohydrate (1 kDa), can be used for cryopreservation of peripheral blood stem cells, more specifically hematopoietic progenitor cell apheresis (HPC(A)) product. (lu.se)
CONCLUSION: Our findings demonstrate that PIM cryopreservation of HPC(A) products provides recovery of CD34+ cells, CD34+ subpopulations, and CFCs similar to that of DMSO cryopreservation and therefore may have the potential to be used for cryopreservation of peripheral blood stem cells. (lu.se)

Assessment of distribution of CD34 epitope classes in fresh and cryopreserved peripheral blood progenitor cells and acute myeloid leukemic blasts. (unimore.it)
It is found on most cells of myeloid origin including neutrophils, eosinophils, basophils and monocytes from normal peripheral blood. (beckman.com)

Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)

Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)

We evaluated 65 procedures in 20 children (13 male, 7 female), aged 18 months (7- 28), with a mean (range) body weight of 10 kg (7-12), a blood volume of 0,8l (0,6- 1,0) and 3,5 times processing of the blood volume per apheresis. (sep.hr)

These results suggest that the exposure to environmental pollutants in utero affects genetic constitution of fetus and increases MN values in their body cells, which is detectable right after birth in peripheral blood lymphocytes. (go.jp)
It is absent from B and T lymphocytes as well as from red blood cells and platelets. (beckman.com)

Conversely, peripheral blood basophils were higher during the ragweed season than before or after (p less than 0.001) in the ragweed-allergic group, whereas the number of NMC was higher during the season than before the season in this group (p less than 0.05). (mcmaster.ca)

White adipose tissue (WAT) plays a key homeostatic role, not only by ensuring efficient energy storage but also by its quick mobilisation (lipids) to ensure peripheral demands. (springer.com)

The defined transcription factors also induce hiHepPCs from endothelial cells circulating in adult human peripheral blood. (elsevierpure.com)

1 University Clinic of Blood Group Serology and Transfusion Medicine, 2 Pediatric University Clinic, Dpt. (sep.hr)
The field of transfusion medicine (TM) plays a crucial role in healthcare with approximately 16 million blood components transfused annually in the US, saving lives in emergencies, surgeries, cancer treatments, and various medical conditions. (cap.org)
4,5 As precision medicine evolves, TM continues to revolutionize patient care by optimizing transfusion strategies and minimizing risks associated with incompatible blood products. (cap.org)
10 The presence of ABO antigens on RBC surfaces requires that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal hemolytic transfusion reactions. (cap.org)

So far several reports have described changes in the expression of surface antigens in progenitor cells and blasts following cryopreservation. (unimore.it)

The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)

The IL-3R plays an important role in hematopoietic progenitor cell growth and differentiation. (bdbiosciences.com)

11 The promise of developing universal blood could eliminate the barrier of matching ABO antigens for blood transfusions, which is time-consuming and limits inventory. (cap.org)
Glycoprotein antigens on the extracellular surface of the RBC membrane determine an individual's blood group. (cap.org)

A peripheral blood smear may be helpful in distinguishing aplasia from infiltrative disease causes. (medscape.com)
Examination of peripheral blood smear and bone marrow is usually diagnostic. (msdmanuals.com)

In addition, this CSF induced faster recoveries of neutrophils in the peripheral blood and progenitor spleen cells of cyclophosphamide (CY)-treated mice. (eurekamag.com)

Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of these diseases. (hindawi.com)
Specifically, we study the ability of endothelial progenitor cells (EPCs) to enhance bone regeneration. (rambam.org.il)
EPCs have been identified in adult bone marrow and in peripheral blood. (rambam.org.il)
Currently our research expanded to investigate the mechanism of EPCs in bone and blood vessel formation and to analyze the phenotype and genotype of these cells. (rambam.org.il)

Nivestym can cause fluid to leak from blood vessels into your body's tissues. (drugs.com)
Your healthcare provider will check your blood during treatment with Nivestym. (drugs.com)

NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
The formation of new vessels in the hypoxic area restores blood flow, provides oxygen and nutriments to the surviving cells, and promotes the migration and engraftment of new cells. (elifesciences.org)

Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)

These findings need to considered when selecting CD34 MoAbs for enumeration and positive selection of stem/progenitor cells for research and clinical purposes. (unimore.it)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)

Infection may produce a symmetrical peripheral polyarthropathy. (cdc.gov)

Dr. Hirano said he hopes the case will alert neurologists to be more vigilant in considering the possibility of MNGIE when faced with a patient with the syndrome of ophthalmoplegia, severe GI dysmotility, extreme cachexia, peripheral neuropathy, and leukoencephalopathy. (lww.com)

Recent advances have enabled the direct induction of human tissue-specific stem and progenitor cells from differentiated somatic cells. (elsevierpure.com)
The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)

HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)

Resilient blood centers implemented operational changes and intensified donor recruitment efforts to stabilize the situation. (cap.org)
16 With the goal of large-scale production of enzyme-treated universal RBC, the focus was turned on treating type A blood (40% of donor population). (cap.org)

Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)

These efforts aim to address challenges like blood shortages, alloimmunization, and improve the overall success and safety of transfusions. (cap.org)

FLAER is also a highly sensitive flow cytometry test for PNH that uses whole blood and binds specifically to glycophosphatidylinositol (GPI) anchor proteins in peripheral blood granulocytes. (medscape.com)

Inflammation of your blood vessels (cutaneous vasculitis). (drugs.com)

The stem cell (or progenitor cell) collection is a portion of the bone marrow transplant process. (upstate.edu)

Under aseptic conditions, venous blood samples were obtained by vein-puncture in the ante-cubital fossa without excessive venous stasis and the mean value of erythrocytes (EC), hemoglobin concentration (HGB), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were measured. (bvsalud.org)

This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot. (drugs.com)

9 Blood centers are actively urging healthy donors to contribute, bearing in mind that only 3% of eligible Americans donate blood. (cap.org)

Anatomy52

Organisms8

Diseases25

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes41

Disciplines and Occupations1

Information Science4

Named Groups2

Health Care10

Transplantation13

Differentiated progenitor cells1

Cells from Peripheral Blood1

Allogeneic3

Autologous progenitor cell1

Haematopoietic progenitor cells1

Cord blood8

Proliferation5

Hematopoietic stem1

Patients13

Stem Cells7

Myeloid2

Chemotherapy1

PBPCs1

Apheresis1

Lymphocytes2

Basophils1

Mobilisation1

Human peripheral1

Transfusion4

Cryopreservation1

Endothelial cells1

Differentiation1

Antigens2

Smear2

Neutrophils1

EPCs4

Nivestym2

Engraftment3

Colonies1

Clinical2

Infection1

Severe1

Tissue2

Immune1

Donor2

Chronic3

Transfusions1

Specifically1

Inflammation1

Cell collection1

Venous1

Clot1

Centers1