Peptide induces. Medical search. Frequent questions

Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities. (wikipedia.org)
Delta-sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. (wikipedia.org)
In another study delta-sleep-inducing peptide stimulated acetyltransferase activity through α1 receptors in rats. (wikipedia.org)
DELTA-SLEEP-INDUCING PEPTIDE (DSIP) was founded in 1989 by Dieter Mauson + Siegmar Fricke. (clongclongmoo.org)
Delta Sleep-Inducing Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "Delta Sleep-Inducing Peptide" by people in this website by year, and whether "Delta Sleep-Inducing Peptide" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Delta Sleep-Inducing Peptide" by people in Profiles. (wakehealth.edu)

Dicentracin-like from asian sea bass fish and moronecidine-like from hippocampus comes: two candidate antimicrobial peptides against leishmanina major infection. (celljournal.org)
Hoskin DW, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. (celljournal.org)
Antimicrobial peptides, nanotechnology, and natural metabolites as novel approaches for cancer treatment. (celljournal.org)
Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications. (celljournal.org)
Aroylated phenylenediamines (APDs) are novel modulators of innate immunity with respect to enhancing the expression of antimicrobial peptides and maintaining epithelial barrier integrity. (researchgate.net)

Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon -like peptide-1 receptor. (ncbcs.org)
Activation of the glucagon-like peptide-1 receptor (GLP-1R) upon ligand binding results in the discharge of insulin from pancreatic cells. (ncbcs.org)
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)

In the present study, we examined the effects of H. erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. (nih.gov)
Mice were administered 10 µg of amyloid β(25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. (nih.gov)
The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide. (nih.gov)
Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42). (ncbcs.org)
Accumulation and deposition of amyloid beta peptide (Abeta) within the mind causes neuronal apoptosis and finally results in Alzheimer's illness (AD). (ncbcs.org)
Amyloid β (Aβ)-peptide induced oxidative stress causes the initiation and progression of AD. (korea.ac.kr)

In studies on rats with metaphit-induced epilepsy DSIP acted as an anticonvulsant, significantly decreasing the incidence and duration of fits suggesting DSIP as a potential treatment for epilepsy. (wikipedia.org)
In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis. (medworm.com)
OM was induced by intraperitoneal injection of 45 mg/kg streptozotocin in male Sprague-Dawley rats. (vt.edu)
It is concluded that plasma levels of ANP are significantly elevated in streptozotocin-induced diabetes in rats, and that atrial tissue stores are significantly depleted in this diabetic model. (vt.edu)
We treated wounds in STZ-induced diabetic rats with heparin mimetic peptide nanofibers and studied repair of full-thickness diabetic skin wounds. (bilkent.edu.tr)
In rats with heroin self-administration experience, we found that subcutaneous administration of an acute dose of 0.3-mg/kg liraglutide was effective in preventing drug-seeking after exposure to three major precipitators: drug-associated cues, stress (yohimbine-induced), and the drug itself. (psu.edu)
Recent studies have shown that UVB irradiation induces primary and secondary hyperalgesia in rats and humans peaking about 24 h after UVB exposure. (lu.se)
This translational model of UVB irradiation will induce rapid changes of neuropeptides implicated in nociceptive signaling in areas known to be of importance for nociception in a time frame, about 24 h after exposure, where also neurophysiological alteration have been described in humans and rats. (lu.se)

Subcellular fractionation and Western blot disclose that stimulation with LL-37 (8 μM) for 2 h triggers release of the mitochondrial protein apoptosis-inducing factor (AIF) to the cytosol, whereas LL-37 causes no release of cytochrome C oxidase subunit IV of the inner mitochondrial membrane, suggesting that LL-37 affects mitochondrial membrane. (lu.se)
or = 0.02 ng/ml of mGLP-1 facilitated cell proliferation and 0.1 ng/ml and 0.5 ng/ml of mGLP-1 rescued SH-SY5Y cells from Abeta(1-42)-induced apoptosis. (ncbcs.org)
Imidazo[1,2-b]pyrazole-7-carboxamides induce apoptosis in human leukemia cells at nanomolar concentrations. (celljournal.org)
Riedl S, Leber R, Rinner B, Schaider H, Lohner K, Zweytick D. Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. (celljournal.org)

Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)

Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth. (mcw.edu)
In the present study we investigated the possible role of atrial natriuretic peptide (ANP), a hormone affecting cardiovascular homeostasis and inducing antimitogenic effects in different cell types, on LPA-induced cell growth and reactive oxygen species (ROS) production in rat aortic smooth muscle (RASM) cells. (mcw.edu)
This study was undertaken to determine whether immunoreactive atrial natriuretic peptide (irANP) concentrations in plasma and atrial tissue are altered in experimental diabetes mellitus (DM), and to compare the response of the DM and normal groups to exogenous administration of ANP. (vt.edu)

abstract = "CEP peptide was synthesized and tested for induction of disease susceptibility using Arabidopsis Col-0. (elsevierpure.com)

On the basis of the hypothesis that cardiovascular risk factors contribute to the pathogenesis of AD, we investigated whether the cardiovascular risk markers midregional proadrenomedullin (MR-proADM) and midregional proatrial natriuretic peptide (MR-proANP) predict a major clinical milestone, ie, conversion from predementia mild cognitive impairment (MCI) to manifest AD. (psychiatrist.com)

To examine the physiology of GLP-2-induced bowel, mice were treated with GLP-2 (2.5 micrograms) or vehicle for 10 days. (nih.gov)
A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice. (iasp-pain.org)
In the present study, we combined masseter muscle tendon ligation (MMTL)-produced myogenic TMD with systemic injection of nitroglycerin (NTG)-induced migraine-like hypersensitivity in mice. (iasp-pain.org)
We observed that mice with MMTL pretreatment have a prolonged NTG-induced migraine-like hypersensitivity, and MMTL also enabled a non-sensitizing dose of NTG to trigger migraine-like hypersensitivity. (iasp-pain.org)
Modified peptides showed enhanced binding to HLA-A2 compared with the native sequences and immunization of HLA-A2 transgenic mice generated high avidity modification specific CD8 responses that killed peptide expressing target cells. (bmj.com)
BALB/c mice immunized with multimeric DWEYSVWLSN develop IgG1 anti-DNA antibodies and glomerular immunoglobulin deposits, leading us to investigate the role of IL-4 in this model of antigen induced lupus. (elsevierpure.com)
Following peptide immunization, IgG1 anti-peptide and anti-DNA antibodies were significantly higher in IL-4 wild type mice, while IgM and IgG3 anti-DNA levels were significantly higher in IL-4 knockout mice. (elsevierpure.com)
This study examined the effects of AP collagen peptides (APCP) containing glycine-proline-hydroxyproline (GPH) on UVB radiation in both human skin fibroblast and SKH-1 hairless mice. (e-jkfn.org)
We have identified a survivin peptide mimic containing human MHC class I epitopes and a potential class II ligand that induces a potent antitumor response in C57BL/6 mice with GL261 cerebral gliomas. (elsevierpure.com)
This peptide is able to elicit both CD8+ CTL and T helper cell responses in C57BL/6 mice. (elsevierpure.com)
Oral administration of Chana 1 at a dose of 50 mg/kg body weight/day significantly improved Aβ-induced learning and memory impairment in mice, as measured in Y-maze and passive avoidance tests. (korea.ac.kr)
Post-natal stress-induced endocrine and metabolic alterations in mice at adulthood involve different pro-opiomelanocortin-derived peptides. (unicas.it)
Wheat peptides with different hydrolysis degree have similar relief effect in constipated mice. (cabi.org)

Second, the new peptides do not contain disulfide bonds, a post-translational modification commonly encountered in animal toxins. (springer.com)
The goal is to assign acquired spectra to known peptide sequences and potential co- and post-translational modifica- tions. (lu.se)

suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ). (wikipedia.org)
The corresponding region of the human survivin molecule represented by peptide SVN53-67 is 100% homologous to the murine protein, but SVN53-67 is weakly immunogenic in man. (elsevierpure.com)
Homologous peptides derived from influenza A, B and C viruses induce variable CD8 + T cell responses with cross-reactive potential. (bvsalud.org)
We next assessed the immunogenicity of NP265-IAV homologue peptides from IBV and ICV and the ability of CD8+ T cells to cross-react towards these homologous peptides . (bvsalud.org)

We evaluated several amino acid substitutions in putative human MHC I anchor positions in SVN53-67 to identify potential peptide mimics that could provide an enhanced antitumor immune response against human glioma and primary central nervous system lymphoma (PCNSL) cells in culture. (elsevierpure.com)
Thus, SVN53-67/M57 may act as a peptide mimic to induce an enhanced antitumor CTL response in tumor patients. (elsevierpure.com)
Some cationic anti-microbial peptides show a wide range of cytotoxic action versus malignant cells, which may lead to developing a novel group of antitumor medications. (celljournal.org)

Ghrelin is a gastrointestinal peptide (synthesized in the stomach) which specifically induces GH secretion. (medscape.com)
these peptides play a role in postprandial insulin secretion. (medscape.com)

In addition, the renal response to exogenously administered ANP appears to be diminished in streptozotocin-induced OM. (vt.edu)

Additionally, we examined the protein level of calcitonin gene-related peptide (CGRP) in the spinal trigeminal nucleus caudalis using immunohistochemistry. (iasp-pain.org)
Collagen peptides are very small pieces of protein from animal collagen. (medlineplus.gov)
We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)

Try our high quality amino acids, resins and reagents and see just how much better your peptides can be! (peptide.com)
For the first time, scientists have successfully created optically active, chiral gold nanoparticles using amino acids and peptides. (chemeurope.com)

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif: N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. (wikipedia.org)
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies. (wikipedia.org)

Moreover, the LPA-induced activation of Akt, a downstream target of PI3K, was completely inhibited by physiological concentrations of ANP, which were also able to inhibit p42/p44 phosphorylation. (mcw.edu)
Ingestion of a collagen peptide containing high concentrations of prolyl-hydroxyproline and hydroxyprolyl-glycine reduces advanced glycation end products levels in the skin and subcutaneous blood vessel walls: a randomized, double-blind, placebo-controlled study. (medlineplus.gov)
Food deprivation and ingestion induce reciprocal changes in neuropeptide y concentrations in the paraventricular nucleus. (bvsalud.org)

In the present study, the anticancer activity of pleurocidin-like peptide WF3 isoform X2 (AMP-WF3), from the Poecilia Mexicana fish, against leukemic cell line Jurkat was evaluated, and the cytotoxicity compared with the effects on normal cells, including peripheral blood mononuclear cells (PBMCs) and human dermal fibroblast (HDF) cells. (celljournal.org)

Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. (peptide.com)
In this study, we identified a novel function of the YIGSR peptide to enhance collagen synthesis in human dermal fibroblasts. (peptide.com)
To elucidate this novel function regarding collagen synthesis, we treated human dermal fibroblasts with YIGSR peptide in both a time- and dose-dependent manner. (peptide.com)
According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. (peptide.com)
This YIGSR peptide-mediated collagen type 1 synthesis was modulated by FAK inhibitor and MEK inhibitor. (peptide.com)
This study clearly reveals that YIGSR peptide plays a novel function on the collagen type 1 synthesis of dermal fibroblasts and also suggests that YIGSR is a strong candidate peptide for the treatment of skin aging and wrinkles. (peptide.com)
Collagen peptides are made by breaking down whole collagen proteins into smaller pieces. (medlineplus.gov)
When taken by mouth, collagen peptides seem to build up in the skin and cartilage. (medlineplus.gov)
Collagen peptides are used for aging skin and osteoarthritis. (medlineplus.gov)
Don't confuse collagen peptides with collagen type I (native), collagen type II (native), or gelatin. (medlineplus.gov)
Taking collagen peptides by mouth seems to improve skin hydration and skin elasticity in older people. (medlineplus.gov)
Taking collagen peptides by mouth does not seem to improve leg muscle strength. (medlineplus.gov)
However, collagen peptides may improve hand-grip strength. (medlineplus.gov)
There is interest in using collagen peptides for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful. (medlineplus.gov)
Collagen peptides are possibly safe. (medlineplus.gov)
Collagen peptides have been safely used in doses up to 10 grams daily for up to 5 months. (medlineplus.gov)
There isn't enough reliable information to know if collagen peptides are safe to use when pregnant or breast-feeding. (medlineplus.gov)
Collagen peptides have most often been used by adults in doses of 2.5-10 grams daily for up to 6 months. (medlineplus.gov)
Kuwaba K, Kusubata M, Taga Y, Igarashi H, Nakazato K, Mizuno K. Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-blinded crossover clinical trial. (medlineplus.gov)
Oral Ingestion of AP Collagen Peptide Leads to Systemic Absorption of Gly-Pro-Hyp, Alleviating HO-Induced Dermal Fibroblast Aging. (medlineplus.gov)

Chemically synthesized GSS induced not only oocyte maturation and ovulation in isolated ovarian fragments, but also unique spawning behavior, followed by release of gametes shortly after the injection. (elsevierpure.com)

For example, GLP-1 potentiates glucose-induced insulin exocytosis. (diabetesjournals.org)
It also increases insulin production by enhancing glucose-induced insulin gene expression. (diabetesjournals.org)

Notably, such induced susceptibility was also evident on Arabidopsis mutants lacking the previously identified receptors, suggesting that the CEP peptide modulates Arabidopsis immunity through an unidentified receptor(s). (elsevierpure.com)
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity. (celljournal.org)
To cite this article: Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M. Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. (cdc.gov)
Contact allergen-induced innate immunity contrast to irritant contact dermatitis (ICD), which evolves emollients may help reduce irritancy and stabilize the barrier as a consequence of direct toxic effects of physical or chemi- function of the skin avoiding the penetration of contact aller- cal agents resulting in keratinocyte damage and local inflam- gens. (cdc.gov)

We conclude that while IL-4 does not materially affect the generation of some autoantibody responses associated with peptide induced autoimmunity, IL-4 deficiency inhibits kidney immunoglobulin deposition. (elsevierpure.com)

This neuropeptide induces mainly delta sleep in mammals. (wakehealth.edu)

A therapeutic goal for AD is to dam the cascade response induced by Abeta. (ncbcs.org)

In this study, we investigated the effect of Chana 1 against Aβ-induced cytotoxicity and cognitive deficits. (korea.ac.kr)

It has been demonstrated that glucagon-like peptide-1 (GLP-1), which is an endogenous insulinotropic peptide secreted from the intestine, binds to its receptor within the mind and possesses neuroprotective results. (ncbcs.org)
Other groups underwent the same procedure, and also received naloxone (Na) to block μ-δ endogenous receptors, or a phosphorothioate antisense oligonucleotide (AS) directed against pro-opiomelanocortin (POMC)-mRNA [to block adrenocorticotropin (ACTH)- and POMC-derived opioid peptides]. (unicas.it)

Furthermore, behavioral deficits in juvenile animals exposed to secondhand smoke were correlated with inhalation-induced peptides. (cdc.gov)

The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the Î²1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. (peptide.com)
Binding and uptake into TM cells was receptor-mediated and suppressible with free peptide. (uni-regensburg.de)
If those measures are not sufficient for glycemic control, patients may be prescribed non- insulin antihyperglycemic medications (eg, injectable glucagon -like peptide-1 [GLP-1] receptor agonists), insulin , or a combination of these medications. (msdmanuals.com)

Mechanistically, both peptides caused a significant reduction at G0/G1 phase, in correlation with an augmented expression of the cell cycle inhibitory proteins p53, p27, p21, necrosis, exacerbated generation of reactive oxygen species and diminished mitochondrial membrane potential, all hallmarks of cellular stress. (nature.com)

In this study, we report the cell-autonomous antiproliferative and cytotoxic activities exhibited by the spider peptide gomesin (AgGom) and gomesin-like homologue (HiGom) in DFTD cells. (nature.com)

Polyproline II-based helical peptides were adsorbed to silver nanocubes through a cysteine linker and induced circular dichroism (CD) in two of their plasmon resonance modes. (iucc.ac.il)
The 2.5 Å X-ray structure of the complex reveals rare features not seen in other IA d /peptide complexes: cysteine in P1, an imino acid in P6, and a large acidic residue in P9. (aai.org)

Methods Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (bmj.com)
We evaluated survivin peptides with predicted binding to human HLA-A*0201 antigen using peptide-loaded dendritic cells from PBMC of patients with these malignancies. (elsevierpure.com)
This first structure of IA d in complex with an autoimmunogenic peptide reveals a previously unrecognized peptide binding motif for IA d with large anchor residues and with GLU in P9 encapsulated by a web of polar contacts that may contribute to stabilization of the complex and to maintenance of antigen presentation in disease. (aai.org)

Results Homocitrullinated peptides from aldolase and cytokeratin were identified, that stimulated CD8-mediated responses in vivo. (bmj.com)

In order to test our hypothesis, we examined, for the first time in vitro , the anti-proliferative properties of the spider-venom peptide gomesin and its analogues as potential therapeutic lead candidates against DFTD. (nature.com)

Gonad-stimulating substance (GSS) of starfish is the only known invertebrate peptide hormone responsible for final gamete maturation, rendering it functionally analogous to the vertebrate luteinizing hormone (LH). (elsevierpure.com)

The change to a polyproline I helix caused nulling of the induced plasmonic CD. (iucc.ac.il)

It stimulates intracellular cAMP production after ligand-induced activation. (medscape.com)

In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). (wikipedia.org)
We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. (unboundmedicine.com)
For example, the short-acting analog of glucagon-like peptide-1 (GLP-1), an incretin hormone that regulates homeostatic feeding, has been shown to reduce responding for rewarding stimuli such as food, cocaine, heroin, and nicotine when administered over several days or weeks. (psu.edu)
Importantly, the action of the synthetic GSS on oocyte maturation and ovulation was mediated through the production of cAMP by isolated ovarian follicle cells, thereby producing the maturation-inducing hormone of this species, 1-methyladenine. (elsevierpure.com)

Glucagon-like peptide-2 (GLP-2) stimulates small intestinal growth through induction of intestinal epithelial proliferation. (nih.gov)

Similarly, the CEP peptide-mediated disease susceptibility was also effective to a non-adapted bacterial pathogen. (elsevierpure.com)

Innate immune system of the airway epithelium consists of several components including the mucus layer, mucociliary clearance of beating cilia, production of host defense peptides, epith. (researchgate.net)

With developed mass spectrometric methods, we have revealed an induced sero-peptidome following pulmonary exposure. (cdc.gov)
Mass [10] together with information on modifications induced by sample prepa- ration procedures for mass spectrometric analysis, but mass changes are only given as integer values. (lu.se)

We found that Chana 1 significantly protected against Aβ-induced neuronal cell death in PC12 cells. (korea.ac.kr)

Repellent guidance cues induce growth cone collapse, characterized by the loss of protrusive lamellipodia and filopodia ( Gallo and Letourneau, 2004 ). (biologists.com)
Axon retraction induced by guidance cues is of fundamental importance during refinement of axonal projections (reviewed in Luo and O'Leary, 2005 ). (biologists.com)

Our results indicate that a pre-existing myogenic TMD can upregulate NTG-induced trigeminal CGRP and enhance migraine-like hypersensitivity. (iasp-pain.org)
Allergic contact dermatitis - hypersensitivity induced obvious consequences. (cdc.gov)

The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported. (lu.se)
Here, we demonstrate that LL-37 is rapidly (within 20 min) internalized by human osteoblast-like MG63 cells, and that the peptide co-localizes with MitoTracker arguing for accumulation in mitochondria. (lu.se)
Utilizing site-directed mutagenesis and gene recombination strategies, we generated a mutated recombinant human glucagon-like peptide-1 (mGLP-1) which has longer half-life as in contrast with native GLP-1. (ncbcs.org)
Human tumor samples were analyzed by targeted mass spectrometry for presence of homocitrullinated peptides. (bmj.com)
We compared the ability of autologous dendritic cells loaded with SVN53-67 peptide and SVN53-67/M57 in CTL assays against allomatched and autologous, survivin-expressing, human malignant glioma and PCNSL cells. (elsevierpure.com)
The human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a small, naturally occurring tri-peptide present in human plasma that also can be released from tissues in case of an injury. (proteinexplorer.org)
The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. (proteinexplorer.org)
The total peptide dosage is about 2.2 μg/kg or, if scaled for the human body, about 140 μg per injection with 10 treatments per day. (proteinexplorer.org)

The purified GSS was a heterodimer composed of 2 different peptides, A and B chains, with disulfide cross-linkages. (elsevierpure.com)

Currently there is intense interest to define the mechanism of action of glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including insulin gene transcription. (diabetesjournals.org)
Role of helicity on the anticancer mechanism of action of cationic-helical peptides. (celljournal.org)

UVB irradiation induced a significant reduction of the proportion of galanin positive DRG neurons for all time points, except at 12 h. (lu.se)

Due to their antagonism for alpha(v)beta(3) and alpha(v)beta(5) integrins, these cyclic RGD pentapeptides effectively ameliorated the CTGF-induced effects and strongly promoted specific nanoparticle association. (uni-regensburg.de)

The TCR recognizes a 12-mer peptide from the alpha subunit of gastric parietal cell H/K ATPase presented in the context of IA d . (aai.org)
[ 21 , 22 ] Indeed, dysregulation of glucose metabolism, decreased processing of proinsulin, and elevated levels of gastric inhibitory peptide and glycated hemoglobin (HbA1c) can be observed before the onset of T2DM in normoglycemic individuals with TCF7L2 polymorphisms. (medscape.com)

Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages from turbot (Scophthalmus maximus L. (researchgate.net)
In the present study, we have thoroughly investigated butyrate-induced production and function of IL-22 in fish macrophages. (researchgate.net)

Peptide-treated Jurkat cells were associated with increased expression of P21, and P53 genes. (celljournal.org)

It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory. (wikipedia.org)

Anatomy13

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Psychiatry and Psychology1

Phenomena and Processes59

Disciplines and Occupations3

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Health Care2

Delta-sleep-i7

Antimicrobial peptides5

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Amyloid6

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Long peptide1

Atrial natriur3

Abstract1

Natriuretic peptide1

Mice13

Post-translational2

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Antitumor3

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Protein4

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DSIP2

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Strongly1

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