Carcinoma, Pancreatic DuctalCell ProliferationPancreatic NeoplasmsCell Line, TumorCell DivisionCell Growth ProcessesGene Expression Regulation, NeoplasticSignal TransductionRNA, Small InterferingAdenocarcinomaXenograft Model Antitumor AssaysNeoplasm InvasivenessMice, NudeDeoxycytidineCells, CulturedApoptosisCell CycleCell DifferentiationBromodeoxyuridineRNA, MessengerCell MovementImmunohistochemistryCell SurvivalBlotting, WesternCell LineReverse Transcriptase Polymerase Chain ReactionPhosphorylationProliferating Cell Nuclear AntigenMice, Inbred C57BLLymphocyte ActivationTumor Cells, CulturedKi-67 AntigenDown-RegulationMice, KnockoutTransfectionFlow CytometryDose-Response Relationship, DrugMice, TransgenicUp-RegulationGene Expression RegulationEpithelial CellsGene ExpressionCyclin D1T-LymphocytesRNA InterferenceTime FactorsStem CellsProto-Oncogene Proteins c-aktCell Transformation, NeoplasticTranscription FactorsThymidineFibroblastsCell CountMuscle, Smooth, VascularGene Knockdown TechniquesCyclin-Dependent Kinase Inhibitor p27Enzyme ActivationMice, Inbred BALB CMolecular Sequence DataExtracellular Signal-Regulated MAP KinasesProto-Oncogene ProteinsAntineoplastic AgentsDisease Models, AnimalHyperplasiaCell Cycle ProteinsDNAProtein-Serine-Threonine KinasesGrowth InhibitorsEnzyme InhibitorsMicroRNAsGene Expression ProfilingMyocytes, Smooth MuscleRats, Sprague-DawleyDNA-Binding ProteinsMitogensProto-Oncogene Proteins c-mycCyclin-Dependent Kinase Inhibitor p21MutationPhenotypeGene Expression Regulation, DevelopmentalNeovascularization, PathologicCell AdhesionBase SequenceMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 3Transforming Growth Factor betaPhosphatidylinositol 3-KinasesG1 PhaseNeoplasm ProteinsProto-Oncogene Proteins p21(ras)Breast NeoplasmsTumor Suppressor Protein p53Real-Time Polymerase Chain ReactionMitogen-Activated Protein Kinase 1Models, BiologicalPlatelet-Derived Growth FactorNuclear ProteinsFibroblast Growth Factor 2Growth SubstancesInterleukin-2