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Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)
Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Below are the most recent publications written about "Proto-Oncogene Proteins p21(ras)" by people in Profiles. (uchicago.edu)

Platelet-Derived Growth Factor (PDGF) is a mitogenic peptide growth hormone carried in the alpha-granules of platelets and is released when platelets adhere to traumatized tissues. (rockland.com)
Platelet Derived Growth Factor-BB Recombinant Protein has been tested by biological activity and is suitable as a control for polyclonal or monoclonal anti-Platelet Derived Growth Factor-BB in immunological assays. (rockland.com)

Overexpression of c-sis causes tumorigenesis. (nih.gov)
Sepase is oncogene and overexpression is sufficient to induce mammary tumors in mice. (separase.com)
Overexpression of individual members of the ISG12 proteins lead to apoptosis in different cell types in culture. (au.dk)
Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (rush.edu)

This project focuses on how the type 1 interferon controlled family of Interferon Stimulated Gene 12 (ISG12) proteins are involved in regulation of programmed cell death (apoptosis). (au.dk)
The OAS proteins have a unique ability to produce 2'-5' Oligoadenylates (2-5A), which bind and activate the ribonuclease RNase L. The RNase L degrades cellular RNAs which in turn inhibits protein translation and induces apoptosis. (au.dk)
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (rush.edu)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)

As proven by detection of nuclear Smad proteins, the TGFB and BMP signaling pathways are lively in many cells of the growth plate and they are controlled by tight temporal and regional patterns of expression of your components in the TGFB superfamily and of their receptors. (sirnalibrary.com)
Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)

As plant genetic engineering has "advanced" the crucial active domains of toxins, and enzyme are "improved" to such an extent that the gene for the original source protein is hardly recognizable. (i-sis.org.uk)

Antimicrobial peptides (AMPs) are an emerging category of therapeutics exerting a wide range of biological activities such as anti-bacterial, anti-fungal, anti-parasitic and anti-tumoral. (unav.edu)

OSM stimulated a rapid and transient increase in c-Fos mRNA and nuclear protein that coincided with complex 2 formation. (uea.ac.uk)
Post-transcriptional regulation of gene expression: Role of AU-rich Element binding proteins in rotaviral mRNA translation, and cellular RNA splicing and polyadenylation. (edu.in)
We therefore asked what role JMJD1B plays in newly synthesized histone maturation by exploiting the knockdown of JMJD1B by treating HeLa cells with siRNA against JMJD1B (siJMJD1B) and observed the reduction of both JMJD1B protein on cytosolic extracts (Fig. 1 b) and mRNA levels (Fig. 1 c) 72 h after the treatment. (biomedcentral.com)
At the ribosome, the processed mRNA is translated to produce proteins from amino acid units. (cdc.gov)

Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. (bvsalud.org)
Although OSM and IL-6 induced STAT (signal transducers and activators of transcription) factors to bind a high affinity Sis-inducible element DNA probe, binding to homologous TIMP-1 promoter sequences was not detected. (uea.ac.uk)
The early promoter initiates production of a large pre-messenger RNA from which messages containing exons and introns are then spliced to generate each of the early proteins. (ga-nz.com)
The other viral promoter initiates production of pre-messenger for structural proteins L1 and L2, which also contain exons and introns, and are similarly spliced prior to translation of the messenger RNA into protein. (ga-nz.com)

Integration disrupts a viral transcription regulatory protein that controls the production of the cancer proteins, leading to their continual and enhanced production [3] ( Recombinant Cervical Cancer Vaccines , SiS 29). (ga-nz.com)

The synonymous codons were assumed to be neutral and to have no effect on the transgenic proteins, and presumed to be safe [2] ( Bt Toxins in Genetically Modified Crops: Regulation by Deceit , SiS 22). (i-sis.org.uk)
Thus, our study provides new mechanistic insights into the regulation of axin protein homeostasis and presents new avenues for targeted Wnt pathway therapies. (plasignaling.com)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
Such transition between active and inactive forms allows for them to serve as molecular switches and to make G proteins suitable for the regulation of a wide range of cellular processes such as signal transduction, cytoskeletal reorganizations, vesicular transport and protein synthesis [ 4 ]. (biomedcentral.com)

The late genes encode the two structural proteins L1 and L2 of the virus capsid. (ga-nz.com)

The identified localization signals can putatively be used for targeting specific proteins and drugs to the inner mitochondrial membrane. (au.dk)

Until the current decade, synonymous mutations were assumed to be neutral, with no effect on the protein or any other functions of the organism. (i-sis.org.uk)
Synonymous mutations may lead to changes in protein folding related to translation pausing, RNA splicing, and alterations in enzyme specificity [1]. (i-sis.org.uk)
Synonymous mutations may lead to ribosome stalling, thereby changing protein folding pathways affecting enzyme activity or antigenicity [5]. (i-sis.org.uk)
It is now clear that synonymous mutations are not neutral but instead frequently adversely affect the proteins encoded. (i-sis.org.uk)
It is reasonable to assume that the synonymous mutations may have created proteins with adverse phenotypes and contributed to the deterioration in public health, and this must now be thoroughly investigated together with mandatory labelling of GM products. (i-sis.org.uk)
Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)

Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)

Some virus proteins function as oncoproteins, transforming the epithelial cells to a precancerous state. (ga-nz.com)

with integration hot spots in chromosome regions homologous to the oncogene E5 of HPV or the structural protein L2 [4]. (ga-nz.com)

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
G proteins constitute a large superfamily of regulatory proteins that show a high similarity in primary structure and organization of the functional center [ 1 - 3 ]. (biomedcentral.com)
The superfamily of G proteins includes three main classes: Ras-like GTPases, G α subunits of heterotrimeric G proteins, and the translation elongation factors. (biomedcentral.com)

It should also be noted that the safety and efficacy of HPV vaccines have been controversial from the start (see [1] The HPV Vaccine Controversy and other articles in the series, SiS 41). (ga-nz.com)

Our study uncovers a new mechanism that controls axin protein stability and Wnt pathway signalling, and its therapeutic exploitation holds promise for treating Wnt-pathway- dependent cancers. (plasignaling.com)

The early genes include those involved in virus replication and transcription along with the oncogenes for cancer development. (ga-nz.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
In addition, proteins with the corresponding master regulatory pathways had been analyzed. (pkc-inhibitors.com)
Bone morphogenic protein and transforming development component B signaling is one of the crucial pathways controlling chondrogenic differentiation while in the ordinary growth plate. (sirnalibrary.com)

A DNA-binding protein that consists of 5 polypeptides and plays an essential role in DNA REPLICATION in eukaryotes. (childrensmercy.org)

In addition, we are engaged in uncovering a signal transduction pathway initiated by the vitamin folic acid leading to activation of the oncogene STAT3. (au.dk)
The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. (uchicago.edu)

The HPV genome consists of 8 genes coding for proteins and a non-protein-coding region with regulatory genes. (ga-nz.com)
Additional regulatory proteins are often required to induce the conformational changes that occur during this cycle: guanine nucleotide exchange factors, which catalyze release of bound GDP and promote its replacement by GTP, and GTPase-activating proteins, which accelerate GTP hydrolysis. (biomedcentral.com)
E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
[ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)

Our current research focuses on how to inhibit cancer cell proliferation and the activation of the oncogene Signal Transducer and Activator of Transcription 3 (STAT3) via the cancer-specific Folate Receptor. (au.dk)

The activities MPS1 and Bub1 Kinase respectively locate the SGO2 in the meiosis I preferably at the centromera and the pericentromer, indicating that SGO2 at the centromera is required for protection.in Meiosis I Centromeric Cohesin is protected by SGE2 from the mediation cleavage of Sepase ensuring that sister chromatics are maintained together until they separation in meiosis II. (separase.com)
Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)

ESPL1 / separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. (separase.com)

This was confirmed and further expanded by observations of Patel and Gordon, who discovered that p210BCR ABL and c ABL are each centrosome connected proteins capable of binding to pericentrin, a protein of your pericentriolar matrix. (pkc-inhibitors.com)

The mice with Knockout Ricor also showed an aberrant location of the BTB associated proteins, which were dispersed over the entire seminiferous epithelium, but the expression levels of the protein remained stable. (separase.com)

We want to identify the peptide sequences in ISG12 responsible for this cellular localization. (au.dk)

Sepased, an enzyme that solves the cohesion of sister chromatids during the transition of metaphase-to-anaphase, plays a central role in chromosomal segregation and cell division. (separase.com)
As a result, in contrast to the localization of the release of the transient Kinetochore from Mitosis Bub1, Meiother Bub1 survive in Kinetochores to Anafase I. Pond Bub1 Meiotic ensured the protection and protection of strong cohesion in the centromeres by working with Heterocromatin Swi6 protein, which binded and stabilized SGO1. (separase.com)
Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. (separase.com)
Disengagement of mom and daugther centriole is usually a prerequisite for centriole duplication and it is offered by proteolytic cleavage of cohesin, a,glue, protein complex that is certainly also responsible for sister chromatide cohesion. (pkc-inhibitors.com)

When found in gene protein coding regions, SNPs can be synonymous, i.e., causing no change in the amino acid encoded, or non-synonymous, when the amino acid is altered. (i-sis.org.uk)
What does this gene/protein do? (cancerindex.org)

Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)

Cellular DNA-binding proteins encoded by the sis gene ( GENES, SIS ). (nih.gov)
Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

It catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome in a GTP-dependent manner during protein synthesis, although it also seems to play a role in other non-translational processes. (biomedcentral.com)

A main characteristic of meiosis is the removal of step-by-step cohesin of cohesin, the protein complex holding sister chromatids together, first of all weapons in meiosis I and then the centromere region of Méiose II. (separase.com)

Ki 67 and sepaase expression levels were detected with immunofluorescence assay and BTB-associated protein expression levels were detected with immunofluorescence and Western blots. (separase.com)
The tecniques employed in the research projects cover mammalian cell culture and baculovirus expression combi-ned with molecular biological analyses of proteins, RNA and DNA as well as analyses of tissue samples. (au.dk)
In this examine, we set out to analyze the quick expression effects of IM to the,oncogene, separase in BCR ABL beneficial and adverse cells. (pkc-inhibitors.com)
We report on separase transcription, protein expression, and Separase proteolytic activity. (pkc-inhibitors.com)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. (childrensmercy.org)

Amyloid Beta Peptide Is an Endogenous Negative Allosteric Modulator of Leptin Receptor. (u-paris.fr)
The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)

Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
In fact, Wnt signallingitselfregulatesthelevelofaxinatseveralsteps,with AXIN2 being a major transcriptional target of the b-catenin-T-cell factor (TCF) com- plexandWntsignallingpromotingthedegradationofaxin12,13.However, the molecular mechanisms that regulate protein homeostasis of destruc- tion complex components and complex assembly remain elusive. (plasignaling.com)
The E7 cancer gene produces a protein that inactivates the retinoblastoma gene - a cancer suppressor gene - of the host cell, thereby promoting cancer [5]. (ga-nz.com)
The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (rush.edu)

All current GM crops use protein coding genes from bacteria that have been altered by introducing synonymous codons, replacing plant-preferred codons for the bacterial codons in order to enhance the production of protein from the transgenes. (i-sis.org.uk)
Instead the original proteins produced in bacteria were used as surrogates in feeding trials. (i-sis.org.uk)

Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

It is the second-most abundant protein after actin, comprising 1-3% of the total protein content in normal growing cells [ 7 , 8 ]. (biomedcentral.com)

The leishmanicidal activity of two synthetic anti-lipopolysaccharide peptides (SALPs), so-called 19-2.5 and 19-4LF was characterized in Leishmania major. (unav.edu)

The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)

However, the toxicity of the transgenic proteins in animals and humans was not studied. (i-sis.org.uk)
In vitro, both peptides were highly active against intracellular Leishmania major in mouse macrophages without exerting toxicity in host cells. (unav.edu)

In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
A key feature of oncogene activity is that a single altered copy leads to unregulated growth. (cancerquest.org)
Ectopic activation of Separase proteolytic activity brings about premature sister chromatide separation and centriole disengagement. (pkc-inhibitors.com)

Anatomy14

Organisms14

Diseases6

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes56

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science3

Health Care1

Proto-oncogene5

Platelet-Derive2

Overexpression4

Apoptosis5

Receptors2

Genetic1

Antimicrobial1

MRNA4

Promoter4

Viral1

Regulation4

Genes encode1

DRUGS1

Mutations7

Phosphorylation2

Structural proteins1

Epithelial1

Homologous1

Superfamily3

Vaccines1

Stability1

Virus replication1

Pathways3

Replication1

Signal transduction2

Regulatory4

Activator1

Kinase3

Mitotic sister chromatid1

Centrosome1

Mice1

Sequences1

Cohesion4

Gene protein2

Mesh1

Cellular3

Ribosome1

Cohesin1

Expression6

Receptor2

Cell8

Bacteria2

Inhibitors1

Actin1

Synthetic1

Regulate1

Toxicity2

Activity3