The human 4'-phosphopantetheine transferase is also capable of phosphopantetheinylation of peptidyl carrier and acyl carrier proteins from prokaryotes. (rhea-db.org)
Transferase center2
MRRF attaches to the large ribosomal subunit in the cleft which has a peptidyl transferase center. (prospecbio.com)
However, it is notable that in ribosomal RNA, many of the post-translational modifications occur in highly functional regions, such as the peptidyl transferase center and the subunit interface, implying that they are important for normal function. (wikidoc.org)
Peptide7
We have structurally characterized the final peptidyl carrier protein domain of the teicoplanin non-ribosomal peptide synthetase machinery: this domain is believed to mediate the interactions with tailoring Oxy enzymes in addition to its function as a shuttle for intermediates between multiple non-ribosomal peptide synthetase domains. (rcsb.org)
The structures exhibit the same general fold as the majority of known carrier protein structures, in spite of the complex biosynthetic role that PCP domains from the final non-ribosomal peptide synthetase module must play in glycopeptide antibiotic biosynthesis. (rcsb.org)
These structures thus support the hypothesis that it is subtle rearrangements, rather than dramatic conformational changes, which govern carrier protein interactions and selectivity during non-ribosomal peptide synthesis. (rcsb.org)
In this study, we confirmed that both GrmH and GrmL, which were shown to constitute a protein complex by a co-purification experiment, were required to catalyze the dehydration, epimerization, and proteolytic cleavage of a precursor peptide GrmA by in vivo experiments. (hokudai.ac.jp)
Copper-dependent metalloenzymes relevant to the clinical phenotype include tyrosinase (pigmentation of skin and hair), lysyl oxidase (elastin and collagen cross-linking), ascorbate oxidase (skeletal development), monoamine oxidase (possibly responsible for pili torti), superoxide dismutase (free-radical detoxification), dopamine beta-hydroxylase (catecholamine production), peptidyl-glycine alpha-amidating mono-oxygenase (bioactivation of peptide hormones), and cytochrome c oxidase (electron transport and possibly responsible for hypothermia). (medscape.com)
The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene . (wikidoc.org)
Peptides1
This technique has frequently been applied to animal tissue slices for the purpose to map proteins, peptides , lipids, sugars or small metabolites to find disease specific bio-markers or to study drag metabolism. (go.jp)
It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506 ) and SIROLIMUS . (nih.gov)
NCBI BLink1
Has 0 Blast hits to 0 proteins in 0 species (source: NCBI BLink). (yokohama-cu.ac.jp)
Ribosome2
MRRF controls the release of ribosome from messenger RNA at the termination of protein biosynthesis. (prospecbio.com)
a molecule of RNA is the catalyst for the peptidyl transferase reaction that takes place on the ribosome. (bartleby.com)
Escherichia4
Part of the gene encoding penicillin-binding protein 5 from Bacillus subtilis 168 was cloned in Escherichia coli with a synthetic oligonucleotide as a hybridization probe. (ox.ac.uk)
Assessing the conformational changes of pb5, the receptor-binding protein of phage T5, upon binding to its Escherichia coli receptor FhuA. (ibs.fr)
It is also a vital medium in protein synthesis because it is the main molecules in DNA translation and transcription (wiki, translation) (wiki, transcription). (bartleby.com)
One type of RNA acts as a messenger between DNA and the protein synthesis complexes known as ribosomes , others form vital portions of the structure of ribosomes, act as essential carrier molecules for amino acids to be used in protein synthesis, or change which genes are active. (wikidoc.org)
Molecule1
Search proteins in UniProtKB for this molecule. (rhea-db.org)
Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis. (go.jp)
Sequence1
A comparison of the predicted amino acid sequence with that of the E. coli penicillin-binding protein 5 indicated that these enzymes showed about 25% identity. (ox.ac.uk)
Polyketide1
These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
Bacterial1
LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
TRNA1
In a thermophilic bacteria, activated sulfur which bond to a sulfur-carrier protein TtuB [Fig. 2] is transferred to tRNA by a sulfur transferase. (go.jp)
Receptor4
ACE-2 is the SARS-CoV and SARS-CoV2 Spike protein receptor in vivo (4-6), functions catalytically as a carboxypeptidase to cleave several substrates including angiotensins I and II, and acts as a partner for B0AT1-family amino acid transporters (1, 2). (rndsystems.com)
METHODS: We report on a protein subunit vaccine comprising the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 spike protein, dimerised with an immunoglobulin IgG1 Fc domain. (bvsalud.org)
Protein of unknown function (DUF2511) [Interproscan]. (ntu.edu.sg)
Copper resistance protein D [Interproscan]. (ntu.edu.sg)
Bundle1
The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. (wikipedia.org)
Family1
Parvulins compose a family of small peptidyl-prolyl isomerases (PPIases) involved in protein folding and protein quality control. (birmingham.ac.uk)
Structures1
Unlike DNA, this structure is not just limited to long double-stranded helices but rather collections of short helices packed together into structures akin to proteins. (wikidoc.org)
Mechanism1
Thus EPA antagonizes loss of skeletal muscle proteins in cancer cachexia by down-regulation of proteasome expression, and this may also be the mechanism for inhibition of tumor growth. (aacrjournals.org)
Molecular1
After process membrane and during S mitosis, FANCD2 dissociates to viral such others that cycle with proteins taken in molecular type trans-membrane, neutral as BRCA1 and RAD51. (erik-mill.de)
Serine residue1
The enzyme is capable of transferring the 4'-phosphopantetheine moiety of coenzyme A to a conserved serine residue in both the acyl carrier protein domain of the human cytosolic multifunctional fatty acid synthase and the acyl carrier protein associated independently with human mitochondria. (rhea-db.org)
Ensembl1
Single stranded binding protein [Ensembl]. (ntu.edu.sg)
Coli1
It is one of the most abundant proteins in cells of E. coli. (wikipedia.org)
Recombinant4
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
2 μg/lane of Biotinylated Recombinant Human ACE-2 Fc Chimera Avi-tag Protein (Catalog # AVI10544) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at ~124 kDa under reducing conditions. (rndsystems.com)
Classification2
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
In case of proteins for which it is possible to identify the secondary structure, symbols are given in the Stride classification (e.g. (edu.pl)
Interaction2
We further demonstrate that this conformational diversity is an essential prerequisite for the directed movement of the 4'-PP cofactor and its interaction with externally acting proteins such as thioesterases and 4'-PP transferase. (rcsb.org)
Dynamic cellular events beyond genetic encodings, such as epigenetics, and intermolecular protein interaction, play critical roles in dictating cellular functions. (go.jp)
Enzyme3
The adenylation domain of the enzyme catalyzes the activation of L-arginine to (L-arginyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. (expasy.org)
BpsA contains an adenylation domain that recognises and sequentially binds two molecules of L-glutamine, an oxidation domain that is believed to oxidise each glutamine monomer, a peptidyl carrier protein domain that binds the phosphopantetheine moiety, and a thioesterase domain that cyclises each glutamine and releases the final bicyclic product from the enzyme. (wgtn.ac.nz)
The human enzyme, which is expressed mainly in the cytosolic compartment in a wide range of tissues, is a 329-residue, monomeric protein. (rhea-db.org)