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  • Vasoactive Intesti
  • Vasoactive intestinal peptide tumor is a rare neuroendocrine neoplasm which causes voluminous watery diarrhea via hypersecretion of electrolytes and water from the intestinal mucosa through a vasoactive intestinal peptide-mediated, cyclic AMP-dependent mechanism. (hindawi.com)
  • A review of literature was performed using MEDLINE, Pubmed, and Cochrane databases in collection of data using MeSH terms including vasoactive intestinal peptide, VIPoma, and WDHA. (hindawi.com)
  • Vasoactive intestinal peptide tumor is a rare neoplasm associated with significant morbidity and mortality through secretion of water and electrolytes in the gastrointestinal tract. (hindawi.com)
  • amide
  • derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide ( amide ) bonds. (wikipedia.org)
  • Amino acids that have been incorporated into peptides are termed "residues" due to the release of either a hydrogen ion from the amine end or a hydroxyl ion from the carboxyl end, or both, as a water molecule is released during formation of each amide bond. (wikipedia.org)
  • These molecule s link to each other by forming a bond (an amide linkage) between the amino group of one peptide to the carboxyl group of another. (everything2.com)
  • opiate
  • For instance, peptides called enkephalins are natural opiate s created by the brain . (everything2.com)
  • Well-known examples are the opioids (e.g., enkephalins), so named because they are endogenous (produced in the human body) peptides (short chains of amino acids) with a strong affinity for the receptors that bind opiate drugs, such as morphine and heroin. (britannica.com)
  • specific peptide
  • The pharmacologic interaction with immune receptors (p-i) model states that drugs can induce the formation of HLA-drug complexes that can activate T-cell immune responses directly without requiring a specific peptide ligand ( 8 ). (pnas.org)
  • antibiotic
  • This is an important breakthrough because peptides are considered to be a possible solution in the fight against antibiotic-resistant bacteria. (empa.ch)
  • The research carried out by Empa and the University of Copenhagen could, therefore, be a first step in the successful fight against antibiotic-resistant bacteria, as peptides use a different mechanism from that used by antibiotics and destroy the membrane of bacteria. (empa.ch)
  • amino acid sequences
  • Cell-penetrating peptides are of different sizes, amino acid sequences, and charges but all CPPs have one distinct characteristic, which is the ability to translocate the plasma membrane and facilitate the delivery of various molecular cargoes to the cytoplasm or an organelle. (wikipedia.org)
  • ELISA
  • coat the peptide to an ELISA plate. (bio.net)
  • Coating a peptide on an ELISA plate has a few inherent problems. (bio.net)
  • You may want to try a different aproach such as biotinylating the peptide and immobilizing it on a Neutravidin coated ELISA plate. (bio.net)
  • antimicrobial
  • They occur in many organisms and constitute natural weapons against bacteria in the body, being known as antimicrobial peptides. (empa.ch)
  • IMAP 2018 will cover both the antimicrobial activity of peptides as well as their role in regulation and modulation of the immune system. (rsc.org)
  • tyrosine
  • The tyrosine residue is an important structural motif that is required for the opioid peptide to bind with its corresponding receptor. (news-medical.net)
  • Microarrays
  • Divided into three sections, the book covers cutting-edge methods and technology, chemoselective strategies for peptide immobilization, and peptide microarrays for medical applications. (springer.com)
  • Fully updated and authoritative, Peptide Microarrays: Methods and Protocols, Second Edition seeks to encourage scientists to apply current peptide array protocols to the study of interesting new biochemical and medical questions and to assist researchers aiming at developing new methods to further develop peptide microarray technology. (springer.com)
  • In Peptide Microarrays: Methods and Protocols , experts in the field provide a cutting-edge view of peptide array technology, its applications, and technical issues. (springer.com)
  • Specificity
  • Here we show that abacavir can bind within the F pocket of the peptide-binding groove of HLA-B*57:01, thereby altering its specificity. (pnas.org)
  • Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. (springer.com)
  • Tumor
  • For example, cytotoxic peptides such as KLAK are conjugated onto dendrimers (polymeric materials with nanometer-scale dimensions) to enhance intracellular delivery and deep tumor penetration capacity. (news-medical.net)
  • chemistry
  • Peptide science routinely utilizes tools and techniques that are common to organic chemistry, p- tein chemistry, biophysical chemistry, enzymology, pharmacology, and molecular biology. (springer.com)
  • In 1977, David Schlesinger of the Harvard University Chemistry Department confirmed that the growth modulating peptide isolated by Pickart was a glycyl-L-histidyl-L-lysine peptide. (wikipedia.org)
  • cleavage
  • GLP-2 is created by specific post-translational proteolytic cleavage of proglucagon in a process that also liberates the related glucagon-like peptide-1 (GLP-1). (wikipedia.org)
  • protocols
  • The purpose of Peptide Analysis Protocols is to provide the novice with sufficient practical information necessary to begin developing useful analysis and separation skills. (springer.com)
  • This volume will also provide those who already possess practical knowledge of the more advanced aspects of peptide science with detailed applications for each of these protocols. (springer.com)
  • Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research. (springer.com)
  • diabetes
  • In type 1 diabetes, the pancreas produces little or no insulin and little or no C-peptide. (kidshealth.org)
  • A C-peptide test is not ordered to help diagnose diabetes, but when a person has been newly diagnosed with diabetes, it may be ordered by itself or along with an insulin level to help determine how much insulin a person's pancreas is still producing (endogenous insulin). (labcorp.com)
  • C-peptide levels may be ordered when a person has been newly diagnosed with type 1 diabetes as part of an evaluation of the person's "residual beta cell function. (labcorp.com)
  • collagen
  • Single-blind case-control studies have demonstrated that marine collagen peptides improve skin elasticity and sebum production in healthy participants. (news-medical.net)
  • strong affinity
  • Further research established that GHK peptide has a strong affinity for copper and exists in two forms - GHK and GHK-Cu. On the basis of the available data, it was proposed that GHK-Cu functions by modulating copper intake into cells. (wikipedia.org)
  • bacteria
  • Peptides are already effective against bacteria when working "alone" - but in combination with the carrier structure they are even stronger. (empa.ch)
  • linkage
  • The "cargo" is associated with the peptides either through chemical linkage via covalent bonds or through non-covalent interactions . (wikipedia.org)
  • antibody
  • A decade later, the mammalian counterpart of bombesin was identified using an anti-bombesin antibody and named gastrin-releasing peptide (GRP). (springer.com)
  • This has the added benefit of inserting a speacer arm between the plate and the peptide, htereby increasing antibody recognition. (bio.net)
  • methods
  • As the technology base for the preparation of increasingly c- plex peptides has improved, the methods for their purification and ana- sis have also been improved and supplemented. (springer.com)
  • bacterial
  • Other peptides are studied because they have or may have value in treating diseases such as cancer , AIDS , and other viral and bacterial diseases. (everything2.com)
  • The reason for this lies in their structure, which results in peptides being broken down relatively quickly inside the human body, before they can have an anti-bacterial impact. (empa.ch)
  • Initial tests with bacterial cultures have shown that the peptides are completely enclosed by the nanocarriers and thus remain stable. (empa.ch)