• To this end, we have developed cell surface marker based approaches to directly identify and isolate lineage-specific precursor cells in adult skeletal muscle. (harvard.edu)
  • After treatment, stem cells are collected from the patient's blood and stored. (clinicaltrials.gov)
  • Mesenchymal stem cells in myeloproliferative disorders - focus on primary myelofibrosis. (amedeo.com)
  • Once there, these stem cells are further required to expand and differentiate to repopulate all of mature cells in the patient's blood. (harvard.edu)
  • In addition, in collaboration with an NIH-funded consortium of investigators interested in applying stem cell transplant-based therapeutics to the treatment of single gene disorders, we also are developing new, robust approaches for precise and directed gene-modification of stem cells, to support the effective use of gene-corrected stem cells for the treatment of sickle cell disease and related disorders. (harvard.edu)
  • Currently, blood-forming stem cells are the only adult stem cell population that has been purified and used for the treatment of human disease. (harvard.edu)
  • Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. (harvard.edu)
  • Cerebral toxoplasmosis in a patient with prolonged CD4 lymphopenia post autologous hemopoietic stem cell transplant. (amedeo.com)
  • Clinical characteristics and treatment outcomes among respiratory syncytial virus (RSV)-infected hematologic malignancy and hematopoietic stem cell transplant recipients receiving palivizumab. (amedeo.com)
  • In a murine transplant model with intensive conditioning, the overall effect of absent CCR5 expression on donor cells results in greater GVHD and donor T-cell expansion. (manchester.ac.uk)
  • Currently, the best treatment is alemtuzumab, monoclonal antibody anti-CD52 antibody, followed by consolidation with a stem cell transplant where possible. (upmc.edu)
  • The end points of this study are engraftment, degree of donor-host chimerism, incidence of acute and chronic GVHD, transplant related morbidity and mortality, disease free survival, as well as overall survival, and overall level and persistence of progeny of gene modified cells. (knowcancer.com)
  • Importantly, failure or inefficiency in any one of these stages of transplantation can cause failure of the stem cell graft, and so, understanding the molecular and cellular processes that permit these stem cell functions is essential for improving transplant outcomes. (harvard.edu)
  • To this end, we are pursuing both genetic and cell biological approaches to defining genes and gene products that control stem cell migration, expansion, differentiation and survival, in order to devise better engraftment strategies that limit transplant-associated complications. (harvard.edu)
  • Human T-cell leukemia virus type-1 (HTLV-1) carriers co-infected with and hepatitis C virus (HCV) have been known to be at higher risk of their related diseases than mono-infected individuals. (biomedcentral.com)
  • A retrovirus, human T-cell leukemia virus type-1 (HTLV-1), and a positive-strand RNA virus, hepatitis C virus (HCV), are completely different in terms of virologic characteristics. (biomedcentral.com)
  • Therapeutic trials to improve the dismal prognosis of adult T-cell leukemia/lymphoma (ATL) among elderly persons who are infected with human T-lymphotropic virus type 1 (HTLV-1) have so far been unsuccessful. (bloodjournal.org)
  • Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child. (scielo.br)
  • Other sexually transmitted diseases might result in the recruitment of inflammatory cells and could increase the risk of HTLV-1 acquisition and transmission. (scielo.br)
  • Human T-cell lymphotropic virus type 1 (HTLV-1) and human T-cell lymphotropic virus type 2 (HTLV-2) belong to the Retroviridae family and the genus deltaretrovirus. (scielo.br)
  • The Human T-cell lymphotropic virus type (HTLV) retrovirus is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T-cell leukemia (ATL), uveitis, infective dermatitis, inflammatory disorders, and emerging syndromes that are associated with HTLV 6 - 9 . (scielo.br)
  • Adult T-cell leukemia (ATL) develops in individuals infected with human T-cell lymphotropic virus-1 (HTLV-1). (nih.gov)
  • HTLV-1-encoded protein Tax (transactivator from the X-gene region) up-regulates Bcl-xL (B-cell lymphoma-extra large) expression and activates interleukin-2 (IL-2), IL-9, and IL-15 autocrine/paracrine systems, resulting in amplified JAK/STAT signaling. (nih.gov)
  • LDH levels are high but there is no hypercalcemia, in contrast to HTLV related adult T-cell/ leukemia lymphoma (ATLL). (upmc.edu)
  • Modifying previously reported techniques, we attempted to increase the efficiency of human T cell leukemia-lymphoma virus (HTLV) transformation of human T lymphocytes. (ashpublications.org)
  • DCs included ten HTLV+ T cell lines with varying degrees of virus expression or seven cell lines that do not express HTLV. (ashpublications.org)
  • The presence of integrated HTLV proviral DNA in the transformed cells was determined by dot blot hybridization, utilizing a cloned probe to the HTLV-I genome. (ashpublications.org)
  • No transformation occurred with T cell donor lines that do not express HTLV. (ashpublications.org)
  • HUT 102 B2 could transform only one activated AIDS sample, the cells of which initially expressed HTLV-like proteins and virions. (ashpublications.org)
  • Transformed cell lines contained subsets of mature T lymphocytes with variable HTLV expression. (ashpublications.org)
  • HTLV-I+ T-cells differed significantly from other T-lymphocyte-derived cells in also having a higher proportion of PDE4 activities, which apparently were not related to selective induction of any one PDE4 mRNA (judged by reverse transcription-polymerase chain reaction) or expression of the HTLV-I regulatory protein Tax. (lu.se)
  • In MJ cells (an HTLV-I+ T-cell line), Jurkat cells, and PBMC-PHA cells, the tyrosine kinase inhibitor herbimycin A strongly inhibited PDE activity. (lu.se)
  • The combination was noted to strongly activate BAX (Bcl-2-associated X protein), effect mitochondrial depolarization, and increase caspase 3/7 activities that lead to cleavage of PARP (poly ADP ribose polymerase) and Mcl-1 (myeloid cell leukemia 1). (nih.gov)
  • The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells . (manchester.ac.uk)
  • The Pb99 gene is specifically expressed in pre-B cells and thymocytes and not in mature B and T cells or nonlymphoid tissues, implying that it may function in early lymphoid development. (manchester.ac.uk)
  • To develop equally robust cell therapies for treating non-blood-cell-related disease, cells with equivalent regenerative function for non-blood tissues must be identified. (harvard.edu)
  • Several in vitro studies have demonstrated the existence of donor derived CD4 and CD8 positive lymphocytes with specific reactivity to recipient leukemia providing a potent graft versus leukemia (GVL) effect, and this GVL effect is area of intense interest both at the NIH and elsewhere. (knowcancer.com)
  • These lymphomas have been classified on the basis of morphologic features characteristic of the different stages of normal B lymphocyte differentiation. (thefreedictionary.com)
  • some varieties contain exclusively one type of cell, such as lymphoblasts or cleaved or uncleaved follicular center cells, and others have a mixture of cells, sometimes including ones that cannot be characterized as to lineage. (thefreedictionary.com)
  • Blood cell lineage Hematopoiesis Erythropoiesis Haematopoiesis Hematopoietic stem cell Hartenstein, V (2006). (wikipedia.org)
  • However, the influential WHO Classification (published in 2001) emphasized a greater emphasis on cell lineage. (wikipedia.org)
  • So far, the researchers have concluded that lineage of the T-cell receptor gene does not predict the behavior of the disease. (wikipedia.org)
  • Additionally, factors that are associated with higher transmission risks include the presence of antibodies against the viral oncoprotein Tax (anti-Tax), a higher proviral load in peripheral blood lymphocytes, and increased cervicovaginal or seminal secretions. (scielo.br)
  • Although SCL mRNA is not detectable in normal thymocytes or peripheral T-lymphocytes, transcriptional activation occurs in T-cell tumours. (manchester.ac.uk)