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  • Insulin
  • The importance of certain micronutrients as cofactors in glucose metabolic pathways, pancreatic β -cell function and in the insulin signaling cascade suggests that deficiency in these micronutrients may play a role in the development of type 2 diabetes. (hindawi.com)
  • 3 However, numerous microenvironmental insults can inhibit the function of the IR/IGF-1R signaling pathways and cause insulin resistance, hyperglycemia and hyperinsulinemia. (pubmedcentralcanada.ca)
  • plays
  • Specifically, metformin suppresses the mTORC1-signaling pathway that plays an important role in sensing the nutrient microenvironment and promoting tumor growth, and is itself an active target for cancer drug development. (pubmedcentralcanada.ca)
  • cannot
  • Humans, too, have this pathway, but it cannot, on its own, produce all the antioxidants needed, which is why athletes drink antioxidant-laced sports drinks and parents tell their children to eat their veggies. (eurekalert.org)