- Opioid peptides produce gastrointestinal inhibition and increase feeding when applied to the brainstem. (psu.edu)
- The present studies were designed to determine the actions of opioid peptides on synaptic transmission within the dorsal motor nucleus of the vagus (DMV) and the localization of μ-opioid receptors. (psu.edu)
- Such specificity may imply that the central inhibitory action of opioid peptides on gastrointestinal function targets selected pathways. (psu.edu)
- The mechanism of disinhibition produced by opioid peptides was studied using intracellular recording in area CA1 of rat hippocampal slices. (omeka.net)
- Since beta-endorphins can bind both mu opioid and kappa-opioid receptors we investigated the effect of a mu specific receptor agonist, D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and a mu specific antagonist, D-Phe-Cys-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) on cardiovascular responses in conscious control and obese rats. (nih.gov)
- In contrast, the amplitude of evoked IPSCs was not altered either by Met-enkephalin or by any of the opioid receptor-selective agonists. (psu.edu)
- This ongoing area of research has led to further investigations into the 1,5-hydrogen atom transfer process and in particular, studies into the effectiveness of deuterium as a protecting group for C-H bonds in radical and carbene chemistry. (exeter.ac.uk)
- Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor, a non-opioid branch of the opioid receptor family, shows structural similarities to traditional opioid receptors but binds opioid with very poor affinity. (sri.com)
- SB-612111 had no intrinsic agonistic activity and did not affect the GIRK current induced by [D-Ala 2 , N-Me-Phe 4 , Gly 5 -ol]-enkephalin, a mu-opioid receptor agonist, when tested at concentrations of up to 1 μM. (sri.com)
- Thus, we investigated opioid effects on intracellular Ca 2+ in cultured rat hippocampal neurons by using fura-2-based microscopic Ca 2+ imaging. (jneurosci.org)
- Pharmacological studies demonstrate that opiates and opioid peptides regulate neuronal activity in a variety of ways, dictated in part by the opioid receptor subtypes that are involved. (jneurosci.org)
- The mouse mu opioid receptor (OPRM1) gene undergoes extensive alternative splicing at both the 3'- and 5'-ends of the gene. (biomedcentral.com)
- This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release of [3H]norepinephrine ([3H]-NE) in rat cortex slices. (nih.gov)
- This study quantitatively investigated the effect of (−)- cis -1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1 -yl]methyl]-6,7,8,9-tetrahydro-5 H -benzocyclohepten-5-ol (SB-612111), a novel non-peptide ligand of NOP receptor, on the native NOP receptors in the midbrain ventrolateral periaqueductal gray (vlPAG), a crucial region for pain regulation. (sri.com)
- leads to psychotropic and excitatory effects in humans1-4. (bvsalud.org)