DiseasesChemicals and DrugsPhenomena and Processes
Penicillin G BenzathineSyphilisPenicillin GPenicillinsPenicillin G ProcainePenicillin AmidasePenicillin VPenicillin Resistance
BenzylpenicillinInjectionSyphilisAntibioticsEffects have not been adequately evaluatedBicillinAntibioticAdditional doses300,000 unitsNeurosyphilisDoseIntramuscularlyAmoxicillinHydrolysisOral penicillinNatural penicillinDosesDrugsShortagesBacteriaUnitsAzithromycinTreatmentAdverse effectsMicroorganismsDoxycyclineAllergyOverdosageBactericidalInhibitsReaction was possiblyAllergicSolubleSensitivityDiseasesInterferesAdultsProtein
Benzylpenicillin8
  • Benzathine penicillin is an ambiguous nickname for either of the following antibiotics: Benzathine penicillin G (benzathine benzylpenicillin) Benzathine penicillin V (benzathine phenoxymethylpenicillin) This disambiguation page lists articles associated with the title Benzathine penicillin. (wikipedia.org)
  • Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. (newlystar-medtech.com)
  • Benzathine benzylpenicillin is the drug of choice for treating yaws. (medscape.com)
  • In remote areas where benzathine benzylpenicillin is unavailable, oral penicillin V for 7-10 days can reduce the prevalence of yaws and is effective in treating individual children with active lesions. (medscape.com)
  • 96% of patients in the azithromycin group were cured, compared with 93% in the benzathine benzylpenicillin group. (medscape.com)
  • Penicillin G potassium (also known as benzylpenicillin potassium, aqueous or crystalline penicillin) occurs as colorless or white crystals, or white crystalline powder. (elephantcare.org)
  • Penicillin G procaine (also known as APPG, Aqueous Procaine Penicillin G, Benzylpenicillin Procaine, Procaine Penicillin G, Procaine Benzylpenicillin) is the pro-caine monohydrate salt of penicillin G. In vivo it is hydrolyzed to penicillin G and acts as a depot, or repository form of penicillin G. It occurs as white crystals or very fine, white crystalline powder. (elephantcare.org)
  • Penicillin G Benzathine (also known as Benzathine Benzylpenicillin, Benzathine Penicillin G, Benzylpenicillin Benzathine, Dibenzylethylenediamine Benzylpenicillin) is the benzathine tetrahydrate salt of penicillin G. It is hydrolyzed in vivo to penicillin G and acts as a long-acting form of penicillin G. It occurs as an odorless, white, crystalline pow-der. (elephantcare.org)
Injection24
  • Penicillin G benzathine injection should never be given intravenously (into a vein) because this may cause serious or life-threatening side effects or death. (medlineplus.gov)
  • Penicillin G benzathine injection is used to treat and prevent certain infections caused by bacteria. (medlineplus.gov)
  • Penicillin G benzathine injection is in a class of antibiotics called penicillins. (medlineplus.gov)
  • Antibiotics such as penicillin G benzathine injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Penicillin G benzathine injection comes as a suspension (liquid) in a prefilled syringe to inject into the muscles of the buttocks or thigh by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Penicillin G benzathine injection may be given as a single dose. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with penicillin G benzathine injection. (medlineplus.gov)
  • If your doctor has told you that you will need additional doses of penicillin G benzathine injection, make sure to keep all appointments to receive your doses on schedule even if you are feeling better. (medlineplus.gov)
  • If you stop using penicillin G benzathine injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Also tell your doctor if you are allergic to any of the ingredients in penicillin G benzathine injection. (medlineplus.gov)
  • If you become pregnant while receiving penicillin G benzathine injection, call your doctor. (medlineplus.gov)
  • If you miss an appointment to receive penicillin G benzathine injection, call your doctor as soon as possible. (medlineplus.gov)
  • Penicillin G benzathine injection may cause side effects. (medlineplus.gov)
  • Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. (nih.gov)
  • Penicillin G benzathine has an extremely low solubility and, thus, the drug is slowly released from intramuscular injection sites. (nih.gov)
  • However, the baby had also received 10 units of penicillin G at about the same time as the mother's injection. (nih.gov)
  • Bicillin C-R (penicillin G benzathine and penicillin G procaine injectable suspension) contains equal amounts of the benzathine and procaine salts of penicillin G. It is available for deep intramuscular injection. (pfizermedicalinformation.com)
  • Background Injection ofbenzatine penicillin G (BPG) every 28days is still the drug of choice for secondary prevention of rheu-matic heart disease (RHD). (ui.ac.id)
  • He received treatment with intramuscular injection of penicillin G benzathine. (cmaj.ca)
  • One mg of penicillin G potassium is equivalent to 1440-1680 USP Units (1355-1595 USP Units for the powder for injection). (elephantcare.org)
  • After reconstitution, penicillin G potassium powder for injection has a pH of 6-8.5, and contains 1.7 mEq of potassium per 1 million Units. (elephantcare.org)
  • One mg of penicillin G sodium is equivalent to 1500-1750 USP Units (1420-1667 USP Units for the powder for injection). (elephantcare.org)
  • After reconsti-tution, penicillin G sodium powder for injection has a pH of 6-7.5, and contains 2 mEq of sodium per 1 million Units. (elephantcare.org)
  • Penicillin G sodium and potassium powder for injection can be stored at room tempera-ture (15-30°C). After reconstituting, the injectable solution is stable for 7 days when kept refrigerated (2-8°C) and for 24 hours at room temperature. (elephantcare.org)
Syphilis20
  • Be aware that Pfizer pharmaceuticals, the sole supplier of benzathine penicillin in the U.S., has reported a shortage of benzathine penicillin (Bicillin LA) due to increased demand for the drug related to the growing national and international epidemic of syphilis. (snohd.org)
  • Insofar as the supply of benzathine penicillin is limited, its use should be prioritized for pregnant patients and babies with congenital syphilis. (snohd.org)
  • In patients with late latent syphilis or syphilis of unknown duration whose adherence with weekly injections of benzathine is uncertain, medical providers should consider giving the patient a single 2.4 million unit intramuscular dose of benzathine penicillin plus a 28 days course of doxycycline 100mg po twice a day. (snohd.org)
  • Many patients with late latent syphilis or syphilis of unknown duration struggle to adhere to a regimen of weekly benzathine penicillin injections. (snohd.org)
  • Pfizer is the sole supplier of benzathine penicillin in the U.S. Local medical providers have alerted local public health that they have had trouble securing benzathine penicillin to treat patients with syphilis. (snohd.org)
  • Additionally, because it is often difficult to assure that patients with late latent syphilis or syphilis of unknown duration receive three injections of benzathine penicillin at weekly intervals, medical providers should consider treating such patients with a regimen that combines a single intramuscular dose of benzathine penicillin with a 28-day course of doxycycline. (snohd.org)
  • Shortages of benzathine penicillin for prevention of mother-to-child transmission of syphilis: An evaluation from multi-country surveys and stakeholder interviews. (medscape.com)
  • BACKGROUND: Benzathine penicillin G (BPG) is the only recommended treatment to prevent mother-to-child transmission of syphilis. (medscape.com)
  • Neurosyphilis developing during treatment of secondary syphilis with benzathine penicillin in a patient without serologic evidence of human immunodeficiency virus infection. (nih.gov)
  • Symptomatic relapse of neurologic syphilis after benzathine penicillin G therapy for primary or secondary syphilis in HIV-infected patients. (nih.gov)
  • How much penicillin cures early syphilis? (nih.gov)
  • A breastfed 1-month-old infant with congenital syphilis developed a Herxheimer reaction 6 hours after its mother received 2.4 million units of benzathine penicillin G intramuscularly. (nih.gov)
  • Recommended treatment schedules for neurosyphilis have included benzathine penicillin (8), although treatment with benzathine penicillin in currently recommended dosages does not achieve treponemicidal antibiotic levels in the cerebrospinal fluid (CSF) of most patients with syphilis, and rare treatment failures have been reported (9-11). (cdc.gov)
  • Long-acting benzathine penicillin G (brand name Bicillin® L-A & others) is the cornerstone of syphilis treatment an is in shortage in the United States. (multco.us)
  • Available data demonstrate that additional doses of benzathine penicillin G, amoxicillin, or other antibiotics in primary and secondary syphilis among persons with HIV infection do not result in enhanced efficacy ( 592 , 593 , 609 ). (cdc.gov)
  • The majority of persons with HIV infection respond appropriately to the recommended benzathine penicillin G treatment regimen for primary and secondary syphilis ( 626 ). (cdc.gov)
  • He was treated presumptively with intramuscular benzathine penicillin 2.4 million units for primary syphilis, oral amoxicillin/clavulanic acid for cellulitis, and paracetamol for pain. (mja.com.au)
  • Gummatous syphilis can be treated with IV Penicillin. (ada.com)
  • It's also been increasingly difficult for medical providers to get benzathine penicillin injections - the main medical weapon against congenital syphilis - because of supply shortages. (wreg.com)
  • Researchers assessed whether the addition of doxycycline to benzathine penicillin G for early syphilis treatment improves serologic outcomes in patients with HIV infection. (clinicaladvisor.com)
Antibiotics2
  • Before using this drug tell your doctor your medical history especially: kidney disease, stomach/intestine diseases, allergies to penicillins or other antibiotics. (patientassistance.com)
  • The name 'penicillin' can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. (newlystar-medtech.com)
Effects have not been adequately evaluated1
  • Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. (nih.gov)
Bicillin4
  • Bicillin C-R 900/300 (benzathine penicillin-procaine penicillin). (drugs.com)
  • Bicillin C-R (benzathine penicillin-procaine penicillin). (drugs.com)
  • Bicillin L-A contains penicillin G benzathine in aqueous suspension with sodium citrate buffer and, as w/v, approximately 0.65% sodium citrate, 0.59% povidone, 0.54% carboxymethylcellulose sodium, 0.53% lecithin, 0.12% methylparaben, and 0.013% propylparaben. (nih.gov)
  • Bicillin L-A contains approximately 0.11 mEq of sodium per 600,000 units of penicillin G (approximately 2.59 mg of sodium per 600,000 units of penicillin G). (nih.gov)
Antibiotic3
  • Penicillin G benzathine is an antibiotic used to treat a variety of bacterial infections. (patientassistance.com)
  • It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. (newlystar-medtech.com)
  • Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. (newlystar-medtech.com)
Additional doses1
  • The patient received her first IM dose of penicillin G benzathine and was referred to receive her two additional doses of penicillin. (ahrq.gov)
300,000 units1
  • Intramuscular administration of 300,000 units of penicillin G benzathine in adults results in blood levels of 0.03 to 0.05 units per mL, which are maintained for 4 to 5 days. (nih.gov)
Neurosyphilis1
  • Recalling the patient's previous symptoms of headache and blurry vision, the allergist placed orders for neurosyphilis treatment (a far higher penicillin dose, and an inappropriate one since neurosyphilis had been ruled out). (ahrq.gov)
Dose6
  • A single IM dose of penicillin G was administered to 10 women. (drugs.com)
  • After 2 IM doses (2 million units/dose) of penicillin G in 15 women, peak and trough milk levels were 120 and 10 units/L, respectively. (drugs.com)
  • the infant had also received 10 units of penicillin G at about the time of the maternal dose. (drugs.com)
  • In such instances, medical provider should consider providing patients with a single dose of benzathine penicillin and a course of doxycycline. (snohd.org)
  • Two women received one dose of 2.4 million units of benzathine penicillin G intramuscularly 20 hours after delivery. (nih.gov)
  • The plan was to initiate the penicillin desensitization protocol if she had an allergic reaction to initial testing, or to give her the first dose of penicillin and have her report to the Department of Public Health for the remaining doses if she did not. (ahrq.gov)
Intramuscularly1
  • The patient was treated with benzathine penicillin G 2.4 million units intramuscularly once a week for 3 weeks. (ccjm.org)
Amoxicillin1
  • The American Academy of Pediatrics recommends using amoxicillin clavulanate, intramuscular ceftriaxone, penicillin VK, intramuscular penicillin G benzathine or cephalexin as alternatives to liquid amoxicillin. (forbes.com)
Hydrolysis3
  • The drug is hydrolyzed to penicillin G. This combination of hydrolysis and slow absorption results in blood serum levels much lower but much more prolonged than other parenteral penicillins. (nih.gov)
  • Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. (newlystar-medtech.com)
  • Storage/Stability/Compatibility - Penicillin G sodium and potassium should be protected from moisture to prevent hydrolysis of the compounds. (elephantcare.org)
Oral penicillin1
  • Some centers choose oral penicillin over BPG.Objectives To compare minimal inhibitory capacity (MIC) andminimal bactericidal capacity (MBC) of oral penicillin V serumwith those of BPG among SGA infected RHD.Methods This was a clinical trial with crossover design study tocompare MIC of penicillin V and BPG. (ui.ac.id)
Natural penicillin1
  • Chemistry - Penicillin G is a natural penicillin and is obtained from cultures Penicillium chrysogenum and is available in several different salt forms. (elephantcare.org)
Doses3
  • Single or multiple doses of penicillin G (100,000 units IM once or every 2 hours for 6 hours) were administered to 10 women. (drugs.com)
  • At the follow-up appointment, the infectious disease attending recommended standard treatment: penicillin G benzathine 2.4 million units IM weekly for 3 doses. (ahrq.gov)
  • The pharmacist's catch prevented an unnecessary hospital admission, a PICC line, and multiple doses of IV penicillin. (ahrq.gov)
Drugs1
  • Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. (newlystar-medtech.com)
Shortages1
Bacteria2
  • Penicillin is not active against penicillinase-producing bacteria or against organisms resistant to beta-lactams because of alterations in the penicillin-binding proteins. (nih.gov)
  • Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. (newlystar-medtech.com)
Units6
Azithromycin1
  • In patients who are allergic to penicillin, erythromycin or the newer macrolides (eg, azithromycin, clarithromycin) appear to be effective. (medscape.com)
Treatment4
  • For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia. (newlystar-medtech.com)
  • Penicillin G benzathine is the standard treatment for the sexually transmitted infection. (beckershospitalreview.com)
  • A meta-analysis comparing bacterial and clinical cure rates in patients with GAS tonsillopharyngitis found that short-course cephalosporin treatment was superior to 10 days of penicillin for bacterial cure rate, that short-course penicillin therapy was inferior to 10 days of penicillin, and that clinical cure rates were similar to bacterial cure rates. (medscape.com)
  • her clinical symptoms were improved with quantitative penicillin treatment. (curehunter.com)
Adverse effects1
  • Limited information indicates benzathine penicillin G produces low levels in milk that are not expected to cause adverse effects in breastfed infants. (nih.gov)
Microorganisms1
  • Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. (nih.gov)
Doxycycline1
  • Doxycycline may be used in adults with a penicillin allergy. (medscape.com)
Allergy2
  • A 48-year-old woman with a history of human immunodeficiency virus infection, migraines, polysubstance abuse, and a penicillin allergy presented to the emergency department with complaints of headache and blurry vision. (ahrq.gov)
  • Because of her allergy history, the patient was first sent to the hospital for penicillin sensitivity testing. (ahrq.gov)
Overdosage1
Bactericidal2
  • The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). (newlystar-medtech.com)
  • Penicillin G benzathine interferes with synthesis of cell wall mucopeptides during active multiplication, which results in bactericidal activity. (medscape.com)
Inhibits1
  • By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. (newlystar-medtech.com)
Reaction was possibly2
  • The reaction was possibly due to penicillin in breast milk. (drugs.com)
  • The reaction was possibly caused by penicillin in breastmilk. (nih.gov)
Allergic1
  • Tetracycline may be used in adults and in children who are older than 8 years and are allergic to penicillin. (medscape.com)
Soluble1
Sensitivity2
  • As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with. (pfizermedicalinformation.com)
  • The penicillin sensitivity test result was negative, so the allergist placed orders to initiate penicillin therapy. (ahrq.gov)
Diseases1
  • Although eradication rates associated with cephalosporins may be superior to those achieved with penicillin, the latter is the recommended drug of choice by the American Heart Association and the Infectious Diseases Society of America. (medscape.com)
Interferes1
Adults1
  • A 10-day course of penicillin V 250 mg twice daily in children and 500 mg twice daily or 250 mg 4 times daily in adults is very effective. (medscape.com)
Protein1