Peripheral blood mesenchymal stem cell transplantation. Medical search. Frequent questions

Mesenchymal stem cells (MSCs) have immunomodulatory properties. (nature.com)
MSCs are multipotent cells characterized by their regenerative capabilities and immunomodulatory properties. (nature.com)
11 The regulatory effect of MSCs on T cells has also been demonstrated in mice models of autoimmune disease such as rheumatoid arthritis and sjogren syndrome (SS). (nature.com)
Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
Several measures have been described to prevent the occurrence of PAL in high-risk patients, however, the potential role of mesenchymal stem cells (MSCs) applied in the parenchymal suture line to prevent postoperative air leak in this setting has not been fully addressed. (bvsalud.org)
In our previously published article, we reported a 5-years follow-up of a phase I/II clinical trial in patients undergoing spinal fusion with autologous mesenchymal stem cells (MSCs) embedded in tricalcium phosphate. (bvsalud.org)
Mesenchymal stem/stromal cells (MSCs) are an attractive potential therapeutic approach in this setting. (bvsalud.org)
Study medication consisted of a suspension of autologous BM-derived MSCs (suspended in a solution of 5-10 mL of saline and 5% human albumin) in a single dose of 0.5-1 × 106 cells/kg of the patient, administered intraosseously with a trocar and under radioscopic control. (bvsalud.org)
Background: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). (uni-hannover.de)
The functional interactions between NK cells and MSCs have the potential to influence the leukemia relapse rate after HSCT. (uni-hannover.de)
Until date, MSC-NK cell interaction studies are largely focussed on bone marrow derived (BM)-MSCs. (uni-hannover.de)
Thus, we studied the interaction of UC-MSCs with unstimulated allogeneic NK cells.Results: UC-MSCs could potently suppress NK cell cytotoxicity in overnight cultures via soluble factors. (uni-hannover.de)
Maximal PGE2 release involved IL-1β priming of MSCs after close contact between the NK cells and UC-MSCs. (uni-hannover.de)
Scientists in South Korea transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes of the placenta (AMSCs) into laboratory mice modeled with oxygen-induced retinopathy. (genengnews.com)
The benefit of using MSCs in stem cell therapy is their ability to self-renew and differentiate into a variety of specialized cell types, such as osteoblasts, chondrocytes, adipocytes, myocardiocytes, and neuron-like cells. (genengnews.com)
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been shown to counter rheumatoid arthritis, autoimmune hepatitis, and systemic sclerosis [ 8 ]. (biomedcentral.com)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (stemcellslab.net)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (stemcellslab.net)
Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (stemcellslab.net)
Therefore, the authors concluded that transplantation of isolated healthy allogeneic MSCs might cure the disease. (stemcellslab.net)
The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (stemcellslab.net)
and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (stemcellslab.net)
Why should mesenchymal stem cells (MSCs) cure autoimmune diseases? (cellsurgicalnetwork.com)
Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
Cell-based therapy utilizing mesenchymal stromal cells (MSCs) is an attractive option for augmenting the fracture repair process. (hindawi.com)
Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)
The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
MSCs have also been derived from embryonic tissues, such as Wharton's jelly and umbilical cord blood [ 13 , 14 ]. (hindawi.com)
Adipose-derived MSCs, in particular, pose an attractive option for cell-based therapy due to their relatively decreased morbidity during isolation and potential for expansion and differentiation [ 12 ]. (hindawi.com)
Multipotential differentiation of MSCs into adipogenic, osteogenic, and chondrogenic cell lineages. (hindawi.com)
MSCs are able to evade the host cell immune system due to their low expression of major histocompatibility complex (MHC) class I molecules and complete lack MHC class II molecules and other costimulatory molecules (CD40, CD40L, CD80, and CD86) required for immune cell stimulation [ 15 - 17 ]. (hindawi.com)
Mesenchymal stem cells ( MSCs) are known to be multipotent stromal cells that can differentiate into a variety of cell types which include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (stemcellsgroup.com)
Thus, these properties of MSCs make these cells potentially ideal candidates for tissue technology. (stemcellsgroup.com)
Mesenchymal stem/stromal cells (MSCs) can be isolated from neonatal tissues, most of which are discarded after birth, including placental tissues, fetal membranes, umbilical cord, and amniotic fluid. (stemcellsgroup.com)
Thus, neonatal tissues are easily available and they have biological advantages in comparison to adult sources that make them a useful source for stem cells including MSCs. (stemcellsgroup.com)
There is growing evidence that mesenchymal stem cells (MSCs) could change the fate of SCI victims by re-establishing spinal cord function. (anova-irm.com)
Recent research has shown that MSCs also support the re-establishment of blood supply to the damaged spinal cord by inducing angiogenesis. (anova-irm.com)
The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
Mesenchymal stem cells (MSCs) have demonstrated promise in augmenting the surgical repair of full thickness tendon tears. (beaumont.org)
Our group recently demonstrated that postoperative mobilization of MSCs from the marrow compartment and into peripheral blood via subcutaneous granulocyte- colony stimulating factor administration enhanced tendon-bone healing in a rat model of surgical repair of a full-thickness supraspinatus tendon tear. (beaumont.org)
The mobilization of endogenous marrow-derived MSCs into peripheral blood and subsequent recruitment via local chemokine delivery may be an efficacious way to enhance tendon repair without the need for ex vivo processing. (beaumont.org)
To learn more about stem cells, do watch this video in which Dr. Riordan discusses about mesenchymal stem cells (MSCs) harvested from fat tissue and the role they play in reducing inflammation, repairing tissue and modulating the immune system. (myradiary.com)
Mesenchymal stem cells (MSCs) are adult stem cells that can be isolated from most adult tissues, including bone marrow, adipose, liver, amniotic fluid, lung, skeletal muscle and kidney. (myradiary.com)
Durham, NC (November 09, 2020) - A new study released today in STEM CELLS might just have solved the mystery behind why mesenchymal stem cells (MSCs) continue to suppress inflammation in the body long after the MSCs are cleared from the system. (stemcellsportal.com)
MSCs are stem cells that can be isolated from bone marrow, adipose and other tissue sources. (stemcellsportal.com)
The study demonstrates that fibulin 5, a protein secreted by human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs), plays an important role in the development of Schwann cells in the peripheral nervous system (PNS). (stemcellsportal.com)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
Forostyak S, Jendelova P, Kapcalova M, Arboleda D, Sykova E. Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. (jamanetwork.com)
Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. (jamanetwork.com)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (stemcellslab.net)
Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. (edu.pl)
MSC = multipotent mesenchymal stromal cell. (hindawi.com)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)
Furthermore, we show expression of MSTN by CML mesenchymal stromal cells, and that myostatin propeptide has a direct and instant effect on CML cells, independent of myostatin, by demonstrating binding of myostatin propeptide to the cell surface and increased phosphorylation of STAT5 and SMAD2/3. (haematologica.org)
however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)

In allogeneic HSCT, donor T cells target malignant hematopoietic cell populations, creating a graft-versus-tumor effect. (medscape.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (ajbm.net)
Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
Because the extent of previous transfusion has been shown to significantly affect the outcomes of patients undergoing hematopoietic cell transplantation (HCT) for aplastic anemia, the rapidity with which these data are obtained is crucial. (medscape.com)
Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)

Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
In parallel, we isolate endothelial progenitor cells from peripheral blood (cooperation with the blood bank of the MHH) and optimize their extracorporeal expansion and development into a confluent cell layer on scaffold materials for endothelialization. (uni-hannover.de)
In addition, we investigate the influence of different shear stress conditions (static vs. dynamic cultivation under pulsatile or laminar flow of different flow velocities) on these endothelial progenitor cells isolated from peripheral blood. (uni-hannover.de)
Isolation of progenitor cells from the bloodstream for endothelialization of the vascular prosthesis was optimized using the principle of dynamic cell cultivation, which places cells under shear stress. (uni-hannover.de)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)

When genetically susceptible individuals are exposed to infection, stress or trauma, cutaneous dendritic cells are activated to produce tumor necrosis factor (TNF)-α and interleukin (IL)-23, which subsequently stimulate the proliferation and differentiation of proinflammatory T cells. (nature.com)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Mesenchymal Stem Cells for Multiple Sclerosis: Does Neural Differentiation Really Matter? (cellsurgicalnetwork.com)
We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
However, the limited amount of stem cells and their tendency to undergo spontaneous differentiation upon extended propagation in vitro restrict their practical application. (biomedcentral.com)
Furthermore, MDLS could promote teratoma formation and enhanced differentiation potential of P19 cells in vivo. (biomedcentral.com)
However, recent studies show that human mesenchymal stem cells isolated from adipose tissue of patients (hASCs, cooperation with the Department of Plastic Surgery of the MHH) have approaches for differentiation in an endothelial direction and positively influence the differentiation of immature endothelial cells into capillaries. (uni-hannover.de)
a) The cells should exhibits plastic adherence (b) The cell should possess specific set of cell surface markers, i.e. cluster of differentiation (CD) 73, D90, CD105 and lack expression of CD14, CD34, CD45 and human leucocyte antigen-DR (HLA-DR). (c) The cells should have the ability to differentiate in vitro into adipocyte, chondrocyte and osteoblast. (stemcellsgroup.com)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
Sadan O, Melamed E, Offen D. Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. (jamanetwork.com)
The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice. (southernbiotech.com)
Chan JK, Lam P. Soluble factors from human fetal bone marrow-derived mesenchymal stem cells: Preparation of conditioned medium and its effect on tumor cells. (edu.pl)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)

Organs and tissues are built up by specialized cells from the pool of stem cells that form shortly after fertilization. (bmrat.org)
Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)
Stem cell therapy has also shown potential for regenerating damaged tissues, promoting healing, and reducing inflammation. (mespoir.com)
Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
The first source of Mesenchymal stem cells was in the bone marrow and considered to be the gold standard for clinical research, although various other sources have being discovered which include: Adipose tissue, Dental pulp, Mobilised Peripheral blood, Amniotic fluid, Joint synovium, synovial fluid, Endosteum, Periosteum, Menstrual blood and birth-derived tissues. (stemcellsgroup.com)
In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)
Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
BUT, when a stem cell divides, the new cell can become a different cell with a more specific function, that is, they become the many specialised cells that constitute tissues such as heart and skin. (myradiary.com)
In fact, groups of stem cells in some adult tissues also give rise to replacement cells that are destroyed through injury, disease or age. (myradiary.com)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
All tissues originate from stem cells. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
Cells Tissues Organs. (cancercentrum.se)

Previously, acute graft versus host disease (GVHD) required symptoms within the first 100 days of transplantation and chronic GVHD after day 100. (medscape.com)
Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival. (ajbm.net)
6. Gao J, Zhang Y, Su L. Advances in prevention of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (ajbm.net)

Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model. (jamanetwork.com)
Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. (uni-hannover.de)
The scientists believe that their technique may advance stem cell therapy toward clinical practice and offer novel therapies for eye diseases in people. (genengnews.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
In clinical trials, stem cell transplantation reduced the CD activity index (SMD − 2.10, P = 0.000), the CD endoscopic index of severity (SMD − 3.40, P = 0.000) and simplified endoscopy score for CD (SMD − 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. (biomedcentral.com)
Clinical outcome of autologous peripheral blood stem cell transplantation in opticospinal and conventional forms of secondary progressive multiple sclerosis in a Chinese population. (cellsurgicalnetwork.com)
Several clinical trials and research studies have demonstrated the potential of stem cell therapy for treating a wide range of medical conditions such as neurological disorders, cardiovascular diseases, orthopedic injuries, autoimmune disorders, and more. (mespoir.com)
This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. (biomedcentral.com)
A new study published in the journal Aging and Disease reported that the intravenous administration of clinical-grade human mesenchymal stem cells into patients with COVID-19 resulted in improved functional outcomes. (thebiotalkmagazine.com)
Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
4. Xue S, Liu F, Zhang Y, Tan Y, Wang J. Clinical study of cord blood mesenchymal stem cells combined with Eltrombopag when treating graft dysfunction after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Tendon repair and regeneration remains a significant clinical challenge, which may be aided by MSC transplantation. (beaumont.org)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)

The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
Stem cell paracrine actions and tissue regeneration. (edu.pl)
Autogenous mesenchymal stem cells from the vertebral body enhance intervertebral disc regeneration by paracrine interaction: An in vitro pilot study. (edu.pl)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant. (hindawi.com)
Overall, the present data suggest that acute repair of neonatal peripheral nerves with fibrin sealant results in neuroprotection and regeneration of motor and sensory axons. (hindawi.com)
and hence being tested in four main areas: tissue regeneration for cartilage, bone, muscle, tendon and neuronal cells for treatment of immune diseases such as RA, MS, etc. (myradiary.com)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
However, its role in aging-related adipose tissue CD4+ T cell activation remains to be investigated. (exposed-skin-care.net)
CD8+ T Cell Activation Compared to CD4+ T cells, CD8+ T cells show a greater increase in adipose tissue in obesity and in aging (31, 43, 106). (exposed-skin-care.net)
Similar to CD4+ T cells, CD8+ T cells exhibit effector memory or effector phenotypes expressing elevated levels of IFN- in obese adipose tissue (31, 44). (exposed-skin-care.net)
The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)
showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
Indeed, CD8+ T cells from mouse adipose tissue respond to cytokines and become activated and proliferate under stimulation of IL-12 and IL-18, which are mainly produced by APCs and are elevated in obese adipose tissue (44). (exposed-skin-care.net)
Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. (ajbm.net)
1. Ozdemir ZN, Civriz Bozdağ S. Graft failure after allogeneic hematopoietic stem cell transplantation. (ajbm.net)

In recent years, developments in stem cell (SC) biology and regenerative medicine have revealed that SCs unexpectedly can be used to treat autoimmune diseases. (biomedcentral.com)

Our bodies contain a pool of stem cells that have the ability to differentiate into any other cell type in the body. (bmrat.org)
However, one of the bottlenecks in the stem cell therapy is that stem cells tend to differentiate into other types of cells during culture in vitro. (biomedcentral.com)
Similarly, they are characterized by an extensive capacity for self-renewal, proliferation, potential to differentiate into multiple lineages and their immune-modulatory role on various cells. (stemcellsgroup.com)
Their ability to differentiate into a variety of cell types, along with their capability to self-renew, repair and heal, make them attractive candidates for therapeutic use. (stemcellsportal.com)

Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
Since the early 1970's, Researchers have been busy working on the further development of basic pancreatic trypsin inhibitor that later become the very model for the rapid development of protein NMR,stem cell therapies,molecular dynamics, regenerative medicine and also for experimental studies such as the world's first artificial pancreas in medical laboratories throughout the world. (stemcellthailand.org)
Durham, NC (Sept. 15, 2020) - Human pluripotent stem cells (hPSCs) hold promise in the field of regenerative medicine for how they give rise to every other cell type in the body and for their ability to propagate indefinitely. (stemcellsportal.com)

Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease. (jamanetwork.com)
Sadan O, Shemesh N, Cohen Y, Melamed E, Offen D. Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases. (jamanetwork.com)
We explored whether stem cell therapy was effective for animal models and patients with Crohn's disease (CD). (biomedcentral.com)
Stem cell transplantation is a valuable supplementary therapy for CD. (biomedcentral.com)
Several studies have evaluated the safety and effectiveness of CD stem cell therapy, but the results remain controversial. (biomedcentral.com)
For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
Mechanisms of oxidative damage in multiple sclerosis and a cell therapy approach to treatment. (cellsurgicalnetwork.com)
Which hospital is best for stem cell therapy in India? (mespoir.com)
There are several hospitals in India that offer stem cell therapy, and determining the "best" hospital for stem cell therapy may depend on various factors such as the specific medical condition, the type of stem cell therapy required, and the individual's health status. (mespoir.com)
It is also important to verify the hospital's credentials, reputation, and experience in providing stem cell therapy. (mespoir.com)
How successful is stem cell therapy in India? (mespoir.com)
Stem cell therapy has shown promising results in India for treating various medical conditions, but its effectiveness may vary depending on the individual's health status, the type of stem cell therapy used, and the specific medical condition being treated. (mespoir.com)
However, it is important to note that stem cell therapy is still considered an experimental treatment in many cases and its long-term safety and effectiveness are still being evaluated through ongoing research. (mespoir.com)
How much does stem cell therapy cost in India? (mespoir.com)
The cost of stem cell therapy in India can vary depending on several factors such as the type of stem cell therapy required, the medical condition being treated, the location of the hospital, and the expertise of the medical professionals. (mespoir.com)
On average, stem cell therapy in India can cost anywhere between INR 2,50,000 to INR 10,00,000 (approximately USD 3,400 to USD 13,500) per session or course of treatment. (mespoir.com)
Co-culture has been applied in cell therapy, including stem cells, and has been reported to give enhanced functionality. (edu.pl)
Liang X, Ding Y, Zhang Y, Tse HF, Lian Q. Paracrine mechanisms of mesenchymal stem cell-based therapy: Current status and perspectives. (edu.pl)
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes is superior to somatic stem cell therapy for restoring cardiac function and oxygen consumption in a porcine model of myocardial infarction. (stembook.org)
Mesenchymal stem cells have been used in cell-based therapy. (thebiotalkmagazine.com)
Stem cell-based therapy has emerged as a therapeutic option with unsolved issues for IUA patients in the past few years. (biomedcentral.com)
Primary endometrial epithelial cells for cell therapy are largely hampered with the extremely limited proliferation capacity of uterine epithelial cells. (biomedcentral.com)
The combination of Stem Cell Therapy with neuromuscular feedback training with HAL may advance success rates in patients with Spinal Cord Injury. (anova-irm.com)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Can Stem Cell Therapy be a Viable Rheumatoid Arthritis Treatment? (myradiary.com)
Indirectly, it also leads me to think about whether stem cell therapy can be a viable alternative treatment for Rheumatoid Arthritis at all. (myradiary.com)

The leading cause of GVHD is hematopoietic stem cell transplantation (HSCT), most commonly allogeneic (between two individuals) rather than autologous (from the same individual). (medscape.com)
Despite attempts to manipulate the immune response before, during, and after transplantation, GVHD remains a primary cause of morbidity and mortality after HSCT. (medscape.com)
Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
In the early reconstitution phase following HSCT, natural killer (NK) cells represent the major lymphocyte population in peripheral blood and display graft-vs-leukemia (GvL) effects. (uni-hannover.de)
His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)

[ 2 ] Solid-organ transplants , blood transfusions, and maternal-fetal transfusions also reportedly cause GVHD. (medscape.com)
For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Hemoglobin electrophoresis and blood-group testing may show elevated levels of fetal hemoglobin and red cell I antigen, suggesting stress erythropoiesis. (medscape.com)

2 Psoriasis is a disease with innate and adaptive immune system disorder and dendritic cells, neutrophils, keratinocytes and T cells play major roles in the pathogenesis. (nature.com)
The proinflammatory T cells secrete inflammatory cytokines, including interferon (IFN)-γ and IL-17, which affect keratinocytes and other leukocytes that forms an amplified immune response. (nature.com)
GVHD occurs when donor immune cells recognize and attack host antigens. (medscape.com)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
Vasculogenically conditioned peripheral blood mononuclear cells inhibit mouse immune response to induced pluripotent stem cell-derived allogeneic cardiac grafts. (stembook.org)
The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure. (hindawi.com)
The beneficial outcomes included an increased number of peripheral lymphocytes and a decline in the C-reactive protein and the disappearance of overactivated cytokine-secreting immune cells by 3-6 days in the circulating blood. (thebiotalkmagazine.com)
Cellular debris and free radicals lead to inflammation and infiltration by immune cells. (anova-irm.com)
Simpson RJ, Bigley AB, Agha N, Hanley PJ, Bollard CM. Mobilizing Immune Cells With Exercise for Cancer Immunotherapy. (ctsicn.org)
This study demonstrates how exosomes, sacs of cell membrane in the body that shuttle proteins and genetic information between cells, and exosome-educated macrophages (EEMs), a type of white blood cell that typically kills microorganisms and removes dead cells, but also could stimulate the action of other immune system cells, can promote ligament healing and reduce scarring. (stemcellsportal.com)
This rejection is due to the body's immune system labeling the cells as "foreign invaders" and setting in motion a series of strategies intended to ward off what it deems an attack - leaving researchers scrambling for a way around this protective measure. (stemcellsportal.com)

Many factors affect the balance between a graft-versus-tumor effect and GVHD, including genetic differences between donor and host and the magnitude of the T-cell response. (medscape.com)
This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)
MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
Granulocyte-colony stimulating factor (G-CSF)-mobilized, T cell-depleted haploidentical paternal stem cells were infused on day 0 together with cultured donor mesenchymal stem cells. (lu.se)
Their potential, however, is hampered by the body's tendency to reject any "allogeneic" cells or tissue, which means that the cells come from a donor other than the patient. (stemcellsportal.com)
The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)

Jin SH, Kweon H, Park JB, Kim CH. The effects of tetracycline-loaded silk fibroin membrane on proliferation and osteogenic potential of mesenchymal stem cells. (edu.pl)
This involves the screening of different pharmacologically active substances with regard to their effect on proliferation behavior and their toxicity to human primary cells and cell lines. (uni-hannover.de)

Cell Transplant. (edu.pl)
The total number of transplant cells calculated was 1×106 cell per kilogram of weight. (thebiotalkmagazine.com)
Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)
Allogeneic hematopoietic stem cell transplant (allo-HCT) findings, nonetheless, still present a chance for recovery. (ajbm.net)
Prior to transplant, the woman was given several drugs to allow her body to accept the new cells. (myradiary.com)

Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
Functional and Electrical Integration of Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Myocardial Infarction Rat Heart. (stembook.org)

One of the main problems within this project is the isolation and cultivation of endothelial cells under the aspect of autologous transplantation. (uni-hannover.de)
We therefore developed a protocol for the targeted use of stem cells in coculture with endothelial cells. (uni-hannover.de)
Novel biodegradable polymers are tested as scaffold material and 3D-printed in fine lattice structures by 3 D bioprinting or electrospinning-writing which are coated with native proteins and seeded with endothelial cells. (uni-hannover.de)
Porous scaffolds prepared by porogen leaching are co-cultured with mesenchymal stem cells and endothelial cells (so called HUVECS= human umbilical venous endothelial cells) and capillary structures are grown. (uni-hannover.de)

CD patients maintained high remission rates for 3-24 months after transplantation. (biomedcentral.com)
Two children are alive and well, with no evidence of disease 40 and 42 months after transplantation. (lu.se)
One patient rejected the graft, was rescued with autologous backup, and died of progressive disease 5 months after transplantation. (lu.se)
Another child relapsed 7 months after transplantation and died 5 months later. (lu.se)

Embryonic stem cells were first identified in mice (Martin, 1981). (bmrat.org)
Embryonic stem cells are pluripotent, meaning they are able to produce all cell types in the body. (bmrat.org)
These cells exist only in earliest stages of embryonic development known as the blastocyst stage. (bmrat.org)
Recently, scientists have discovered how to reprogram normal cells to behave like embryonic stem cells. (bmrat.org)
This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)
In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
It is expressed in ESCs, embryonic germ (EG) cells and embryonic carcinoma (EC) cells and essential for early embryonic development [ 14 , 15 ]. (biomedcentral.com)
2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
Embryonic stem cells are stem cells derived from the inner cell mass of an early, preimplantation stage embryo known as a blastocyst. (bvsalud.org)

After 2-4 days of transplantation, all the symptoms disappeared in all patients. (thebiotalkmagazine.com)

Detection of the transplanted cells in the retina illustrated their ability to migrate from the site of injection to the injured tissue. (genengnews.com)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
Those are due to the unique characteristics of stem cells, such as immunological tolerance, migration, and tissue reparation. (bmrat.org)
Stem cells continue to play a role in repairing damaged tissue and replacing cells that are lost every day. (bmrat.org)
This stem-cell spheroid may be applied for tissue-engineering purposes. (edu.pl)
Isolation and characterization of human mesenchymal stem cells from gingival connective tissue. (edu.pl)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)

Sadan O, Melamed E, Offen D. Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease. (jamanetwork.com)

Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. (jamanetwork.com)
Janson CG, Ramesh TM, During MJ, Leone P, Heywood J: Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis. (inhibitorkit.com)

To investigate and compare the effect of two different anesthesia methods on expression of peripheral blood inflammatory cytokines IL-1β and IL-17 in patients with surgery for liver cancer. (biomedres.info)
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)

Patients who undergo bone marrow transplantation usually are hospitalized until marrow engrafting is established and blood counts are within the reference range. (medscape.com)
It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. (southernbiotech.com)
Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. (southernbiotech.com)
NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (stemcellslab.net)
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. (cellsurgicalnetwork.com)
Cells such as T and B lymphocytes, macrophages, bone marrow, lymph nodes tested negative for ACE2. (thebiotalkmagazine.com)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms. (ctsicn.org)
FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche. (ctsicn.org)
Bone marrow transplantation. (umn.edu)
Long-term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial. (ajbm.net)
Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
Aplastic anemia is diagnosed with blood and bone marrow studies. (medscape.com)
This condition is defined by the finding of a hypoplastic bone marrow that has fatty replacement and that may have relatively increased nonhematopoietic elements, such as mast cells. (medscape.com)
What is radically new and is causing a change in the way we view health and wellness is the discovery that adult stem cells in the bone marrow have the ability to become virtually any kind of cell types in the body. (myradiary.com)

Intravenous infusion of MSC results in their accumulation in lungs, here they secrete multiple paracrine factors, these factors play a role in protecting or rejuvenating alveolar epithelial cells, counteracting fibrosis, and treating pneumonia. (thebiotalkmagazine.com)

To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
The researchers concluded that although further studies are needed to confirm the effect of AMSCs on neovascular diseases, the data collected in their study provided insights into the mechanisms by which these cells exert their therapeutic effects. (genengnews.com)
Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)
Therapeutic potential of HGF-expressing human umbilical cord mesenchymal stem cells in mice with acute liver failure. (edu.pl)

A paucity of platelets, red blood cells (RBCs), granulocytes, monocytes, and reticulocytes is found in patients with aplastic anemia. (medscape.com)

Therefore, finding a way to effectively maintain the pluripotency of stem cells cultured in vitro is important for the application of stem cells. (biomedcentral.com)

After UMSC transplantation (UMSCT), the frequencies of Tregs and CD4 + memory T cells were significantly increased, and the frequencies of T helper (Th) 17 and CD4 + naive T cells were significantly decreased in peripheral blood (PB) of psoriasis patients. (nature.com)
Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
A group of CD 14ᐩ CD11cᐩ CD11 bmid regulatory dendritic cell populations increased after MSC treatment The patients receiving MSC infusion displayed a decreased level of tumor necrosis factor-alpha, a major pro-inflammatory cytokine. (thebiotalkmagazine.com)
Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study. (ctsicn.org)
11. Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. (ajbm.net)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)

A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E + resting peripheral lymphocytes whereas Ly-6.2 strains (e.g. (southernbiotech.com)

Conditionally reprogrammed physiological endometrial epithelial cells provide a novel strategy in IUA clinics in a personalized or generalized manner and also serve as a physiological model to explore biology of endometrial epithelial cells and mechanisms of IUA. (biomedcentral.com)

A blastocyst contains an inner cell mass including a clump of around 150 cells that eventually will generate the entire body of the adult animal. (bmrat.org)
Less than a decade ago, adult stem cells were still believed to have intrinsic limitations as to their ability to become other types of cells (believed to be limited to becoming only blood cells). (myradiary.com)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)

While still subject of ongoing research, any of the ingredients of the mesenchymal stem cell secretome and their specific activities have been identified. (anova-irm.com)
32, 33 All of these factors are potent ingredients of stem cell secretome. (anova-irm.com)

Anatomy21

Organisms4

Diseases15

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology1

Phenomena and Processes21

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science1

Named Groups2

Health Care6

MSCs57

Stromal12

Hematopoietic cell7

Progenitor cells13

Differentiation12

Bone marrow derived5

Tissues17

Graft-versus-3

Clinical23

Regeneration10

Adipose tissue11

Allogeneic hematopoietic stem c2

Autoimmune1

Differentiate4

Regenerative medicine3

Therapy30

HSCT7

Fetal4

Immune12

Donor6

Proliferation2

Transplant6

Myocardial infarction2

Endothelial cells4

Months after transplantation4

Embryonic10

Days of transplantation1

Tissue8

Improves1

Amyotrophic lateral s2

Cytokines4

Marrow21

Intravenous1

Therapeutic4

Aplastic anemia1

Vitro1

Patients6

Granulocyte-colony1

Lymphocytes1

Biology1

Adult3

Secretome2