Postoperative pulmonary complications contribute significantly to overall perioperative morbidity and mortality rates. (medscape.com)
Even if guidelines are already available to manage anesthesia and surgery of obese patients, the assessment of the perioperative morbidity and mortality from heart and brain disorders in morbidly obese surgical patients will be challenging in the next years. (benthamscience.com)
We report initial experience of MIE to determine the morbidity and mortality associated with this procedure during learning phase. (hindawi.com)
PH has been associated with an increase in perioperative morbidity and mortality, particularly when complicated by an acute PH crisis and a failing right ventricle (RV). (medscape.com)
Chemotherapy15
Perioperative chemotherapy (adjuvant ou neoadjuvant) has been developed in order to improve these results. (bcan.org)
Thanks to randomized trials and meta-analysis, it can be concluded that perioperative chemotherapy increases overall survival with an absolute benefit of 5%, equating to a survival rate of 50% at 5 years for nonorgan-confined tumours. (bcan.org)
Investigators therefore designed a randomized phase III study to compare the efficacy of GC and HD-MVAC in term of progression-free survival in patients for whom chemotherapy has been decided, before or after radical cystectomy. (bcan.org)
This phase III trial compares perioperative chemotherapy (given before and after surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable/resectable). (rochester.edu)
The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI. (helsedirektoratet.no)
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. (helsedirektoratet.no)
A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer. (helsedirektoratet.no)
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. (helsedirektoratet.no)
Generally, clinically staged T1N + M0 and T2-T4aN(any)M0 gastric cancer requires surgical resection with adequate lymphadenectomy, together with perioperative or adjuvant chemotherapy. (frontiersin.org)
Results of a phase II study on the use of neoadjuvant chemotherapy (FOLFIRINOX or GEM/nab-PTX) for borderline-resectable pancreatic cancer (NUPAT-01). (springermedizin.at)
In the phase II/III PRODIGE 4/ACCORD 11 trial, patients with metastatic pancreatic cancer were randomly assigned to receive gemcitabine or a combination chemotherapy regimen consisting of oxaliplatin/irinotecan/fluorouracil/leucovorin (FOLFIRINOX). (jnccn.org)
The question of whether a chemotherapy holiday is safe may be answered by the results of the phase II PANOPTIMOX-PRODIGE 35 trial. (jnccn.org)
Peter Schmid, MD, PhD, of Queen Mary University of London, discusses phase III findings from the KEYNOTE-522 study, which showed neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab continues to improve event-free survival compared with neoadjuvant chemotherapy alone in patients with early-stage triple-negative breast cancer, regardless of pathologic complete response (Abstract LBA18). (ascopost.com)
Mark M. Awad, MD, PhD, of Dana-Farber Cancer Institute, discusses phase III findings from the CheckMate 816 trial, which showed a potential clinical benefit to neoadjuvant nivolumab plus ipilimumab vs chemotherapy in patients with resectable non-small cell lung cancer (NSCLC) (Abstract 1261O). (ascopost.com)
As reported in The Lancet Oncology by Sun Young Rha, MD, and colleagues, the phase III KEYNOTE-859 trial has shown that the addition of first-line pembrolizumab to chemotherapy was associated with a statistically significant improvement in overall survival in patients with HER2-negative advanced. (ascopost.com)
Pembrolizumab2
Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial. (nature.com)
Jonathan D. Spicer, MD, PhD, of McGill University, discusses findings from the KEYNOTE-671 study of perioperative pembrolizumab for patients with resectable early-stage non-small cell lung cancer (NSCLC). (ascopost.com)
Anesthesia2
One hundred sixty perioperative cardiac arrests within 24 h of surgery were identified from an anesthesia database of 217,365 anesthetics. (cdc.gov)
Conclusion: As judged by an independent study commission, anesthesia-related cardiac arrest occurred in 37 of 160 cardiac arrests within the 24-h perioperative period. (cdc.gov)
Nurses10
Safety-related best practices for ASCs include guidance from the Association of periOperative Registered Nurses , the Society of Gastroenterology Nurses and Associates , and the American Society of PeriAnesthesia Nurses , she says. (healthleadersmedia.com)
In this specialty area, perioperative nurses care for patients from all age groups and work in various surgical subspecialties. (stlawrencecollege.ca)
Perioperative nurses are an integral part of the interprofessional team, caring for patients during their most vulnerable time, and advocating for them in the operating room when they cannot do so for themselves. (stlawrencecollege.ca)
Perioperative practical nurses must work well under pressure, multitask, and have strong teamwork skills. (stlawrencecollege.ca)
Students are introduced to the perioperative nurses professional association - the Operating Room Nurses' Association of Canada (ORNAC) and begin to understand how the association guides professional practice through the use of the ORNAC standards. (stlawrencecollege.ca)
The perioperative environment requires nurses to have detailed knowledge of surgical instruments and specialized equipment. (stlawrencecollege.ca)
Since the 1990s the Association of Perioperative Registered Nurses (AORN) has recommended the evacuation of all surgical smoke. (cdc.gov)
Mary J. Ogg, MSN, RN, CNOR, is a Senior Perioperative Practice Specialist with the Association of periOperative Registered Nurses (AORN). (cdc.gov)
These specialized nurses provide emotional support to patients and their families, closely monitor patients' well-being throughout the perioperative period, and facilitate the transition from the operating room to the recovery phase. (johnnyholland.org)
Neoadjuvant3
Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. (helsedirektoratet.no)
Short-course neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer: A multicenter randomized phase-II trial (NORPACT-1). (springermedizin.at)
Ze-rui Zhao, PhD, of China's Sun Yat-sen University Cancer Center, discusses new phase II findings on stereotactic body radiation therapy (SBRT) with sequential immunochemotherapy as a neoadjuvant treatment of patients with resectable non-small cell lung cancer (NSCLC). (ascopost.com)
Patient's4
The scope of activities during the preoperative phase includes the establishment of the patient's baseline assessment in the clinical setting or at home, carrying out preoperative interview and preparing the patient for the anesthetic to be given and the surgery. (nurseslabs.com)
R esponding to a patient's perioperative hypothermia is one thing. (aorn.org)
What problems does tolerance present in the management of this patient's perioperative pain? (medscape.com)
Patients27
In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
The number of patients is based on the median progression-free survival rate of 50% at 3 years observed in patients treated with GC (standard arm A) in the perioperative setting. (bcan.org)
The primary concern of perioperative care is to provide better conditions for patients before an operation (sometimes construed as during operation) and after an operation. (wikipedia.org)
Findings from a systematic review of perioperative advance care planning suggest the importance and value that various types of decision aids have for patients to clarify their goals and specify others who can make decisions for them in case of unexpected surgical difficulties. (wikipedia.org)
The goal of perioperative pulmonary management is to identify patients at high risk of significant postoperative pulmonary complications, so that appropriate interventions can be provided to minimize that risk. (medscape.com)
The present review will recapitulate the new mechanisms underlying the Heart-brain Axis (HBA) vulnerability during the perioperative period in healthy and morbidly obese patients. (benthamscience.com)
The perioperative management for these patients can be one of the following: continue warfarin therapy, withhold warfarin therapy for a period of time before and after the procedure, or temporarily withhold warfarin therapy and also provide a "heparin bridge" during the perioperative period. (medscape.com)
The greatest problem encountered is that no consensus exists regarding the optimal perioperative management of anticoagulation for patients who have been receiving long-term warfarin therapy. (medscape.com)
The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) study included 3007 patients with nonvalvular atrial fibrillation who were receiving long-term therapy with dabigatran, rivaroxaban, or apixaban. (medscape.com)
This article focuses on the perioperative management of patients with PH who present for noncardiac surgical procedures. (medscape.com)
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. (nih.gov)
The safety review committee for the phase 1/2 Acclaim-1 trial has ruled that the study evaluating quaratusugene ozeplasmid in combination with osimertinib in patients with advanced non-small cell lung cancer can proceed to the phase 2 expansion portion. (onclive.com)
As we move into the phase 2 expansion portion of the trial, we remain steadfast in our efforts to bring new therapies to lung cancer patients with unmet medical need. (onclive.com)
In phase 1, patients received quaratusugene ozeplasmid intravenously at doses of 0.06 mg/kg, 0.09 mg/kg, or 0.12 mg/kg once every 21 days plus 80 mg of osimertinib per day. (onclive.com)
In phase 2, patients will be randomly assigned to receive the RP2D of 0.12 mg/kg of IV quaratusugene ozeplasmid once every 3 weeks plus 80 mg of oral osimertinib per day or osimertinib monotherapy. (onclive.com)
Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie. (helsedirektoratet.no)
As with many aspects of the perioperative environment, a few small steps can make a major difference in order to keep patients comfortable, safe and - ultimately - satisfied. (aorn.org)
This research concerns perioperative recovery for patients undergoing major abdominal surgery. (figshare.com)
The first phase was to assess the feasibility of introducing fast track surgery in our unit by recruiting patients undergoing reversal of loop ileostomy so as to reduce hospital stay. (figshare.com)
The third phase, compared the use of video education in the psychological preparation of patients undergoing elective colorectal resection with information leaflets and verbal information. (figshare.com)
The fourth phase, compared short term outcomes between patients undergoing elective colorectal resection early in the week(Monday to Wednesday) with those later in the week(Thursday to Friday). (figshare.com)
The investigators enrolled 63 patients with planned radical prostatectomy for localized prostate cancer and randomized 56 to receive perioperative EPO or placebo. (medpagetoday.com)
This program offers online theory courses, simulation and real-world clinical experience, to provide the Registered Nurse with the necessary knowledge and skills to competently care for patients undergoing surgery in both the scrub and circulating role while working efficiently and effectively in the perioperative environment. (stlawrencecollege.ca)
NAPOLI-3: A randomized, open-label phase 3 study of liposomal irinotecan + 5‑fluorouracil/leucovorin + oxaliplatin (NALIRIFOX) versus nab-paclitaxel + gemcitabine in treatment-naïve patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). (springermedizin.at)
In a combined analysis of two Chinese phase II trials (RC48-C005 and RC48-C009) reported in the Journal of Clinical Oncology, Sheng et al found that the antibody-drug conjugate disitamab vedotin-an anti-HER2 antibody conjugated with monomethyl auristatin-produced promising results in patients with. (ascopost.com)
In the phase II TITAN-RCC trial reported in The Lancet Oncology, Grimm et al found that a strategy of nivolumab monotherapy with or without nivolumab/ipilimumab as an immunotherapeutic boost was associated with activity in patients with metastatic clear cell renal cell carcinoma. (ascopost.com)
Gastric1
Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. (helsedirektoratet.no)
Minimally invasive3
The aim of this observational study was to investigate the learning curve of one experienced surgeon introducing minimally invasive Oxford phase 3 UKA into his routine clinical practice. (springer.com)
The first 50 consecutive cases of minimally invasive Oxford phase 3 UKA performed by one surgeon were evaluated to determine whether there was an association between outcomes and the cumulative number of cases performed, indicating the presence of learning curve. (springer.com)
Minimally invasive Oxford phase 3 UKA for anteromedial osteoarthritis is a demanding procedure, but satisfactory outcomes can be achieved after approximately 25 cases. (springer.com)
Foreign to the general nursing population, these are the familiar work surroundings for the perioperative nurse. (medleague.com)
Students have the opportunity to reflect on continuing professional development and consider how they will support the future of perioperative nursing as well as lead clinical change. (stlawrencecollege.ca)
Placebo1
Perioperative treatment to preserve nerve function did not significantly improve erectile function after surgery for prostate cancer, a randomized, placebo-controlled study showed. (medpagetoday.com)
Care7
Perioperative care is the care that is given before and after surgery. (wikipedia.org)
Warming during this phase of care is not only important for inadvertent hypothermia prevention, but also a proven way to bolster patient satisfaction. (aorn.org)
As anesthesiologists, we see it as our responsibility to help mitigate this anxiety response as part of a comprehensive perioperative care plan. (ama-assn.org)
Students gain understanding of the perioperative nurse's role throughout all phases of care, with a focus on intra-operative care. (stlawrencecollege.ca)
Students apply the ORNAC standards as they learn the detailed roles of both the scrub and circulating nurse throughout the phases of care. (stlawrencecollege.ca)
It covers all phases of perioperative care, from the time people are booked for surgery until they are discharged afterward. (bvsalud.org)
In the transoperative phase, the well employed technical surgery and the meticulous perioperative care can minimize the frequency of complications and limit its gravity 1 . (bvsalud.org)
Postoperative5
This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
Perioperative may refer to the three phases of surgery: preoperative, intraoperative, and postoperative, though it is a term most often used for the first and third of these only - a term which is often specifically utilized to imply 'around' the time of the surgery. (wikipedia.org)
BACKGROUND: Since clinically relevant postoperative pancreatic fistula (CR-POPF) can cause intra-abdominal hemorrhage and abscesses, leading to surgery-related deaths after pancreaticoduodenectomy (PD), its preoperative prediction is important to develop strategies for surgical procedures and perioperative management. (bvsalud.org)
Although usual, the removal of these teeth may present possible complications in the postoperative phase, even when the proper recommendation and planning are employed. (bvsalud.org)
Thus, the goal of this article was to comprehend the mechanism, use and proper designation of the LLLT as an influencer of the clinical picture in the postoperative phase in SETMs, as well as the formulation of a usage protocol for surgeries in a University Dental Clinic in Santa Catarina. (bvsalud.org)
Versus1
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial. (nature.com)
Survival1
Progression-free survival (PFS) is the primary end point for the phase 2 portion. (onclive.com)
Surgery4
The process of caring for the patient continues during the intraoperative phase until the completion of surgery. (medleague.com)
Introduction: Major recent advances in modern surgery have focussed on processes and pathways relating to perioperative recovery. (figshare.com)
The second phase, compared laparoscopic colorectal surgery with open colorectal surgery with regards to hospital stay and complication rates. (figshare.com)
We continuously monitor your child at all phases of surgery and in recovery, making sure your child is safe, that we have answered any questions you have about your child's procedure and that you stay informed about your child's condition. (childrensnational.org)
Surgical procedures1
It offers advice for healthcare professionals on surgical procedures and en. (bvsalud.org)
Management2
One of the reasons for graft failure after renal transplantation is inadequate graft perfusion caused by mis-management of perioperative hydration policy. (intechopen.com)
Guidelines about perioperative management will be developed as the second phase of the study. (aofoundation.org)
Preoperative phase1
The preoperative phase is used to perform tests, attempt to limit preoperational anxiety and may include the preoperative fasting. (wikipedia.org)
Elective1
Objective -To study the effects of a synthetic, dog-appeasing pheromone (sDAP) on the behavioral, neuroendocrine, immune, and acute-phase perioperative stress responses in dogs undergoing elective orchiectomy or ovariohysterectomy. (avma.org)
Trial5
Full safety data from the phase 1 portion of the trial did not reveal any dose-limiting toxicities. (onclive.com)
We are proud of the notable progress we made during the phase 1 portion of the Acclaim-1 clinical trial, and the safety review committee recommendation to move into the phase 2 expansion portion of the trial is another validation for our [quaratusugene ozeplasmid] development program," Rodney Varner, chairman, president, and chief executive officer of Genprex, stated in a news release. (onclive.com)
Genprex receives safety review committee approval to advance to phase 2 expansion portion of Acclaim-1 clinical trial of Reqorsa in combination with Tagrisso in advanced non-small cell lung cancer. (onclive.com)
The ERECT trial progressed clinical evaluation of EPO in erectile dysfunction to the phase II setting. (medpagetoday.com)
Another frequently used regimen, nab-paclitaxel + gemcitabine, was evaluated in the global phase III MPACT trial. (jnccn.org)
Recovery1
The surgical extraction of third molars can result in potential complications such as pain, swelling and trismus, along with discomfort in the recovery phase. (bvsalud.org)
Subsequent1
Legal and ethical considerations, communication, and documentation standards are presented in this course to be built upon in subsequent perioperative courses. (stlawrencecollege.ca)
Prevention2
N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)
Students develop an understanding of foundational perioperative principles including patient safety, asepsis and infection prevention. (stlawrencecollege.ca)
Efficacy2
As HD-MVAC has been shown to be associated with higher response rates than MVAC in bladder metastatic disease, also a better efficacy of HD-MVAC can be suspected in the perioperative setting. (bcan.org)
Phase 2 will assess the efficacy of this combination. (rochester.edu)
OUTCOMES1
A podium presentation will feature noteworthy patient-reported outcomes from the registrational Phase 1b/2 EV‐103 Cohort K study. (businesswire.com)
Environment3
This course provides a foundational overview of the perioperative setting, including the design and flow of the perioperative environment, the roles and responsibilities of the perioperative nurse, an introduction to the interprofessional team, and an overview of different surgical modalities. (stlawrencecollege.ca)
Students learn about advancements in technology and are introduced to common equipment specific to the perioperative environment. (stlawrencecollege.ca)
In this final theory course, students learn about special considerations within the perioperative environment including specific patient populations and emergency events. (stlawrencecollege.ca)