Pdgfra derived tyrosine kinase. Medical search. Frequent questions

In a phase III trial of almost 500 patients with unresectable or metastatic treatment-refractory GIST, the tyrosine kinase inhibitor (TKI) avapritinib resulted in similar progression-free survival (PFS) compared with the antiangiogenesis agent, regorafenib [4]. (nursingcenter.com)
QINLOCK is a kinase inhibitor indicated for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib. (nih.gov)
The high efficacy of tyrosine kinase inhibitor, imatinib mesylate (IM), is well-documented in patients with hypereosinophilic syndromes (HES) and detectable rearrangements of platelet-derived growth factor receptor α or β (PDGFRA/B) [1]. (efim.org)
TTT-3002, a tyrosine kinase inhibitor is one of the most potent FLT3 inhibitors. (cancer-research-network.com)
Avapritinib, another tyrosine kinase inhibitor, should be used as first-line therapy for patients with a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations. (msdmanuals.com)
Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor. (ncats.io)
Sunitinib was evaluated for its inhibitory activity against a variety of kinases and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2, and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony-stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET). (ncats.io)
SUTENT is a kinase inhibitor indicated for the treatment of: Gastrointestinal stromal tumor (GIST) after disease progression on or intolerance to imatinib mesylate. (ncats.io)
Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. (biomedcentral.com)
A comprehensive picture of the landscape of receptor tyrosine kinases (RTKs) targetability was presented at the Molecular Analysis for Precision Oncology (MAP) Congress 2022, adding further knowledge on the use of tyrosine kinase inhibitor (TKI) monotherapy across cancer types (Abstract 6MO). (esmo.org)
Avapritinib is an oral tyrosine kinase inhibitor. (oncnursingnews.com)
Crystal structure of FMS KINASE domain with a small molecular inhibitor, PLX3397. (guidetomalariapharmacology.org)
Treatment with a targeted tyrosine kinase inhibitor (TKI), sorafenib, may be an effective alternative for patients with advanced gastrointestinal stromal tumours (GIST) that are resistant to standard therapies. (ecancer.org)

FIP1L1-PDGFRA associated hypereosinophilic disorders are sensitive to treatments with tyrosine kinase inhibitors such as imatinib mesylate (imatinib). (atlasgeneticsoncology.org)
Patients with hypereosinophilic syndrome historically carried a poor prognosis before the successful therapeutic application of tyrosine kinase inhibitors. (atlasgeneticsoncology.org)
Qinlock is a medication used for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST), who have received different types of treatment with 3 or more kinase inhibitors, including imatinib, sunitinib and regorafenib. (everyone.org)
Due to the comprehensive inter- and intralesional heterogeneity of level of resistance mutations within specific patients it's been recommended that tyrosine kinase inhibitors (TKI) are improbable to possess curative potential within this disease (2). (academicediting.org)
In conclusion, PDGFRα -derived peptides are novel inhibitors of the cell-associated unfold of HCMV and facilitate the investigation of this transmission mode. (aetox.com)
Although next generation Abelson kinase inhibitors such as dasatinib or nilotinib may expand the role for these agents in MPDs, targeted inhibition of the mutant kinase JAK2 V617F is more likely to make significant therapeutic gains in the classic MPDs of PV, ET, and PMF. (elsevierpure.com)
The greatest thing that's happened to CML and to me is obviously the advent of the tyrosine kinase inhibitors (TKIs) because I'm no longer having very depressing conversations about patients who were ineligible for transplant or were facing transplant but maybe didn't have a donor. (medscape.com)
8-13 Tyrosine kinase inhibitors (TKI) (imatinib, sunitinib, and regorafenib) have dramatically changed the treatment landscape and outcomes for gastrointestinal stromal tumour (GIST), one of the most common STS subtypes. (emjreviews.com)

Sunitinib inhibits KIT and other members of the split-kinase-domain family of receptor tyrosine kinases. (elsevierpure.com)
Pan-cancer characterization of receptor tyrosine kinases alterations to sort targetable drivers from passengers. (esmo.org)

There are oncogenic kinase mutations in most GISTs. (patient.info)
75-80% of GISTs have mutations of the KIT receptor tyrosine kinase. (patient.info)
10% have mutations in tyrosine kinase platelet-derived growth factor receptor alpha (PDGFRA). (patient.info)
The different kinase mutations produce different clinical features and also have an impact on which part of the gastrointestinal tract the tumour affects, as well as how aggressive the tumour is. (patient.info)
Those tumors with PDGFRA mutations show a predilection for gastric GISTs with epithelioid morphology. (surgpath4u.com)
Approximately 85-90% of GISTs have c-kit mutations and of those that are negative for c-kit mutations, 35% exhibit PDGFRA mutations. (surgpath4u.com)
Mutations in these receptors lead to constitutive activation of the tyrosine kinase signaling pathway, thus permitting uninhibited cellular proliferation (Kumar). (surgpath4u.com)
KIT and PDGFRA mutations are mutually exclusive in the majority (but not all) of cases (Miettinen). (surgpath4u.com)
harbor PDGFRA mutations (Kumar, Fletcher). (surgpath4u.com)
Elling C, Erben P, Walz C, Frickenhaus M, Schemionek M, Stehling M. Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease. (medscape.com)
Research into the oncogenic mechanisms of GISTs has found that these tumors frequently contain activating gene mutations in either platelet-derived growth factor receptor A ( PDGFRA ) or a receptor tyrosine protein associated with a mast cell growth factor receptor encoded by the KIT gene. (biomedcentral.com)
GISTs are characterized by mutations in a receptor tyrosine protein (encoded by the KIT gene) associated with a mast cell growth factor receptor or in the gene encoding platelet-derived growth factor receptor A ( PDGFRA ). (biomedcentral.com)
Mutations in KIT or the receptor tyrosine kinase PDGFRA are the hallmarks of molecular diagnosis of GIST. (biomedcentral.com)
None of the five patients tested had mutations in KIT or PDGFRA. (elsevierpure.com)
PDGFRA is found in many body tissues, so it also will be important to determine whether mutations in this enzyme might play a role in other cancers," said author Michael Heinrich , M.D., associate professor of medicine at the Portland VA Medical Center and Oregon Health & Science University Cancer Institute. (ohsu.edu)
Using a novel molecular technology, Heinrich and his colleagues found that 14 of 40 (35 percent) GIST tumors lacking KIT mutations instead had mutations in the related receptor tyrosine kinase, PDGFRA. (ohsu.edu)
It is estimated that 6% of patients with newly diagnosed GIST have a PDGFRA exon 18 mutation, and PDGFRA mutations represent the most common variants. (oncnursingnews.com)
Mutations in the KIT and PDGFRA genes are associated with both familial and sporadic GISTs. (medlineplus.gov)
Mutations in the KIT and PDGFRA genes lead to proteins that no longer require ligand binding to be activated. (medlineplus.gov)

An interstitial deletion del(4)(q12q12) generating a FIP1L1-PDGFRA fusion gene is observed in diverse eosinophilia-associated hematologic disorders like hyperseosinophilic syndrome (HES), systemic mastocytosis (SM) and chronic eosinophilic leukemia (CEL). (atlasgeneticsoncology.org)
Occasionally, the FIP1L1-PDGFRA fusion can be identified in patients with acute myeloid leukemia or B-cell or T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma and sporadically in myeloid sarcoma (Metzgeroth et al. (atlasgeneticsoncology.org)
FIP1L1-PDGFRA rearrangement has been found in a variety of cell lineages (neutrophils, monocytes, eosinophils, CD34+ cells, mast cells and even lymphoid) consistent with an origin in an hematopoietic stem cells or early progenitors progenitor (Gotlib and Cools, 2008). (atlasgeneticsoncology.org)
The cause of FIP1L1-PDGFRA associated hypereosinophilic syndrome is unknown as well as its association with predominantly male sex. (atlasgeneticsoncology.org)
Data support a FIP1L1-PDGFRA fusion incidence of approximately 10-20% among patients presenting with idiopathic hypereosinophilia (Gotlib and Cools, 2008). (atlasgeneticsoncology.org)
However, in unselected patients with eosinophilia only 3% of were found to carry the FIP1L1-PDGFRA fusion (Pardanani et al. (atlasgeneticsoncology.org)
however chronic eosinophilic leukemia with FIP1L1-PDGFRA is likely to be responsive also to dasatinib, nilotinib, sorafenib and midostaurin (PKC412) (Lierman et al. (atlasgeneticsoncology.org)
Targeted therapy has dramatically changed the prognosis of patients carrying the FIP1L1-PDGFRA fusion which show an excellent response to low-dose imatinib. (atlasgeneticsoncology.org)
The cryptic interstitial deletion on chromosome band 4q12 leading to FIP1L1-PDGFRA fusion is quite unique as it is generated by a cryptic chromosomal deletion, rather than a translocation (Gotlib and Cools, 2008). (atlasgeneticsoncology.org)
Because FIP1L1-PDGFRA is generated by a cryptic deletion at 4q12 that is only 800 kb in size, it remains undetected with standard cytogenetics. (atlasgeneticsoncology.org)
One of the best techniques to detect the presence of the FIP1L1-PDGFRA fusion gene is using triple-color FISH probes hybridizing to the region between the FIP1L1 and PDGFRA genes incorporating the CHIC2 (cysteine-rich hydrophobic domain 2) gene. (atlasgeneticsoncology.org)
Most of these IM responders were found to possess an interstitial deletion in chromosome 4q12 leading to constitutively active tyrosine kinase, FIP1L1-PDGFRA (F/P) [2]. (efim.org)

Efficacy of imatinib mesylate is well established in CEL with FIP1L1-platelet-derived growth factor-α (PDGFRα) rearrangement. (elsevierpure.com)

However, among 13 patients whose tumors harbored a platelet-derived growth factor receptor alpha (PDGFRA) D842V mutation, avapritinib improved progression-free survival (median not reached versus 4.5 months). (nursingcenter.com)
Gastrointestinal stromal tumors are tumors of the gastrointestinal tract derived from mesenchymal precursor cells in the gut wall. (msdmanuals.com)
The defective protein, a mutated form of the enzyme platelet-derived growth factor receptor alpha (PDGFRA), may serve as a target for new "smart-bomb" therapies against gastrointestinal stromal tumors (GIST). (ohsu.edu)
Tumors expressing abnormal KIT or PDGFRA proteins were indistinguishable in cellular changes that drove tumor growth. (ohsu.edu)
The FDA has approved the therascreen PDGFRA kit to identify patients with gastrointestinal stromal tumors who may benefit from treatment with avapritinib. (oncnursingnews.com)

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. (wikipedia.org)
PDGFRb is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (thermofisher.com)

Significant benefits were obtained when empiric use of imatinib in CEL and CMML led to significant clinical benefit and the discovery of the role of rearrangements of the platelet derived growth factor receptor-alpha (PDGFRa-FIP1L1 in CEL and SMCD) and -beta (PDGFRb through TEL-PDGFRb) for CMML). (elsevierpure.com)
PDGFRb is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. (thermofisher.com)
the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. (scbdd.com)

the T674I mutation in the ATP-binding region of PDGFRA (mutation of the threonine at position 674) is the most common. (atlasgeneticsoncology.org)
Based on these data, we consider avapritinib to be an acceptable option for patients with PDGFRA D842V mutation-positive GIST who have experienced progression on both imatinib and sunitinib. (nursingcenter.com)
In the laboratory, Heinrich and colleagues also are exploring other protein defects that may cause some GIST cases, potential new drugs to target the PDGFRA mutation and the possible role of abnormal PDGFRA in other cancers. (ohsu.edu)
Avapritinib is approved as a treatment option for adult patients with unresectable or metastatic GIST whose disease harbors a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including DGFRA D842V mutations. (oncnursingnews.com)
The companion diagnostic is designed to detect the D842V somatic mutation in the PDGFRA gene using genomic DNA that has been extracted from a patient's formalin-fixed paraffin-embedded tumor tissue. (oncnursingnews.com)
The approval was supported by findings from the phase 1 NAVIGATOR trial (NCT02508532), which demonstrated that among patients with a PDGFRA exon 18-mutation (n = 43), the agent elicited an 84% overall response rate (95% CI, 69%-93%), including a 7% complete response rate and a 77% partial response rate. (oncnursingnews.com)
About 80 percent of cases are associated with a mutation in the KIT gene, and about 10 percent of cases are associated with a mutation in the PDGFRA gene. (medlineplus.gov)
Patients with GIST, a soft tissue sarcoma that occurs in the stomach, small bowel, or other sites in the GI tract, usually have a mutation in the KIT or PDGFRA gene. (ecancer.org)
In patients with a known PDGFRA D842V mutation conferring imatinib resistance, sunitinib is a reasonable option. (medscape.com)

Examination of the different signaling cascades induced by RTKs established Ras/mitogen-activated protein kinase (MAPK), PI-3 kinase, and phospholipase-γ (PLCγ) pathways as key downstream mediators of PDGFR signaling. (wikipedia.org)
Dimers of PDGFR consist of either homodimers of alpha/alpha, beta/beta, or heterodimers of alpha/beta and serve as a substrate for its kinase activity. (cytekbio.com)
Olaratumab, a fully human IgG1 monoclonal antibody that targets platelet-derived growth factor receptor (PDGFR)-α, combined with doxorubicin resulted in a near doubling of overall survival (OS) compared with doxorubicin alone. (emjreviews.com)
Other more common STS also demonstrate potentially targetable aberrations in VEGFR, PDGFR-α and β, and cyclin-dependent kinases (CDK), suggesting a need for study of additional targeted therapies. (emjreviews.com)

This is especially true in the case of mutant tumor DNA derived "driver" and "drug-resistant" alleles that are present in the circulating cell-free tumor DNA (cfDNA) in the peripheral blood circulation of GIST patients. (biomedcentral.com)

KIT and PDGFRA are mutated in approximately 85% and 5%, respectively, of GISTs. (biomedcentral.com)
A new OHSU/VA study is near completion to determine Gleevec's effectiveness against GISTs caused by abnormal PDGFRA rather than KIT. (ohsu.edu)

Fms-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expresses on hematopoietic cells. (cancer-research-network.com)
FLT3 (Fms-like tyrosine kinase 3, CD135) is a cytokine receptor which belongs to the receptor tyrosine kinase class III. (cancer-research-network.com)
The French study used pan-cancer public databases (MSK-IMPACT / MSK-MET) and in-house sequencing data (including from the PROFILER and PROFILER 02 trials) to look at the molecular landscape of cancers with alterations in EGFR, HER2, PDGFRA, KIT, FLT3, NTRK1-2-3, ROS1, ALK, RET, MET and FGFR1-2-3-4. (esmo.org)

The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. (wikipedia.org)
Tyrosine phosphorylation sites in growth factor receptors serve two major purposes-to control the state of activity of the kinase and to create binding sites for downstream signal transduction molecules, which in many cases also are substrates for the kinase. (wikipedia.org)
The second part of the tyrosine kinase domain in the PDGFβ receptor is phosphorylated at Tyr-857, and mutant receptors carrying phenylalanine at this position have reduced kinase activity. (wikipedia.org)
C-kit (also known as KIT or CD117) and PDGFRA (platelet derived growth factor receptor alpha) are receptors which contain the enzyme tyrosine kinase. (surgpath4u.com)
KIT receptors belong to the Class III receptor tyrosine kinase (RTK) family, which also includes PDGFRA (platelet-derived growth factor receptor A) and CSF1R (colony stimulating factor 1 receptor). (cancer-research-network.com)
Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)

In platelet-derived growth factor receptor alpha (PDGFRA)-associated hypereosinophilic syndrome, eosinophilia is associated with formation of the FLIP1L1/PDFGRA gene, with resultant increased tyrosine kinase activity. (medscape.com)

BRAF kinase, a critical effector of the ERK signaling pathway, is hyperactivated in many cancers. (nature.com)
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. (scbdd.com)

Blueprint Medicines announces FDA approval of Ayvakit (avapritinib) for the treatment of adults with unresectable or metastatic PDGFRA exon 18 mutant gastrointestinal stromal tumor. (oncnursingnews.com)

The data presented in this work suggest that EGFR, KRAS, BRAF, ALK, PIK3CA, PDGFRA, and DDR2 may not be driver genes in primary pulmonary adenoid cystic carcinoma. (biomedcentral.com)

MET is a gene that encodes a receptor tyrosine kinase that is activated upon binding with hepatocyte growth factor (HGF, or Scatter Factor). (shu.edu)
The product is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. (creativebiomart.net)

The KIT and PDGFRA genes provide instructions for making receptor proteins that are found in the cell membrane of certain cell types. (medlineplus.gov)

Sites of tyrosine phosphorylation involved in binding signal transduction molecules have been identified in the juxtamembrane domain, the kinase insert, and in the C-terminal tail in the PDGFβ receptor. (wikipedia.org)
The phosphorylated tyrosine residue and in general three adjacent C-terminal amino acid residues form specific binding sites for signal transduction molecules. (wikipedia.org)
Upon interaction with the activated receptor, the catalytic activities become up-regulated, through tyrosine phosphorylation or other mechanisms, generating a signal that may be unique for each type of signal transduction molecule. (wikipedia.org)

Description: The APA5 monoclonal antibody reacts with the mouse CD140a molecule, the alpha chain of the platelet derived growth factor receptor (PDGF receptor). (cytekbio.com)
PDGF R alpha (Platelet-Derived Growth Factor Receptor alpha) is a transmembrane receptor tyrosine kinase that can form homodimers or heterodimers with PDGF R beta when engaged by dimers of the PDGF ligands. (bio-techne.com)
Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. (creativebiomart.net)

When a ligand attaches (binds), the KIT or PDGFRA receptor protein is turned on (activated), which leads to activation of a series of proteins in multiple signaling pathways. (medlineplus.gov)
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. (scbdd.com)
Description: Determined in an ELISA assay detecting tyrosine phosphorylation using immobilised recombinant CSF-1R protein. (guidetomalariapharmacology.org)

Of note is, that IM was found to be ineffective in most HES patients with unknown or negative PDGFRA rearrangement. (efim.org)

Promotes phosphorylation and activation of SRC family kinases. (scbdd.com)

KIT and PDGFRA are clients for HSP90 a key chaperone and a good target in many cancers (2 8 9 Mutated forms of the proteins are also dependent on the chaperone for his or her stability (10). (academicediting.org)
2) Lysine acetylation in histones and various other proteins is certainly effected with the active interplay of acetyltransferase (HAT) and deacetylase (HDAC) enzymes, which is certainly analogous towards the regulation of serine, threonine, and tyrosine phosphorylation by kinases and phosphatases. (smartrailexpo-europe.com)

The extracellular region of the receptor consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. (wikipedia.org)
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. (cancer-research-network.com)

KIT and platelet-derived growth factor receptor alpha (PDGFRA) genotyping of tumor tissue were performed. (elsevierpure.com)
The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. (thermofisher.com)
however, no combination has led to a survival benefit over doxorubicin alone until the recent use of olaratumab, a monoclonal antibody targeting platelet-derived growth factor-α. (emjreviews.com)
Agents targeting vascular endothelial growth factors, platelet-derived growth factors, and cyclin-dependent kinases 4 and 6 have all shown some efficacy in various STS subtypes. (emjreviews.com)
Platelet-derived growth factor B, commonly known as PDGFB, plays an important role in various biological processes and its dysregulation has been associated with several pathological conditions. (creativebiomart.net)

Eosinophils are derived from hematopoietic stem cells initially committed to the myeloid line and then to the basophil-eosinophil granulocyte lineage. (medscape.com)
The chronic myeloproliferative disorders (MPDs) include the spectrum of clonal hematopoietic stem cell disorders whose phenotype derive from the primary cell expanded in a proliferative state. (elsevierpure.com)

On day E10.5 of murine development, the metanephric mesenchyme secretes glial cell line-derived neurotrophic factor (GDNF). (j-organoid.org)

In conjunction with dimerization and kinase activation, the receptor molecules undergo conformational changes, which allow a basal kinase activity to phosphorylate a critical tyrosine residue, thereby "unlocking" the kinase, leading to full enzymatic activity directed toward other tyrosine residues in the receptor molecules as well as other substrates for the kinase. (wikipedia.org)

Dimerization is a prerequisite for the activation of the kinase. (wikipedia.org)

Should cancer therapy be tailored based on receptor tyrosine kinase alterations? (esmo.org)

Mesa, RA 2007, ' Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders ', Biologics: Targets and Therapy , vol. 1, no. 2, pp. 129-138. (elsevierpure.com)
Mesa, Ruben A. / Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders . (elsevierpure.com)
Description: Measuring inhibition of kinase activity in a biochemical assay. (guidetomalariapharmacology.org)

Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. (scbdd.com)

Heinrich and his colleagues had been studying KIT receptor tyrosine kinase for years when they became interested in a new drug that was producing astounding remissions in clinical trials with patients suffering from chronic myelogenous leukemia, a blood cancer. (ohsu.edu)

PDGFRa is a receptor tyrosine kinase that forms dimers on the surface upon ligand binding and phosphorylates substrates. (cytekbio.com)

Tyr-857 has therefore been assigned a role in positive regulation of kinase activity. (wikipedia.org)

Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)
CD140a is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (cytekbio.com)

Characteristic feature of PDGFRA-associated disorders is eosinophil overproduction in the bone marrow resulting in increased blood eosinophils. (atlasgeneticsoncology.org)

Anatomy18

Organisms6

Diseases6

Chemicals and Drugs165

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Inhibitor13

Inhibitors8

Receptor tyrosin2

Mutations19

FIP1L1-PDGFRA12

Imatinib mesylate1

Tumors5

Cell surface tyrosine2

PDGFRB3

Mutation9

Pdgfr4

GIST1

GISTs2

FLT33

Receptors6

Hypereosinophilic syndrome1

Signaling pathway2

Unresectable or metastatic1

BRAF1

Gene2

Genes1

Signal transduction3

PDGF3

Protein3

Rearrangement1

Phosphorylation and activation1

Proteins2

Intracellular2

Platelet5

Hematopoietic2

Glial cell l1

Phosphorylate1

Dimerization1

Alterations1

Inhibition3

ERK11

Patients1

Ligand1

Activity1

Adult2

Eosinophil1