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  • Fleming's
  • Fleming's penicillin paper was published in 1929 in the British Journal of Experimental Pathology , and the discovery was largely ignored until scientists at Oxford University recognized its importance it in the early 1940s. (news-medical.net)
  • Then a worldwide depression dried up funding for scientific research and wasn't until 1938 that Chain happened upon Fleming's paper on penicillin. (healthcentral.com)
  • tetanus
  • Penicillin is effective against a wide range of disease-bearing microorganisms, including pneumococci, streptococci, gonococci, meningococci, the clostridium that cause tetanus, and the syphilis spirochete. (factbites.com)
  • therapeutic
  • Although he recognized the therapeutic potential of penicillin , it was not until 1941 that a group of biologists working in England, including Oxford s Sir H. Florey and E. Chain , purified the substance and established its effectiveness against infectious organisms and its lack of toxicity to humans. (factbites.com)
  • SIDE EFFECTS: -Administration of therapeutic dosages of penicillin G can result in abortion in sows. (alibaba.com)
  • Florey
  • With the support of the Rockefeller Foundation, Florey and his colleague Norman Heatley traveled to the United States in the summer of 1941 to see whether there is any interest of the American pharmaceutical industry to produce penicillin on a large scale. (news-medical.net)
  • Florey injected penicillin into a 43-year-old policeman named Albert Alexander. (healthcentral.com)
  • Florey and his team decided to use it only on sick children who did not need such large amounts of penicillin until their methods of production improved. (healthcentral.com)
  • Penicillium
  • Fleming named the contaminated fungus Penicillium rubrum (later correctly identified as Penicillium notatum ), which was the reason for naming the active substance penicillin. (news-medical.net)
  • medication
  • The physician s Desk Reference does not list a specific activity time in the body for penicillin V, but the medication is rapidly cleared by the kidneys as fast as it is absorbed from the gastrointestinal tract. (druginfonet.com)
  • scientists
  • Because the discovery and uevelopment of penicillin is rightly regarded as one of the greatest achievements in medical history, many of the scientists who worked on it have been highly honored. (factbites.com)
  • United States and British scientists working on the penicillin mass-production process knew that thousands of lives hung in the balance because a wounded soldier could die from an infected wound even if the wound itself was not fatal. (reference.com)
  • Discovery
  • The discovery of penicillin and the scope of its possible usage is arguably the most important scientific discovery of the 20th century. (news-medical.net)
  • The accidental discovery of penicillin in the twentieth century may be one of the greatest milestones in medical history. (factbites.com)
  • 1943
  • penicillin production using fermentation began to increase dramatically by early 1944, while the production of the drug in the United States jumped from 21 billion units in 1943, to more than 6.8 trillion units in 1945. (news-medical.net)
  • Production of penicillin in the U.S. jumped from 21 billion units in 1943 to 1,663 billion units in 1944 to 6.8 trillion in 1945. (healthcentral.com)
  • drug
  • The globalization of penicillin in the years immediately after the Second World War was swift, visible and interesting, and made this important antimicrobial drug both a political and a medical resource. (news-medical.net)
  • The typical process of desensitization has excellent success for patients who have experienced immediate reactions to penicillin and involves introduction of very tiny doses of the penicillin drug either orally or intravenously every 15-20 minutes over a period of 4 hours or so. (aaaai.org)
  • it has a nucleus but not a cell wall and, therefore, does not respond to penicillin--a drug that acts on cell walls. (chicagotribune.com)
  • The drug is penicillin. (healthcentral.com)
  • Restrictions that were initially placed on penicillin to prioritize its use in the war effort were eventually lifted and the drug became available through U.S. consumer pharmacies on March 15, 1945. (reference.com)
  • production
  • Now, in cooperation with pharmaceutical manufacturer Sandoz, TU Wien has succeeded in analysing and comprehensively replicating a penicillin production process using a computer model. (eurekalert.org)
  • The process model and algorithms developed at TU Wien are now being used by Sandoz GmbH for its penicillin production process. (eurekalert.org)
  • The U.S. annual production of penicillin reached more than 133,000 billion units in 1949. (reference.com)