• We measured serum C-reactive protein, procalcitonin (PCT) and calprotectin levels, and plasma pentraxin 3 (PTX3) and presepsin levels, along with whole-blood white cell counts, at three time-points, and examined their association with microbial aetiology and adverse clinical outcomes in CAP. (ersjournals.com)
  • Increased admission levels of C-reactive protein, PCT and calprotectin were associated with bacterial aetiology of CAP, while increased admission levels of PCT, PTX3 and presepsin were associated with adverse short-term outcome. (ersjournals.com)
  • Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear. (oncotarget.com)
  • Dietary intakes, anthropometric parameters, lipid profile, and inflammatory markers (i.e., pentraxin 3 [PTX3], high-sensitivity C-reactive protein [hs-CRP], and interleukin 18) were measured. (bvsalud.org)
  • Background: Long pentraxin 3 (PTX3) is an acute-phase protein secreted by various cells, including leukocytes and endothelial cells. (tmu.edu.tw)
  • The gold standard blood culture along with complete blood count (CBC), lactate dehydrogenase (LDH), C-reactive protein (CRP), procalcitonin (PCT), presepsin (PSN), pentraxin3 (PTX3), and monocyte chemoattractant protein-1(MCP-1) could detect the microbial bloodstream infection. (ekb.eg)
  • Systemic inflammation evoked by LPS also produced greater increases in proinflammatory cytokines, pentraxin 3, and inducible nitric oxide synthase transcription in prion-diseased mice than in control mice and induced microglial expression of IL-1β. (jneurosci.org)
  • In the bone microenvironment, breast cancer cells produce osteoclast (OC)-activating cytokines, including parathyroid hormone-related protein (PTH-rP), prostaglandin E 2 (PEG 2 ), and interleukin-11 (IL-11) [ 5 ], which can increase expression of receptor activator of nuclear factor-κB ligand (RANKL) by osteoblasts (OBs). (oncotarget.com)
  • Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
  • It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. (wikipedia.org)
  • C-reactive protein (CRP) is an acute-phase protein of the pentraxin family produced in the liver in response to inflammatory signals, particularly interleukin-6, which is synergistically enhanced by IL-1β. (nature.com)
  • Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. (caslab.com)
  • In this context, there is abundant evidence that clinical depression is an immuno-inflammatory disorder characterized by among other things increased levels of PICs and acute phase proteins, including C-reactive protein and haptoglobin [ 11 - 20 ]. (biomedcentral.com)
  • CRP -- an acute phase serum protein - is a surrogate for the pro-inflammatory interleukin IL-6. (medscape.com)
  • An acute phase protein that belongs to the pentraxin family of proteins. (yashraj.com)
  • This protein is produced mainly in the liver and adipose tissue and is described as an acute phase protein. (czytelniamedyczna.pl)
  • It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE. (bvsalud.org)
  • Igg Antibody Laboratories manufactures the igg antibody self reactive reagents distributed by Genprice. (stainingkit.com)
  • In clinical depression, however, a transition occurs to sensitization of immuno-inflammatory pathways, progressive damage by oxidative and nitrosative stress to lipids, proteins, and DNA, and autoimmune responses directed against self-epitopes. (biomedcentral.com)
  • The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. (frontiersin.org)
  • The Clinical Significance and Potential Role of C-Reactive Protein in Chronic Inflammatory and Neurodegenerative Diseases. (egoo.health)
  • The protein encoded by this gene belongs to the pentaxin family. (caslab.com)
  • with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)
  • It is not related to C-peptide (insulin) or protein C (blood coagulation). (wikipedia.org)
  • Modest weight loss in overweight adults decreases serum leptin and high molecular weight adiponectin, and increases pentraxin-3 concentrations in a manner that correlates with increased insulin sensitivity. (wustl.edu)
  • Amyloid fibrils are protein polymers comprising identical monomer units (homopolymers). (medscape.com)
  • [ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
  • [ 6 ] In humans, about 23 different unrelated proteins are known to form amyloid fibrils in vivo. (medscape.com)
  • The assembly of misfolded proteins into amyloid fibrils involves an intermediate form, i.e., soluble amyloid precursor (AP), which exerts cytotoxic function. (longdom.org)
  • Using a series of fusion proteins corresponding to the different structural domains of TSP, binding of [125I]DCN to TSP was found to be dependent of the N-terminal domain and, to a lesser extent, of the type 1 repeats and the C-terminal domain of TSP. (embl.de)
  • Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. (embl.de)
  • Like C-reactive protein (CRP), it belongs to the pentraxin superfamily. (tmu.edu.tw)
  • Horseradish peroxidase conjugated protein A was used for signal developing instead of secondary antibody incubated at room temperature for 1.5 hours. (ptglab.com)
  • The Igg Antibody Self Reactive reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (stainingkit.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2) in samples from Tissue homogenates, cell lysates and other biological fluids. (operatiebrp.nl)
  • It has a pentagonal (pentaxin) structure. (bvsalud.org)
  • C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. (wikipedia.org)
  • Alzheimer's possesses complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. (benthamscience.com)
  • It is a member of the pentraxin family of proteins. (wikipedia.org)
  • It is a member of the small pentraxins family. (wikipedia.org)
  • The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. (embl.de)
  • [ 2 ] It is a member of pentraxin family of proteins and is synthesized by liver. (medscape.com)
  • CRP belongs to the pentraxin family of calcium dependent ligand-binding plasma proteins. (medicinepaper.net)
  • The pentraxin family named for it electron micrographic appearance from the Greek penta (five), ragas (berras). (medicinepaper.net)
  • SAP is a member of the pentraxin protein family . (guidetopharmacology.org)
  • Mitogen-activated protein kinases (MAPKs) consist of a family of protein-serine/protein-threonine kinases followed by proline, prevalent in mammals (Pearson et al. (frontiersin.org)
  • SAP is a member of the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened beta-jellyroll structure similar to that of the legume lectins. (biobool.com)
  • The later discovery of hepatic synthesis (made in the liver) demonstrated that it is a native protein. (wikipedia.org)
  • Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
  • We reveal the potential to exploit interactions of sPLA 2 s with other proteins in medical terms, for the development of original diagnostic and therapeutic procedures. (ijbs.com)
  • Amyloidosis results from the accumulation of pathogenic amyloids-most of which are aggregates of misfolded proteins-in a variety of tissues. (medscape.com)
  • 1981) Amyloid P-component (protein AP) in localized amyloidosis as revealed by an immunocytochemical method. (guidetopharmacology.org)
  • Here, we reviewed the physiological/pathological roles and therapeutic significance of nearly all the proteins associated with AD that addresses putative as well as probable targets for developing effective anti-AD therapies. (benthamscience.com)
  • On diagnostic grounds of AD C-reactive protein, pentraxins, collapsin response mediator protein-2, and growth-associated protein-43 represent the future of new possible biomarkers for diagnosing AD. (benthamscience.com)
  • Analysis of proteome i.e. allows to individuate proteins that act as biomarkers, for patient-centered research strategies. (springeropen.com)
  • 9. Pepys MB, Dash AC, Fletcher TC, Richardson N, Munn EA, Feinstein A. (1978) Analogues in other mammals and in fish of human plasma proteins, C-reactive protein and amyloid P component. (guidetopharmacology.org)
  • Description: A sandwich ELISA kit for detection of Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425198/1/Protein_C_and_Protein_S. Accessed October 3, 2023. (unboundmedicine.com)
  • All types of amyloid consist of one major fibrillar protein that defines the type of amyloid. (medscape.com)
  • 1977) Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein. (guidetopharmacology.org)
  • The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. (embl.de)
  • Unless otherwise stated all data on this page refer to the human proteins. (guidetopharmacology.org)
  • Human SAP has 51% sequence homology with C-reactive protein (CRP) Both SAP and CRP are evolutionary conserved in all vertebrates and also found in distant invertebrates such as the horseshoe crab. (biobool.com)
  • The structural diversity of sPLA 2 -BPs reveals sPLA 2 s as very promiscuous proteins, and we offer some structural explanations for this nature that makes these proteins evolutionarily highly advantageous. (ijbs.com)
  • [ 5 ] CRP is a 224-residue protein with a molecular weight of 25106 Da. (medscape.com)
  • Shortchain pentraxins, which include both SAP and C-reactive protein (CRP), are pattern recognition molecules that bind to diverse ligands and promote the clearance of microbes and cell debris. (longdom.org)
  • Whether these pentraxins interact with AP and cofactor containing amyloid and subsequently. (longdom.org)
  • HSPs, which ameliorate oxidative stress, calpains, which help in regulating synaptic plasticity, and calmodulin-like skin protein (CLSP) with its neuroprotective role are few promising future targets for developing anti-AD therapies. (benthamscience.com)
  • C-reactive protein (CRP) is involved in a wide range of diseases. (nature.com)
  • 3. Avan A, Tavakoly Sany SB, Ghayour-Mobarhan M, Rahimi HR, Tajfard M, Ferns G. Serum C-reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice. (egoo.health)
  • Protein C and Protein S." Davis's Lab & Diagnostic Tests , 7th ed. (unboundmedicine.com)
  • Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425198/1/Protein_C_and_Protein_S. (unboundmedicine.com)
  • Importantly, significantly upregulated SV2A protein levels were found in both NEPC cell lines and tumor tissues. (bvsalud.org)
  • 4. Yu N, Cui H, Chen X, Chang Y. Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus. (egoo.health)
  • These proteins either arise from proteins expressed by cells at the deposition site (localized), or they precipitate systemically after production at a local site (systemic). (medscape.com)
  • The last few decades were concentrated over identifying and studying protein targets of AD. (benthamscience.com)
  • How any of these misfolded proteins are controlled by the host remains obscure. (longdom.org)
  • Host proteins used by Candida Albicans during its life cycle. (polygenicpathways.co.uk)
  • The two are initially tested together because a deficiency in Protein S may affect Protein C activity. (unboundmedicine.com)
  • 1982) The structure and binding characteristics of serum amyloid protein (9.5S alpha 1-glycoprotein). (guidetopharmacology.org)
  • Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. (embl.de)