Pentolinium has been reported to offer more prolonged ganglionic blockade and has less severe untoward effects than hexamethonium. (wikipedia.org)
Splanchnic nerve section, ganglionic blockade with pentolinium tartrate or ß2 adrenoreceptor antagonism with ICI 118551 all blocked IL-10 responses. (bvsalud.org)
Treatment1
TNF responses were disinhibited by splanchnic denervation or pentolinium treatment, but not by ICI 118551. (bvsalud.org)
Hydralazine2
Reprinted from CrrcuLatTion Vol. XIII, No. 6, June, 1956 Printed in U.S.A, Results of Prolonged Treatment with Pentolinium Tartrate with Special Reference to the Addition of Rauwolfia, Hydralazine or Both By Evwarp D. Freis, M.D., anp Inst M. Witson, M.D. A series of 96 patients with severe hypertension has been treated with pentolinium tartrate for an average period of 12 months. (nih.gov)
Various combinations of hypo- tensive agents were tested and it was concluded that in general the combination of pentolinium tartrate, Rauwolfia and hydralazine resulted in the greatest reduction of blood pressure with the least degree of side effects due to ganglionic "blockade. (nih.gov)
Ansolysen2
Formulated as the pentolinium tartrate salt, it is also known as Ansolysen. (wikipedia.org)
Pentolinium tartrate (Ansolysen) was generously supplied by Daniel LL. (nih.gov)
Orally2
Pentolinium can be given orally (20mg three times a day), injected intramuscularly, or administered intravenously. (wikipedia.org)
These reports indicated that pentolinium tartrate was an orally effective, potent, antihypertensive drug that appeared to be useful in the treatment of patients with more severe, fixed types of hypertension. (nih.gov)
Ganglionic2
Pentolinium is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist. (wikipedia.org)
Pentolinium has been reported to offer more prolonged ganglionic blockade and has less severe untoward effects than hexamethonium. (wikipedia.org)
Hypertension1
Pentolinium and hexamethonium combined with Rauvolfia was reported in 1955 to be effective in the outpatient management of moderate to severe hypertension, with satisfactory orthostatic reduction in blood pressure but there are significant untoward effects attributable to the use of the hexamethonium. (wikipedia.org)
Treatment2
All except 15 of these patients were hospitalized prior to or during the initiation of treatment with pentolinium. (nih.gov)
Severity Indices of Patients Prior to Treatment with Pentolinium Tartrate Parameter No. of nD of Male. (nih.gov)
Term1
In the present report, the long-term experience with pentolinium tartrate both alone and in combination with certain other hypotensive agents is presented. (nih.gov)