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  • lesions
  • Brain calcification in hypoxic-ischemic lesions: an autopsy review. (semanticscholar.org)
  • Further use of these MRI techniques and neurodevelopmental follow up will show the functional consequences of these brain lesions. (bmj.com)
  • Typical manifestations of these conditions are the presence of glutamate excitoxicity, neuroinflammation and oxidative stress, the combination of which can potentially result in apoptotic-necrotic cell death, generation of brain lesions and long-lasting functional impairment. (mdpi.com)
  • In fact, LPS pre-exposure has been reported to aggravate HI brain lesions in post-natal day 1 (P1) and P7 rat models that are respectively equivalent - in terms of brain development - to early and late human preterm newborns. (biomedcentral.com)
  • Interleukin-1 receptor antagonist (IL-1ra) reduced the extent of brain lesions confirming the involvement of IL-1β response in their pathophysiology. (biomedcentral.com)
  • Inflammation
  • Infection-inflammation combined with hypoxia-ischemia (HI) is the most prevalent pathological scenario involved in perinatal brain damage leading to life-long neurological disabilities. (biomedcentral.com)
  • Acute cell death, inflammation and oxidative stress were evaluated at 24 h by studying caspase-3 activity, MDA measurement as well as Iba-1 immunochemistry in the brain. (dxy.cn)
  • neonates
  • This represents an improvement over CWNIRS for detecting brain health, brain development, and response to therapy in neonates. (jove.com)
  • Studies have suggested that NGR1 may be a viable treatment of hypoxic-ischemic brain damage (HIBD) in neonates by reducing endoplasmic reticulum stress via estrogen receptors (ERs). (springer.com)
  • cerebral palsy
  • Perinatal ischemia is a common cause of cerebral palsy and other human morbidity. (unizg.hr)
  • Perinatal brain damage underlies an important share of motor and neurodevelopmental disabilities, such as cerebral palsy, cognitive impairment, visual dysfunction and epilepsy. (mdpi.com)
  • The NNNS is a noninvasive neonatal assessment tool with demonstrated validity as a predictor, not only of medical outcomes such as cerebral palsy diagnosis, neurological abnormalities, and diseases with risks to the brain, but also of developmental outcomes such as mental and motor functioning, behavior problems, school readiness, and IQ. (jove.com)
  • mice
  • Multiple imaging modalities were employed in the analysis, including magnetic resonance imaging (MRI), histological Nissl staining, as well as immunohistochemical staining of exvivo day three and seven postnatal mice brains. (unizg.hr)
  • In the present study, we determined whether intranasal, intraperitoneal or intracerebral treatment with a smaller TAT-OPN peptide is neuroprotective in neonatal mice with HI brain damage. (uu.nl)
  • University of Oregon neuroscientists report that two areas of the mouse brain combine representations of what is heard and anticipated, guiding behavior that leads mice to the best reward. (news-medical.net)
  • preterm
  • Since its introduction in early 1950s, electroencephalography (EEG) has been widely used in the neonatal intensive care units (NICU) for assessment and monitoring of brain function in preterm and term babies. (jove.com)
  • In the theoretical part, we will present animations to illustrate how a preterm brain gives rise to spontaneous and evoked EEG activities, both of which are unique to this developmental phase, as well as crucial for a proper brain maturation. (jove.com)
  • congenital
  • It has the first place in mortality in our country without considering perinatal pathologies and congenital malformations. (readbyqxmd.com)
  • genetic syndromes (such as Aicardi's syndrome and Down's syndrome), hypoxic or ischaemic brain damage, congenital infections, and trauma. (51digg.info)
  • endogenous
  • Hence, there is a dramatic need to develop new effective therapies aimed to prevent acute brain damage and enhance the endogenous mechanisms of long-term brain repair. (mdpi.com)
  • The brain has potent defenses against superoxide including dietary free-radical scavengers (ascorbate,α -tocopherol), the endogenous tripeptide glutathione, and enzymatic antioxidants. (biologists.org)
  • Expression of endogenous osteopontin (OPN), a multifunction glycoprotein, is strongly upregulated in the brain after neonatal HI. (uu.nl)
  • The capacity to release catecholamines within the CNS may play a pivotal role in endogenous protection to brain ischemia. (beds.ac.uk)
  • perfusion
  • Representative quantified ASL data showed that the mean density normalized perfusion was 8.86 ml/min/g during hypoxia, 8.26 ml/min/g during normoxia and 8.46 ml/min/g during hyperoxia, respectively. (jove.com)
  • Despite a recognized role of Laser Doppler perfusion monitoring as part of the current guidelines for experimental cerebral ischemia, a number of technical difficulties exist that limit its widespread use. (jove.com)
  • occlusion
  • Conclusion In our model of perinatal asphyxia induced by partial cord occlusion in premature lambs, the administration of higher doses of WIN55212 -2 produced transient hypotension with a cerebrovascular vasodilation. (bmj.com)
  • rats
  • To investigate the expression and significance of follistatin, activin A and bone morphogenetic protein-4 (BMP-4) in normal brain tissues of rats and the brain tissues with hypoxic and ischemicgin. (jove.com)
  • Here, we describe how to set up dissociated cultures of sympathetic neurons derived from the SCG of perinatal rats so that they are responsive to the selective dendrite-promoting activity of Matrigel or BMPs. (jove.com)
  • oxygen
  • Decreased oxygen to the fetal brain (cerebral anoxia): Certain complications of pregnancy or delivery can impair oxygen delivery to the fetal brain. (dailymirror.lk)
  • Whether similar oxygen fluctuations will create pathological changes in the grey and white matter of the brain is unknown. (jove.com)
  • Before being introduced in the hypoxia chamber, the air and the 10% oxygen mixture were humidified and heated to 36 °C with the heated water bath. (bio-protocol.org)
  • To better understand these processes, we are investigating the regulation and function of the hypoxia-inducible factor (HIF) family of transcription factors in neurons exposed to different oxygen tensions. (rochester.edu)
  • Some of these therapies are focused on prevention of the production of reactive oxygen species, anti-inflammatory effects, anti-apoptotic interventions and in a later stage, the stimulation of neurotrophic properties in the neonatal brain which could be targeted to promote neuronal and oligodendrocyte regeneration. (mdpi.com)
  • Brain-imaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) yield measures of cerebral glucose and oxygen metabolism, but these techniques require the administration of radionucleotides, so they are used in only the most acute cases. (jove.com)
  • We investigated the possibility of using more sophisticated NIRS optical methods to quantify cerebral oxygen metabolism at the bedside in healthy and brain-injured newborns. (jove.com)
  • Entorhino-hippocampal organotypic slice cultures challenged with oxygen and glucose deprivation (OGD) are established in vitro models which mimic cerebral ischemia. (jove.com)
  • neurodegenerative
  • We believe this new template may be important because it's showing different mechanisms of action-different ways to interact with neurons, possibly with a good therapeutic effect for such diseases as epilepsy, hypoxia-ischemia and several neurodegenerative disorders," said Alban Pereira, a postdoctoral researcher in Scripps' CMBB. (acronymfinder.com)
  • ALS is a progressive neurodegenerative disease that affects motor neurons (MNs) in the brain and the spinal cord. (huji.ac.il)