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Peripheral Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationTransplantation, AutologousHematopoietic Stem Cell MobilizationLeukapheresisGranulocyte Colony-Stimulating FactorTransplantation, HomologousBlood Component RemovalStem CellsHematopoietic Stem CellsAntigens, CD34Transplantation ConditioningHematologic NeoplasmsGraft vs Host DiseaseMelphalanGraft SurvivalBone Marrow TransplantationCyclophosphamideCombined Modality TherapyStem Cell TransplantationBlood CellsMultiple MyelomaBusulfanAntineoplastic Combined Chemotherapy ProtocolsTissue DonorsBlood Cell CountTreatment OutcomeCord Blood Stem Cell TransplantationLymphoma, Non-HodgkinEtoposideAntineoplastic Agents, AlkylatingMyeloablative AgonistsThiotepaRecurrenceHematopoiesisHistocompatibilityTransplantation ChimeraRemission InductionImmunosuppressive AgentsBlood DonorsIfosfamideWhole-Body IrradiationHistocompatibility TestingBone Marrow PurgingPlatelet CountEmbryonic Stem CellsInfectionRetrospective StudiesDisease-Free SurvivalCytarabineTime FactorsVidarabineLeukemiaSalvage TherapyLeukocytes, MononuclearPOEMS SyndromeAdult Stem CellsCell SeparationSurvival RateImmunomagnetic SeparationVincristineTransplantation, IsogeneicRecombinant ProteinsFlow CytometryBone Marrow DiseasesImmunophenotypingBone MarrowHodgkin DiseaseLeukocyte CountPlatelet TransfusionSurvival AnalysisNeoplasmsColony-Forming Units AssayProchlorperazineBone Marrow CellsLymphomaCarmustineStem Cell FactorCytomegalovirus InfectionsLeukemia, Myeloid, AcuteAnemia, AplasticPluripotent Stem CellsFeasibility StudiesAntigens, CDLymphocyte DepletionAmyloidosisCell DifferentiationDoxorubicinCyclosporineHematologic DiseasesT-LymphocytesCells, CulturedLeukemia, Myelogenous, Chronic, BCR-ABL PositiveCarboplatinLeukocyte TransfusionBlood Group IncompatibilityFollow-Up StudiesStem Cell NicheNeoplasm, ResidualKidney Transplantation
DonorBone marrow transplantsChemotherapyUmbilical cordDonation2020PBSCTHSCTEngraftmentOutcomesApheresisBiol Blood Marrow TransplantPatient'sHigh dosePlateletsDonors lead to more successfulAplastic AnemiaRegimenTransplantation in patientsHematopoietic cell transplantationComplicationsCyclophosphamideType of transplantCorneal transplantsOrgan transplantMobilization and collection2000Kidney transplantRecipientAllogeneic TransplantAutologous transplant1998Survival2019UndergoLifesaving stem cell donorsLymphoma2021ClinicalPatients engrafted2022InfusionMultiple myeloma patientsMononuclearDiseasesCord blood transplantProgenitor cellRecipientsAdultSickle cell diASCTLymphomasMortality
Donor32
  • Only 30 percent of patients with diseases treatable with a bone marrow transplant can find a suitable donor among their family members. (wikipedia.org)
  • There are more than 90 marrow and stem cell donor registries in 56 countries. (wikipedia.org)
  • If a donor declines to donate via one method, the transplant center may or may not be able to accept the other, based on the clinical needs of the patient. (wikipedia.org)
  • The National Marrow Donor Program (NMDP) is a nonprofit organization founded in 1986 and based in Minneapolis, that operates the Be The Match Registry of volunteer donors and cord blood units. (wikipedia.org)
  • Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
  • OUTLINE: This is a dose-escalation study of LMB-2 immunotoxin-treated, selectively-depleted donor T cells. (knowcancer.com)
  • LMB-2 immunotoxin is added to the PBMCs in order to selectively deplete T cells from the donor PBMCs. (knowcancer.com)
  • LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
  • Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
  • In a little over 4,800 cases, the blood came from an unrelated donor. (healthline.com)
  • The other 70 percent of patients must search the registry in the hope that a volunteer donor is a close enough match for a transplant to work. (giftoflife.org)
  • Bone marrow or PBSC cells are donated by an adult donor between 18 and 40 years of age. (icla.org)
  • The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant from unrelated donor peripheral blood stem cells (PBSC). (mycancergenome.org)
  • But for the transplant to work, Maxine must find a matching donor, and matches are based on a tissue type called HLA, Human Leukocyte Antigens. (m-umedan1.com)
  • We, at Artemis, are doing cord blood, unrelated donor and Haplo-identical (taking father or mother as donor) transplant, so that all the patients who need transplant can have a donor. (artemishospitals.com)
  • Allogeneic Transplant - uses cells from a family member, unrelated donor or umbilical cord blood unit. (artemishospitals.com)
  • A 26-year-old woman with a history of ESRD from C1q nephropathy, living-related kidney transplant in early 2012, and allograft nephrectomy in 2015, received a deceased donor kidney transplant (DDKT). (lidsen.com)
  • Healthy stem cells can come from a donor, or they can come from your own body. (medicaljump.com)
  • Before this, finding an unrelated stem cell donor was virtually impossible. (anthonynolan.org)
  • £40 could add a donor to the stem cell register - that donor could go on to save the life of a child like Anthony. (anthonynolan.org)
  • The Effect of Aging and Pre-Donation Comorbidities on the Related PBSC Donor Experience: A Report from the Related Donor Safety Study (RDSafe). (stembook.org)
  • One is the Peripheral blood stem cell (PBSC) donation - collecting the stem cells from the circulating blood of the donor. (kkltrust.org)
  • Check to see if you can become a blood stem cell donor. (kkltrust.org)
  • First blood stem cells are extracted from the donor. (netlify.app)
  • Put it simply, they can become any type of cell When you register as a potential donor, you're routinely asked to confirm that you would be willing to donate both peripheral stem cells and/or bone marrow (to 15 Feb 2011 Are there any risks or side effects of G-CSF? (netlify.app)
  • The rest of the blood is returned back to the patient or donor. (bonemarrowtest.com)
  • Apheresis produces no side effects or discomfort for the blood stem cell donor. (bonemarrowtest.com)
Bone marrow transplants5
Chemotherapy14
  • During the last part of the 20th century, clinical trials have shown that the basis for treating high-risk neuroblastoma should consist of induction chemotherapy, consolidation with high dose chemotherapy + stem cell transplant. (acco.org)
  • The stem cell transplants use the patient's own previously stored stem cells obtained from either the bone marrow or peripheral blood (PBSC) to replace the bone marrow, which is destroyed by the high-dose chemotherapy. (acco.org)
  • Potential improvements in all components of therapy (induction chemotherapy, intensive consolidation with stem cell transplant, and post-transplant therapy) have occurred since the CCG-3891 study. (acco.org)
  • All patients received multi-agent induction chemotherapy for 6 cycles, including an initial 2 cycles of high-dose cyclophosphamide plus topotecan followed by blood stem cell collection. (oncologynurseadvisor.com)
  • Prior to transplant, patients receive high doses of chemotherapy to prepare their body for the transplant. (icla.org)
  • High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies. (uni-koeln.de)
  • Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
  • abstract： PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)
  • Chemotherapy and stem-cell transplantation in patients with multiple myeloma: a practice guideline of the Cancer Care Ontario Practice Guidelines Initiative. (cancertreatmenttoday.org)
  • A bone marrow transplant is a medical procedure performed to replace bone marrow that has been damaged or destroyed by disease, infection, or chemotherapy. (medicaljump.com)
  • In such cases, stem cells can be harvested, or grown, before you start chemotherapy or radiation treatment. (medicaljump.com)
  • They typically involve harvesting your cells before beginning a damaging therapy to cells like chemotherapy or radiation. (medicaljump.com)
  • OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
  • To investigate effects of the preautografting administration of rituximab on the mobilization and engraftment of peripheral blood stem cells (PBSC), we retrospectively analyzed the outcomes of 43 newly diagnosed diffuse-large B-cell lymphoma patients who received CHOP chemotherapy with or without rituximab as a first-line treatment before autologous PBSC transplantation (PBSCT). (elsevierpure.com)
Umbilical cord2
  • The use of umbilical cord blood (UCB) has been steadily increasing, and UCB transplantation (UCBT) currently accounts for one-third of all allogeneic HCTs. (apbmt.org)
  • Nelly Zarate, a risk management framework liaison for DHR Health, was the only woman of the Umbilical cord blood contains stem cells, which can be used as an alternative to bone marrow to av C Sia · 2004 · Citerat av 6 - The generation of autoantibodies to islet cells can be observed for as many as 10 years transplant donated by diabetic HLA-identical siblings, or allogeneic donors [21, 22]. (netlify.app)
Donation21
  • Bone marrow donation can take place privately, where you directly contact a care center or transplant center caring for someone you know. (healthline.com)
  • PBSC donation involves a procedure called apheresis. (healthline.com)
  • After a blood test confirmed that she was the best match for her recipient, Gift of Life helped organize Julia's donation at a local collection center. (giftoflife.org)
  • There are two methods of donating, Peripheral Blood Stem Cell (PBSC) donation, and Bone Marrow donation. (m-umedan1.com)
  • A PBSC donation is similar to donating blood platelets. (m-umedan1.com)
  • Learn how marrow donation works, the steps of a patient transplant, steps of donation, and factors that can impact the likelihood of finding a match. (bethematch.org)
  • After bone marrow or PBSC donation, most donors are back to their normal routine in a few days. (bethematch.org)
  • Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. (childrensmercy.org)
  • It still amazes me that she was found and that they managed to get the blood marrow donation to me at the peak of COVID. (curetoday.com)
  • When it's time to donate, you'll donate blood stem cells either through a peripheral blood stem cell (PBSC) or marrow donation depending on the needs and best course of action for the patient. (curetoday.com)
  • Blood stem cell donation is almost as simple as blood donation. (kkltrust.org)
  • The department undertakes routine services like blood donation and apheresis including plateletpheresis, leukapheresis, blood grouping and Rh typing, crossmatching, Direct and Indirect Coomb's test, washed packed cells, auto-immune hemolytic anemia workup, blood component separation, Transfusion transmitted infections (TTI) testing, storage and issue of blood products. (iacr.in)
  • There is a possibility of side effects or complications Below are answers to common questions about stem cell donation. (netlify.app)
  • Female donors of child-bearing age 30 May 2020 The risks of this type of stem cell donation are minimal. (netlify.app)
  • Myth 3: Stem cell donation is inconvenient. (netlify.app)
  • Leading up to the time of the stem cell donation, most people are able to give themselves injections of filgrastim at home, so they don't need to go to the doctor every day. (netlify.app)
  • Back to top Myth 2: Making a stem cell donation is difficult and painful. (netlify.app)
  • A bone marrow donation happens in one of two ways: In the first, blood is from a donor's arm, put in a machine where stem cells are separated, and returned Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort. (netlify.app)
  • Stem cell transplantation for severe autoimmune disorders, with side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors, J Clin Apher. (netlify.app)
  • essay Research paper on cognitive technology stem cell controversy essay, essay New year's resolution essay for student blood donation camp report essay. (netlify.app)
  • This is the procedure used for a Peripheral Blood Stem Cell (PBSC) Donation. (bonemarrowtest.com)
20208
PBSCT5
  • Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • In cases of unrelated HCT, PBSC transplantation (PBSCT) still comprises only a very small percentage, which reflects the fact that unrelated PBSCT did not come into use in Japan until 2010. (apbmt.org)
  • Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
  • Larger studies are required to determine the impact of rituximab on the mobilization and function of PBSC as well as whether a survival advantage exists in patients who undergo auto-PBSCT with rituximab. (elsevierpure.com)
HSCT9
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD). (haematologica.org)
  • This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes. (sparkcures.com)
  • One needs to differentiate between tandem transplants, a planned sequence of two high dose treatments with HSCT salvage, and a second transplant, an approach of consolidating the first autologous HSCT with another HSCT ONLY if the first one appears partially effective. (cancertreatmenttoday.org)
  • Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. (lidsen.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Engraftment4
  • The patient received peripheral blood stem cells (PBSC) and had successful engraftment with complete hematological recovery. (lvhn.org)
  • Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • These results indicated no adverse effect of rituximab on the mobilization and engraftment of PBSC. (elsevierpure.com)
Outcomes6
  • We conduct research to improve transplant outcomes provide support and resources for patients, and partner with a global network. (bethematch.org)
  • For help with understanding these statistics, please see Understanding Transplant Outcomes . (bethematch.org)
  • In this month's Pharmacy SIG Literature Update: Impact of anti-T-lymphocyte globulin dosing on GVHD in MUD SCT, impact of MRD status before alloHCT on outcomes in secondary AML, low-dose post- transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of GVHD in MUD SCT and more. (astct.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • We reviewed data from 24 transplant centers in Asia, Australia, Europe, and North America to determine the outcomes of stem cell collection including methods used, cell yields, effects on disease activity, and complications in patients with autoimmune diseases. (northwestern.edu)
  • Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes. (stembook.org)
Apheresis7
  • The stem cells are collected through a procedure called apheresis, the same process used to collect several other types of blood components. (wikipedia.org)
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • During apheresis, blood comes out of your body through a needle in one arm. (healthline.com)
  • An apheresis machine will collect the needed cells from your circulating blood, then the remaining blood is returned to you. (m-umedan1.com)
  • 20x10(6)/mu l peripheral CD34+ cells after mobilization but prior to apheresis. (uni-koeln.de)
  • Poor mobilizers given plerixafor collected more CD34+ cells during the first apheresis session, leading to a decrease in the average number of apheresis sessions needed. (uni-koeln.de)
  • When corrected for patient weight and apheresis volume, progenitor cell yields tended to vary by underlying disease, prior medication history and mobilization regimen. (northwestern.edu)
Biol Blood Marrow Transplant1
Patient's6
  • The transplant physician requests one source based on the patient's circumstances. (wikipedia.org)
  • The stem cells are taken by a courier to the patient's transplant center. (wikipedia.org)
  • A bone marrow transplant takes a donor's healthy blood-forming cells and puts them into the patient's bloodstream, where they begin to grow and make healthy red blood cells, white blood cells, and platelets. (icla.org)
  • If you are chosen as the best match for a patient, the patient's doctor will request that you donate either bone marrow or peripheral blood stem cells (PBSC). (bethematch.org)
  • Once it's decided that a corneal transplant is required, the patient's name is listed at a registered centre. (artemishospitals.com)
  • A simple, painless process in which blood is drawn from a patient's or donor's arm and circulated through a filter which removes stem cells from the blood. (bonemarrowtest.com)
High dose4
Platelets3
Donors lead to more successful2
Aplastic Anemia2
  • This transplant has the potential to cure the rare condition she is battling, Severe Aplastic Anemia. (m-umedan1.com)
  • Relapsed patients who previously met hematologic criteria for severe aplastic anemia do not have to meet these hematologic criteria for severe aplastic anemia at time of relapse to be eligible for transplant. (sparkcures.com)
Regimen5
  • Toxicity or regimen-related mortality is not increased by tandem transplant," Dr Park said. (oncologynurseadvisor.com)
  • The secondary objectives are to evaluate the relapse-free and overall survival after hematopoietic stem cell transplant as well as to evaluate the incidence of acute and chronic graft-versus-host disease after this preparative regimen. (mycancergenome.org)
  • Another strategy is the incorporation of novel agents, such as thalidomide, Velcade, or Revlimid, into the treatment regimen either before or after transplant. (cancertreatmenttoday.org)
  • Preliminary results of several randomized trials comparing tandem and single autologous transplants, which have not been followed as long, have also shown superior event-free survival with the tandem regimen in most studies. (cancertreatmenttoday.org)
  • The researchers in this study aimed to investigate the effect of foot reflexology on laboratory parameters, intake/output/weight and medication regimen after kidney transplant surgery. (lidsen.com)
Transplantation in patients1
  • Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
Hematopoietic cell transplantation5
  • [ 1 ] Acute GVHD describes a distinctive syndrome of dermatitis (see the image below), hepatitis, and enteritis developing within 100 days after allogeneic hematopoietic cell transplantation (HCT). (medscape.com)
  • Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
  • Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
  • The Japanese Society of Hematopoietic Cell Transplantation (JSHCT) has been conducting a nationwide survey on HCT since 1993, in which HCTs performed at participating centers are registered with the JSHCT every year. (apbmt.org)
  • Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic cell transplantation program (Part I): Minimum requirements and beyond. (stembook.org)
Complications4
  • CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
  • What Are the Complications Associated with a Bone Marrow Transplant? (medicaljump.com)
  • The above symptoms are typically short-lived, but a bone marrow transplant can cause complications. (medicaljump.com)
  • Today, it's driving ground-breaking research to reduce post-transplant complications and improve quality of life after transplant. (anthonynolan.org)
Cyclophosphamide4
  • Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
  • Patients in the first cohort did not receive post-transplant (PT)-cyclophosphamide (Cy) and 3 patients were transplanted. (nih.gov)
  • Methods of PBSC mobilization included G-CSF (5, 10, or 16 μg/kg/day) or cyclophosphamide (2 or 4 g/m 2 ) with either G-CSF (5 or 10 μg/kg/day) or GM-CSF (5 μg/kg/day). (northwestern.edu)
  • Three patients died as a result of cyclophosphamide-based stem cell collection (2.6% of patients mobilized with cyclophosphamide). (northwestern.edu)
Type of transplant2
  • The hypothesis states that the 100 day mortality after this type of transplant will be significantly below the accepted standards, which is about 30% for unrelated donors. (mycancergenome.org)
  • Your transplant doctor will talk to you about the type of transplant and cell source that is most likely to work best for you based on your disease and other health factors. (artemishospitals.com)
Corneal transplants2
Organ transplant2
  • Cryptococcosis is a common invasive fungal infection in solid organ transplant recipients (SOTR) that can be challenging to manage. (lidsen.com)
  • Between 1997 and 2006, he studied abdominal surgery at the Peking Union Medical College Cancer Hospital under the Chinese Academy of Medical Sciences, digestive surgery at the Toyama Medical and Pharmaceutical University (now University of Toyama) in Japan, and organ transplant at the Beijing Armed Police Corps Hospital Organ Transplantation Research Institute. (chinaorganharvest.org)
Mobilization and collection4
  • This analysis aims to evaluate the effects of prolonged lenalidomide induction and isatuximab- or elotuzumab-containing quadruplet induction therapies on PBSC mobilization and collection. (biomedcentral.com)
  • The patients were evaluated based on PBSC mobilization and collection parameters, including overall collection results, CD34 + cell levels in peripheral blood, leukapheresis (LP) delays, overall number of LP sessions, and the rate of rescue mobilization with plerixafor. (biomedcentral.com)
  • However, during stem cell mobilization and -collection, no study-specific therapeutic intervention was performed. (biomedcentral.com)
  • Eligible subjects will undergo hematopoietic stem cell (HSC) mobilization and collection (leukapheresis). (ucsd.edu)
20001
  • This center has been performing allogeneic transplants since 1985 and has been an NMDP/Be The Match transplant center since February 2000. (bethematch.org)
Kidney transplant7
  • However, the risk of transmission from SARS-CoV-2 positive donors to kidney transplant recipients is unknown. (lidsen.com)
  • Fluid management intra- and post-operatively for kidney transplant recipients (KTR) is essential to maintain adequate perfusion to the kidney. (lidsen.com)
  • Its combined pancreas-kidney transplant operation in 1999 set a precedent in Shanxi Province. (chinaorganharvest.org)
  • It has also undertaken a number of kidney transplant research projects. (chinaorganharvest.org)
  • In September 2001, the hospital conducted its first pancreas-kidney transplant in collaboration with the Third Hospital of Peking University. (chinaorganharvest.org)
  • In 2006, it collaborated with the general surgery department to complete the autonomous region's first combined pancreas-kidney transplant. (chinaorganharvest.org)
  • If subject has had a kidney transplant, he or she must be at least one-year post kidney transplant status. (ucsd.edu)
Recipient4
  • A cell separating machine filters out the stem cells, which can then be infused into the recipient. (wikipedia.org)
  • Occasionally, a recipient needs an additional infusion of peripheral blood stem cells (PBSC) to help the transplant fully take hold. (giftoflife.org)
  • We discuss a case of disseminated cryptococcosis in a transplant recipient. (lidsen.com)
  • The doctor performing the transplant will decide which procedure will be used to extract the stem cells based on what he or she thinks will be best for the recipient. (netlify.app)
Allogeneic Transplant1
  • The second presentation was by Dr. Courtney Fitzhugh, M.D , Lasker Clinical Research Scholar, Laboratory of Early Sickle Mortality Prevention on the NIH Experience in Nonmyeloablative Allogeneic Transplant for SCD. (nih.gov)
Autologous transplant3
  • A tandem autologous transplant, also known as a double autologous transplant, requires the patient to undergo two planned autologous stem cell transplants within 6 months. (cancertreatmenttoday.org)
  • The issue of allogeneic after autologous transplant is reviewed under a separate heading. (cancertreatmenttoday.org)
  • Autologous Transplant - It uses your own cells which are collected from the blood stream and stored for your transplant. (artemishospitals.com)
19981
Survival5
  • For overall survival for all patients transplanted with a specific disease, please see U.S. Patient Survival report at bloodcell.transplant.hrsa.gov. (bethematch.org)
  • Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
  • The 5-year probability of overall survival (OS) after allogeneic HCT was estimated to be 56% (95% confidence interval[CI], 55%- 57%) for patients receiving a transplant while in CR, and 22% (95% CI, 21%-23%) for those who were experiencing active disease. (apbmt.org)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • For many people with blood cancers or blood disorders, receiving stem cells from a stranger is their best chance of survival. (gn.org)
20192
Undergo2
  • Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
  • Also doctors and technologists from other hospitals undergo training in plateletpheresis, PBSC harvest and BMT related activities. (iacr.in)
Lifesaving stem cell donors1
  • A gift of £10 a month could sign up three lifesaving stem cell donors every year. (anthonynolan.org)
Lymphoma6
  • Gift of Life facilitates transplants for children and adults suffering from life-threatening illnesses, including leukemia, lymphoma, other cancers and genetic diseases. (wikipedia.org)
  • A bone marrow or cord blood transplant is used to treat more than 70 diseases, including leukemia, lymphoma, and sickle cell disease. (icla.org)
  • Bone Marrow Transplant is the only cure for Thalassaemia, Aplastic Anaemia, Leukaemia (Blood Cancer), Lymphoma and Immunodeficiencies. (artemishospitals.com)
  • A stem cell transplant can be the cure for those of us with life-threatening blood cancers like leukemia and lymphoma. (curetoday.com)
  • Blood cancers such as Leukemia, lymphoma, and myeloma can be treated with a blood stem cell transplant. (kkltrust.org)
  • Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
20213
Clinical6
  • abstract： PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
  • Working in partnership with Leukaemia UK and NHS Blood and Transplant, IMPACT is launched - aiming to improve stem cell transplants through clinical trials. (anthonynolan.org)
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
  • This study is a Phase 1/2 clinical trial that will assess the safety and efficacy of enriched gene-corrected hematopoietic stem cells isolated from patients affected with cystinosis . (ucsd.edu)
Patients engrafted1
  • One of the 3 patients engrafted but lost the graft at 7 months post-transplant. (nih.gov)
20224
  • While this is rare, it does happen and Julia was asked to donate PBSC a second time in December 2022. (giftoflife.org)
  • Blood Adv. 2022. (stembook.org)
  • Blood 2022, 140: 7308-7310. (yale.edu)
  • Blood 2022, 140: 7086-7087. (yale.edu)
Infusion1
  • An A-ALC cell infusion containing 0.5 x 109 cells/kg was chosen as a cutoff to evaluate for prognosis. (astct.org)
Multiple myeloma patients1
  • While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. (biomedcentral.com)
Mononuclear1
  • mononuclear cells (PBMCs). (cdc.gov)
Diseases3
  • Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
  • This procedure is most often used to help children fighting blood cancer and other life-threatening diseases, and accounts for less than 10% of transplants. (m-umedan1.com)
  • For some diseases, transplant offers, the only potential cure but only about 25-30% patients have siblings who are eligible to be donors. (artemishospitals.com)
Cord blood transplant3
Progenitor cell1
  • Trends in the approaches to, and results of, progenitor cell mobilization are suggested by this survey. (northwestern.edu)
Recipients3
  • Rev In- including 2 renal transplant recipients fect Dis. (cdc.gov)
  • The majority of stem cell recipients rely on indwelling central venous catheters situated in superior vena cava or right atrium. (lvhn.org)
  • Despite preventative measures, including vaccination, severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection may result in severe illness, particularly in immunosuppressed transplant recipients. (lidsen.com)
Adult3
  • We at Artemis have both Adult & Paediatric transplant physicians taking care of transplant patients. (artemishospitals.com)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • PBSC mobilization was the preferred technique for adult stem cell collection in America, Australia, and Europe. (northwestern.edu)
Sickle cell di1
  • In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
ASCT3
  • Statistical analysis Statistical analysis was performed for the overall cohort and with regard to the number of reinfused CD34+ cells at ASCT. (exposed-skin-care.net)
  • vs., versus Characterization of HD/ASCT treatment according to the Baloxavir number of transplanted CD34+ cells To answer the clinically important question whether the number of transplanted CD34+ cells impacts hematopoietic reconstitution after HD/ASCT therapy and achieving homogenization, we focused on the first HD/ASCT therapy in the patients course of treatment (groups 1 and 2). (exposed-skin-care.net)
  • This trial confirmed the results of other trials that demonstrated a substantial incidence of symptomatic hypotension in MM patients in the peri-transplant period following ASCT. (astct.org)
Lymphomas1
Mortality2