AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Fetal BloodSpinal CordLeukocytes, MononuclearSpinal Cord InjuriesUmbilical CordAntigens, CD34LymphocytesHematopoietic Stem CellsCells, CulturedFlow CytometryPeripheral NervesBlood BanksInfant, NewbornT-LymphocytesBlood CellsLymphocyte ActivationMonocytesHematopoietic Stem Cell TransplantationImmunophenotypingAntigens, CDPeripheral Blood Stem Cell TransplantationPregnancyCell SeparationLeukocyte CountPeripheral Nervous SystemPhytohemagglutininsB-LymphocytesCell DifferentiationTime FactorsPeripheral Nervous System DiseasesLeukocytesCytokinesBlood Cell CountCD4-Positive T-LymphocytesInterferon-gammaBone Marrow CellsColony-Forming Units AssayHematopoietic Stem Cell MobilizationMaternal-Fetal ExchangeRNA, MessengerPolymerase Chain ReactionPeripheral Vascular DiseasesBone MarrowInterleukin-2Killer Cells, NaturalMice, SCIDT-Lymphocyte SubsetsSpinal Cord DiseasesAntigens, CD45HematopoiesisTransplantation, HomologousAntibodies, MonoclonalGranulocyte Colony-Stimulating FactorLeukapheresisGraft vs Host DiseaseLymphocyte CountAntigens, CD3Spinal Cord CompressionCell Culture TechniquesTransplantation, AutologousHistocompatibility TestingReverse Transcriptase Polymerase Chain ReactionBlood PreservationMolecular Sequence DataCytotoxicity, ImmunologicHematologic NeoplasmsPeripheral Nerve InjuriesStem CellsMice, Inbred NODBiological MarkersGraft SurvivalLymphocyte SubsetsCD8-Positive T-LymphocytesTransplantation ConditioningAntigens, CD38Cell DivisionCord Blood Stem Cell TransplantationNeutrophilsSpermatic CordHLA-DR AntigensPokeweed MitogensCase-Control StudiesPhenotypeCoculture TechniquesPeripheral Arterial DiseaseRecombinant ProteinsHIV-1Tumor Necrosis Factor-alphaBase SequenceEnzyme-Linked Immunosorbent AssayCell LineDendritic CellsSpinal Cord NeoplasmsCell CountSpinal Cord IschemiaInterleukin-4ADP-ribosyl CyclaseRosette FormationGranulocytesMembrane Glycoproteins
Progenitor cellsDonorsTransplantsTransplantTransplantationPlacentalDerived from bone marrowDonorHSCTSpinal cordUmbilical cord-derivedMononuclear cellsMonocytesTissuesCollected from the umbilical cordFetalNervous systemCellsAdultMSCsSmearLymph nodesMaternal bloodDisordersVesselsPatientsUnits of cord bloodSymptoms2020Graft-versus-ImmuneSignificantly higherTransfusionTissueCellOxygenInvolvementAdultsClinicallyNeuropathyLymphoma
Progenitor cells6
  • In one study, the expression of ZNF280D was compared between endothelial progenitor cells in cord blood and peripheral blood. (wikipedia.org)
  • CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • In addition to bone marrow, alternative sources of haemopoietic progenitor cells such as mobilized peripheral blood donations or cord blood are being used increasingly. (rlbuht.nhs.uk)
  • It is also intended for use in testing pools of human plasma and pools of human serum composed of equal aliquots of not more than 16 individual specimens from donors of whole blood, blood components, hematopoietic stem/progenitor cells sourced from bone marrow, peripheral blood or cord blood, and from donors of donor lymphocytes for infusion. (fda.gov)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Donors11
  • To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • Dendritic cell subsets were isolated from 3 peripheral blood donors and 3 cord blood donors. (nih.gov)
  • Monocytes were isolated from 3 cord blood donors. (nih.gov)
  • To investigate cord blood as a possible solution to a critical public health need: finding appropriate hematopoietic transplants for patients who have no matched bone marrow donors. (schoolandyouth.org)
  • Human CD14 Monocytes isolated from Peripheral Blood (hMoCD14 -PB) from single donors. (promocell.com)
  • 9 Blood centers are actively urging healthy donors to contribute, bearing in mind that only 3% of eligible Americans donate blood. (cap.org)
  • The Procleix® Ultrio Elite Assay is a qualitative in vitro nucleic acid amplification test to screen for human immunodeficiency virus type 1 (HIV-1) RNA,hepatitis C virus (HCV) RNA, and/or hepatitis B virus (HBV) DNA, and detect human immunodeficiency virus type 2 (HIV-2) RNA in plasma and serum specimens from individual human donors, including donors of whole blood, blood components, and source plasma, and from other living donors. (fda.gov)
  • It is also intended for use in testing plasma and serum to screen organ and tissue donors when specimens are obtained while the donor's heart is still beating, and in testing blood specimens from cadaveric (non-heart-beating) donors. (fda.gov)
  • The NMDP performs thistask by maintaining a registry of morethan 4.9 million volunteer donors ofmarrow and peripheral blood stemcells (PBSC) and 12 cord blood bankscontaining more than 25,000 units ofumbilical cord blood. (cancernetwork.com)
Transplants11
  • In 2020, there were more than 23,000 bone marrow or cord blood transplants in the United States. (healthline.com)
  • Cord blood and haploidentical (half-matched) transplants are used to treat an increasing number of patients. (bmtinfonet.org)
  • Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
  • Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. (biologynews.net)
  • Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
  • BMT InfoNet is dedicated to providing transplant patients, survivors and their loved ones with emotional support and high quality, easy-to-understand information about bone marrow, peripheral blood stem cell and cord blood transplants. (schoolandyouth.org)
  • Website provides basic information about cord blood transplants. (schoolandyouth.org)
  • Stem cell transplants can use either cord blood stem cells or bone marrow stem cells and consist of the following stages: preparation, transplant procedure and recovery period. (pregnancy-info.net)
  • This guide provides an overview of the stages of cord blood transplants. (pregnancy-info.net)
  • Also known as the conditioning regimen, the preparatory stage of cord blood transplants involves high doses of chemotherapy and in some cases radiation treatment, which is used to treat the whole body in a process known as total body irradiation (TBI). (pregnancy-info.net)
  • The preparatory stage of cord blood transplants ranges from 4 to 10 days, depending on the patient's age, the nature of the disease (including whether the disease is active), as well as whether the patient has undergone any previous treatments. (pregnancy-info.net)
Transplant21
  • This preliminary study indicates that freshly collected cord blood transfusion may cause a transient transplant impact of transfused cord blood CD34 stem cells on the host without provoking clinical graft vs host disease perhaps due to a possible background structural or functional immune suppression in advanced malignancy. (bmrat.org)
  • In most cases, the person received a transplant of their own blood. (healthline.com)
  • About 18,000 people each year need a bone marrow or cord blood transplant to treat a life threatening illness. (healthline.com)
  • A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • A bone marrow or cord blood transplant is used to treat more than 70 diseases, including leukemia, lymphoma, and sickle cell disease. (icla.org)
  • A bone marrow transplant takes a donor's healthy blood-forming cells and puts them into the patient's bloodstream, where they begin to grow and make healthy red blood cells, white blood cells, and platelets. (icla.org)
  • When needed for a transplant, the cord blood unit can be shipped to the transplant center. (schoolandyouth.org)
  • Provides free cord blood banking for a full family member with a need for transplant. (schoolandyouth.org)
  • The study involved targeted mutational analysis of samples obtained before stem cell transplant from 1,514 MDS patients enrolled at the Center for International Blood and Marrow Transplant Research Repository between 2005 and 2014. (ascopost.com)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • The treatment dose is higher compared to patients who are not undergoing a cord blood transplant. (pregnancy-info.net)
  • The cord blood transplant procedure is performed one to two days after preparation for the transplant has been completed. (pregnancy-info.net)
  • If the stem cells being used for the cord blood transplant procedure are from an adult donor , the donation will be completed on the day of the transplant. (pregnancy-info.net)
  • However, if umbilical cord stem cells are being used, they will be transferred to the transplant center prior to the transplant procedure. (pregnancy-info.net)
  • During the transplant procedure, the cells are infused (transmitted into the body) using an IV line, similar to a blood transfusion process. (pregnancy-info.net)
  • However, the patient's immune system will be weaker than average for several months following a cord blood transplant. (pregnancy-info.net)
  • Because outpatient care for a cord blood transplant can require daily checkups, it can be beneficial for the patient to choose a transplant center that is close to the patient's home. (pregnancy-info.net)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Transplantation20
Placental4
  • In the present study, 46 sex and HLA-randomized patients suffering from advanced malignancy and anemia (Hb 8 Gm percent or less) were treated with placental cord blood transfusion. (bmrat.org)
  • and parasitemia at delivery in maternal peripheral blood, placental blood, and in infant umbilical cord blood. (ajtmh.org)
  • Only 17 women had malaria ( Plasmodium falciparum ), 6 with peripheral parasitaemia and 11 with both peripheral parasitaemia and placental malaria. (who.int)
  • peripheral blood, or placental/umbilical cord blood). (cdc.gov)
Derived from bone marrow1
Donor5
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • In a little over 4,800 cases, the blood came from an unrelated donor. (healthline.com)
  • Neonatal naive T cells were isolated from 1 peripheral blood donor. (nih.gov)
  • Resilient blood centers implemented operational changes and intensified donor recruitment efforts to stabilize the situation. (cap.org)
  • 16 With the goal of large-scale production of enzyme-treated universal RBC, the focus was turned on treating type A blood (40% of donor population). (cap.org)
HSCT1
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Spinal cord6
  • 1983 Organic psychosis without anaemia or spinal cord symptoms in patients with vitamin B12 deficiency. (twitlonger.com)
  • They emphasise that psychiatric manifestations may be the first symptoms of vitamin B12 deficiency and thus antedate anaemia and spinal cord disease. (twitlonger.com)
  • They may experience weakness and loss of sensation due to problems with the nerves connecting the brain and spinal cord to muscles and sensory cells (peripheral nervous system). (medlineplus.gov)
  • Normal voiding is essentially a spinal reflex modulated by the central nervous system (brain and spinal cord), which coordinates function of the bladder and urethra. (medscape.com)
  • The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
  • The signal transmitted by the brain is routed through 2 intermediate segments (the brainstem and the sacral spinal cord) prior to reaching the bladder. (medscape.com)
Umbilical cord-derived4
  • Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple. (oncotarget.com)
  • The immunoregulatory function of T regulatory cells (Tregs) is impaired in multiple sclerosis (MS). Recent studies have shown that umbilical cord-derived mesenchymal stem cells (UC-MSCs) exert regulatory effect on the functions of immune cells. (oncotarget.com)
  • We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
  • Therefore, we performed a phase 1/2a, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs (UMSCs) in the treatment of psoriasis and to preliminarily explore the possible mechanisms. (nature.com)
Mononuclear cells2
  • Studies of CD34 levels after 72 hours of transfusion showed an initial rise followed by a fall in twenty-two cases, two cases registered very little effect on the CD34 level, i.e., no change from the baseline, and the rest of the cases demonstrated a sustained rise from the baseline, i.e, 56% to 99% of peripheral mononuclear cells and a sustained high CD34 level. (bmrat.org)
  • Primary Human Mononuclear Cells isolated from umbilical cord blood and peripheral blood (PBMC). (promocell.com)
Monocytes1
Tissues3
  • MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
  • However, they can also be parted from other available tissues including peripheral blood, cord blood, fallopian tube. (medgadget.com)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Collected from the umbilical cord2
Fetal5
  • Cord blood is a safe alternative of adult blood for transfusion given its content of fetal and adult haemoglobin, platelet and WBC counts, and a plasma filled with inflammatory and non-inflammatory cytokines and growth factors. (bmrat.org)
  • The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)
  • The intervillous space of the placenta is a part of the fetal-maternal interface, where maternal blood enters to provide nutrients and gas exchange. (frontiersin.org)
  • The pregnant woman's arterial blood fills the intervillous space of the placenta, where it comes in direct contact with the fetal villi protruding from the fetal part of the placenta. (frontiersin.org)
  • Fetal blood vessels run inside the villi, and gas and nutrients are exchanged over a thin membrane of fetal cytotrophoblasts and syncytiotrophoblasts ( 1 ). (frontiersin.org)
Nervous system4
  • The blood brain barrier restricts the permeation of molecules and cells through the circulatory system into the central nervous system. (genengnews.com)
  • Because the autonomic nervous system maintains internal physiologic homeostasis, disorders of this system can be present with both central as well as peripheral nervous system localization. (medscape.com)
  • Besides nerve localization in the peripheral nervous system, it occurs in diseases of the presynaptic neuromuscular junction such as botulism and myasthenic syndrome. (medscape.com)
  • The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)
Cells45
  • NK cells were obtained from peripheral blood (PB) of healthy volunteers. (springer.com)
  • CD34 cells were collected from peripheral blood 72 hours after transfusion and variations were analyzed for prognostic implication. (bmrat.org)
  • Bone marrow is where your body makes blood cells. (healthline.com)
  • A machine removes the blood-forming cells from your blood and returns the rest of the material back to your body through a needle in the opposite arm. (healthline.com)
  • Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
  • NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
  • Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
  • Chronic granulomatous disease (CGD) is a type of primary immunodeficiency (PI) in which one group of the body's white blood cells, called neutrophils, fail to make the hydrogen peroxide, bleach, and other chemicals needed to fight bacterial and fungal infections. (primaryimmune.org)
  • A phenotypically and functinoally distinct subset of human blood dendritic cells expressing CD11b is specific of the neonatal environment. (nih.gov)
  • We have employed whole genome microarray expression profiling to identify the specific gene signature of CD11b+ cord blood dendritic cells as compared to their adult peripheral blood counterparts. (nih.gov)
  • Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood. (biologynews.net)
  • Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
  • Previous efforts to expand cord blood have resulted in ineffective NK cells. (biologynews.net)
  • Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
  • Zweidler-McKay's study involves selecting out NK cells from cord blood. (biologynews.net)
  • As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion. (biologynews.net)
  • These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias. (biologynews.net)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • Thanks to recent progresses, stem cells have been extensively employed to study Plasmodium liver and blood cycle in vitro . (wjgnet.com)
  • The three sources of stem cells include bone marrow, umbilical cord blood, and peripheral blood. (oncologynurseadvisor.com)
  • Researchers are investigating several approaches, such as enzymatic treatments of RBCs, the generation of RBCs from human induced pluripotent stem cells, and the development of artificial oxygen carriers, all with the goal of advancing universal blood. (cap.org)
  • A new study has moved researchers a step forward towards using specialised T cells from umbilical cord blood for treating blood cancers. (b-s-h.org.uk)
  • γδ T cells derived from adult peripheral blood have shown poor efficiency. (b-s-h.org.uk)
  • So a team from Singapore General Hospital investigated using cord blood as a source for γδ T cells, growing cells from samples obtained from the Singapore Cord Blood Bank. (b-s-h.org.uk)
  • The researchers believe the ability to harness and enhance the action of γδ T cells could be used to treat solid and blood cancers. (b-s-h.org.uk)
  • Co-author Professor Goh Yeow Tee added: "Umbilical cord blood-derived gamma delta cells are currently under-utilised, with the main concern that there may not be enough of these T-cells for clinical application, but our study has shown that it is potentially feasible. (b-s-h.org.uk)
  • 2023) "Cord blood-derived Vδ2+ and Vδ2− T cells acquire differential cell state compositions upon in vitro expansion. (b-s-h.org.uk)
  • Mucosal-associated invariant T (MAIT) cells and effector memory (EM) T cells were enriched in the intervillous blood compared to peripheral blood, suggesting that MAIT cells and other EM T cells home to the placenta during pregnancy. (frontiersin.org)
  • Furthermore, pregnant women had lower proportions of peripheral blood MAIT cells compared to non-pregnant women. (frontiersin.org)
  • A multivariate factor analysis indicated that high levels of MIF and CCL25 were associated with high proportions of MAIT cells in intervillous blood. (frontiersin.org)
  • Neuroacanthocytosis encompasses a group of genetically heterogenous disorders characterized by neurologic signs and symptoms associated with acanthocytosis, an abnormality of red blood cells. (medscape.com)
  • p>Blood has three main cell types: red blood cells (which carry oxygen), white blood cells (which fight infection) and platelets (which clot the blood). (nemours.org)
  • New blood cells (called "stem cells") begin in the bone marrow - the red spongy material found inside the bones - and are released to the bloodstream when mature. (nemours.org)
  • They begin to produce red and white blood cells as well as platelets, a procedure that is known as engraftment. (pregnancy-info.net)
  • This type of cancer interferes with the normal functioning, growth, and development of blood cells that are involved in fighting infection and producing healthy blood cells. (ndtv.com)
  • It is the cancer of the lymphatic system and the lymph nodes and particularly affects a type of white blood cells, called lymphocytes. (ndtv.com)
  • Leukaemia on the other hand is a type of cancer that affects all white blood cells and prevents them from carrying out their main function-fighting off infections. (ndtv.com)
  • Myeloma is a type of cancer affecting the plasma, which is also a type of white blood cells that produce antibodies to ward off infections. (ndtv.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
  • The formation of this structure starts from the remnants cells of the tooth lamina which are organized as a fibrous cord leaving the reduced epithelium of the enamel organ towards the oral mucosa 9,10 . (bvsalud.org)
  • In this cord, there is the presence of countless chemical mediators, including EGF (epithelial growth factor), a substance secreted by the epithelial cells having the capacity of stimulating the formation of clasts and consequently a bone resorption, making impossible the filling of the cord area by alveolar bone, always leaving a space surrounding this cord, so-called the gubernacular canal (figures 1 to 3 ) 8.9 . (bvsalud.org)
Adult1
  • Peripheral blood adult cDC2 (CD20- CD11c+ CD14- BDCA1+ CD11b- ), neonatal cord blood cDC2 (CD20- CD11c+ CD14- BDCA1+ CD11b-) and neonatal cord blood cDC2b (CD20- CD11c+ CD14- BDCA1+ CD11b+) were FACS purified from BDCA1+ magnetically. (nih.gov)
MSCs1
  • Key findings Peripheral blood MSCs (PB-MSCs) and umbilical cord MSCs (UC-MSCs) showed the highest, while periodontal ligament MSCs (PDL-MSCs) and adipose tissue MSCs (AT-MSCs) the lowest values of both the replication potential and RTL. (mendeley.com)
Smear4
  • Patients may have advanced neuropsychiatric manifestations of cobalamin deficiency and yet not be anemic, have a normal blood smear, and even have serum cobalamin levels in the normal range. (twitlonger.com)
  • [ 6 ] . At some point during the course of the disease, most patients manifest acanthocytosis on the peripheral blood smear, ie, a certain percentage of the patients' erythrocytes (typically 10-30%) have an unusual starlike appearance with spiky- or thorny-appearing projections. (medscape.com)
  • A peripheral maternal blood smear was ni infants considered by their mothers to be made by finger prick. (who.int)
  • A cord smear was smaller than average at birth was nearly 3 prepared from the blood of the umbilical times that of infants estimated to be normal stump. (who.int)
Lymph nodes1
  • Langerin is not detected in purified DCs isolated from peripheral blood, lymph nodes or thymus. (beckman.com)
Maternal blood2
Disorders2
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • Also, certain blood disorders such as myelodysplastic syndrome can also increase the chances of developing leukaemia. (ndtv.com)
Vessels1
  • Clusters of enlarged blood vessels that form small, dark red spots on the skin (angiokeratomas) are characteristic of this form of the disorder. (medlineplus.gov)
Patients3
  • From the cord blood transfusion impact we could clinically divide the enrolled advanced cancer patients to a relatively good (Group A) and bad prognostic(Group B) variety of cancer. (bmrat.org)
  • 2 Karl Landsteiner's discovery of ABO blood groups and Rh factor in the early 20th century led to the provision of matched blood products to patients to prevent hemolytic complications and enhance safety. (cap.org)
  • 3 Today, serologic and molecular techniques, along with laboratory information systems and electronic health records, contribute to precise blood product management and personalized transfusion therapies, particularly benefiting complex patients with sickle cell disease, thalassemia, and other diseases requiring chronic transfusion support. (cap.org)
Units of cord blood1
  • The youngest patient, suffering from non-Hodgkin's lymphoma (Case 3), was a 16-year-old boy who received eight units of cord blood to combat anemia. (bmrat.org)
Symptoms1
  • They, like the nervous system's symptoms, may precede the characteristic changes in the blood by many months. (twitlonger.com)
20201
  • According to Globocon 2020, nearly 20,000 cases of childhood blood cancer are diagnosed every year, leukaemia being the most common type, contributing up to 15,000 cases. (ndtv.com)
Graft-versus-1
  • Blood tests will also be performed in order to evaluate the patient's recovery and monitor potential complications, including Graft-Versus-Host-Disease (GVHD) or graft failure (a rare condition that occurs in less than 5% of cases). (pregnancy-info.net)
Immune2
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • After engraftment occurs, the patient's blood cell count will continue to rise, resulting in increased immune system strength. (pregnancy-info.net)
Significantly higher2
  • The results show that expression was significantly higher in cord blood. (wikipedia.org)
  • The levels of several chemokines were significantly higher in intervillous compared to peripheral blood, including macrophage migration inhibitory factor (MIF), CXCL10, and CCL25, whereas CCL21, CCL27 and CXCL12 were lower. (frontiersin.org)
Transfusion3
  • The field of transfusion medicine (TM) plays a crucial role in healthcare with approximately 16 million blood components transfused annually in the US, saving lives in emergencies, surgeries, cancer treatments, and various medical conditions. (cap.org)
  • 4,5 As precision medicine evolves, TM continues to revolutionize patient care by optimizing transfusion strategies and minimizing risks associated with incompatible blood products. (cap.org)
  • 10 The presence of ABO antigens on RBC surfaces requires that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal hemolytic transfusion reactions. (cap.org)
Tissue3
  • The DCGM4 antibody has been used to determine the differentiation of the CD1a+/CD11c+ subset of blood DCs into LCs, and in the characterization of DCs infiltrating breast carcinoma tissue. (beckman.com)
  • Newborn Possibilities Program® offers free cord blood and tissue processing and five years of storage to qualifying families in the U.S. (schoolandyouth.org)
  • The gubernacular cord is a structure composed of conjunctive tissue which link the tooth follicle to the overlying gingiva, showing the function of guiding or directing the course of the tooth eruption. (bvsalud.org)
Cell4
  • CD1a+ DCs derived from CD34+ cord blood cell cultures in the presence of GM-CSF and TNF-α express Langerin between day 8 and 12. (beckman.com)
  • Thousands of blood drives were canceled in the early weeks of the pandemic, resulting in a significant deficit of about 150,000 red blood cell (RBC) units according to the American Red Cross (ARC). (cap.org)
  • We have characterized the T cell composition and chemokine profile in paired intervillous and peripheral blood samples from healthy mothers giving birth following term pregnancies. (frontiersin.org)
  • The intervillous blood (IVB) is exchanged 2-3 times per minute ( 1 ), suggesting that the cell composition in IVB may reflect that of peripheral blood (PB). (frontiersin.org)
Oxygen1
  • Blood plays an important role in the overall functioning of the body, supplying oxygen, nutrients, oxygen, antibodies and hormones to different organs. (ndtv.com)
Involvement1
  • Few peripheral neuropathies are associated with pure or predominantly small fiber involvement. (medscape.com)
Adults1
  • Clinically, Hodgkin's lymphoma is the most common and affects more than 50% of adults diagnosed with blood cancer. (ndtv.com)
Clinically1
  • Most clinically significant shortages are seen in the availability of universal blood , ie, type O RBC. (cap.org)
Neuropathy1
  • Peripheral was suspected and the investigation of creatine phosphokinase, lactate dehy- neuropathy is a rare adverse effect as- sequential sputum samples confirmed drogenase and protide were normal. (who.int)
Lymphoma1
  • There are primarily three types of blood cancer including lymphoma, leukaemia and myeloma and are characterised by the specific components of blood that it affects. (ndtv.com)