• In a series of papers that followed, many of them also in PNAS, additional code associations were made by using RNA polymers of mixed composition to program radioactive peptide synthesis (1 radiolabeled and 19 unlabeled amino acids). (pnas.org)
  • A strain encoding eRF1 lacking the C-terminal 32 amino acids is not viable, whereas deletion of the C-terminal 19 amino acids is viable but shows a termination defect in vivo causing an enhancement of nonsense suppression. (elsevier.com)
  • Synthetic peptide, corresponding to a region within amino acids 200-250 of Human ZNF787 in entry NP_001002836.2. (abcam.cn)
  • Translation requires the specific attachment of amino acids to tRNAs by aaRS and subsequent delivery of aa-tRNAs to the ribosome by elongation factor. (mdpi.com)
  • He also initiated research on the nonribosomal synthesis of linear and cyclic (antibiotic) peptides by specifically arranged multienzyme complexes with pantetheine at its active center and on the milieu dependence of the chemical phosphate potential of phosphorylated amino acids in phosphoproteins. (encyclopedia.com)
  • Amino acids are joined to form unbranched polypeptides by a peptide bond. (slideserve.com)
  • This is proposed to have occurred as a result of a short peptide insertion (37 amino acids in length), which facilitates the formation of the bond between the mitochondrial ribosome and mtIF2. (news-medical.net)
  • Furthermore, nonsense suppression assays have shown that overexpression of Rli1 is able to compensate for the inefficient termination caused by certain release-factor mutations, although it is unknown whether this is due to the recycling activity of Rli1 or to a distinct activity ( 20 ). (pnas.org)
  • Reverse Transcriptase enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough. (nih.gov)
  • The resulting EF-Tu·GDP needs to be recycled by its guanine-nucleotide exchange factor, EF-Ts, which promotes the exchange of GDP with GTP thus enabling a new round in the elongation cycle to take place. (au.dk)
  • Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. (string-db.org)