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  • patient's
  • However, the ability to interrogate a patient's immune state before surgery and predict recovery is highly desirable in perioperative medicine.To evaluate a patient's presurgical immune state, cell-type-specific intracellular signaling responses to ex vivo ligands (lipopolysaccharide, interleukin [IL]-6, IL-10, and IL-2/granulocyte macrophage colony-stimulating factor) were quantified by mass cytometry in presurgical blood samples. (stanford.edu)
  • Sickle Cell Di
  • Sickle Cell Disease (SCD) is an inherited disease of red blood cells caused by a gene mutation involving a single amino acid substitution in the hemoglobin gene. (parentsguidecordblood.org)
  • Sickle cell disease is a group of inherited red blood cell disorders characterized by abnormal hemoglobin (hemoglobin S). Normally these cells are disc-shaped, giving it the flexibility to easily move throughout the body to deliver oxygen. (georgiactsa.org)
  • tissue
  • In vitro expression of IL-17A in response to pneumococci was assayed: lymphoid tissue from vaccinated mice expressed significantly more IL-17A than controls, and IL-17A expression from peripheral blood samples from immunized mice predicted protection in vivo. (nih.gov)
  • clinical
  • Immune correlates identified in presurgical blood samples mirrored correlates identified in postsurgical blood samples.Convergent findings in pre- and postsurgical analyses provide validation of reported immune correlates and suggest a critical role of the toll-like receptor 4 signaling pathway in monocytes for the clinical recovery process. (stanford.edu)
  • units
  • The estimated minimum requirement to satisfy the needs of South Africa is a public UCB bank with 10 000 cord blood units representing the most common haplotypes that mirror the genetic diversity of the population. (scielo.org.za)
  • 10-12 This should take into account that the cost for a usable banked cord blood unit is about R9 000, 13 which translates to R90 million to establish a South African public UCB bank with 10 000 units. (scielo.org.za)
  • The initial capital outlay, however, will be recovered in due time if the programme continues to expand and the cord blood units can be sold on a cost-recovery basis. (scielo.org.za)
  • treatment
  • The conventional approach to treatment is based on the correction of haemoglobin status through regular blood transfusions and iron chelation therapy for iron overload. (cochrane.org)
  • maternal
  • A precise understanding of healthy fetomaternal immunity is the important first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal outcomes. (stanford.edu)
  • This highly interactive functional map of healthy fetomaternal immunity builds the core reference for a growing data repository that will allow inferring deviations from normal associated with adverse maternal and neonatal outcomes. (stanford.edu)
  • disorder
  • Thalassemia is an inherited autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions. (cochrane.org)
  • collection
  • Following collection, the cord blood unit will be sent to one of our manufacturing facilities where it will be processed, tested and stored in a special freezer. (blood.ca)
  • patient
  • Although over 90% of children born with SCD will survive to adulthood in the US, ongoing organ damage results in a steep rise in mortality in early adulthood such that the median survival for a patient with SCD in the US is in the 40's, almost half that of an unaffected healthy sibling. (parentsguidecordblood.org)