Our method allows for the identification of the proteins, identification of redox-sensitive cysteines within proteins, and quantification of the redox status of individual cysteine-containing peptides. (hindawi.com)
By modulating the function of translation initiation and elongation factors, amino acids regulate the translation of mRNA on a global scale and also act to cause preferential changes in the translation of mRNAs encoding particular proteins or families of proteins. (psu.edu)
Detailed biochemical analysis has implicated a new actin-capping protein and has shown that one of the cross-linking proteins is Elongation Factor 1a, suggesting a link between chemotaxis and growth control. (elsevierpure.com)
Additional regulatory proteins are often required to induce the conformational changes that occur during this cycle: guanine nucleotide exchange factors, which catalyze release of bound GDP and promote its replacement by GTP, and GTPase-activating proteins, which accelerate GTP hydrolysis. (biomedcentral.com)
The superfamily of G proteins includes three main classes: Ras-like GTPases, G α subunits of heterotrimeric G proteins, and the translation elongation factors. (biomedcentral.com)
Required during the elongatio1
Protein factors uniquely required during the elongation phase of protein synthesis. (bvsalud.org)
Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate, eEF2. (nature.com)
The pathways that control protein translation were investigated by immunoblotting explant lysates for PKR, PERK (PKR like endoplasmic reticulum kinase), eIF2a (eukaryotic initiation factor 2a), eEFs (eukaryotic elongation factors), and AMP-dependent kinase. (ox.ac.uk)
Explants were also loaded in the presence of inhibitors of PKR, the fibroblast growth factor (FGF) receptor and PI3 kinase. (ox.ac.uk)
Methods: To unravel the mechanism of action of ketamine, we treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific inhibitor tatCN21 peptide. (haifa.ac.il)
The expression stability of five commonly used housekeeping genes [beta-actin (ACTB), elongation factor 1-alpha (EF1A), ubiquitin (UBQ), glyceraldehyd-3-phosphate dehydrogenase (GAPDH) and tubulin alpha (TUBA)] were monitored in salmonid cell lines CHSE-214 and RTS11 after infection with two of the most fastidious fish pathogens, the facultative bacterium Piscirickettsia salmonis and the aquabirnavirus IPNV (Infectious Pancreatic Necrosis Virus). (pucv.cl)
The other two elongation factors, SseEF1A3 and SseEF1A4 , represent novel genes that are mainly expressed in gills and skin. (biomedcentral.com)
Ribosomal1
In this study, 242 bambusicolous Apiospora were isolated from various bamboo materials (branches, culms, leaves, roots, and shoots) and examined using DNA sequence similarity based on the internal transcribed spacer, 28S large subunit ribosomal RNA gene, translation elongation factor 1-alpha, and beta-tubulin regions. (korea.ac.kr)
Subunit1
Phylogenetic analysis of fragments of the calmodulin ( cmdA ), translation elongation factor ( tef1 ), RNA polymerase second largest subunit ( rpb2 ), and β-tubulin ( tub ) loci revealed that strain CBS 143874 was closely related to isolate NRRL 25615, a known but undescribed phylogenetic species belonging to the African clade of the Fusarium fujikuroi species complex. (knaw.nl)
Post-translationally modified3
Eucaryotic elongation factor 2 (EF-2) contains a post-translationally modified histidine residue termed diphthamide that is specifically ADP-ribosylated by diphtheria toxin (DT) or Pseudomonas exotoxin A. To analyze the potential physiological role of ADP-ribosylation of EF-2 by cellular ADP-ribosyl transferase, we constructed DT-resistant, non-ADP-ribosylatable Saccharomyces cerevisiae EF-2 by site-directed mutagenesis and expressed the mutant EF-2 in yeast. (nih.gov)
Post-translationally modified peptides are involved in many aspects of plant growth and development. (elifesciences.org)
Proteolytic processing is required for all post-translationally modified signaling peptides to release the peptide entity from its precursor. (elifesciences.org)
Initiation3
However, amino acids do not directly regulate the function of translation initiation and elongation factors, but instead modulate signaling through pathways traditionally considered to be solely involved in mediating the action of hormones. (psu.edu)
The process is broken into three stages: initiation, elongation, and termination. (vcell.science)
In the brain, mRNA translation is a critical cellular mechanism, providing tailored responses to the different demands of general homeostasis and synaptic plasticity, and is regulated in both its initiation and elongation phases [ 6 ]. (nature.com)
Flagellin1
They sense PAMPs such as chitin from fungal cell wall, sulfated peptides, flagellin elongation factors etc. (wikipedia.org)
Receptor1
However, we recently found that the eEF2 (elongation) pathway is affected by dopamine D1 receptor activation in an NMDA receptor-dependent manner [ 22 ]. (nature.com)
Gene2
AtPEP 1, a 23-amino acids precursor peptide encoded by c-terminal of PROPEP 1 gene, is considered to be a DAMP associated molecule in Arabidopsis. (wikipedia.org)
Following cleavage of the signal peptide upon entry into the endoplasmic reticulum (ER), the peptide precursors are processed in the cis-Golgi by the subtilase SBT6.1. (elifesciences.org)
EEF22
it directly interacts with the elongation factor, eEF2, to reduce eEF2/ribosome-activated GTP hydrolysis in vitro and inhibit peptide elongation of CPEB2-bound RNA in vivo. (nih.gov)
A key element regulating the elongation phase is the eukaryotic elongation factor (eEF2) pathway [ 8 ]. (nature.com)
Precursor1
Our work highlights the complexity of post-translational precursor maturation allowing for stringent control of peptide biogenesis. (elifesciences.org)
Codon1
When a stop codon is encountered in the A-site, a release factor enters the A-site and translation is terminated. (vcell.science)
Hydrolysis1
Factors that utilize energy from the hydrolysis of GTP to GDP for peptide chain elongation. (childrensmercy.org)
Eukaryotic elongation factor 1 alpha (eEF1A) is one of the four subunits composing eukaryotic translation elongation factor 1. (biomedcentral.com)
The eukaryotic translation elongation factor 1 alpha, currently termed eEF1A, is a member of the G protein family, and one of the four subunits that compose the eukaryotic elongation factor 1 [ 5 , 6 ]. (biomedcentral.com)
Amino1
Again, the growing peptide chain of amino acids is transferred from the petidyl tRNA to the amino acid of the tRNA in the aminoacyl site. (vcell.science)
MRNA3
This process involves several key molecules including mRNA, the small and large subunits of the ribosome, tRNA, and finally, the release factor. (vcell.science)
As elongation continues, the growing peptide is continually transferred to the A-site tRNA, the ribosome moves along the mRNA, and new tRNAs enter. (vcell.science)
This process of peptide synthesis continues as the ribosome moves along the mRNA, and the future protein grows longer. (vcell.science)
Mutagenesis1
By increasing the efficiency with which RNA pol II reads through oxidative lesions, elongation factors can contribute to transcriptional mutagenesis, an activity that could have implications for the generation or progression of human diseases. (elsevierpure.com)
Functional1
Functional amyloids play a beneficial role in a variety of physiologic processes (eg, long-term memory formation, gradual release of stored peptide hormones). (medscape.com)
MeSH1
GTP Phosphohydrolase-Linked Elongation Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Release1
Instead, a release factor enters the ribsome. (vcell.science)
Sequence1
Which of the P4Hs act on signaling peptides, and whether or not they differ in preference for proline in a certain sequence context is still unclear. (elifesciences.org)
Unique1
Diarrheagenic strains of E. coli can be classified into 5 key "pathotypes," each of which has unique virulence factors Virulence factors Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. (lecturio.com)
Similar2
AtPEPs are functionally similar to systemin, an 18 residues peptide which plays critical role in defense signal and induced in response to wounding, jasmonate and ethylene. (wikipedia.org)
These findings can be used in developing models for more accurate estimation of grain pack factor and to determine the mass of grain inside bins and other storage structures. (illinois.edu)
Website1
This graph shows the total number of publications written about "GTP Phosphohydrolase-Linked Elongation Factors" by people in this website by year, and whether "GTP Phosphohydrolase-Linked Elongation Factors" was a major or minor topic of these publications. (childrensmercy.org)