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  • tissues
  • 2. in transplantation biology, denoting individuals (or tissues) that are of the same species but antigenically distinct. (thefreedictionary.com)
  • SHIV-DNA levels in cell suspensions obtained from these tissues were quantified by PCR. (natap.org)
  • Estimated number of CD4+ T-cells per million cells in tissues at necropsy is indicated in Table S1. (natap.org)
  • By definition, stem cells are capable of self-renewal and differentiating into many cell types to form tissues in humans and other organisms. (icr.org)
  • In this review, we address the concept of whether stem cells can repair injured tissues, 1-4 with emphasis on ischemic heart disease. (ahajournals.org)
  • The therapy is composed of cells derived from a patients' own adipose tissue that are isolated in the lab and are designed to induce angiogenesis in ischemic tissues. (cureus.com)
  • Cell therapy is not intended as a temporary solution, but a new alternative allowing natural repair of diseased vessels and tissues using the patient's own cells. (cureus.com)
  • The drastic damage to brain tissues following ischemic stroke includes not only destruction of a heterogeneous population of brain cell types, but also major disruption of neuronal connections and vascular systems. (frontiersin.org)
  • apheresis
  • Through the use of sophisticated apheresis machines, the transfusion specialists separate patient blood into its cellular and liquid fractions and, depending on the particular disease process, cleanse an individual's blood of either harmful cellular material or soluble plasma factors. (upenn.edu)
  • tumor
  • Another application is the collection of mononuclear cells for the manufacturing of chimeric antigen receptor-modified T cells (CAR-T cells) for the treatment of leukemia and several solid tumor cancers and for the manufacture of dendritic cell vaccines for breast, ovarian, and brain cancers. (upenn.edu)
  • regeneration
  • Satellite cells are spare stem-cells responsible for muscle growth and regeneration. (biomedcentral.com)
  • The last ten years however has seen an explosion of cell based therapeutic approaches stimulating cardiac regeneration and in the process augmenting function in the heart following injury. (hindawi.com)
  • Nevertheless, the search continues for the optimal cell type that can promote "true cardiac regeneration," supplement the lost cardiomyocytes, and at the same time form the angiogenic support structure. (hindawi.com)
  • One of the first stem cell types to be used for cardiac regeneration was derived from the mononuclear fraction of the bone marrow and the cells were designated as bone marrow mononuclear cells [ 1 ]. (hindawi.com)
  • Myocardial regeneration is perhaps the most widely studied and debated example of stem cell plasticity. (ahajournals.org)
  • To further understand the role of stem cells in regeneration, it is incumbent on us to develop instrumentation and technologies to monitor myocardial repair over time in large animal models. (ahajournals.org)
  • We discussed obstacles and future perspectives of the cell-based therapy, with a special focus made on protection and regeneration of the lost functions after injury/degeneration of adult central nervous system. (operamedphys.org)
  • multipotent
  • Stem cells persist throughout development and into the adult where they are referred to as multipotent adult stem cells. (icr.org)
  • Adult stem cells are capable of differentiating into one of several (multipotent) cell types, but presumably not into any cell type (although this dogma is now being challenged). (icr.org)
  • Multipotent cells can give rise to a restricted subset of tissue-specific cell types (within one germ layer). (operamedphys.org)
  • adult
  • We have obtained a rare litter of six GRMD dogs (3 males and 3 females) born from an affected male and a carrier female which were submitted to a therapeutic trial with adult human stem cells to investigate their capacity to engraft into dogs muscles by local as compared to systemic injection without any immunosuppression. (biomedcentral.com)
  • Adult stem cells are maintained throughout the body, they are currently used in many clinical applications, and if a patient uses his own adult stem cells, an immune response causing tissue rejection is avoided. (icr.org)
  • The haemopoietic stem cells found in bone marrow provide a good example of adult stem cell function. (icr.org)
  • Adult stem cells from these niches are currently being used to treat a number of diseases and more applications are in clinical trials. (icr.org)
  • Adult stem cells from bone marrow are used to treat more than 70 diseases including leukemia and breast cancer. (icr.org)
  • 8 Clinical trials with neural stem cells to treat a neurodegenerative disease, amyotrophic lateral sclerosis (ALS), 9 and bone marrow stem cells to replace damaged heart tissue from the effects of myocardial ischaemia (decreased blood flow to the heart associated with heart attack) 10 have also demonstrated the potential of adult stem cell treatments. (icr.org)
  • immature
  • Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic? (biomedcentral.com)
  • Human Immature Dental Pulp Stem Cells (hIDPSC) were transplanted into 4 littermate dogs aged 28 to 40 days by either arterial or muscular injections. (biomedcentral.com)
  • This B cell population, which is normally present at low frequency in the peripheral blood of healthy individuals, can be further divided, depending on the expression of CD10, into immature/transitional B cells (CD10 + ) or exhausted tissue-like memory B cells (CD10 − ) [ 13 - 15 ]. (hindawi.com)
  • immune
  • Clinical translation effects were analyzed since immune reactions by blood exams and physical scores capacity of each dog. (biomedcentral.com)
  • No signs of immune rejection were observed and these results suggested that hIDPSC cell transplantation may be done without immunosuppression. (biomedcentral.com)
  • B cells alteration was related to an increase in Torque teno virus (TTV) load, used as surrogate marker of immune function. (hindawi.com)
  • Through direct or indirect effects, HIV-1 infection leads to several perturbations on most cells of the immune system. (hindawi.com)
  • The persistent viral replication induces loss of CD4 + T cells and a general chronic cellular activation that affect viability, subsets distribution, phenotype, and function of all the major immune cell populations [ 1 ]. (hindawi.com)
  • B cells exhibit numerous effects of HIV-1-induced immune activation. (hindawi.com)
  • 7 Using stem cells from another niche in the body will make it possible to treat an individual who is suffering from organ failure with their own stem cells, eliminating an immune response that frequently leads to tissue rejection of a transplanted organ. (icr.org)
  • To obtain information about the effects of interferon-gamma and aldesleukin on the number, function, and activation state of immune effector-cells including T-cells and B-cells. (knowcancer.com)
  • We propose that the expression of selected RNA-based HIV-1 inhibitors in the CD4+ cells derived from GM-HSPC will protect them from HIV-1 infection and results in a sufficient immune repertoire to control HIV-1 viremia resulting in a functional cure for HIV-1/AIDS. (mdpi.com)
  • HLA class I molecules are expressed on almost all nucleated cells and play a key role in the immune responses to pathogens, cancer cells, and autoantigens. (frontiersin.org)
  • injection
  • Electromechanical mapping was performed to identify ischemic but viable regions of myocardium for injection of cells (versus saline). (ahajournals.org)
  • The intramyocardial injection of cells or saline did not result in cardiac enzyme elevation, perforation, or pericardial effusion. (ahajournals.org)
  • ASCs are a patient-derived ("autologous") cell transplantation technology that is delivered to the patient via intramuscular injection. (cureus.com)
  • leukapheresis
  • UCB were processed by isolating the mononuclear cell (MNC) layer using Ficoll-Paque to make the nature similar to leukapheresis products. (koreamed.org)
  • Other procedures include removing elevated levels of white cells ("leukapheresis") to prevent the neurological and pulmonary damage resulting from impeded blood flow that can be experienced by newly diagnosed leukemic patients (hyperleukocytic syndrome) or removing and exchanging red blood cells for fresh banked cells ("erythrocytapheresis") to prevent or treat the pain and morbidity experienced by patients undergoing sickle cell crises. (upenn.edu)
  • antigen
  • It is designed to act against the cluster of differentiation antigen 20 (CD20) antigen that is found on the surface of both normal B lymphocytes or on the malignant lymphoma cells. (clinicaltrials.gov)
  • When rituximab attacks the CD20 antigen, it can kill the lymphoma cells. (clinicaltrials.gov)
  • Rats
  • The existence of neovascularization in the transplanted rats of cbMNC provide hope in accelerating repairment of the neuronal cells and functional outcome. (pubstemcell.com)
  • disease
  • Although in the majority of cases, peripheral artery disease is caused by atherosclerotic occlusion, radiation therapy-associated vasculopathy has been reported . (cureus.com)
  • therapy
  • Since the collateral formations are important for outcome after stroke, understanding the effect of human cbMNC on angiogenesis and its potency for accelerating repairment of neuronal cells that would contribute to funcional outcome will give alternative therapy in the future. (pubstemcell.com)
  • Most of the salutary effects of cell therapy have been attributed to these few surviving cells and recent efforts have focused on boosting the survival, proliferation, and cardiac commitment of the donated stem cell population. (hindawi.com)
  • Homing and migration of the adoptively transferred stem cells are another important determinant for the success of cell therapy. (hindawi.com)
  • 350 cells/ μ L) and highly active antiretroviral therapy (HAART) untreated. (hindawi.com)
  • We will review the emerging literature in the nascent field of stem cell plasticity and describe new instrumentation to deliver and monitor stem cell activity in myocardial therapy. (ahajournals.org)
  • In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. (frontiersin.org)
  • Neurorestorative stem cell-based therapy is currently a major priority for stroke research ( 5 , 6 ). (frontiersin.org)
  • tissue
  • Myoblasts transplantation has also been tried for skeletal muscle tissue engineering [ 6 ] but it failed due to the immunogenic properties of these cells. (biomedcentral.com)
  • Discovery of tissue specific stem cells capable of forming cardiac cell types has revolutionized cardiac medicine. (hindawi.com)
  • These are promising outcomes that indicate that the cells have the ability to modulate cardiac repair programs leading to replacement of the lost tissue. (hindawi.com)