Peptide blood brain barrier. Medical search. Frequent questions

The role of Aβ as a toxic element in the disease has been widely explored through multiple techniques, including in vivo and in vitro application of synthetic peptides as well as in novel transgenic mouse models created to overexpress Aβ. (nature.com)
2019 ) Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers. (neurotree.org)

May 3, 2023 -- Northwestern Medicine scientists have used a novel, skull-implantable ultrasound device to allow the delivery of intravenously injected chemotherapy into the brain. (scienceboard.net)

The hormone is made in the beta cells of the pancreas, and the stimulus for its secretion into the blood stream is a rise in the blood glucose concentration. (weeksmd.com)
This approach has revealed several new mechanisms and biomarkers associated with AD, including alteration of glycogen metabolism, the toxicity of various amyloid peptides aggregation forms, and secretion of a variety of pathology-specific molecules. (lu.se)

The blood-brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood. (wikipedia.org)
The blood-brain barrier is formed by endothelial cells of the capillary wall, astrocyte end-feet ensheathing the capillary, and pericytes embedded in the capillary basement membrane. (wikipedia.org)
The BBB results from the selectivity of the tight junctions between the endothelial cells of brain capillaries, restricting the passage of solutes. (wikipedia.org)
The BBB is composed of endothelial cells restricting passage of substances from the blood more selectively than endothelial cells of capillaries elsewhere in the body. (wikipedia.org)
Measurement of brain uptake of various blood-borne solutes showed that newborn endothelial cells were functionally similar to those in adults, indicating that a selective BBB is operative at birth. (wikipedia.org)
Circumventricular organs (CVOs) are individual structures located adjacent to the fourth ventricle or third ventricle in the brain, and are characterized by dense capillary beds with permeable endothelial cells unlike those of the blood-brain barrier. (wikipedia.org)
Treatment with Outgrowth Endothelial Cells Protects Cerebral Barrier against Ischaemic Injury Cytotherapy. (nottingham.ac.uk)
The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. (dissertations.se)
We have ordered Brain derived Endothelial Cells or BECs. (neuromics.com)
We study ubiquitination and autophagy in induced pluripotent stem cell-derived brain-capillary endothelial cells, pericytes, astrocytes, microglia, and neurons. (uniklinikum-jena.de)
There are insulin receptors on the capillary endothelial cells making up the blood-brain barrier (BBB) and it is proposed that these may play a role, along with exogenously administered insulin, in enhancing the transport of drug molecules across the BBB. (weeksmd.com)

Angiochem is developing a focused product pipeline, including small molecules and biologics, for the potential treatment of a wide range of CNS diseases, including primary brain cancer, brain metastases, lysosomal storage diseases and pain. (angiochem.com)
Thus far, ERT has been largely unsuccessful in improving central nervous system manifestations of the lysosomal storage diseases, putatively due to difficulty in penetrating the blood-brain barrier. (medscape.com)

A proof-of-concept study conducted in a mouse model of Alzheimer's disease offers new evidence that copper isotopes can be used to detect the amyloid-beta protein deposits that form in the brains of people living with -- or at risk of developing -- Alzheimer's. (sciencedaily.com)
Understand the role of amyloid peptides (including amyloid-beta, IAPP, TDP-43) in blood-brain barrier (BBB) alterations and how it affects the progression of AD. (lu.se)

Angiochem is a clinical-stage biotechnology company discovering and developing new breakthrough peptide drug conjugates that leverage the LRP-1 mediated pathway to cross the BBB to treat neurological diseases. (angiochem.com)
Zhou X, Smith QR, Liu X . Brain penetrating peptides and peptide-drug conjugates to overcome the blood-brain barrier and target CNS diseases. (uh.edu)

Protein-targeted small-molecule discovery projects are also of interest, and current projects include the mechanism of tight junction formation and the transport of beta-amyloid across the blood-brain barrier. (rochester.edu)
AggreSure beta-Amyloid (1-40) peptide is pretreated and tested for aggregation using SensoLyte® ThT Aβ40 Aggregation kit (Cat# AS-72213). (anaspec.com)
however, other forms of beta-Amyloid peptides are also present. (anaspec.com)

The global peptide therapeutics market was valued at US$ 25.6 Bn in 2021, and is expected to exhibit a healthy CAGR of 11% during the forecast period (2022-2025). (medgadget.com)
Mar. 10, 2022 Researchers report that they found high levels of the protein Fli-1 in the brains of deceased Alzheimer's patients. (sciencedaily.com)
2022 ) Role of Teneurin C-Terminal Associated Peptides (TCAP) on Intercellular Adhesion and Communication. (neurotree.org)

He showed that mast cells secrete inflammatory mediators that disrupt the gut-blood-brain barriers, thus playing a critical role in brain inflammation and autism. (autismone.org)
We further identified a dramatic shift in circulating peptides, found to be mediators of systemic bioactivity and a promising source of health-effect biomarkers. (cdc.gov)
The trigeminal nerve fibers around basal cerebral and meningeal vessels are triggered (various stimuli are possible), and a vicious cycle starts in which the nerve terminals release calcitonin gene-related peptide (CGRP), substance P, vasoinhibitory peptide (VIP), and other mediators of local neurogenic inflammation and vasodilatation. (medscape.com)

These populations include the orexigenic neuropeptide Y (NPY) and anorexigenic proopiomelanocortin (POMC) neurons that have projections to key neurons in other hypothalamic nuclei and higher brain centers in order to orchestrate the feeding responses. (researchgate.net)
Instead, a single pair of neurons in the female fly's brain mediates the sex-induced memory effect, according to study author Thomas Preat , a neuroscientist at the Industrial Physics and Chemistry Higher Educational Institution (ESPCI) in Paris. (the-scientist.com)
Then, "by chance" Preat says, he was attending a talk at a fly conference when the presenter revealed incidental data showing those neurons produced the sex peptide receptor. (the-scientist.com)
Neurotensin can activate glial cells that contribute to brain inflammation, has cytotoxic actions on neurons, and increases seizure activity in animal models as well as activating mast cells. (autismone.org)
Toni N ., Song H., Ming GL "Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain", PNAS 2015 July 13. (chuv.ch)
Our strategy is to investigate the effect of AD risk factors like stress, inflammation, metabolic changes, and amyloidogenesis, on different types of brain cells including pericytes, astrocytes, neurons, and NG2 cells. (lu.se)

1988). The resulting damage leads to loss of membrane permeability, reduced ion uptake, loss of plasma ions, and changes in blood parameters relating to respiration. (canada.ca)
However, peptides like oxytocin are characterized by weak blood-brain barrier permeability, and so can only by efficiently delivered to the brain via intracerebroventricular (ICV) administration. (neurosciencenews.com)

Gelatin's short peptides - glyprolines - consist of amino acids of glycine and proline. (medicalnewstoday.com)
Peptides are short chains of amino acids that can target specific biological pathways involved in the disorder. (researchpeptides.net)

and transferrin receptor (TfR) over-expressed on the blood brain barrier (BBB). (unina.it)
To provide a peptide, etc., capable of passing through the blood-brain barrier (BBB) by binding to a human transferrin receptor (hTfR). (justia.com)

The future upgrade in this case will be to use the above mentioned coating strategy with peptides able to selectively target liver and cardiovascular tissues. (unina.it)

Early-onset Alzheimer's disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC). (mdpi.com)
Could Leaky Blood Vessels in the Brain Be a Culprit in Alzheimer's Disease? (sciencedaily.com)
Could lowering brain cholesterol reduce Alzheimer's-like damage? (medicalnewstoday.com)
Though age related changes in BBB function may also represent an adaptation for healthy ageing, but results in consequence in a dysfunctional BBB, which often correlate with the progressive cause of brain diseases like the development of neural diseases, including late-onset Alzheimer's disease (LOAD). (uniklinikum-jena.de)
Age-dependent disturbed immune plasticity of microglia and disturbed blood-brain barrier BBB functionality may provide early phenotypes of late-onset Alzheimer's disease (LOAD). (uniklinikum-jena.de)
The cognitive decline and memory loss observed in Alzheimer's disease (AD) is attributed to the accumulation of β-amyloid protein (Aβ), which impairs neural function in the brain. (neurosciencenews.com)

The developmental aspect of drug transport across the blood-brain barrier (BBB) was investigated. (dissertations.se)

Special attention will be given to novel approaches to deliver therapeutic agents to the brain, including the use of BBB-peptide shuttles and monoclonal antibodies. (irbbarcelona.org)

Cells of the barrier actively transport metabolic products such as glucose across the barrier using specific transport proteins. (wikipedia.org)
A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism. (rutgers.edu)

The BBB is distinct from the quite similar blood-cerebrospinal fluid barrier, which is a function of the choroidal cells of the choroid plexus, and from the blood-retinal barrier, which can be considered a part of the whole realm of such barriers. (wikipedia.org)

We recently reported that modeled acute exposure to multi-walled carbon nanotube s (MWCNT) increased systemic inflammation, induced vascular dysfunction, disrupted the blood-brain barrier (BBB) and induced neuroinflammation. (cdc.gov)
For example, some peptides may regulate neuroinflammation or oxidative stress processes that contribute to the pathophysiology of the disorder. (researchpeptides.net)

Biological tests demonstrated that peptide functionalized O/W NEs are able to accumulate and internalize in specific cells, when specific peptides are exposed, thanks to ligand-receptor binding. (unina.it)
This has led to the exploration of alternative treatment approaches, including peptide-based agents, that target specific biological pathways involved in the disorder. (researchpeptides.net)
Peptide-based schizophrenia agents work by targeting specific biological pathways involved in the disorder. (researchpeptides.net)
It has been demonstrated that AD has biological causes and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. (anaspec.com)

Not all vessels in the human brain exhibit BBB properties. (wikipedia.org)

Therapeutic efficacy of peptide therapeutics is relatively superior as compared to other marketed drugs, resulting in their higher adoption among physicians. (medgadget.com)

2020 ) Corticotropin-Releasing Factor: An Ancient Peptide Family Related to the Secretin Peptide Superfamily. (neurotree.org)
2020 ) Information Processing in Affective Disorders: Did an Ancient Peptide Regulating Intercellular Metabolism Become Co-Opted for Noxious Stress Sensing? (neurotree.org)

Blood Adv. 2021 Aug 10;5(15):3021-3031. (uh.edu)

Serum levels of a peptide called neurotensin were significantly higher in young children with autism. (autismone.org)
In WT mice, 1613 (34%) of 4759 reproducibly quantified serum peptide factors were significantly responsive across all exposures (5% FDR) with half (785) directly dependent on MMP-9, speaking to the sizeable, though non-exclusive, role of MMP-9 in production of the MWCNT-responsive peptidome. (cdc.gov)

Prof Tang speaks with ecancertv at ESMO 2016 about successes with ANG1005, a conjugate of paclitaxel with a peptide which can cross the blood brain barrier. (angiochem.com)
Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model. (uh.edu)
Previously, the most potent chemotherapy drugs, paclitaxel and carboplatin, were not used in treating the deadly brain cancer glioblastoma because they could not permeate the blood-brain barrier to reach the aggressive tumor. (scienceboard.net)
Paclitaxel injected directly into the brain can result in brain irritation and meningitis. (scienceboard.net)
The researchers were also able to quantify the effect of the ultrasound-based blood-brain barrier opening, measuring an approximately four- to six-fold increase in paclitaxel and carboplatin concentrations in the human brain. (scienceboard.net)
Participants receive a two-drug combination of paclitaxel and carboplatin -- a combination also used to treat other cancers -- delivered to their brain via the ultrasound technique to investigate whether this treatment prolongs their survival. (scienceboard.net)

There is a part that binds copper and another part that binds to these amyloid peptides," Mirica said. (sciencedaily.com)
Other questions arising from the work include those relating to a protein called MIP, which also binds to the sex peptide receptor and is produced in mated and unmated female and male flies alike. (the-scientist.com)

TNF-a evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor Immunobiology. (nottingham.ac.uk)
Angiochem's engineered-peptide technology overcomes those limitations by binding to the LRP1 receptor, which provides a gateway into the brain. (acs.org)
In addition, intraperitoneally administered Colivelin suppresses memory impairment caused by a muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzilate, indicating that a substantial portion of intraperitoneally administered Colivelin passes through the blood-brain barrier and suppresses functional memory deficit. (jneurosci.org)

The blood-brain barrier acts effectively to protect brain tissue from circulating pathogens and other potentially toxic substances. (wikipedia.org)
When they first tested their compounds in mouse brain tissue, the researchers saw that their agents' affinity for amyloid deposits was limited. (sciencedaily.com)
HBMECs were isolated from normal human brain tissue. (neuromics.com)
Finally, GBM presents rapid proliferation rate and infiltrating capacity in the healthy brain tissue thanks to the co-existence and crosstalk of several subpopulations within its microenvironment. (frontiersin.org)
Finally, the distribution of the IN-administered oxytocin derivative in brain tissue was profiled by imaging of a fluorescent-tagged oxytocin derivative. (neurosciencenews.com)
At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. (thermofisher.com)
Our work also spans from human brain tissue and cohort studies to in vitro and animal studies which is line with Multiparks translational initiative. (lu.se)
In the field of Dental Radiology, during clinical practice, contact with drops of saliva, splashes of blood, invisible pieces of body tissue and secretions occur all the time. (bvsalud.org)

2019 ) Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuronal Function and Behavior in Mammals. (neurotree.org)
2019 ) Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. (neurotree.org)

Peptide therapeutics are witnessing substantial demand, owing to increasing application in the treatment of various chronic disease such as cancer, cardiovascular diseases, hematologic diseases, and gastro-intestinal diseases. (medgadget.com)
The COVID-19 pandemic has been severely affecting the global economic order, and, in turn, the peptide therapeutics market. (medgadget.com)
In terms revenue generation, among the applications, cancer outperformed other application types, owing to greater prevalence of the disease as well as higher efficacy of peptide therapeutics in cancer treatment. (medgadget.com)
Various peptide therapeutics are patented, and, in the mid of this decade, a majority of these patents are expected to reach their expiry dates, leading to higher generic competition. (medgadget.com)
Parenteral route continues to hold the leading revenue share in the peptide therapeutics market, owing to effective drug delivery and higher therapeutic index. (medgadget.com)
Leading players in the peptide therapeutics market, such as AstraZeneca plc, Merck Co. & Inc., and Elli Lily, are concentrating on business expansions through joint ventures and distribution agreements, and are capturing untapped market potential. (medgadget.com)
Additionally, market incumbents are entering into collaborations in order to expand their regional presence and manufacturing capabilities in the global peptide therapeutics market. (medgadget.com)
The global peptide therapeutics market is segmented in detail to cover every aspect of the market and present a complete market intelligence approach to the reader. (medgadget.com)

Ghrelin, growth hormone-releasing peptide, is a hormone which is secreted by the food-deprived stomach and stimulates food intake during starvation [4]. (researchgate.net)
The pineal gland secretes the hormone melatonin "directly into the systemic circulation", thus melatonin is not affected by the blood-brain barrier. (wikipedia.org)
Experimentation has shown that oxytocin, a peptide hormone primarily responsible for parturition, bonding, and lactation, also regulates cognitive behavior in the rodent central nervous system (CNS). (neurosciencenews.com)

Prof. Oka explains the broader implications of their work, "The oxytocin derivative enters the brain more efficiently. (neurosciencenews.com)

An enriched-peptide fraction was extracted and assessed by untargeted data-independent mass spectrometry while brains were assessed by immunofluorescence microscopy. (cdc.gov)
Jiao W, Chatton JY, Genoud C. Mitochondria morphometry in 3D datasets obtained from mouse brains with serial block-face scanning electron microscopy. (unil.ch)

The blood-brain barrier restricts the passage of pathogens, the diffusion of solutes in the blood, and large or hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of hydrophobic molecules (O2, CO2, hormones) and small non-polar molecules. (wikipedia.org)
The barrier also restricts the passage of peripheral immune factors, like signaling molecules, antibodies, and immune cells, into the CNS, thus insulating the brain from damage due to peripheral immune events. (wikipedia.org)
This thesis examines the transport of exogenous molecules across the blood-brain barrier (BBB), focusing on active efflux, using positron emission tomography (PET), computer simulation and modelling. (dissertations.se)
The blood-brain barrier (BBB) forms a selective gateway for the entrance and exit of all factors and molecules in and out of the brain. (uniklinikum-jena.de)

As a result, the repertoire of drugs that can be used to treat brain disease is limited. (scienceboard.net)

Radiotherapy or surgery for brain metastases was completed at least 4 weeks prior to the first administration of investigational product. (who.int)

An in vitro study was performed to find differentially expressed genes in brain capillary-rich fractions of the brain in rats of different ages. (dissertations.se)

Peptide-based agents can target glutamate receptors to modulate glutamatergic neurotransmission. (researchpeptides.net)

Permeable capillaries of the sensory CVOs (area postrema, subfornical organ, vascular organ of the lamina terminalis) enable rapid detection of circulating signals in systemic blood, while those of the secretory CVOs (median eminence, pineal gland, pituitary lobes) facilitate transport of brain-derived signals into the circulating blood. (wikipedia.org)
The blood-brain barrier (BBB) represents a complex interface between the brain parenchyma and systemic blood circulation, strictly controlling exchange of substances between the two sites. (dissertations.se)

Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. (mdpi.com)

Humanin (HN) is a short bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-causative genes and amyloid-β (Aβ) in vitro . (jneurosci.org)
All research peptides for sale are for in-vitro research only. (researchpeptides.net)

The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. (dissertations.se)
Gaining insight into these transport mechanisms is expected open the door to new general and efficient approaches to facilitate the delivery of new drugs into the brain for the treatment of CNS disorders. (irbbarcelona.org)

Outgrowth Endothelial Progenitor Cells Restore Cerebral Barrier Function Following Ischaemic Damage: the impact of nox2 inhibition European Journal of Neuroscience. (nottingham.ac.uk)
Braun S., Moss J., Toni N. , Jessberger S. "Programming hippocampal neural stem/progenitor cells into oligodendrocytes enhances remyelination in the adult brain after injury" Cell Reports , 2015 Jun 23;11(11):1679-85. (chuv.ch)

My laboratory is interested in numerous facets of central nervous system pathology, particularly in developmental neurotoxicology, traumatic brain injury, and the differential responses of various CNS cell types to insult. (rutgers.edu)

Substance P reversibly compromises the integrity and function of blood-brain barrier Peptides. (nottingham.ac.uk)
The ultrasound and microbubble-based opening of the blood-brain barrier is transient, with most of the blood-brain barrier integrity restored within one hour following this procedure in humans. (scienceboard.net)

Ageing of the blood-brain barrier (BBB) results from an accumulation of deficiencies with contributions of senescence, increased inflammation, and oxidative stress. (uniklinikum-jena.de)

A protein present in the ejaculate of male fruit flies activates long-term memory formation in the brains of their female partners. (the-scientist.com)
It's "very interesting," Isaac continues, because until now, sex peptide-a protein produced in the male reproductive system and found in ejaculate-was. (the-scientist.com)

We wanted to see if PAS-CPPs-oxytocin could be delivered more efficiently to the mouse brain for clinical application, and if it improved cognitive functional behavior in mice," states Prof. Oka. (neurosciencenews.com)

Green Tea Polyphenols Modify the Gut Microbiome in db/db Mice as Co-Abundance Groups Correlating with the Blood Glucose Lowering Effect. (rutgers.edu)
Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β-amyloid peptide (25-35)-induced memory impairment in mice " by Chikamasa Yamashita et al. (neurosciencenews.com)

Dr. Liu's research interest is to develop molecularly targeted drug delivery systems, such as nanoparticles, nanoconjugates and prodrugs, to improve tumor specific delivery of small molecule anticancer drugs and biologics (RNAs, peptides, and antibodies) to target cancer metastasis. (uh.edu)
Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective therapies is a pharmaceutical challenge and an unmet medical need. (frontiersin.org)
Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
Subsequently, a near infrared light irradiating the head must cross multiple barriers to reach the tumor site without causing any local damage. (frontiersin.org)
To be effective, this approach requires coverage of a large region of the brain adjacent to the cavity remaining in the brain after glioblastoma tumor removal. (scienceboard.net)

Antibodies are too large to cross the blood-brain barrier, and only certain antibiotics are able to pass. (wikipedia.org)
To be effective, however, such diagnostic agents also must be able to cross the blood-brain barrier. (sciencedaily.com)
Angiochem gets an up-front payment of as much as $31.5 million plus research funding it will use to develop enzyme replacement therapies (ERTs) that can cross the blood-brain barrier. (acs.org)

Separately, 1119 (69%) peptide factors were significantly shifted a full 4-weeks after the larger 40 microg bolus dose, supporting a prolonged impact to circulating factors. (cdc.gov)

Piggybacking on the homing mechanism that the immune system uses to direct white blood cells could enable the targeted delivery of drugs in children with. (scienceboard.net)
At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)

Conversion of cholesterol to 24S-OHC is mediated by cholesterol 24S-hydroxylase in the brain, which is the major pathway for oxysterol elimination, followed by oxidation through hepatic first-pass metabolism by CYP39A1. (mdpi.com)
Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway. (anaspec.com)
Previous work had confirmed that both CPPs and the PAS benefit the nose-to-brain delivery pathway. (neurosciencenews.com)

ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (nottingham.ac.uk)
The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. (dissertations.se)

In some cases, a drug has to be administered directly into the cerebrospinal fluid where it can enter the brain by crossing the blood-cerebrospinal fluid barrier. (wikipedia.org)
The blood-brain barrier (BBB) is a special conformation of cellular membranes that has at times served to confound effective drug therapy for intra-CNS conditions, most notably tertiary neurosyphilis. (weeksmd.com)
Temozolomide, the current glioblastoma chemotherapy, crosses the blood-brain barrier, but is a weak drug. (scienceboard.net)
These findings allow optimization of the ultrasound activation and drug delivery sequence to maximize drug penetration into the brain. (scienceboard.net)

A new era of brain-penetrant therapies is opening up, as companies hook up drugs to transferrin receptors or use viral capsids to hitch a ride into previously inaccessible regions. (nature.com)

Pericytes are mural cells located on the abluminal membrane of the brain endothelium, involved in BBB formation and maintenance. (dissertations.se)

Several studies in rodents show that females experience remarkable plasticity within the brain during pregnancy," writes Rezaval. (the-scientist.com)
We have previously shown that oxytocin reverses amyloid 𝛽 peptide (25-35) (A 𝛽 25-35 )-induced impairment of synaptic plasticity in rodents. (neurosciencenews.com)

Anatomy22

Organisms4

Diseases11

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology1

Phenomena and Processes19

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Synthetic peptides2

20231

Secretion2

Endothelial cells11

Lysosomal storage2

Amyloid-beta2

Conjugates2

Beta-amyloid3

20223

Mediators3

Neurons6

Permeability2

Amino acids2

Transferrin receptor2

Selectively1

Alzheimer's6

Transport across the Blood-Brain B1

Monoclonal antibodies1

Proteins2

Choroidal1

Neuroinflammation2

Biological4

Vessels1

Marketed drugs1

20202

20211

Serum2

Paclitaxel6

Binds2

Receptor3

Tissue8

20192

Therapeutics8

Hormone3

Implications1

Microscopy2

Molecules4

Disease1

Metastases1

Expressed genes1

Glutamate1

Systemic blood2

Homeostasis1

Vitro2

Disorders2

Progenitor cells2

Traumatic brain1

Integrity2

Inflammation1

Protein2

Cognitive1

Mice2

Tumor5

Cross3

Significantly1

Immune2

Pathway3

Research2

Drug4

Therapies1

Endothelium1

Plasticity2