• The MIH1 monoclonal antibody specifically binds to CD274, which is also known as, B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1 (PDCD1 ligand, PDCD1L1, PDCD1LG1), or Programmed death ligand 1 (PD-L1, PDL1). (bdbiosciences.com)
  • Human recombinant protein fragment corresponding to amino acids 19-239 of human PD-L1/CD274(NP_054862) produced in HEK293 cells. (origene.com)
  • CD274 and PD-L2 (CD273) are type I transmembrane glycoproteins that belong to the B7 family and serve as ligands for CD279 (Program Death 1/PD-1). (bdbiosciences.com)
  • B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. (kactusbio.com)
  • PD-L1 / B7-H1 / CD274 specific IgG was purified by Cynomolgus PD-L1 / B7-H1 / CD274 affinity chromatography. (novoprolabs.com)
  • This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Cynomolgus PD-L1 / B7-H1 / CD274. (novoprolabs.com)
  • 2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. (novoprolabs.com)
  • CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. (elabscience.com)
  • CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. (elabscience.com)
  • Moreover, blocking antibody against PD-1 promotes tumor growth both in SW480 cells and mice CRC xenografts in an adaptive immune-independent manner. (jcancer.org)
  • Although immune checkpoint inhibitors represented by PD-1-blocking antibody are initially achieved in clinical trials, there are still many patients that cannot benefit from it [ 1 , 3 - 5 ]. (jcancer.org)
  • Dose response curve for Biotinylated Anti-PD-L1 Antibody, hFc Tag with the EC50 of 10.0ng/ml determined by ELISA. (kactusbio.com)
  • Profile of anti-PD-L1 (clone MIH1) reactivity on MIT76 transfected cells analyzed by flow cytometry. (bdbiosciences.com)
  • A combinatorial treatment of anti-PD-L1 and anti-PD-1 demonstrated a noticeable improvement in efficacy of the drugs compared to the same dose of single agent (top figure) without affecting the body weight of the animals (bottom figure). (appliedstemcell.com)
  • Immobilized Cynomolgus PD-L1, hFc Tag at 1ug/ml (100ul/well) on the plate. (kactusbio.com)
  • Recombinant Cynomolgus PD-L1/B7-H1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Phe19-Arg238. (kactusbio.com)
  • The purity of Cynomolgus PD-L1 is greater than 95% as determined by SEC-HPLC. (kactusbio.com)
  • Cynomolgus PD-L1 on Tris-Bis PAGE under reduced conditions. (kactusbio.com)
  • It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)
  • PD-L2 is a second ligand for PD-1 and inhibits T cell activation. (bdbiosciences.com)
  • PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. (kactusbio.com)
  • This PD-L1 and CD40 double knockin strain is established by crossing PD-L1-HU and CD40-HU mice together. (appliedstemcell.com)
  • As one of the crucial immune checkpoint molecules, PD-1 belongs to the CD28/CTLA-4 family [ 6 ]. (jcancer.org)
  • PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. (novoprolabs.com)
  • Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regulating the tumor cell-intrinsic PD-1 remains to be further elucidated. (jcancer.org)
  • 2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. (novoprolabs.com)
  • 2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. (novoprolabs.com)
  • Engagement of PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. (bdbiosciences.com)
  • Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M, Wang T. C. tropicalis promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy. (jcancer.org)
  • The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
  • In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. (jcancer.org)
  • We also demonstrated that high concentrations of C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression in colon cancer cells. (jcancer.org)
  • This shows that C. tropicalis promotes CRC progression via controlling the expression of tumor cell-intrinsic PD-1. (jcancer.org)
  • Combining autophagy inhibitor with C. tropicalis treatment partly blocked the CRC tumor growth and reversed the downregulation of PD-1. (jcancer.org)
  • This study shows that PD-1 is a tumor suppressor in CRC. (jcancer.org)
  • C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression via enhancing tumor cells autophagy levels to promote CRC progression. (jcancer.org)
  • 2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. (novoprolabs.com)
  • The expression of human PD-1 and PD-L1 in double humanized PD-1&PD-L1 mice was confirmed by FACS. (appliedstemcell.com)
  • In vivo validation of double humanized PD-1&PD-L1 mice. (appliedstemcell.com)
  • 2 μg/mL (100 μL/well) of immobilized Human PD-L1-mFc can bind Anti-Human PDL1 mAb-FC with an ED50 value of 4.09 μg/mL. (medchemexpress.com)
  • PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. (novoprolabs.com)
  • In addition, we proved that colon cancer cell lines express PD-1 receptors. (jcancer.org)
  • Knockdown of PD-1 enhanced SW480 viability in-vitro, while overexpression of PD-1 diminished cell viability. (jcancer.org)
  • CRC cell growth induced by C. tropicalis is partially offset in the presence of PD-1 overexpression. (jcancer.org)
  • By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. (novoprolabs.com)
  • The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. (elabscience.com)
  • PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. (bdbiosciences.com)
  • However, the expression and function of PD-1 in colon cancer cells has not been reported. (jcancer.org)
  • Mechanistically, we found that C. tropicalis modulates the expression of PD-1 via increasing the autophagy traffic in colon cancer cells. (jcancer.org)
  • 4. Anti-CD19 chimeric antigen receptor T cells secreting anti- pd-l1 single-chain variable fragment attenuate pd-l1 mediated T cell inhibition. (nih.gov)
  • As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). (arigobio.cn)
  • The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. (arigobio.cn)
  • The MyD88/IL1 receptor (IL1R) axis regulated programmed cell death (PD)-1 expression on TAMs by promoting recruitment of NF-κBp65 to the Pdcd1 promoter. (aacrjournals.org)
  • PDCD1 and PDCD1LG1 polymorphisms affect the susceptibility to multiple myeloma. (cdc.gov)
  • Increased PD-1 Level in Severe Cervical Injury Is Associated With the Rare Programmed Cell Death 1 (PDCD1) rs36084323 A Allele in a Dominant Model. (cdc.gov)
  • 1. [Effect of HDAC Inhibitor Chidamide on pd-l1 Expression in Peripheral T-Cell lymphoma ]. (nih.gov)
  • 14. Double/triple hit lymphoma in the gastrointestinal tract: clinicopathological features, pd-l1 expression and screening strategy. (nih.gov)
  • Thus, the MyD88/IL1R axis maintains the immunosuppressive function of TAMs and promotes tumor growth by regulating PD-1 expression. (aacrjournals.org)