Peptides and peptide mimics. Medical search. Frequent questions

The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported - demonstrating a potential pathway to synthetic analogues of lasso peptides. (rsc.org)
This compound is a synthetic analogue of the peptide hormone somatostatin and it is used to treat acromegaly (a condition where the body produced too much growth hormone). (wikipedia.org)
Antimicrobial peptides are promising agents for the treatment of bacterial infections and recent studies indicate that Pep19-2.5, a synthetic anti-lipopolysaccharide (LPS) peptide (SALP), efficiently neutralises pathogenicity factors of Gram-negative (LPS) and Gram-positive (lipoprotein/-peptide, LP) bacteria and protects against sepsis. (nature.com)
PNAs are synthetic DNA, or RNA, mimics that consist of nucleobases attached to a polyamide backbone. (pr.com)

Peptides are amino acids that are the building blocks of certain proteins needed by the skin, like collagen and elastin. (glowinggorgeous.com)
Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases. (wikipedia.org)
We report the observation of intermediate structures in the self-assembly of the peptide KFE8 (FKFEFKFE), designed with alternating polar and nonpolar amino acids. (acs.org)
This demonstrates that the synthesis of peptides sized 100-200 amino acids is not beyond the capabilities of our current PeptideSyn technology. (pr.com)
100 amino acids, with the longest peptide it has made to date being 169 amino acids. (pr.com)

The most important use of natriuretic peptides is in helping to establish the diagnosis of heart failure (HF) in a patient in the urgent care setting in whom the diagnosis is uncertain. (medscape.com)
The single most validated and established use of natriuretic peptides remains the diagnosis of CHF but, as discussed below, other conditions are increasingly being recognized in which natriuretic peptides may have a role. (medscape.com)
Natriuretic peptides are also being used to evaluate valvular heart diseases. (medscape.com)

We previously reported the isolation of five GD2-mimicking peptides from the LX-8 phage display library with the monoclonal antibody (mAb) 14G2a. (edu.pl)
In addition we demonstrate that the phage environment was involved in the process of selection of our peptides. (edu.pl)
We can conclude that our findings add to the knowledge on factors governing selections of peptide mimetics from phage-display libraries. (edu.pl)

The Prelude system enabled us to quickly design and optimize the synthesis of the peptide mimics of the ebolavirus N-trimer," he said. (genengnews.com)
This work reports the synthesis of a known osteoprotegerin peptide analogue, YCEIEFCYLIR (OP3-4), and its tagging with a gadolinium chelate, a standard contrast agent for magnetic resonance imaging. (brighton.ac.uk)
This work reports the synthesis of aknown osteoprotegerin peptide analogue, YCEIEFCYLIR (OP3-4), and its tagging with a gadoliniumchelate, a standard contrast agent for magnetic resonance imaging. (brighton.ac.uk)
LifeTein was awarded the fastest peptide synthesis service in 2021 by New world Report, thanks to their speedy custom protein, antibody, and chemical services for biotech, pharma, academia, government customers, and diagnostics. (pr.com)
LifeTein provides the fastest turnaround time and most reliable quality in the industry, using their proprietary microwave-assisted heating technology for peptide synthesis. (pr.com)
Regarded as the fastest peptide synthesis service in 2021 by New World Report, LifeTein also provides custom protein, antibody, and chemical services for biotech, pharma, academia, government customers, and diagnostics. (pr.com)
Being recognized as the Fastest Peptide Synthesis Service is a tremendous honor for LifeTein. (pr.com)
LifeTein's primary focus is peptide synthesis service. (pr.com)
The company has developed proprietary PeptideSyn technology, which provides a platform for continuous peptide synthesis using Fmoc and Boc chemistry, microwave technology, and a proprietary solid support resin. (pr.com)
The company takes great pride in this acknowledgement of the speed of its peptide synthesis as well. (pr.com)
Peptidomimetic oligomers can frequently be synthesized using efficient solid phase synthesis procedures similar to peptide synthesis. (nih.gov)

A complex of 5 bio-identical peptides - Visibly improve skin elasticity, rejuvenation and moisturization while reducing wrinkles and fine lines. (glowinggorgeous.com)

With half-lives of some peptides and proteins only being a few minutes, they are very ineffective in drug delivery. (wikipedia.org)
Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation CHEMISTRY-A EUROPEAN JOURNAL. (nottingham.ac.uk)
There, the peptides are attached to MHC class I proteins. (medlineplus.gov)
Because there are no peptides for MHC class I proteins to bind, they are broken down, which results in a shortage of MHC class I proteins on the surface of cells. (medlineplus.gov)
Mutations in another gene involved in the attachment of peptides to MHC class I proteins very rarely cause BLS I. (medlineplus.gov)

These findings provide novel insights into how peptidases control synaptic activity within the amygdala and presents restoration of endogenous peptide activity during withdrawal as a viable option to mitigate withdrawal-induced disruptions in emotional learning circuits and rescue the relapse behaviors exhibited during opioid withdrawal and beyond into abstinence. (jneurosci.org)
For over two decades, Artur Schmidtchen and his research group have studied endogenous peptides, smaller protein fragments in the body with the ability to both kill bacteria and neutralize the bacterial toxins released during an infection. (lu.se)

Using a serum or moisturizer that contains peptides can lead to firmer, younger-looking skin, and maybe even fewer breakouts. (glowinggorgeous.com)
This serum has high-performance concentrate with a signature blend of five peptides that work together to refresh and renew skin as it firms, smooths, and hydrates. (glowinggorgeous.com)
Especially now as we are transitioning into our fall routine, you can add peptides either in serum, toner or moisturizer form and they'll definitely keep your skin moisturized. (glowinggorgeous.com)
It's light weight and packed with powerful peptides, this clinical grade serum works quickly and over time to increase firmness and elasticity, diminish fine lines and wrinkles and help improve the skin barrier. (glowinggorgeous.com)
BareMinerals STRENGTH & LENGTH Serum-Infused Mascara is made with a plant-powered vegan serum with Red Clover Flower and peptides, proven to strengthen and enhance for visibly longer, healthier lashes over time. (ulta.com)

As a result, the RBD peptide was used for monoclonal antibody production and the antibody was successfully made and licensed to a reputable pharmaceutical company. (pr.com)

Coordinadora del grup d'investigació "Biomimetic Supramolecular Chemistry and Materials", desenvolupa la seua activitat investigadora en el àmbit dels materials orgànics supramoleculars amb especial interés en els materials biomimetics i en la seua aplicació en biomedicina i en catàlisi. (uji.es)

peptide therapeutics mimic such functions. (wikipedia.org)
Peptide Therapeutics are seen as relatively safe and well-tolerated as peptides can be metabolized by the body. (wikipedia.org)

Peptidomimetics are classes of molecules that mimic structural and functional attributes of polypeptides. (nih.gov)

We evaluated survivin peptides with predicted binding to human HLA-A*0201 antigen using peptide-loaded dendritic cells from PBMC of patients with these malignancies. (elsevierpure.com)
We compared the ability of autologous dendritic cells loaded with SVN53-67 peptide and SVN53-67/M57 in CTL assays against allomatched and autologous, survivin-expressing, human malignant glioma and PCNSL cells. (elsevierpure.com)
In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)

The use of peptide mimics as drug targets played a key role in the development of treatments for HIV, and we believe this approach can be applied to the treatment of Ebola," pointed out Dr. Kay, who added that the team relied on a peptide synthesizer from Tucson-based Protein Technologies to carry out the research. (genengnews.com)
The corresponding region of the human survivin molecule represented by peptide SVN53-67 is 100% homologous to the murine protein, but SVN53-67 is weakly immunogenic in man. (elsevierpure.com)
The AAEGD sequence taken from the viral major coat protein, p8, and added to the C-termini of the peptides \#65, \#85 and \#94 significantly improved their binding to the mAb, 14G2a. (edu.pl)
Using patch-clamp electrophysiology in brain slices prepared from male rats, we reveal that opioid withdrawal abruptly reduces the ability of these peptides to inhibit neurotransmission, a direct consequence of a protein kinase A (PKA)-driven increase in the synaptic activity of peptidases. (jneurosci.org)
By mimicking the natural structure of peptides from the protein thrombin, researchers have designed a peptide-based treatment, sHVF18. (lu.se)
moves (transports) protein fragments (peptides) from foreign invaders into the endoplasmic reticulum. (medlineplus.gov)

In a study the researchers demonstrate how they, by mimicking a substance naturally present in the body, can neutralize toxic substances from bacteria and thereby mitigate harmful inflammation that could otherwise lead to sepsis. (lu.se)
The peptides´ functions are crucial - if the infection and inflammation are not contained, it can lead to sepsis. (lu.se)

Here, we present expansions to the ROSETTA platform that enable structure prediction and design of five non-peptidic oligomer scaffolds (noncanonical backbones), oligooxopiperazines, oligo-peptoids, [Formula: see text]-peptides, hydrogen bond surrogate helices and oligosaccharides. (nih.gov)

In agreement with previous studies, both peptides, as well as their equimolar mixture, were found to remain upon adsorption in a surface-aligned topology and to induce significant membrane perturbation, as evidenced by membrane thinning and hydrocarbon order parameter changes in the vicinity of the inserted peptide. (muni.cz)
Thus, SVN53-67/M57 may act as a peptide mimic to induce an enhanced antitumor CTL response in tumor patients. (elsevierpure.com)
Antimicrobial peptides (AMPs) are a class of promising antibiotic molecules as they present broad action spectrum, potent activity, and do not easily induce resistance. (frontiersin.org)
Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)

Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions. (muni.cz)
By application of analogs with amino acid substitutions and sequence truncations, we elucidated the structure-activity relationships necessary for the interactions between the 14G2a mAb and the peptide \#94 (RCNPNMEPPRCF). (edu.pl)

A collaborative team led by Debra Eckert, Ph.D., research assistant professor of biochemistry, and Michael S. Kay, M.D., Ph.D., professor of biochemistry, have identified a peptide sequence that is conserved in all known species of Ebola and is thought to control the virus' entry into human cells. (genengnews.com)
Additionally, we significantly optimized binding of the leading peptide sequence \#94 to the mAb 14G2a. (edu.pl)
Affinity studies confirmed that the HCDR3 peptides containing the sequence YDVPDY and Gly104 had affinities in the nanomolar range (K d = 7.6 nM) comparable to the HA epitope. (lih.lu)
Peptide-Membrane Binding: Effects of the Amino Acid Sequence. (acs.org)

This peptide complex increases the elasticity of the skin around the eyes by 40% and helps to eliminate spider veins. (smorodinanatural.com)

These effects were particularly pronounced for the so-called synergistic mixture of 1:1 (mol/mol) L18W-PGLa/MG2a and cannot be accounted for by a linear combination of the membrane perturbations of two peptides individually. (muni.cz)

The goal of our current study was to analyze and optimize the binding of the peptide mimetics to the mAb 14G2a. (edu.pl)

Further insight into how self-assembly and peptide hormones are related has been provided by studies on self-assembling amyloid structures formed by peptide hormones and neuropeptides. (wikipedia.org)

Reduced peptide control of neurotransmission in the amygdala shifts the excitatory/inhibitory balance of inputs onto accumbens-projecting amygdala cells involved in relapse. (jneurosci.org)
This likely disrupts peptide-dependent emotional learning processes in the amygdala during withdrawal and may direct behavior toward compulsive drug use. (jneurosci.org)

PEGylation is the attachment of polyethylene glycol (PEG) chains to the peptide via covalent bonds, helping to increase molecular weight, and limit enzymatic degradation as a result of steric hindrance caused by adding the PEG. (wikipedia.org)

These peptides have also proven to be powerful tools in managing the harmful inflammatory response that occurs in the body as a result of the infection. (lu.se)

This exchange rate increased significantly in peptides with bulky R-groups (phenylalanine) between the cysteine and histidine. (elsevierpure.com)

Find that Viral miRNAs Mimic Human. (genengnews.com)

In patients with a prior diagnosis of heart failure, knowledge of optivolemic natriuretic peptide values is important when interpreting elevated levels of these molecules. (medscape.com)

N- and O-glycosylation in which carbohydrates are attached to the peptide are naturally occurring, where N-glycosylation occurs through the amine group of an asparagine residue to form an amide bond. (wikipedia.org)

It contains a peptide complex of natural origin which is based on dipeptides: carnosine and anserine. (smorodinanatural.com)
Mutations in the TAP1 or TAP2 gene prevent formation of the TAP complex, which impairs the transport of peptides into the endoplasmic reticulum. (medlineplus.gov)

Taken together, the experimental results and the in silico data allowed us to probe in detail the mechanism of the molecular mimicry of GD2 by the peptides. (edu.pl)

The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses. (elifesciences.org)
When these immune system cells recognize the peptides as harmful, they launch an immune response to get rid of the foreign invaders. (medlineplus.gov)

Self-Assembly of Block Heterochiral Peptides into Helical Tapes. (acs.org)

We evaluated several amino acid substitutions in putative human MHC I anchor positions in SVN53-67 to identify potential peptide mimics that could provide an enhanced antitumor immune response against human glioma and primary central nervous system lymphoma (PCNSL) cells in culture. (elsevierpure.com)

Another chemical modification is the attachment of glycosyl (carbohydrate) units to the peptide to help with peptide delivery to target sites. (wikipedia.org)

Now, drawing inspiration from the body's own defence mechanisms based on peptides, we have developed a new approach to treating severe bacterial infections", says Artur Schmidtchen, professor in dermatology and venereology and senior consultant at Skåne University Hospital, who led the study. (lu.se)

Cationic steroid antibiotics (CSA)-13, a nonpeptide mimic of antimicrobial peptides with antibacterial activity on planktonic cultures, was evaluated for its ability to interact with sessile cells. (montana.edu)

Researchers at the University of Utah are working on using peptide mimics as drug target surrogates to develop new treatments for Ebola. (genengnews.com)
This peptide mimic can be used as a target to identify new drug treatments to control the Ebola virus, according to the investigators. (genengnews.com)

Peptide hormones and neuropeptides form dense-cored aggregates that pack into dense-core vesicles (DCVs), which are used to temporarily store peptide messengers in secretory cells. (wikipedia.org)

We addressed the onset of synergistic activity of the two well-studied antimicrobial peptides magainin 2 (MG2a) and PGLa using lipid-only mimics of Gram-negative cytoplasmic membranes. (muni.cz)
The early onset of dimerization of L18W-PGLa and MG2a at low peptide concentrations consequently appears to be key to their synergistic dye-releasing activity from lipid vesicles at high concentrations. (muni.cz)

Avoiders exhibited higher CRF peptide levels in CeA that did not appear to be locally synthesized. (nature.com)
The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines for managing heart failure have incorporated using natriuretic peptide levels in establishing the prognosis and disease severity of chronic heart failure and acutely decompensated heart failure. (medscape.com)

In this study, peptides containing a cysteine thiol and histidine imidazole group were designed to mimic the active site of the cysteine protease papain. (elsevierpure.com)

We have identified a survivin peptide mimic containing human MHC class I epitopes and a potential class II ligand that induces a potent antitumor response in C57BL/6 mice with GL261 cerebral gliomas. (elsevierpure.com)

Peptides are generally considered safe, and while they're a promising skin care ingredient, more research is needed on their efficacy. (glowinggorgeous.com)

Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations. (acs.org)

As a result of this, increasing the size of a peptide drug is a good starting point to improve half-life. (wikipedia.org)
Drug-Embedded Nanovesicles Assembled from Peptide-Decorated Hyaluronic Acid for Rheumatoid Arthritis Synergistic Therapy. (acs.org)

Peptide mimetics are novel approaches in the design of antigens for vaccine development. (edu.pl)

Anatomy13

Organisms12

Diseases3

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology1

Phenomena and Processes61

Disciplines and Occupations4

Technology, Industry, Agriculture6

Information Science4

Health Care2

Synthetic4

Amino acids5

Natriuretic Peptides3

Phage3

Synthesis11

Reducing wrinkles1

Proteins5

Endogenous2

Serum5

Monoclonal antibody1

Chemistry1

Therapeutics2

Polypeptides1

Dendritic cells3

Protein6

Sepsis2

Hydrogen bond1

Induce4

Interactions2

Sequence4

Elasticity1

Membrane1

Optimize1

Structures1

Amygdala2

Molecular weight1

Proven1

Significantly1

Viral1

Molecules1

Naturally1

Complex2

Mechanism1

Recognize2

Self-assembly1

Immune response1

Attachment1

Bacterial1

Ability1

Target2

Cells1

Activity2

Levels2

Study1

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Drug2

Design1