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  • counts
  • and filgrastim (G-CSF) IV or SC once daily beginning on day 1 and continuing until blood counts recover. (clinicaltrials.gov)
  • Severe plastic anemia can lead to problems with bone marrow platelet production and result in low blood platelet counts, which require frequent platelet transfusions to improve blood clotting. (clinicaltrials.gov)
  • To evaluate the effectiveness and safety of horse-ATG (with cyclosporine) in increasing blood counts and reducing the need for transfusions in aplastic anemia patients who have failed to respond to prior immunosuppressive treatment with rabbit-ATG and cyclosporine. (clinicaltrials.gov)
  • Patients 2 years of age and older who have consistently low blood platelet counts related to aplastic anemia that has not responded to conventional treatment with rabbit-ATG. (clinicaltrials.gov)
  • Myelodysplastic Syndrome
  • First prize of military medical achievement award in June 2005 Military medical achievement award in March 2006 Second prize of military medical achievement award in September 2007 Honourable title of the 3rd merit in 2008 Her accomplishments include over 100 published research articles, including four articles that have been recorded by SCI (JCO: 18.4, Blood: 10.55, BBMT 3.86) aplastic anemia and myelodysplastic syndrome. (wikipedia.org)
  • Lymphoma
  • Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow. (wikipedia.org)
  • clinical
  • In the majority of clinical trials investigating the effects of intracoronary cell transplantation, the primary end point comprises changes in LV volumes and EF in comparison with a control group over time ( 5-7 ). (onlinejacc.org)
  • John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 - 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health. (wikipedia.org)
  • chronic
  • Signs and symptoms of WM include weakness, fatigue, weight loss, and chronic oozing of blood from the nose and gums. (wikipedia.org)
  • neutrophils
  • Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low blood neutrophils due to a number of causes. (wikipedia.org)
  • In 1983-84 his group succeeded in identifying and purifying a human growth factor, G-CSF, that stimulates white blood cell production (neutrophils). (wikipedia.org)
  • Mild
  • Mild bone pain usually results due to the excessive stem cell crowding within the bone marrow. (wikipedia.org)
  • The most commonly observed adverse effect is mild bone pain after repeated administration and local skin reactions at the site of injection. (wikipedia.org)
  • commonly
  • While the bone marrow is commonly involved, the detection of the neoplastic infiltrate may be difficult due to diffuse, interstitial pattern. (wikipedia.org)
  • intestinal
  • 2005 Treatment of Jining serious radiation accidents and extremely severe bone marrow and intestinal radiation 2006 Developed an original creativity of microtransplantation for the treatment of leukemia. (wikipedia.org)
  • recipient
  • If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required for adequate collection. (wikipedia.org)
  • murine bone
  • Tolerogenic DCs have been generated in the presence of 1,25(OH) 2 D 3 , the active form of vitamin D 3 , and of vitamin D 3 analogues from both human blood monocytes and murine bone marrow and shown to induce Treg ( 8 , 9 , 10 ). (jimmunol.org)
  • donor
  • Until now insulin replacement is still the major therapy, because islet transplantation has been limited by donor availability and by the need for long-term immunosuppression. (jove.com)
  • tumors
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • In the majority of cases the damage results from physical trauma such as car accidents, gunshots, falls, or sports injuries, but it can also result from nontraumatic causes such as infection, insufficient blood flow, and tumors. (wikipedia.org)
  • thymus
  • Histologically, each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. (wikipedia.org)
  • The thymus consists of two lobes, merged in the middle, surrounded by a capsule that extends with blood vessels into the interior. (wikipedia.org)
  • vascular
  • Peripheral vascular disease is a crucial health issue that affects an estimated 27 million people. (ahajournals.org)
  • When these findings are taken together, combination therapy with MNC transplantation and AM infusion may have additional or synergetic effects on therapeutic angiogenesis for the treatment of severe peripheral vascular disease. (ahajournals.org)
  • vessels
  • Cardiovascular disease, also called heart disease, is a broad medical term used to describe a group of conditions that affect the blood vessels or the heart. (stemcelltherapy.me)
  • This network forms an adventitia to the blood vessels, which enter the cortex via septa near the junction with the medulla. (wikipedia.org)
  • Disorders
  • At one end of this spectrum of hematological disorders, detection of one of these myeloma proteins in an individual's blood or urine indicates the presence of a common and clinically silent disorder termed MGUS, i.e. monoclonal gammopathy of undetermined significance. (wikipedia.org)
  • laboratory
  • Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications and screen for bone marrow toxicity. (wikipedia.org)
  • transfusion
  • Transmission of HTLV-I is believed to occur by sexual contact, from mother to child via breastfeeding, and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles. (wikipedia.org)
  • cell
  • We investigated whether AM enhances bone marrow cell-induced angiogenesis. (ahajournals.org)
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • In the mid-1990s, my research group began to devise a method to establish endothelial cell cultures from human peripheral blood, with an ultimate goal of examining interindividual heterogeneity of endothelial biology. (jci.org)
  • Truly endothelial, BOEC are progeny of a transplantable cell that originates in bone marrow, a putative endothelial progenitor. (jci.org)
  • Human peripheral blood from normal donors was stained using a combination of anti-human CD3 monoclonal antibody (clone: S4.1) for the cell surface antigens, and anti-human/mouse ZAP-70 monoclonal antibody (clone: 1E7.2), for intracellular detection. (antikoerper-online.de)
  • One cell-based replacement technique is called autologous chondrocyte implantation (ACI) or autologous chondrocyte transplantation (ACT). (wikipedia.org)
  • Most people are diagnosed without symptoms as the result of a routine blood test that shows a high white blood cell count. (wikipedia.org)
  • CLL is usually first suspected by a diagnosis of lymphocytosis, an increase in a type of white blood cell, on a complete blood count test. (wikipedia.org)
  • HSCs can replenish all blood cell types (i.e., are multipotent) and self-renew. (wikipedia.org)
  • This process indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur. (wikipedia.org)
  • Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal. (wikipedia.org)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
  • These rearrangements result in increased expression of blood cell development genes by promoting gene transcription and through epigenetic changes. (wikipedia.org)
  • Common side effects include low white blood cell counts, loss of appetite, vomiting, hair loss, and bleeding from the bladder. (wikipedia.org)
  • The enzyme suggested as a tumor marker in malignant disease is the cytosolic cell cycle dependent TK1 that is present during cell division in quantities much larger than TK2 and is therefore set free to the circulation in quantities that completely dominate the activity of thymidine kinase in blood and other body fluids. (wikipedia.org)
  • vitro
  • In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP), contribute to the development of bone marrow-derived tolerogenic DCs in vitro and in vivo. (jimmunol.org)
  • nerve
  • Leukodystrophies affect the growth and/or development of myelin, the fatty covering which acts as an insulator around nerve fibers throughout the central and peripheral nervous systems. (wikipedia.org)
  • Biological
  • Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a collagen membrane. (wikipedia.org)
  • ischemic
  • 6,7 A recent study has demonstrated that blood flow recovery in ischemic limb and tumor angiogenesis are substantially impaired in heterozygous AM knockout mice. (ahajournals.org)
  • Spinal cord injury can be traumatic or nontraumatic, and can be classified into three types based on cause: mechanical forces, toxic, and ischemic (from lack of blood flow). (wikipedia.org)
  • shown
  • Recently, we have shown that VIP/PACAP affect bone marrow-derived DC (BM-DC) differently, depending on the DC maturation state ( 17 ). (jimmunol.org)