• This fusion peptide framework may thus provide a straightforward design for immobilizing bioactive sequences on hydroxyapatite for biomaterials, tissue engineering, and vaccine applications. (labome.org)
  • Experiments investigating proteolysis revealed that all monomeric peptides are degraded similarly by IDE and plasmin, but that the Flemish peptide was degraded significantly more slowly by NEP than wild type Abeta or any of the other mutant peptides. (arctichealth.org)
  • Additionally , GST-Spa310 was unable to bind to the in vitro transcribed/translated Cyclin E . At first , co-immunoprecipitation experiments indicated a weak binding between Spa310 peptide and Cdk2 . (temple.edu)
  • Zhang Y, McCormick L, Gilliam A. Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. (labome.org)
  • Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the surface of the molecule in an attempt to identify the minimal structure responsible for the immunostimulatory activity of IL 1. (semanticscholar.org)
  • A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity. (semanticscholar.org)
  • 3. The method according to claim 2, wherein the foreign substance is a mature polypeptide originating in any biological species, or a precursor polypeptide thereof, and the construct for transferring a foreign substance is a synthetic polypeptide containing an amino acid sequence corresponding to the mature polypeptide or precursor polypeptide thereof as the foreign substance, and the amino acid sequence of the carrier peptide fragment. (patentsencyclopedia.com)
  • The adsorption on hydrophobic and hydrophilic silica-based surfaces of the integrin-binding PHSRN peptide and the single-residual-mutated analogues, PHSEN and PHSFN, is investigated by comparative QCM-D, XPS, SFG measurements and molecular dynamics calculations. (chalmers.se)
  • N-terminal amino acid sequencing of the fragment indicated that the protease cleaves LAPP at the Abeta-N-terminus. (arctichealth.org)
  • In a study, various peptide fragments related to eglin c, which consists of 70 amino acid residues, were synthesized by a conventional solution method and their inhibitory effects on leukocyte elastase, cathepsin G and alpha-chymotrypsin were examined. (biosyn.com)
  • Although still less potent than Os, the determined minimum bactericidal concentration (MBC) for each peptide indicated that amidation increases the bactericidal activity of Os(3-12) by 16-fold against Escherichia coli and by 8-fold against both Pseudomonas aeruginosa and Bacillus subtilis. (up.ac.za)
  • 2. BACKGROUND Recently, a large number of peptides have been identified which exhibit an ability to inhibit fusion-associated events, and, importantly, also exhibit potent antiviral activity. (allindianpatents.com)
  • When the LAPP was treated with chondroitinase ABC prior to proteolysis, the activity to generate the fragment was inhibited, but pretreatment with heparitinase resulted in no effect. (arctichealth.org)
  • The antiviral activity of the peptides synthesized was studied in MDCK cell cultures against the pandemic influenza strain A/California/07/2009 (H1N1) pdm09. (scipeople.ru)
  • Peptide PB1 (6 - 14) with both termini modified showed maximum antiviral activity, its inhibitory activity manifesting itself during the early stages of viral replication. (scipeople.ru)
  • The broad range of virus-inhibiting activity of PB1 (6-14) peptide was confirmed using a panel of influenza A viruses of H1, H3 and H5 subtypes including those resistant to oseltamivir, the leading drug in anti-influenza therapy. (scipeople.ru)
  • In comparison amidation enhanced the activity of the peptide towards Staphylococus aureus by only 2-fold. (up.ac.za)
  • Several fragments of CART have been tested to try and uncover the pharmacophore, but the natural splicing products CART 55-102 and CART 62-102 are still of highest activity, with the reduced activity of smaller fragments thought to indicate that a compact structure retaining all three of CART's disulphide bonds is preferred. (wikipedia.org)
  • In this study, a peptide fragment Os(3-12), based on a defensin from the tick Ornithodoros savignyi, was amidated at the C-terminus. (up.ac.za)
  • The aim of the present study was to investigate the potential retinoprotective effects of different PACAP fragments (PACAP 4-13, 4-22, 6-10, 6-15, 11-15, and 20-31) and related peptides (secretin, glucagon) in BCCAO-induced ischemic retinopathy. (hindawi.com)
  • Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion. (labome.org)
  • ThT fluorescence, CD and FTIR spectroscopy, and AFM and TEM imaging reveal that in both conjugates the peptide retained its fibrillating properties and formed fibrils. (sigmaaldrich.com)
  • Our results revealed significant neuroprotection by PACAP 1-38 but did not reveal retinoprotective effect of the PACAP fragments or related peptides. (hindawi.com)
  • This graph shows the total number of publications written about "Peptide Fragments" by people in this website by year, and whether "Peptide Fragments" was a major or minor topic of these publications. (ucdenver.edu)
  • Applying fibril-forming peptides in nanomaterial design is still challenged by the difficulties in understanding and controlling how fibrils form. (sigmaaldrich.com)
  • Neprilysin (NEP), insulin degrading enzyme (IDE) and plasmin play a major role in Abeta catabolism, therefore we compared the ability of these enzymes to degrade wild type and mutant monomeric Abeta peptides. (arctichealth.org)
  • Our results suggest that the safety and efficacy issues previously encountered in other A β vaccination trials may be successfully addressed by using micelle-encapsulated peptides. (ingentaconnect.com)
  • Native hippocampal APP prepared from normal brain, however, did not generate the 16 kDa peptide by the protease treatment. (arctichealth.org)
  • At high concentration , the treatment of Spa310 peptide was able to arrest cells at the G0/G1 phase of the cell cycle and reduce the growth of xenografted tumors in nude mice . (temple.edu)
  • Once the structure of an AMP is altered it is altered it is necessary to revaluate the properties of this AMP compared to the unaltered peptide. (up.ac.za)
  • Below are the most recent publications written about "Peptide Fragments" by people in Profiles. (ucdenver.edu)
  • CART expression is regulated by several peripheral peptide hormones involved in appetite regulation, including leptin, cholecystokinin and ghrelin, with CART and cholecystokinin having synergistic effects on appetite regulation. (wikipedia.org)
  • Native lymphocyte APP (LAPP) prepared from normal or AD-derived lymphoblastoid cells was degraded by the protease, generating a 16 kDa Abeta-bearing C-terminal fragment of APP. (arctichealth.org)
  • Vasopressin, endothelin and adrenomedullin are vasoactive peptides that regulate vascular tone and might play a role in hypertensive diseases. (uzh.ch)
  • Some data indicated the endoplasmic reticulum might play a role in transporting Spa310 peptide from cytoplasm to the nucleus . (temple.edu)
  • This led to suggestions that CART may play a role - though not being the only peptide - in satiety. (wikipedia.org)
  • PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). (nutritionsteroids.com)
  • In conclusion, vasoactive peptide fragments are elevated in hemodialysis patients because of accumulation and, most likely, increased release. (uzh.ch)
  • After performing BCCAO, the right eyes of the animals were treated with PACAP fragments or related peptides intravitreal (100 pM), while the left eyes were injected with saline serving as control eyes. (hindawi.com)