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  • mice
  • Circadian PER1 protein expression was found to be retained in melatonin receptor double knockout mice with an increased amplitude as measured by semiquantitative Western blot analysis. (nih.gov)
  • contributes
  • 7 Given the critical role of ENaC in sodium transport and BP control, the results suggest that the clock contributes to circadian fluctuations in sodium excretion and BP. (ahajournals.org)
  • Insect
  • In haematophagous insect vectors the circadian clock coordinates feeding activity, which is important for the dynamics of pathogen transmission. (nih.gov)
  • temporal
  • These results define the temporal and spatial coordinates of factors that initiate Clk expression, imply that circadian photoreceptors are not activated until the end of embryogenesis, and suggest that PER functions in a different capacity before oscillator cell development is initiated. (nih.gov)
  • Because wound healing defects were also seen in multiple circadian clock-deficient mouse lines, our results therefore suggest that coupling of the cell cycle to the circadian clock via NONO may be useful to segregate in temporal fashion cell proliferation from tissue organization. (pnas.org)
  • Cells
  • A novel CLK antiserum is used to show that CLK expression in the larval CNS and adult brain is limited to circadian oscillator cells. (nih.gov)
  • Recent work from our group demonstrated that c-Src protein-tyrosine kinase activity triggers differentiation of mouse embryonic stem (mES) cells to primitive ectoderm-like cells. (nih.gov)
  • and enriched in potential linear binding motifs, protein-binding sites and post-translational modifications (PTMs) indicating its probable role in PTEN function and transport across cells. (queensu.ca)
  • Western blot analysis of extracts from 3T3 cells, treated with PMA (125ng/ml, 30mins), using Period Circadian Protein 2 (Phospho-Ser662) antibody. (genetex.com)
  • Western blot analysis of extracts from 3T3£-HeLa and K562 cells, using Period Circadian Protein 2 (Phospho-Ser662) Antibody. (genetex.com)
  • transcripts
  • Those transcripts included: Dlat (dihydrolipoamide S-acetyltransferase, the E2 compoment of the pyruvate dehydrogenase complex linking glycolysis to TCA cycle), Cs (citrate synthase in TCA cycle), and Cox18 (cytochrome c oxidase assembly protein 18). (nih.gov)
  • species
  • Next generation sequencing technologies will facilitate the study of vector genomes/transcriptomes both among and within species and illuminate some of the species-specific patterns of adaptive circadian phenotypes that are observed in the field and in the laboratory. (nih.gov)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • accumulate
  • and only the noncycling proteins accumulate as a function of adult age. (uni-muenster.de)
  • 2003). In the first loop, PER and TIM proteins start to accumulate in the cytoplasm at ZT12[zeitgeber time where ZT0 is lights on and ZT12 is lights off in a light/dark (LD)12:12cycle], about 6-8 h after their respective mRNAs. (nih.gov)
  • utilization
  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (nih.gov)