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  • Rats
  • Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats," Journal of Pharmacy and Pharmacology , vol. 51, no. 6, pp. 715-722, 1999. (hindawi.com)
  • exposure
  • In this study, we investigated whether exposure to oleanolic acid (OA) enhances the protective effects of preconditioning on PC12 cells exposed to 6-hydroxydopamine (6-OHDA). (hindawi.com)
  • In preconditioned cells, we found that cell viability remained high following exposure to 6-OHDA (150 μ M). OA treatment enhanced the protective effects of preconditioning. (hindawi.com)
  • Hyperbaric exposure most likely causes direct lesions of neural cells. (biomedsearch.com)
  • Exposure to 6-OHDA resulted in unfolded protein response (UPR) in differentiated PC12 cells as evidenced by an increased level of endoplasmic reticulum (ER)-localized transmembrane signal transducer IRE1α, adaptive response proteins ATF-4 and proapoptotic transcription factor CHOP. (nih.gov)
  • death induced
  • On the other hand, cell death induced by 25-OH-cholesterol was prevented by treatment with vitamin E and methyl-beta-cyclodextrin. (biomedsearch.com)
  • Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy. (springer.com)
  • metabolism
  • Metabolism of vitamin d in human promyelocytic leukemia cells (hl-60) ii. (biomedsearch.com)
  • Polyol pathway and protein kinase C activity of rat Schwannoma cells," Diabetes/Metabolism Research and Reviews , vol. 19, no. 2, pp. 131-139, 2003. (hindawi.com)
  • transduction
  • This study aims to investigate the anti-proliferative effect of TSN in PC12 cells and its role on IGF-1R signaling transduction. (mdpi.com)
  • Neurites
  • Indirect immunofluorescence localization of these polypeptides in NGF-treated PC12 cells reveals a punctate pattern concentrated in neurites. (springer.com)
  • serum
  • PC12 cells were grown as monolayer cultures in medium supplemented with serum in the presence of 125I-NGF. (jneurosci.org)
  • 125I-NGF also was not detected in nuclear subcellular fractions prepared from cells grown in serum-supplemented medium either in suspension for 1 d or in monolayer cultures for 1 to 8 d. (jneurosci.org)
  • U. S. A. 76: 1269-1273), about 60% of the cell-bound 125I-NGF was found in the nuclear pellet after cell fractionation if the cells had been kept previously in suspension for 1 d in phosphate-buffered saline supplemented with 0.2% glucose, 0.1% bovine serum albumin, and 125I-NGF. (jneurosci.org)
  • Growth of a rat neuroblastoma cell line in serum-free supplemented medium. (springer.com)
  • Resveratrol
  • J.-H. Jang and Y.-J. Surh, "Protective effect of resveratrol on β -amyloid-induced oxidative PC12 cell death," Free Radical Biology and Medicine , vol. 34, no. 8, pp. 1100-1110, 2003. (hindawi.com)
  • TrkA
  • Taken together, our results demonstrate the presence of caveolae in PC12 ceils, which contain the high affinity NGF receptor TrkA, and the specific involvement of these cholesterol-enriched plasma membrane microdomains in the propagation of the NGF-induced signal. (csic.es)
  • proteins
  • The 14-3-3 protein is a family of acidic, dimeric proteins distributed widely among eukaryotic cells. (springer.com)
  • Ichimura T., Itagaki C., Wakamiya A., Isobe T. (2002) Interaction of Tyrosine Hydroxylase and 14-3-3 Proteins in PC12 Cells. (springer.com)
  • receptor
  • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor," Nature , vol. 325, no. 6106, pp. 733-736, 1987. (hindawi.com)
  • peptide
  • Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against β -amyloid peptide-induced toxicity in SH-SY5Y cells," Chemico-Biological Interactions , vol. 181, no. 1, pp. 115-123, 2009. (hindawi.com)
  • cytotoxicity
  • However, agents known to prevent neuronal programmed cell death (cyclic AMP, KCl, aurintricarboxylic acid, and cycloheximide) failed to prevent the 25-OH-cholesterol-mediated cytotoxicity. (biomedsearch.com)
  • Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells," Journal of Ethnopharmacology , vol. 130, no. 2, pp. 290-298, 2010. (hindawi.com)
  • Modulation
  • A. Miccheli, R. Ricciolini, E. Piccolella, M. Delfini, and F. Conti, "Modulation of human lymphoblastoid B cell line by phorbol ester and sphingosine. (hindawi.com)
  • Pathways
  • Petiot A, Ogier-Denis E, Blommaart EFC, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. (springer.com)
  • assay
  • 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay was used to assess the cell viability. (springer.com)
  • contrast
  • In contrast to observations made in other cell types, whole-cell patch clamp recording of neuronal PC12 cells revealed that treatment with 25-OH-cholesterol did not significantly alter calcium influx through voltage-dependent channels. (biomedsearch.com)
  • treatment
  • To approach this hypothesis, caveolae were disrupted by treatment of PC12 cells with cholesterol binding drugs. (csic.es)
  • NGF treatment increased the activities of long chain acyl-CoA synthetases (LCASs), including oleoyl-CoA synthetase and arachidonoyl-CoA synthetase, by 150-580% over control, but cholinephosphotransferase activity rose by only 60%, suggesting that the synthesis of DAG in the cells was increased to a greater extent than its utilization. (biomedsearch.com)