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  • PBP2a
  • Additionally, structures of the acyl-PBP complexes of PBP2a with nitrocefin, penicillin G and methicillin allow, for the first time, a comparison of an apo and acylated resistant PBP. (rcsb.org)
  • strains
  • Intense selective pressure resulting from the continual exposure of N. gonorrhoeae to fluoroquinolones resulted in the emergence of resistant strains with altered GyrA and ParC proteins ( 3 , 6 , 21 , 22 , 23 ). (asm.org)
  • In 2000 we isolated gonococcal strains with reduced susceptibilities to penicillin and cephems including cefixime, which is recommended as therapy for gonococcal urethritis, during an investigation into the cause of clinical failure in patients with gonococcal urethritis treated with oral cephems. (asm.org)
  • transglycosylase
  • Vollmer W, von Rechenberg M, Holtje JV (1999) Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli . (springer.com)
  • residues
  • Apart from the active-site (Ser44), Lys47, Ser110-Gly-Asn, Asp175 and Lys213-Thr-Gly were identified as the residues making up the conserved boxes of this protein family. (biochemj.org)
  • mechanism
  • Tipper DJ, Strominger JL (1965) Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. (springer.com)
  • reaction
  • Wise EMJ, Park JT (1965) Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in the cell wall mucopeptide synthesis. (springer.com)