Cell SurvivalPC12 CellsSurvival RateDisease-Free SurvivalApoptosisSurvivalSurvival AnalysisGraft SurvivalSignal TransductionCell Line, TumorTime FactorsTreatment OutcomeCells, CulturedCell ProliferationCell DeathKaplan-Meier EstimatePhosphorylationProto-Oncogene Proteins c-aktRetrospective StudiesCell LineProto-Oncogene ProteinsPhosphatidylinositol 3-KinasesProtein-Serine-Threonine KinasesAntineoplastic AgentsNeoplasm StagingRNA, Small InterferingBlotting, WesternMice, Inbred C57BLProportional Hazards ModelsEnzyme ActivationMice, KnockoutFollow-Up Studiesbcl-X ProteinImmunohistochemistryProto-Oncogene Proteins c-bcl-2bcl-Associated Death ProteinAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsLung NeoplasmsGene Expression Regulation, NeoplasticCaspase 3TransfectionCombined Modality TherapyMutationCell DifferentiationTumor Cells, CulturedCell DivisionPrognosisAutophagyReverse Transcriptase Polymerase Chain ReactionRNA, MessengerNeoplasmsCaspasesModels, BiologicalNF-kappa BMice, TransgenicRNA InterferenceEnzyme InhibitorsDose-Response Relationship, DrugGene Expression RegulationUp-RegulationApoptosis Regulatory ProteinsAdenocarcinomaTumor Suppressor Protein p53Neoplasm MetastasisDNA-Binding ProteinsNeuronsIn Situ Nick-End LabelingNeoplasm Recurrence, LocalTumor Markers, BiologicalCisplatinMultivariate AnalysisDown-RegulationCell CycleGene Knockdown TechniquesMolecular Sequence DataChromonesDisease ProgressionRadiation ToleranceProstatic NeoplasmsDisease Models, AnimalCytoprotectionTranscription FactorsMembrane ProteinsDrug Resistance, NeoplasmDNA DamageCell HypoxiaMorpholinesGene ExpressionBrain NeoplasmsMitogen-Activated Protein KinasesOxidative StressDoxorubicinInhibitor of Apoptosis ProteinsMice, NudeLiver NeoplasmsMitochondriaNeoplasm ProteinsMice, Inbred BALB CProtein Binding