Penicillin resistant clinical streptococcus pneumoniae. Medical search. Frequent questions

It also has limited activity against highly-penicillin-resistant S pneumoniae isolates. (medscape.com)
Confirmed cases with isolates from normally sterile sites were investigated by medical record reviews to determine the clinical presentation, underlying medical conditions (including HIV-infection status), and hospitalization and antibiotic use within the preceding 6 months. (cdc.gov)
This report summarizes the results of that analysis, which found that the percentage of IPD nonmeningitis S. pneumoniae isolates categorized as susceptible, intermediate, and resistant to penicillin changed from 74.7%, 15.0%, and 10.3% under the former breakpoints to 93.2%, 5.6%, and 1.2%, respectively, under the new breakpoints. (cdc.gov)
2 µ g/mL, respectively, for all pneumococcal isolates, regardless of clinical syndrome or route of penicillin administration. (cdc.gov)
S. pneumoniae infections in persons with noninvasive isolates (e.g., from sputum) were not considered IPD cases. (cdc.gov)
Among isolates from patients without meningitis, the number of penicillin-susceptible isolates increased from 4,797 (74.7%) under the former breakpoints to 5,989 (93.2%) using the new breakpoints for intravenous treatment ( Figure 1 ). (cdc.gov)
ABSTRACT Susceptibility of 88 clinical Streptococcus pneumoniae isolates, 116 Haemophilus influenzae isolates and 80 Moraxella catarrhalis isolates to 6 fluoroquinolones--ciprofloxacin, ofloxacin, levofloxacin, trovafloxacin, grepafloxacin and gemifloxacin--were determined. (who.int)
No isolates were resistant to gemifloxacin or grepafloxacin. (who.int)
National surveillance for drug-resistant S. pneumoniae (DRSP) is limited to testing invasive isolates from sentinel hospitals in 13 states. (cdc.gov)
To determine the extent of antimicrobial susceptibility testing of S. pneumoniae and the prevalence of penicillin resistance among pneumococcal isolates from July 1992 through June 1993, in August 1993 the Connecticut Department of Public Health and Addiction Services (DPHAS) surveyed all 44 hospitals with clinical microbiology laboratories in Connecticut. (cdc.gov)
Hospital laboratories were asked whether pneumococcal isolates were tested for resistance to penicillin, which isolates were tested, which tests were used, the number of isolates tested from different body sites from July 1992 through June 1993, and the minimal inhibitory concentrations (MICs) for any resistant isolates. (cdc.gov)
Nine laboratories screened pneumococcal isolates by disk diffusion, then confirmed penicillin resistance by determination of a quantitative MIC. (cdc.gov)
Nine laboratories determined the penicillin MIC for all pneumococcal isolates. (cdc.gov)
Penicillin-resistant isolates were reported from four of 14 hospitals. (cdc.gov)
Eighteen isolates (2.1%) from any body site were penicillin resistant, including five (1.3%) of 400 isolates from usually sterile sites. (cdc.gov)
Overall, three isolates (one each from blood, sputum, and nasal fluid) were highly resistant. (cdc.gov)
Two of these isolates had penicillin MICs greater than or equal to 4.0 ug/mL. (cdc.gov)
in comparison, during 1992, seven (1.3%) of 544 such isolates were highly resistant (4,6). (cdc.gov)
In some pediatric populations, up to 30% of pneumococcal isolates are penicillin resistant at some level, with a substantial proportion of strains resistant to multiple drugs (3). (cdc.gov)
Almost all of these isolates were sensitive to penicillin, cefotaxime, amoxycillin, choloramphenicol, erythromycin and ofloxacin and resistant to cotrimoxazole and gentamicin. (ox.ac.uk)
In January 2008, the Clinical and Laboratory Standards Institute published new Minimum Inhibitory Concentration (MIC) breakpoints for defining susceptibility of S. pneumoniae isolates to penicillin. (cdc.gov)
In a poster entitled "In Vitro Activity of the Novel Antibacterial ACX-362E against Clostridioides difficile " the in vitro activity of ACX-362E was tested against 104 contemporary clinical isolates of C. difficile including 30 identified epidemic strains (e.g., ribotype 027) as well as 36 toxin-producing strains. (acurxpharma.com)
Introduction We performed a study to describe the clinical profile, antimicrobial susceptibility and prevalent serotypes of pneumococcal isolates from children with suspected invasive pneumococcal disease (IPD) admitted to a tertiary care hospital in South India. (johnshopkins.edu)
Two isolates belonging to the 19F and 19B serotypes were resistant to penicillin (on Etest). (johnshopkins.edu)
the S. pneumoniae isolates from these two patients belonged to the non-vaccine serotype 19B and serotype 19F and demonstrated in vitro resistance to penicillin and erythromycin. (johnshopkins.edu)
The broth microdilution methods was used to determine minimum inhibitory concentrations (MIC) of blood-borne isolates according to guildlines of the Clinical and Laboratory Standards Institute (CLSI). (biomedcentral.com)
More than 91% Enterobacteriaceae isolates, belonging to Escherichia coli , Klebsiella pneumoniae , Enterobacter cloacae and Serratia marcescens , were susceptible to amikacin, meropenem, and tigecycline. (biomedcentral.com)
Meropenem resistance was observed in 8% of K.pneumoniae isolates worldwide. (biomedcentral.com)
Extended-spectrum β-lactamase (ESBL) was produced in 15.9 and 20.9% E.coli and K.pneumoniae isolates, respectively. (biomedcentral.com)
Vancomycin-resistant (VR) isolates represented 1.4% of Enterococcus faecalis (VR. (biomedcentral.com)
The overall AMR of invasive S. pneumoniae isolates was low. (who.int)
With the inclusion of PCV13 in the National Immunization Program, continued monitoring of the prevailing serotypes of S. pneumoniae isolates in the Philippines is needed to guide disease and AMR control measures. (who.int)
Confirmation of example, serotypes 19F, 14, 23F, 9V and 6B have been identification and AST of isolates were performed using found to be resistant to penicil in and macrolides. (who.int)

RÉSUMÉ La sensibilité de 88 isolats cliniques de Streptococcus pneumoniae , de 116 isolats d' Haemophilus influenzae et de 80 isolats de Moraxella catarrhalis à six fluoroquinolones - ciprofloxacine, ofloxacine, lévo- floxacine, trovafloxacine, grépafloxacine et gémifloxacine - a été déterminée. (who.int)
caused by Streptococcus pneumoniae (excluding penicillin-resistant strains), Streptococcus pyogenes, Haemophilus influenzae (including beta-lactamase-producing strains), or Moraxella (Branhamella) catarrhalis (including beta-lactamase-producing strains). (globalrph.com)
CEFTIN tablets are indicated for the treatment of pediatric patients (who can swallow tablets whole) with acute bacterial otitis media caused by susceptible strains of Streptococcus pneumoniae , Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or Streptococcus pyogenes . (rxlist.com)
CEFTIN for oral suspension is indicated for the treatment of pediatric patients aged 3 months to 12 years with acute bacterial otitis media caused by susceptible strains of Streptococcus pneumoniae , Haemophilus influenzae (including β-lactamase-producing strains), Moraxella catarrhalis (including β-lactamase-producing strains), or Streptococcus pyogenes . (rxlist.com)
Streptococcus pneumoniae , nontypeable Haemophilus influenzae , and Moraxella catarrhalis are the most commonly isolated middle-ear pathogens. (medscape.com)
Streptococcus pneumoniae , Haemophilus influenzae and Moraxella catarrhalis are often involved in respiratory infections associated with wheezing, but there is no evidence for their active role in asthma pathogenesis or exacerbation. (medscape.com)
[ 10 ] Other bacteria, although common in children's airways, such as Streptococcus pneumoniae , Haemophilus influenzae and Moraxella catarrhalis , seem to play no role in asthma exacerbations, although the available data are over 30 years old. (medscape.com)
Typical bacterial pathogens that cause CAP include Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis . (medscape.com)

However, pneumococci with reduced penicillin sensitivity are often resistant to macrolides, and macrolide resistance among S. pyogenes varies globally. (msdmanuals.com)
Pharyngitis And/Or tonsillitis caused by Streptococcus pyogenes. (globalrph.com)
CEFTIN tablets are indicated for the treatment of adult patients and pediatric patients (13 years and older) with mild-to-moderate pharyngitis/tonsillitis caused by susceptible strains of Streptococcus pyogenes . (rxlist.com)
CEFTIN for oral suspension is indicated for the treatment of pediatric patients aged 3 months to 12 years with mild-to-moderate pharyngitis / tonsillitis caused by susceptible strains of Streptococcus pyogenes . (rxlist.com)
The efficacy of CEFTIN in the treatment of penicillin -resistant strains of Streptococcus pyogenes has not been demonstrated in clinical trials. (rxlist.com)
Owing to pediatric pneumococcal vaccination, however, the prevalence of pneumococcal serotypes not covered by the vaccines (eg, Alloiococcus otitidis, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa ) are increasingly being isolated in patients with acute otitis media (AOM). (medscape.com)
The present study from May 2006 to June 2007 included 107 strains of Streptococcus pneumoniae and 94 strains of Streptococcus pyogenes. (bvsalud.org)

In 15 of the 33 laboratories, penicillin susceptibility testing was limited to qualitative disk diffusion (using an oxacillin disk). (cdc.gov)
Population-based survey of antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from meningitis patients in Salvador, Brazil. (fiocruz.br)
Antimicrobial who were seen and 85 923 who were given medication susceptibility profiling of S. pneumoniae has played from January to December 2012. (who.int)
Comparing the occurrence of antibiotic resistance between different regions over time requires that the clinical microbiology laboratories uses the same susceptibility breakpoints and Sweden has used those established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) for many years. (folkhalsomyndigheten.se)
These are Staphylococcus aureus ;resistant to methicillin (MRSA), Streptococcus pneumoniae with reduced susceptibility or resistance to penicillin (PNSP), Enterococcus faecalis and Enterococcus faecium resistant to vancomycin (VRE), and Enterobacterales (previously Enterobacteriaceae) with ESBL (including AmpC) or ESBL-CARBA. (folkhalsomyndigheten.se)
Multidrug resistance (MDR) bacteria is defined as non-susceptibility to one or more antimicrobials on three or more antimicrobial classes, while strains that are non-susceptible to all antimicrobials, are classified as extreme drug-resistant strains [ 2 ]. (biomedcentral.com)

Streptococcus pneumoniae has become a leading cause of bacteremia, pneumonia, meningitis, and otitis media in the United States. (cdc.gov)
The presentation of the condition consists of pneumonia, endocarditis, and meningitis, all caused by Streptococcus pneumoniae. (wikipedia.org)
Streptococcus pneumoniae is the cause of Osler's triad of meningitis, pneumonia, and endocarditis. (wikipedia.org)
Pneumonia and endocarditis are usually treated with beta-lactam therapy penicillin, which has been said to be the most effective but sources have said that some bacterial strains are resistant to penicillin. (wikipedia.org)
High doses of penicillin do not affect pneumonia. (wikipedia.org)
Streptococcus pneumoniae (pneumococcus) is a common cause of pneumonia and meningitis in the United States. (cdc.gov)
Those breakpoints remain unchanged for patients without meningitis who can be treated with oral penicillin (e.g., for outpatient pneumonia). (cdc.gov)
Streptococcus pneumoniae is an important cause of community-acquired bacterial pneumonia, meningitis, acute otitis media, and other infections (1). (cdc.gov)
Streptococcal Infections Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. (msdmanuals.com)
Streptococci cause a wide range of infections in humans including pneumonia, endocarditis, meningitis, bacteremias, skin and soft tissue lesions. (solunum.org.tr)
Between February 1997-December 1998, 23 strains of S.pneumoniae from the sputa of adult patients who had pneumonia were isolated. (solunum.org.tr)
The results suggest that procaine penicillin may still be useful in the empirical therapy of pneumococcal pneumonia. (solunum.org.tr)
Community-acquired pneumonia caused by S. pneumoniae or H. Influenzae (including beta-lactamaseproducing strains). (globalrph.com)
Streptococcus pneumoniae causes many clinical syndromes, depending on the site of infection (e.g., acute otitis media, pneumonia, bacteremia, or meningitis). (cdc.gov)
This QIDP-designated antibiotic is now undergoing global Phase 3 clinical study in the indication of complicated urinary tract infections and an all-ventilated pneumonia patient study would follow. (wockhardt.com)
Clinical indications so far include skin and soft tissue infections, community-acquired or nosocomial pneumonia due to MRSA, VRE bacteremia and community-acquired pneumonia due to penicillin-resistant Streptococcus pneumoniae. (qxmd.com)
Childhood pneumonia: clinical features It is not possible to distinguish between bacterial and viral pneumonia on clinical grounds alone! (studyslide.com)
we have found that studies assessing the diagnostic accuracy of clinical, radiological, and laboratory tests for bacterial childhood pneumonia have used a heterogeneous group of gold standards, and found, at least in part because of this, the index tests have widely different accuracies. (studyslide.com)
Coverage against Streptococcus pneumoniae is inadequate, making the use of ciprofloxacin inappropriate in patients with community-acquired pneumonia. (aafp.org)
Indications for use include nosocomial pneumonia, intra-abdominal infections and serious penicillin- or cephalosporin-resistant S. pneumoniae infections. (aafp.org)
Streptococcus pneumoniae is a human pathogen that is responsible for causing pneumonia, otitis media, meningitis, and other infectious diseases. (mdpi.com)
Streptococcus pneumoniae poses a serious public At present, more than 94 different pneumococcal health concern because it causes a wide range serotypes have been classified based on the unique poly- of diseases including otitis media, septicaemia, saccharide characteristics and composition expressed meningitis and pneumonia. (who.int)
The term "typical" CAP refers to a bacterial pneumonia caused by pathogens such as S pneumoniae , H influenzae , and M catarrhalis . (medscape.com)

The serogroup/serotypes (SGTs) and antimicrobial susceptibilities to 10 antimicrobial agents of 110 clinical strains of Streptococcus pneumoniae were determined. (inspq.qc.ca)
Since this time the increasing emergence of penicillin-resistant strains of Streptococcus pneumoniae have created a serious therapeutic problem. (solunum.org.tr)

Breakpoints are MICs that define infections as susceptible (treatable), intermediate (possibly treatable with higher doses), and resistant (not treatable) to certain antimicrobials. (cdc.gov)
In January 2008, after a reevaluation that included more recent clinical studies, the Clinical and Laboratory Standards Institute (CLSI) published new S. pneumoniae breakpoints for penicillin (the preferred antimicrobial for susceptible S. pneumoniae infections). (cdc.gov)
At present, there are only a few reports samples from patients with clinical indi- globally on resistance of common respira- cations of respiratory tract infections. (who.int)
ALAMEDA, Calif., Aug. 2, 2006 - Cerexa Inc. today announced positive top-line results for the Phase 2 clinical trial of Ceftaroline for the treatment of complicated skin and skin structure infections (cSSSI). (nlvpartners.com)
We look forward to advancing Ceftaroline into Phase 3 clinical trials for complicated skin and other community and hospital acquired infections. (nlvpartners.com)
Cerexa Inc. is an innovation-driven biopharmaceutical company based in Alameda, Calif., that is focused on discovering, developing and commercializing a growing portfolio of novel anti-infective therapies for the treatment of serious, antibiotic-resistant infections. (nlvpartners.com)
Tigecycline was approved by the Food and Drug Administration in 2005, and is particularly useful in the treatment of multi-drug resistant infections, which are especially hard to treat. (kenyon.edu)
Editorial Note: The spread of DRSP strains may increase the public health impact of S. pneumoniae infections because of increased morbidity and reductions in the effectiveness of antimicrobial treatment for pneumococcal disease. (cdc.gov)
Pneumococcal Infections Streptococcus pneumoniae (pneumococci) are gram-positive, alpha-hemolytic, aerobic, encapsulated diplococci. (msdmanuals.com)
Because they are active against atypical respiratory pathogens, they are often used empirically for lower respiratory tract infections, but another drug is often necessary to cover macrolide-resistant pneumococci. (msdmanuals.com)
To reduce the development of drug-resistant bacteria and maintain the effectiveness of VANTIN and other antibacterial drugs, VANTIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (globalrph.com)
Vancomycin has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. (pfizermedicalinformation.com)
however, the safety and effectiveness of vancomycin in treating clinical infections due to these microorganisms have not been established in adequate and well-controlled clinical trials. (pfizermedicalinformation.com)
Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
All our novel antibiotics (WCK 771, WCK 2349, WCK 4873, WCK 4282, WCK 5222 and WCK 6777) are designed to address current and future unmet needs in the management of community-acquired and/or hospital-acquired infections caused by resistant bacterial pathogens. (wockhardt.com)
It is comprehensively active against macrolide or penicillin or quinolone-resistant Streptococcus pneumoniae as well as entire range of pathogens involved in community respiratory tract infections. (wockhardt.com)
WCK 6777 is being developed as once-daily therapy for infections caused by carbapenem-resistant Gram-negative pathogens. (wockhardt.com)
And if you have a new antibiotic, you do really want to hold it in reserve for those resistant infections. (bioedonline.org)
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major public health concerns in India, MRSA infections continue to be therapeutically challenging both in hospitals and in the community. (vjim.org)
Linezolid is currently showing great promise for the treatment of multi-resistant Gram-positive infections, both in the community and in a hospital setting. (qxmd.com)
We anticipate that this new generation of antimicrobial agents will provide adequate cover in the future for infections that cause significant treatment failures so far, such as VRE- associated endocarditis, bone and joint multi-drug resistant infections and possibly central nervous system infections, both in adult and children populations. (qxmd.com)
Acurx Pharmaceuticals is a publicly held clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. (acurxpharma.com)
The number of nosocomial infections caused by drug-resistant bacteria accounts for about 30% of the total of hospitalized infections (Lima et al. (springeropen.com)
The National Center for Disease Control and Prevention (CDC) reported that in the United States, at least 2 million cases of severe infections are caused by one or more antimicrobial-resistant bacteria each year, among which 30,000 patients die from such infections (Thomas et al. (springeropen.com)
Hence, it is important for the clinical treatment of infections to have the information derived from epidemiological data, which differ in scope and focus, i.e., data collected from around the world, different regions,countries, provinces, and hospitals. (biomedcentral.com)
streptococcus pneumoniae causes 5% of all cases of septic arthritis and is more often responsible for polyarticular infections than other organisms. (lookfordiagnosis.com)
Infections with resistant bacteria did not decrease the time to in-hospital mortality, for both healthcare- or community-associated infections. (biomedcentral.com)
Of these compounds some are already approved by official agencies, some are still in study, but the need of new antibiotics still does not cover the increasing prevalence of antibiotic-resistant bacterial infections. (biomedcentral.com)
The phenomenon of sulfonamide-resistant infections was first discussed in the late 1960s, but the mechanism of action underlying the effectiveness of sulfa drugs only gradually became known, with increasing knowledge of the interaction between PABA and this important class of antibiotics. (interactionsguide.com)
Four plants often cited by traditional practitioners (Marrubium vulgare, Thymus pallidus, Eryngium ilicifolium and Lavandula stoechas) are tested against Streptococcus pneumoniae responsible for pharyngitis, rhinitis, otitis and sinusitis infections. (bvsalud.org)
Clinical experience suggests that, in addition to acute viral infections of the airways, focal bacterial infections, such as sinusitis or bronchitis, may also worsen asthma symptoms in children, but there is no research-based evidence for this connection. (medscape.com)

Plasmid Dynamics in KPC-Positive Klebsiella pneumoniae during Long-Term Patient Colonization. (cdc.gov)
It is also a potent inhibitor of Ambler class A and C β-lactamases including Klebsiella pneumoniae carbapenemases. (wockhardt.com)
The microorganisms mainly involved in the resistance process, so called the ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and enterobacteriaceae ) were the main targets. (biomedcentral.com)

Trimethoprim-sulfamethoxazole (TMP-SMX) is effective against many aerobic gram-positive and gram-negative bacteria, but its use in bacterial meningitis is limited to patients with Listeria monocytogenes meningitis who have a penicillin allergy. (medscape.com)
Carbapenems inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins. (medscape.com)
Bacterial cultivation is the main method in diagnosing Streptococcus pneumoniae. (wikipedia.org)
Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae (non-betalactamase- producing strains only), or M. catarrhalis. (globalrph.com)
The list ranks 12 bacteria or bacterial families and is topped by carbapenem-resistant Acinetobacter baumannii . (bioedonline.org)
[ 1 ] Among various resistant bacterial pathogens isolated around the world, methicillin-resistant Staphylococcus aureus (MRSA) is one of the major public health concerns. (vjim.org)
The Phase 1 clinical trial was first-in-man for a new class of antibiotics which work by inhibiting DNA synthesis in certain bacterial cells (pol IIIC inhibitors). (acurxpharma.com)
In this research, the combined anti-drug-resistant bacterial activities of these active ingredients were investigated. (springeropen.com)
From the discovery of penicillin in 1929 by Fleming to the end of the last century, great achievements have been made in developing anti-infective drugs, and bacterial infectious diseases have been effectively treated and controlled (Fleming 1980 ). (springeropen.com)
However, the inappropriate use of antibiotics in clinical and non-clinical treatment has led to increased spread of bacterial resistance and damaged the human micro-ecological balance, often resulting in the failure of clinical antibacterial treatment. (springeropen.com)
Nowadays, the continuous development and the spread of bacterial resistances pose some questions about their future and represent a serious threat for their clinical utility, leading to an urgent requirement for new compounds. (biomedcentral.com)
The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)

Because of the emergence of PNSP, in December 1994, the New York City Department of Health (NYCDOH) amended the New York City health code to require reporting of PNSP to monitor the local prevalence of resistance to penicillin. (cdc.gov)

Empiric antimicrobial therapy should cover all likely pathogens in the context of this clinical setting. (medscape.com)
Due to the broad activity of BAL30072 against multidrug-resistant Gram-negative pathogens including those that pose a biothreat, the Biomedical Advanced Research and Development Authority (BARDA), a division within the U.S. Department of Health and Human Services, entered a contract with Basilea for up to USD 89 million for the development of BAL30072. (basilea.com)
Pol IIIC is required for DNA replication of many Gram-positive pathogens, including Clostridioides as well as Enterococcus , Staphylococcus , and Streptococcus . (acurxpharma.com)

OBJECTIVES: The objective of this study is to see the clinical profile of invasive pneumococcal disease, antibiotics sensitivity pattern and prevalent serotypes in children admitted at Patan Hospital. (ox.ac.uk)
Data are scarce on the prevailing Streptococcus pneumoniae serotypes in the Philippines, including the relative antimicrobial resistance (AMR) of these bacteria. (who.int)
2 Invasive pneumococcal in the Africa-Eastern Mediterranean region, whereas disease (IPD), defined as infection of normally sterile serotypes 1 and 14 were prevalent in Europe and Latin sites of the body with S. pneumoniae , most frequently America. (who.int)
Data are lacking on the prevailing pneumococcal axone and levofloxacin was done fol owing the method serotypes in the Philippines, including their resistance to described by the Clinical and Laboratory Standard Insti- specific antimicrobials. (who.int)

2 The changes in breakpoints will likely result in a surveillance artifact in drug resistant S. pneumoniae reporting and further complicate interpretation of the reported data. (cdc.gov)
The World Health Organization (WHO) has for the first time released a list of drug-resistant bacteria that pose the greatest threat to human health - and for which new antibiotics are desperately needed. (bioedonline.org)
This work provides an insight into the effect of traditional Chinese medicine on drug-resistant bacteria. (springeropen.com)
Emergence of drug resistant Streptococcus pneumoniae may by associated with severe clinical outcomes. (johnshopkins.edu)
Exacerbation of Myasthenia gravisThere have been reports that erythromycin may aggravate the weakness of patients with myasthenia gravis.Development of Drug-Resistant BacteriaProlonged or repeated use of erythromycin may result in an overgrowth of non-susceptible bacteria or fungi. (drugcentral.org)
In the last two decades multi drug resistant microorganisms (both hospital- and community-acquired) challenged the scientific groups into developing new antimicrobial compounds that can provide safety in use according to the new regulation, good efficacy patterns, and low resistance profile. (biomedcentral.com)

their activity against Chlamydia pneumoniae and Mycoplasma pneumoniae is more variable. (aafp.org)
Mycoplasma pneumoniae may, like viruses, induce wheezing and asthma exacerbation. (medscape.com)

Unlike marketed cephalosporins, Ceftaroline exhibits bactericidal activity against the most resistant strains of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). (nlvpartners.com)
Penicillin-resistant Streptococcus pneumoniae , methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis , and vancomycin-resistant Enterococcus species are several examples of species that have developed an antibiotic resistance but are still affected by tigecycline (Greer 2006). (kenyon.edu)
Linezolid is the first approved member of a new generation of antibiotics, the synthetic oxazolidinones, to become available, with a broad spectrum of in vitro activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis and vancomycin-resistant Enterococcus faecium. (qxmd.com)
Acurx's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D pipeline includes early stage antibiotic candidates that target other Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin- Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP). (acurxpharma.com)
Pathogen resistance is occurring, particularly among P. aeruginosa and methicillin-resistant Staphylococcus aureus . (aafp.org)

Second-generation fluoroquinolones, such as gatifloxacin and moxifloxacin, have excellent cerebrospinal fluid (CSF) penetration, and animal models suggest that they are effective in penicillin- and ceftriaxone-resistant pneumococcal meningitis. (medscape.com)
Because the blood-brain barrier limits penetration of penicillin into the cerebrospinal fluid (CSF), no intermediate category for meningitis exists. (cdc.gov)
Cases were categorized as meningitis or nonmeningitis based on medical record review (e.g., clinical presentation) and source of the isolate. (cdc.gov)
If a case was classified as meningitis on the basis of the patient's clinical presentation but pneumococcus was isolated from blood rather than CSF, the new meningitis breakpoints were applied to the blood isolate ( 1 ). (cdc.gov)
Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study. (fiocruz.br)
Clonally related penicillin-nonsusceptible Streptococcus pneumoniae serotype 14 from cases of meningitis in Salvador, Brazil. (fiocruz.br)

Ceftaroline has also demonstrated bactericidal activity against penicillin-resistant Streptococcus pneumoniae and common gram-negative bacteria. (nlvpartners.com)
Clinical improvement has been reported independent of the presence or absence of chronic airway infection 11 and with antibiotic levels below the minimum inhibitory concentrations of several pathogenic bacteria 15 . (ersjournals.com)
A geospatial analysis of flies and the spread of antimicrobial resistant bacteria. (cdc.gov)
Researchers say the list is a useful reminder of the danger of bacteria that are becoming resistant to antibiotics. (bioedonline.org)
Bacteria that produce this enzyme are resistant to certain classes of antibiotics. (bioedonline.org)
With regards to its antimicrobial action, linezolid has a predominantly bacteriostatic action, rather than a bacteriocidal effect and is active against Gram-positive bacteria that are resistant to other antibiotics. (qxmd.com)
Due to the widespread abuse of antibiotics, the number of multidrug-resistant microorganisms (known as super bacteria) is increasing at a significant rate. (springeropen.com)
3 There are suggestions that as resistant bacteria increase and the available antibiotics decrease transmission from inpatients to the larger population will increase and become a problem to the general public. (bmj.com)
S. pneumoniae are encapsulated, nonsporulating, facultative anaerobic, lancet-shaped Gram-positive bacteria that reside in the human nasopharynx. (mdpi.com)
Four types of antibiotic resistant bacteria are monitored according to the Communicable Diseases Act and epidemiological typing is carried out on all notifiable forms of resistance. (folkhalsomyndigheten.se)
Streptococcus suis is a zoonotic pathogen causing disease in both animals and humans, and the emergence of increasingly resistant bacteria to antimicrobial agents has become a significant challenge globally. (mdpi.com)

Historical clues and physical examination findings may suggest a causative pathogen, but the clinical signs and symptoms of CAP are not sufficiently specific to reliably differentiate the exact etiologic agent. (medscape.com)

Empiric therapy also depends on prevalence of cephalosporin-resistant S pneumoniae (DRSP). (medscape.com)
Although information regarding resistance to other antimicrobial drugs was unavailable in the Connecticut survey, the overall prevalence of penicillin-resistant strains in Connecticut was low through June 1993. (cdc.gov)
Concern about the rising prevalence of resistant pneumococcal strains is increasing, but the clinical relevance is uncertain. (lookfordiagnosis.com)

WCK 771 is an arginine salt of levonadifloxacin, a broad-spectrum benzoquinolizine sub-class of fluoroquinolone with a potent activity against Staphylococcus aureus including MRSA, quinolone-resistant S. aureus and vancomycin-non-susceptible strains (VISA and VRSA). (wockhardt.com)
Levonadifloxacin (LND) is a broad-spectrum benzoquinolizine fluoroquinolone with potent activity against quinolone-resistant S. aureus and MRSA phenotypes developed by an Indian company Wockhardt. (vjim.org)
Staphylococcus aureus (including MRSA) Remember to consider tuberculosis, endemic fungal disease (histoplamosis), aspiration pneumonitis, Pneumocystis jiroveci, pertussis, CMV, and other etiologic agents in certain age groups and in specific clinical settings! (studyslide.com)

Nasopharyngeal colonization by Streptococcus pneumoniae is a prerequisite for IPD [5]. (cdc.gov)

Chlamydia pneumoniae and, in recent studies, Chlamydia trachomatis , may not only induce asthma exacerbations but may also be involved in the pathogenesis of chronic asthma. (medscape.com)

It is resistant to carbapenem antibiotics, a 'last resort' antibiotic used only when all other treatments have failed. (bioedonline.org)
As of September 2016, about 40 new antibiotics were in clinical development for the US market, compared with hundreds of cancer drugs. (bioedonline.org)
Since the discovery of penicillin, the majority of antibiotic development has been focused on discovering new antibiotics from microbial sources or synthesizing new compounds using existing antibiotic scaffolds, which has however constrained the antibiotic development using other ways. (springeropen.com)
[ 14 ] In clinical practice, antibiotics are often prescribed for children with an asthma exacerbation. (medscape.com)

since then, in the United States, there has been increased identification of penicillin-nonsusceptible S. pneumoniae (PNSP) (defined as minimum inhibitory concentration {MIC} to penicillin greater than or equal to 0.1 ug/mL), especially penicillin-resistant S. pneumoniae (PRSP) (defined as MIC to penicillin greater than or equal to 2.0 ug/mL). (cdc.gov)
The surveillance case definition for PNSP included S. pneumoniae isolated from any anatomical site with a MIC to penicillin greater than or equal to 0.1 ug/mL confirmed by an approved National Committee for Clinical Laboratory Standards (NCCLS) methodology (3). (cdc.gov)

Zidebactam is a first-in-class β-lactam enhancer with a potent inhibition of penicillin binding protein (PBP) 2 of all the clinically relevant Gram-negative organisms including Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacterales. (wockhardt.com)

To document the bacteriologic and clinical efficacy of gatifloxacin in recurrent/nonresponsive acute otitis media (AOM). (tau.ac.il)

The first case reports of infection with penicillin-resistant pneumococci were made in Australia in 1967 and South Africa in 1977, respectively. (solunum.org.tr)

3 This week the Danish Chief Medical Officer, Einar Krag, has called together colleagues from the European Union and their advisors for a conference on "the microbial threat" to "assess the strategies to prevent and control the emergence and spread of antimicrobial resistant micro-organisms. (bmj.com)

This study is designed to fill that gap by describing the serotype distribution and AMR of S. pneumoniae in the Philippines from 2012 to 2018. (who.int)

Although S. pneumoniae was once considered to be routinely susceptible to penicillin, since the mid-1980s the incidence of resistance of this organism to penicillin and other antimicrobial agents has been increasing in the United States (1-4). (cdc.gov)

The MICs of all cephalosporins, tetracycline, trimethoprim-sulfamethoxazole, and chloramphenicol increased along with the MICs of penicillin G. However, erythromycin resistance and clindamycin resistance were observed more frequently among the intermediately penicillin-resistant strains. (inspq.qc.ca)
The chance finding that erythromycin treatment radically improved the clinical outcome of a patient with diffuse panbronchiolitis rekindled interest in the use of macrolides as a potential treatment in other inflammatory airway disorders, e.g. cystic fibrosis 8 . (ersjournals.com)
AST for penicillin, erythromycin, co-trimoxazole, ceftriaxone and levofloxacin was done following the Clinical and Laboratory Standard Institute recommendations. (who.int)
Patients should be monitored for clinical symptoms of colchicine toxicity (See WARNINGS).Erythromycin has been reported to increase the systemic exposure (AUC) of sildenafil. (drugcentral.org)

The clinical cure rate was 96.8% for subjects treated with Ceftaroline and 88.9% for those treated with standard therapy of vancomycin, with or without adjunctive aztreonam, in the clinically evaluable population. (nlvpartners.com)
The combination of vancomycin and an aminoglycoside acts synergistically in vitro against many strains of Staphylococcus aureus , Streptococcus bovis , enterococci, and the viridans group streptococci. (pfizermedicalinformation.com)
Clinical results were presented from the Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Phase 1 Study to Determine the Safety, Pharmacokinetics, Food, and Fecal Microbiome Effects of ACX-362E Administered Orally to Healthy Subjects which had a secondary objective to determine the fecal microbiome effects of ACX-362E compared to those of oral vancomycin. (acurxpharma.com)

Multiple resistance was observed for 32 strains, of which 25 were highly resistant to penicillin G and belong to SGT 23F. (inspq.qc.ca)

The potential clinical coverage of WCK 5222 includes metallo- β-lactamase-expressing Enterobacterales & P. aeruginosa and carbapenem-resistant A. baumannii. (wockhardt.com)

Five (21.7%) were intermediately resistant to penicillin (0.12-1 g/ml), 18 (78.3%) were penicillin-susceptible ( 0.06g/ml) strains. (solunum.org.tr)

In terms of Streptococcus pneumoniae, it is also used to confirm the causative bacterium. (wikipedia.org)

Background: Antimicrobial resistance in Streptococcus pneumoniae has compromised the effectiveness of therapy for pneumococcal diseases and asymptomatic nasopharyngeal carriers play an important role in transmission of resistant strains. (bvsalud.org)

No patients had especially Streptococcus pneumoniae , thus taken antimicrobials for the 2 weeks pre- making them more efficacious in the treat- ceding the study. (who.int)

Data presented include the clinical results from its Phase 1 clinical trial that was successfully completed in August 2019. (acurxpharma.com)

Antimicrobial resistant microorganisms are found in people, animals and the environment and can spread globally. (who.int)
These multidrug-resistant microorganisms will increase the rate of morbidity and mortality in related diseases. (springeropen.com)

7 , in a 2-yr double-blind placebo-controlled study, showed that the combination of macrolide and methylprednisolone produced no significant clinical benefit in steroid-dependent asthma but, instead, resulted in an increase in steroid-induced side-effects, e.g. accelerated loss of bone density and increased sugar levels. (ersjournals.com)

Streptococcus pneumoniae grew in 38 blood samples, 5 cerebrospinal fluid and 3 pleural fluids. (ox.ac.uk)

Anatomy2

Organisms20

Diseases14

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes10

Information Science1

Health Care1

Isolates33

Haemophilus8

Pyogenes7

Susceptibility6

Pneumonia23

Strains of Streptococcus pneumoniae2

Infections31

Klebsiella3

Bacterial12

Resistance to penicillin1

Pathogens3

Serotypes4

Drug-resistant6

Mycoplasma2

Methicillin-resist5

Meningitis6

Bacteria11

Pathogen1

Prevalence3

MRSA3

Colonization1

Chlamydia1

Antibiotics4

PNSP2

Pseudomonas1

Otitis1

Pneumococci1

Emergence1

Serotype1

Susceptible to penicillin1

Erythromycin4

Vancomycin3

Highly resistant to penicillin1

Carbapenem-resistant1

Intermediately resistant1

Causative1

Nasopharyngeal1

Antimicrobials1

20191

Microorganisms2

Macrolide1

Cerebrospinal fluid1