Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the formyl peptide receptor 1 (FPR1) gene. (wikipedia.org)
FPR1 is the premiere receptor for the pro-inflammatory actions of formyl peptides. (wikipedia.org)
β-Adrenergic receptor (βAR) dysfunction in acute myocardial infarction (MI) is associated with elevated levels of the G-protein-coupled receptor kinase-2 (GRK2), which plays a key role in heart failure progression. (mssm.edu)
G protein coupled receptor kinase type 2 (GRK2) plays an important role in the development and maintenance of cardiac hypertrophy and heart failure even if its exact role is still unknown. (cnr.it)
Chronic/pathologic GPCR signaling elicits the interaction of the G-protein Gbetagamma subunit with GPCR kinase 2 (GRK2), targeting the receptor for internalization, scaffolding to pathologic signals, and receptor degradation. (cusabio.com)
However, non-formylated peptide ligands have also been found for this receptor class. (lookformedical.com)
GRK2-mediated receptor phosphorylation is preceded by the agonist-dependent membrane association of this enzyme. (duke.edu)
Antibody6
Description: A polyclonal antibody for detection of GRK2 Phospho-Ser685) from Human, Mouse, Rat. (lifchem.com)
This GRK2 Phospho-Ser685) antibody is for WB, ELISA. (lifchem.com)
Grk2 Antibody is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. (affbiotech.com)
These peptide usually contains the epitope recognized by the antibody. (affbiotech.com)
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns. (affbiotech.cn)
GRK52
CCG215022 is a potent GRK2 and GRK5 inhibitor. (adooq.com)
CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. (adooq.com)
Regulates2
The kinase dead mutant and a synthetic inhibitor of GRK2 activity exerted the opposite effect, suggesting that GRK2 regulates hypertrophy through upregulation of NFkappaB activity in a phosphorylation-dependent manner. (cnr.it)
GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis. (mdbioproducts.com)
Inhibitor1
PKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor. (adooq.com)
Kinase2
The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. (adooq.com)
Rather, selectivity is achieved through the stabilization of a special inactive conformation within the GRK2 kinase domain. (phosphorylase-signal.com)
ELISA1
ELISA(peptide): For ELISA detection of antigenic peptide. (affbiotech.com)
Selective2
In two different in vivo models of left ventricle hypertrophy (LVH), the selective inhibition of GRK2 activity prevented hypertrophy and reduced NFkappaB transcription activity. (cnr.it)
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D2R through GRK2. (cusabio.com)
Affinity3
M3R activation-induced GRK2 recruitment is Ggamma subtype dependent in which Gbetagamma dimers with low cell membrane-affinity Ggamma9 exhibited a two-fold higher GRK2-recruitment compared to high affinity Ggamma3 expressing cells. (cusabio.com)
In this study, consensus substrate motifs for GRK2 were identified from the sequences of GRK2 protein substrates, and 17 candidate peptides were synthesized to identify peptide substrates with high affinity for GRK2. (elsevierpure.com)
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific). (affbiotech.com)
Protein5
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
A new study reports on the crucial role the protein GRK2 plays in regulating the body's internal clock. (neurosciencenews.com)
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse iNOS. (genetex.com)
Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
Brain natriuretic peptide (BNP) is very high (higher than 1000 pg/ml), confirming the significant dysfunction of the heart, and in 50% C-reactive protein is high (higher than 9 mg/l), which may indicate a worst prognosis [ 3 ]. (biomedcentral.com)
GRK31
The GRK2 subfamily, consisting of GRK2 and GRK3, are ubiquitously selleck chemical expressed. (phosphorylase-signal.com)
Overexpression2
In H9C2 cells, GRK2 overexpression increased atrial natriuretic factor (ANF) activity and enhanced phenylephrine-induced ANF response, and this is associated with an increase of NFkappaB transcriptional activity. (cnr.it)
Results demonstrate that GPR3 signals at the plasma membrane and can be silenced by GRK2/beta-arrestin overexpression. (cusabio.com)
Hypertrophy1
In this study, we assessed the effect of GRK2 on the regulation of cardiac hypertrophy. (cnr.it)
Inhibition1
Inhibition of GRK2 via expression of a peptide βARKct transferred by molecular cardiac surgery with recirculating delivery (MCARD) may be a promising intervention. (mssm.edu)
Synthetic1
various synthetic N-formyl and non-formylated peptides that show distinguishing differences from those that interact with FPR2 and FPR3. (wikipedia.org)
Troponin1
Moreover, the N-terminal prohormone of brain natriuretic peptide (NTproBNP)and troponin I were also elevated after CPB and remained at high levels until 48 hours after surgery. (fapesp.br)
GPCRs1
A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs. (cusabio.com)
Degradation1
Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting. (uam.es)
Innate1
FPR1 binds with and is activated by: bacterial and mitochondrial N-formyl peptides and thereby initiates innate host immune responses. (wikipedia.org)
Progression1
eIF3d promotes gallbladder cancer (GBC) progression mainly via eIF3d-GRK2-AKT axis and it may be used as a prognostic factor. (cusabio.com)
Therapeutic3
Our results suggest a previously undisclosed role for GRK2 in the regulation of hypertrophic responses and propose GRK2 as potential therapeutic target for limiting LVH. (cnr.it)
The therapeutic targeting of eIF3d-GRK2 axis may be a potential treatment approach for GBC. (cusabio.com)
16 (5) GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis. (genetex.com)
Responses2
Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. (lookformedical.com)
GRK2 desensitizes flow-induced responses in osteoblasts. (geneticsmr.com)
Fragment1
Peptide mass tolerance for data source searches was established to 5?fragment and ppm mass tolerance was place to 0.4?Da. (stemcellresearchformichigan.com)
Interaction2
This interaction is of unknown physiological significance although peptide T20/DP178 is a licensed anti-retrovirus agent (pentafuside) termed Enfuvirtide which acts at the level of HIV-target cell fusion and is used clinically to treat HIV-1 infection). (wikipedia.org)
Targeting this pathologic Gbetagamma-GRK2 interaction has been suggested as a possible strategy for the treatment of HF. (cusabio.com)
Rabbit1
Description: Rabbit polyclonal to Phospho-GRK2 (Ser685). (lifchem.com)
Cellular1
This peptide may be a useful tool for investigating cellular signaling pathways regulated by GRK2. (elsevierpure.com)
Tolerance1
Induction of bystander tolerance and immune deviation after Fel d 1 peptide immunotherapy. (mdbioproducts.com)
Heart1
Because the discovery of a linkage involving the overexpres sion of GRK2 and heart failure, GRK2 continues to be thought to be a pharmaceutical target for the remedy of cardiovascular illness. (phosphorylase-signal.com)