Peptide activated. Medical search. Frequent questions

We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos. (nih.gov)
Orthologous to human MAPK1 (mitogen-activated protein kinase 1). (nih.gov)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Epithelial Neutrophil Activating Peptide 78 (ENA78) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (elisareagents.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Epithelial Neutrophil Activating Peptide 78 (ENA78) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisareagents.com)
Description: A sandwich ELISA kit for detection of Epithelial Neutrophil Activating Peptide 78 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisareagents.com)

Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. (wikipedia.org)
Treatments with monoclonal antibodies have been investigated to target pituitary adenylate cyclase-activating polypeptide or its receptors for the treatment of primary headache disorders. (wikipedia.org)
PARs or Protease Activated Receptors function as receptors for Thrombin. (anaspec.com)
These receptors are activated when the amino terminus of the receptor is cleaved by specific serine proteases - thrombin (PAR-1, 3 and 4) and trypsin (PAR-2). (anaspec.com)
Peptide-induced keratinocyte migration was mediated by purinergic receptors and metalloproteases. (nature.com)
Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)
partner to activate cellular receptors. (news-medical.net)
In fact, these peptides produced by keratinocytes were found to form complexes with extracellular self-nucleic acids, allowing transport into intracellular compartments of pDC where they efficiently activate nucleic acid-sensing Toll-like receptors ( Lande et al . (chuv.ch)
A family of proteinase-activated receptors that are specific for THROMBIN. (bvsalud.org)
Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. (bvsalud.org)
It activates the complement system and binds to Fc receptors. (medscape.com)

Following activation by agonists such as thrombin, platelets release storage granules and membrane vesicles that contain prothrombotic (e.g., fibrinogen), mitogenic (e.g., platelet derived growth factor), immunomodulatory (e.g., neutrophil-activating peptide 2), and adhesive (e.g., platelet endothelial cell adhesion molecule) proteins. (hindawi.com)
Peptides pass on this information by binding to and activating specialized receptor proteins on the outside of a cell. (news-medical.net)
kinked proteins bound weakly, but effectively activated the receptor when they finally docked in. (news-medical.net)
These proteins show similar domain architectures as known organelle-targeted expression regulators of the octotrico peptide repeat type in algae and plants. (frontiersin.org)
However, most drugs act as haptens, binding covalently to serum or cell-bound proteins, including peptides embedded in major histocompatibility complex (MHC) molecules. (msdmanuals.com)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
The use of amino acids, proteins and peptides is not considered to have any environmental impact. (janusinfo.se)
According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00), vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)

It binds to vasoactive intestinal peptide receptor and to the pituitary adenylate cyclase-activating polypeptide receptor. (wikipedia.org)
identified an association of a SNP in the gene coding for pituitary adenylate cyclase-activating polypeptide (PACAP), implicating this peptide and its receptor (PAC1) in PTSD. (wikipedia.org)
Pituitary adenylate cyclase-activating peptide has been shown to interact with secretin receptor. (wikipedia.org)
The protease-activated thrombin receptor-1 (PAR-1) can be activated by both the tethered ligand exposed by thrombin cleavage and a synthetic peptide having the tethered ligand sequence (thrombin receptor agonist peptide or TRAP). (nih.gov)
We conducted a mutational analysis of extracellular residues of the receptor potentially involved in interaction with both the tethered ligand and the soluble peptide agonist. (nih.gov)
The data presented herein demonstrate that murepavadin activates human MCs via MRGPRX2 and murine MCs via MrgprB2 and that MRGPRX2 is resistant to b-arrestin-mediated receptor regulation. (listlabs.com)
Our results demonstrate that GPR139 is a peptide receptor, activated by ACTH, α-MSH, β-MSH, the conserved core motif HFRW as well as a potential endogenous peptide α-MSH1-9. (ku.dk)
Our thrombin & related peptides group includes PAR peptides and their agonists/antagonists that are relevant to the study of sequence-specific models of thrombin receptor activation and in turn, their modulatory roles in cardiovascular and circulatory systems. (anaspec.com)
Synthetic thrombin receptor peptides or thrombin receptor activating peptides (TRAPs) generated by thrombin's proteolytic activity are considered full agonists, which are studied in relation to thrombin signaling, platelet activation, protein phoshorylation etc. (anaspec.com)
One subset of the G-protein coupled receptor (GPCR) superfamily is that which is activated by a peptide carrying an obligatory positively charged residue (GPCR-PA+). (sbir.gov)
I think most molecular scientists have an image of this peptide bound to the receptor as having a single ideal shape. (news-medical.net)
By going back and forth, but never completely popping off the receptor, you get to keep signaling and be more effective as a signal-inducing peptide,' says Gellman. (news-medical.net)
This model was supported by data showing a GLP-1-like peptide bound to its receptor in the two different shapes. (news-medical.net)
Recent studies have identified the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. (jci.org)
Los pequeños péptidos sintéticos que contienen la secuencia peptídica N-terminal no enmascarada pueden activar también el receptor en ausencia de actividad proteolítica. (bvsalud.org)
Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity. (bvsalud.org)
A cryptic peptide ligand contained within the N-terminal of the thrombin receptor. (bvsalud.org)
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are hypothalamic peptides sharing considerable sequence homology which are postulated to be hypophysiotrophic releasing factors. (ox.ac.uk)
To conclude, we show that amoxicillin-modified peptides bind to both components of the risk haplotype to stimulate DILI patient T cells and describe the importance of the position of nucleophilic lysine residue in the HLA binding peptide sequence. (liverpool.ac.uk)
Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the vasoactive intestinal peptide/secretin/glucagon family , has an amino acid sequence identity of 68% with vasoactive intestinal polypeptide (VIP). (eurogentec.com)

We developed here, for the first time, a novel spatiotemporal cancer targeted therapy applying engineered E. coli bacteria with capability of expressing cardiac peptides under hypoxic conditions of tumor. (authorea.com)
Results IV Administered bacteria bearing constructs could specifically localize at tumor site and express cardiac peptides under hypoxic conditions. (authorea.com)
Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide. (ox.ac.uk)
Thus our results suggest that Pak1 activation achieved by specific bioactive peptide represents a potential novel therapeutic strategy for cardiac hypertrophy and associated ventricular arrhythmias. (ox.ac.uk)

DNA double-helix binds regulatory peptides similarly to transcription factors. (nel.edu)
Khavinson V, Shataeva L, Chernova A. DNA double-helix binds regulatory peptides similarly to transcription factors. (nel.edu)

PAP enhances p21 activated kinase 1 (Pak1) activity by increasing the level of phosphorylated Pak1 in cultured neonatal rat ventricular myocytes (NRVMs). (ox.ac.uk)
Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
Using patch-clamp electrophysiology in brain slices prepared from male rats, we reveal that opioid withdrawal abruptly reduces the ability of these peptides to inhibit neurotransmission, a direct consequence of a protein kinase A (PKA)-driven increase in the synaptic activity of peptidases. (jneurosci.org)

pituitary adenylate cyclase-activating polypeptide is similar to vasoactive intestinal peptide. (wikipedia.org)

These findings provide novel insights into how peptidases control synaptic activity within the amygdala and presents restoration of endogenous peptide activity during withdrawal as a viable option to mitigate withdrawal-induced disruptions in emotional learning circuits and rescue the relapse behaviors exhibited during opioid withdrawal and beyond into abstinence. (jneurosci.org)

The manuscript demonstrates that a mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in the human bronchial epithelial cell line model VA10. (peerj.com)
Zasloff M ( 2015 ) Peer Review #3 of 'Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells (v0.2)' . (peerj.com)
Here we found that levels of cathelicidin, an antimicrobial peptide, were increased in colon cancer tissues compared to noncancerous tissues. (oncotarget.com)
We discovered that one of these antimicrobial peptide called LL37 not only triggers innate immune activation but also acts as an epidermal autoantigen targeted by autoimmune T cells in psoriasis Lande et al . (chuv.ch)
These LL37-specific autoimmune T cells produce Th17 cytokines which, on one hand, elicit the psoriatic phenotype and, on the other hand, sustain the antimicrobial peptide expression by keratinocytes, providing a feedback loop that perpetuates skin inflammation in psoriasis. (chuv.ch)
In Systemic Lupus Erythematosus (SLE) we demonstrated that circulating immune complexes are also composed of nucleic acid-antimicrobial peptide complexes. (chuv.ch)

Furthermore, treatment with cathelicidin neutralizing antibody de-activated the Wnt/β-catenin signaling pathway in tumor cells both in vivo and in vitro . (oncotarget.com)
Cathelicidin activated Wnt/β-catenin signaling by inducing phosphorylation of PTEN, leading to activation of PI3K/Akt signaling and subsequent phosphorylation of GSK3β, resulting in stabilization and nuclear translocation of β-catenin. (oncotarget.com)

Cooperative phosphorylation at these sites by both enzymes was observed in vitro and reflected in vivo by the predominance of the peptide phosphorylated on both sites, as opposed to singly phosphorylated peptides. (nih.gov)
In the present study, we explored the effect of a bioactive peptide (PAP) on angiotensin II (Ang II)-induced hypertrophy and associated ventricular arrhythmias in in vitro and in vivo models. (ox.ac.uk)

Increase of energy accumulation elicits leptin release and simultaneous inhibition of orexigenic neurons expressing neuropeptide Y (NPY) and agouti-related peptide (AgRP), as well as activation of the anorexigenic proopiomelanocortin (POMC) neurons within the hypothalamic arcuate nucleus (ARC). (frontiersin.org)
PACAP38 , derived from a 176-amino acid precursor (preproPACAP), is a 38-amino acid peptide discovered as an ovine hypothalamic neuropeptide. (eurogentec.com)

Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. (wikipedia.org)
In order to ascertain if either peptide has a similar effect in man, PACAP and VIP were infused at 3·6 pmol/kg per min into six healthy male volunteers, and an LHRH test was performed 30 min after the infusion was commenced. (ox.ac.uk)

We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years. (nel.edu)
We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturati. (nel.edu)

Recently we have shown that GPR139 is activated by the amino acids l-tryptophan and l-phenylalanine (EC50 values of 220 μM and 320 μM, respectively), as well as di-peptides comprised of aromatic amino acids. (ku.dk)
Using amino acids not normally found in natural peptides, Cary was able to produce two types of shapes. (news-medical.net)

Both isoforms of pituitary adenylate cyclase-activating polypeptide (pituitary adenylate cyclase-activating polypeptide-38 and pituitary adenylate cyclase-activating polypeptide-27) have been implicated in migraine pathogenesis. (wikipedia.org)
A Danish research group led by Dr. Messoud Ashina found that intravenous infusion of pituitary adenylate cyclase-activating polypeptide-38 induced migraine attacks in 58% of people with migraine, whilst the corresponding migraine induction rate was 55% for pituitary adenylate cyclase-activating polypeptide-27. (wikipedia.org)
The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)

We have identified the factors that activate skin pDC and uncovered a fundamental function of cationic antimicrobial peptides in breaking innate tolerance to self-nucleic acids released by dying cells and activate skin pDC ( Lande et al . (chuv.ch)
The isolation process may even generate cationic peptides as degradation products. (ift.org)
These cationic peptides can also be generated by enzymatic activity (Tomita et al. (ift.org)

Similarly, bioactive peptides, which are specific protein fragments that are thought to have physiological health benefits, are good candidates for cosmeceutical components that provide enzyme-modulating activity. (dovepress.com)

The findings could help improve drug design for these diabetes drugs and possibly other therapeutic peptides. (news-medical.net)

This gene encodes adenylate cyclase-activating polypeptide 1. (wikipedia.org)
Adenylate cyclase-activating polypeptide 1 not only is a hypophysiotropic hormone (i.e. a substance that induces activity in the hypophysis), but also functions as a neurotransmitter and neuromodulator. (wikipedia.org)

Turoctocog alfa is a recombinant human coagulation factor VIII and once activated by thrombin cleavage the resulting rFVIIIa has the same structure as endogenous FVIIIa. (janusinfo.se)

Each of these dusts significantly impaired the ability of alveolar macrophages to be activated by the chemotactic peptide, FMLP. (cdc.gov)

Going forward, Gellman says drug makers should consider whether their peptides of choice may similarly benefit from being able to adopt multiple shapes. (news-medical.net)

In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)
The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. (kjpp.net)

Moreover, we found that peptides consisting of nine or ten N-terminal residues of α-MSH activate GPR139 in the submicromolar range. (ku.dk)
Amoxicillin forms protein adducts that are postulated to activate T cells, by conjugating with lysine residues. (liverpool.ac.uk)
Peptides carrying lysine residues for amoxicillin binding in positions (KP) 2-6 and anchors for the HLA-DRB1*15:01-DQB1*06:02 haplotype were designed. (liverpool.ac.uk)

Compared to a peptide locked into this helical shape, a peptide engineered to form a sudden kink near its end better activated its cellular target, which promotes insulin release from the pancreas. (news-medical.net)
2011 ). This pathway is also activated in injured skin, but it is self-limited, providing a well-controlled initial inflammatory stimulus that promotes the wound healing response (Gregorio et al . (chuv.ch)

Antimicrobial peptides (AMPs) are a promising antibiotic alternative that physically disrupts the membrane of bacteria resulting in rapid bactericidal activity, however clinical translation of AMPs has been hindered by their susceptibility to protease degradation. (whiterose.ac.uk)
This likely disrupts peptide-dependent emotional learning processes in the amygdala during withdrawal and may direct behavior toward compulsive drug use. (jneurosci.org)

These results suggest that although both agonists can activate PAR-1, there are profound differences in the ability of thrombin and TRAP to activate PAR-1. (nih.gov)

Further, the CDR-based peptides inhibited the priming of lymph-node cells (LNC) of mice immunized using the same peptides or using the monoclonal anti-DNA 16/6Id+ Abs of either mouse or individual origins. (cancercurehere.com)
The CDR1-structured peptide was also proven to prevent auto-Ab creation in BALB/c neonatal mice which were immunized afterwards with NGFR either pCDR1 or the pathogenic auto-Ab (7). (cancercurehere.com)
In today's report, the power from the CDR1-structured peptide to immunomodulate SLE induced in BALB/c mice was examined. (cancercurehere.com)

A peptide based on complementarity-determining region (CDR)-1 of a monoclonal murine anti-DNA Ab that bears the common idiotype, 16/6Id, was synthesized and characterized. (cancercurehere.com)
Two peptides predicated on the sequences from the complementarity-determining locations (CDR) from the pathogenic murine monoclonal anti-DNA Ab (5G12) that bears the order CB-7598 16/6 Identification were synthesized. (cancercurehere.com)

Antimicrobial peptides are promising agents for the treatment of bacterial infections and recent studies indicate that Pep19-2.5, a synthetic anti-lipopolysaccharide (LPS) peptide (SALP), efficiently neutralises pathogenicity factors of Gram-negative (LPS) and Gram-positive (lipoprotein/-peptide, LP) bacteria and protects against sepsis. (nature.com)
Activated form of natural antimicrobial improves safety of beef and poultry by preventing attachment and growth of bacteria. (ift.org)
Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)

The T cells response was HLA class II restricted and the amoxicillin-modified peptides bound selectively to HLA-DRB1*15:01 and/or DQB1*06:02. (liverpool.ac.uk)
The aim of this study was to identify GPC3-derived long peptides (GPC3-LPs) carrying promiscuous HLA class II-restricted T helper (Th) cell epitopes. (elsevierpure.com)

Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons. (nel.edu)
This study aimed to (1) investigate whether amoxicillin-modified HLA-DRB1*15:01-DQB1*06:02 binding peptides selectively activate DILI patient T cells and (2) define the nature of the T-cell response with respective to antigen structure. (liverpool.ac.uk)
These peptides provide key information to cells that affects metabolism, such as by controlling blood sugar. (news-medical.net)
Reduced peptide control of neurotransmission in the amygdala shifts the excitatory/inhibitory balance of inputs onto accumbens-projecting amygdala cells involved in relapse. (jneurosci.org)
Haptens may also bind directly to class II MHC molecules, directly activating T cells. (msdmanuals.com)

A new generation of drugs is likely to emerge from peptides, including those found in animal venoms. (scielo.br)

As an anti-coagulant , thrombin functions to down-regulate the coagulation process as it (fibrin-bound from its pro-coagulant property) complexes with thrombomodulin present on the endothelial cell surface and activates protein C, an anticoagulant proteinase. (anaspec.com)

The hypothalamus secretes a small peptide called Thyroid Releasing Hormone. (cdc.gov)
When T4 is converted to T3 it produces the more active thyroid hormone and activates the pathway. (cdc.gov)

Thrombin is a serine protease of the chymotrypsin family and is produced by the enzymatic cleavage of two sites on prothrombin (its inactive precursor) by activated Factor Xa. (anaspec.com)

All three peptides, as well as their conserved core motif HFRW, were found to activate GPR139 in the low μM range. (ku.dk)
We also found that this pathway is over-activated in psoriasis and lupus, where it drives chronic inflammation and disease initiation ( Nestle et al . (chuv.ch)

Differentially expressed molecules on activated DC? (bio.net)

Anatomy13

Organisms12

Diseases2

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Psychiatry and Psychology1

Phenomena and Processes59

Disciplines and Occupations3

Technology, Industry, Agriculture6

Information Science4

Health Care2

Mitogen-Activa2

Epithelial Neutrophil Activating Peptide3

Receptors11

Proteins8

Receptor18

Sequence3

Cardiac4

Binds2

Kinase3

Vasoactive1

Endogenous peptide1

Antimicrobial peptide6

Cathelicidin2

VIVO2

Hypothalamic2

PACAP2

Synthetic peptide2

Amino2

Pituitary3

Cationic3

Bioactive1

Therapeutic1

Polypeptide2

Thrombin cleavage1

Macrophages1

Similarly1

Secretion2

Residues3

Promotes2

Disrupts2

TRAP1

Mice3

Monoclonal2

Bacteria3

Class II restricted2

Cells5

Drugs1

Bound1

Hormone2

Precursor1

Found2

Molecules1