Loading...
  • doses
  • In studies, secobarbital sodium and pentobarbital sodium have been found to lose most of their effectiveness for both inducing and maintaining sleep by the end of 2 weeks of continued drug administration at fixed doses. (nih.gov)
  • The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these types of compounds. (sciencemag.org)
  • This is done because large concentrated doses of pentobarbital may cause vomiting. (thefullwiki.org)
  • With a scheduled execution just two days away, the Texas Department of Criminal Justice refused Monday to return lethal doses of pentobarbital to the Houston-area pharmacy that compounded the drug and sold it to the state to kill murderers. (typepad.com)
  • In our study, the preemptive analgesic state was created by doses of pentobarbital sufficient to produce loss of righting reflex (16-20 mg [centered dot] kg sup -1). (asahq.org)
  • Because pentobarbital is antinociceptive at the spinal level while suppressing the descending inhibitory system supraspinally, we speculate that increasing doses produce a continuum of effects from disinhibition to suppression of the spinal nociceptive system, resulting in hyperalgesia to analgesia. (asahq.org)
  • In high doses, pentobarbital causes death by respiratory arrest . (hitchhikersgui.de)
  • Pentobarbital can induce death when used in high doses. (hitchhikersgui.de)
  • GABA
  • Pentobarbital, like the endogenous neurotransmitter gamma-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of [3H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [3H]diazepam for the benzodiazepine receptor. (sciencemag.org)
  • To the Editor:-In an interesting article, Gilron and Coderre demonstrated lack of analgesic effect of systematically administered pentobarbital in the rat formalin test, contradictory to our results that showed that pentobarbital produces preemptive analgesia via activation of GABA A receptors. (asahq.org)
  • Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons. (diva-portal.org)
  • [3,Prolongation of the open-time of the GABA A receptor-chloride channel by pentobarbital [2,partially depolarizes the postsynaptic membrane, enhancing conductance at the NMDA receptor-mediated calcium channel. (asahq.org)
  • Similarly, chronic pentobarbital sodium treatment did not alter the basal binding of [3H]GABA and t-butylbicyclophosphoro[35S]thionate. (aspetjournals.org)
  • The efficacy (Emax) values of GABA, pentobarbital and neurosteroid, 5 alpha-pregnan-3 alpha-ol-20-one, on [3H]flunitrazepam binding were significantly decreased, whereas their potency (EC50) values were not altered after chronic pentobarbital sodium treatment. (aspetjournals.org)
  • Taken together, these results suggest that chronic pentobarbital sodium treatment produces heterologous uncoupling of the GABA-BZ receptor ionophore complex. (aspetjournals.org)
  • morphine
  • Pentobarbital administered intracerebroventricularly to mice has been shown previously to inhibit the analgesic action of morphine given intrathecally. (aspetjournals.org)
  • Second, lorglumide and PD135,158 given intrathecally also eliminated the antianalgesic effect of intracerebroventricularly administered pentobarbital against intrathecal morphine. (aspetjournals.org)
  • Thus, the results indicated that pentobarbital antianalgesia was obtained through activation of a descending system to the spinal cord where cholecystokinin inhibited the spinal analgesic action of morphine. (aspetjournals.org)
  • Because pentobarbital given i.c.v. antagonizes the analgesic action of morphine given i.t., the antagonism appears to involve a descending modulatory mechanism ( Wang and Fujimoto, 1993 ). (aspetjournals.org)
  • rats
  • Intake of ethanol by rats, at a dose of 10 to 12 g/kg daily for two weeks, led to a slower onset and shorter duration of pentobarbital-induced sleep (30 mg/kg i.p.) than in pair-fed controls with isocaloric substitution of sucrose for ethanol. (aspetjournals.org)
  • In the study by Gilron and Coderre, where pentobarbital failed to show analgesia, even rats receiving the largest dose (20 mg [centered dot] kg sup -1) did not lose righting reflex, indicating that this dose was relatively smaller than our largest dose when the sensitivity of animals to pentobarbital is taken into account. (asahq.org)
  • Mivazerol, a new alpha 2-adrenergic agonist, blunts cardiovascular effects following surgical stress in pentobarbital-anesthetized rats. (curehunter.com)
  • euthanize animals
  • It was recently revealed on information and belief that Defendants were knowingly, recklessly and/or negligently selling certain of the Contaminated Dog Foods from the DogStar Kitchens containing pentobarbital, a substance largely used to euthanize animals. (truthaboutpetfood.com)
  • metabolism
  • Pentobarbital undergoes first-pass metabolism in the liver and possibly the intestines. (thefullwiki.org)
  • The results show a significant tendency for the left-going behavior to persist under pentobarbital sodium in Group II, but not with saline injections in Group I. These results were interpreted as further evidence for a correlation between the level of acetylcholine metabolism and the capacity for more adaptive behavior. (ovid.com)
  • drugs
  • Michael Lee Wilson, 38, was executed using a cocktail of drugs including pentobarbital, prison officials confirmed to TIME. (time.com)
  • Pentobarbital has been used or considered as a substitute for other drugs traditionally used for capital punishment in the United States when they are in short supply. (hitchhikersgui.de)
  • Pentobarbital belongs to the group of drugs that slows down the brain activity and nervous system. (rehabnear.me)
  • Doctors also use pentobarbital drugs to treat seizures and to put patients into a deep slumber in preparation for surgery. (rehabnear.me)
  • overdose
  • On the other hand, if you have been receiving both medications, discontinuing PENTobarbital may increase the blood levels of HYDROcodone, which could lead to an overdose. (drugs.com)
  • Pentobarbital overdose occurs when a person intentionally or accidentally takes too much of the medicine. (indiatoday.in)